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https://www.readbyqxmd.com/read/29328473/detection-of-high-grade-neoplasia-in-air-dried-cervical-pap-smears-by-a-microrna-based-classifier
#1
Mikhail K Ivanov, Sergei E Titov, Sergei A Glushkov, Victoria V Dzyubenko, Anastasia V Malek, Polina A Arkhangelskaya, Roman B Samsonov, Andrey A Mikhetko, Elena V Bakhidze, Igor V Berlev, Nikolay N Kolesnikov
Recent studies have shown that changes in the expression levels of certain microRNAs correlate with the degree of severity of cervical lesions. The aim of the present study was to develop a microRNA-based classifier for the detection of high-grade cervical intraepithelial neoplasia (CIN ≥2) in cytological samples from patients with different high-risk human papillomavirus (HR-HPV) viral loads. For this purpose, raw RT-qPCR data for 25 candidate microRNAs, U6 snRNA and human DNA in air-dried PAP smears from 174 women with different cervical cytological diagnoses, 144 of which were HR-HPV-positive [40 negative for intraepithelial lesion or malignancy (NILM), 34 low-grade squamous intraepithelial lesions (L-SIL), 57 high-grade squamous intraepithelial lesions (H-SIL), 43 invasive cancers], were statistically processed...
January 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29321123/comparative-analysis-of-women-with-notable-subjective-health-indicators-compared-with-participants-in-the-australian-longitudinal-study-on-women-s-health-cross-sectional-survey
#2
Christoph Schnelle, Eunice J Minford, Vanessa McHardy, Jane Keep
BACKGROUND: At least six communities with unusually good health and longevity have been identified, but their lifestyles aren't adopted widely. Informal evidence suggests that women associated with Universal Medicine (UM), a complementary medicine health care organization in Eastern Australia and the United Kingdom with normal lifestyles, also have several unusual health indicators. OBJECTIVE: Our objective was to determine how UM participants compared with women in the Australian population at large on a variety of health indicators...
January 10, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29315626/comparison-of-the-digene-hybrid-capture-2-and-roche-cobas-4800-hpv-tests-for-detection-of-cin2-in-a-referral-population-in-japan
#3
Toshiyuki Sasagawa, Toshiyuki Maehama, Yasuhiro Osaka, Jinichi Sakamoto, Takeo Shibata, Satoko Fujita, Masahiro Takakura, Hiroaki Takagi
To examine validity of the hybrid capture-2 and cobas 4800 HPV tests, 396 women including 188 women visiting for cancer screening, and 208 referral cases were examined with both HPV tests and the liquid-based cervical Pap test. Concordant results between the HPV assays were observed in 333 cases (coincident rates; 84.1%, kappa value; 0.682). The sensitivity for CIN2+ was 98.6% (69/70) and 82.9% (58/70) for HC2 and cobas 4800 (McNemar's test; P = 0.0026). The sensitivity for CIN3+ was 97.2% (35/36) and 83...
January 5, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29311237/evaluation-of-cpxra-as-a-therapeutic-target-for-uropathogenic-escherichia-coli-infections
#4
Lana Dbeibo, Julia J van Rensburg, Sara N Smith, Kate R Fortney, Dharanesh Gangaiah, Hongyu Gao, Juan Marzoa, Yunlong Liu, Harry L T Mobley, Stanley M Spinola
CpxRA is an envelope stress response system found in all species of Enterobacteriaceae; CpxA has kinase activity for CpxR and phosphatase activity for phospho-CpxR, a transcription factor. CpxR also accepts phosphate groups and acetyl phosphate, a glucose metabolite. Activation of CpxR increases transcription of genes encoding for membrane repair and downregulates virulence determinants. We hypothesized that activation of CpxR could serve as an antimicrobial/antivirulence strategy and discovered compounds that activate CpxR in Escherichia coli by inhibiting CpxA phosphatase activity...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29308849/postactivation-potentiation-effect-of-overloaded-cycling-on-subsequent-cycling-wingate-performance
#5
Kenji Doma, Anthony S Leicht, Moritz Schumann, Akinori Nagata, Kazuma Senzaki, Carl E Woods
BACKGROUND: This study examined the postactivation potentiation effects of overloaded cycling on subsequent Wingate performance. METHODS: Twenty anaerobic-trained men took part in this study. The participants were randomly allocated to complete three testing sessions separated by 7 days. Each week, participants either undertook a control session (CON) consisting of a sub-maximal cycling warm-up protocol followed by a Wingate test, or separate sessions involving an overloaded 10-second cycling PAP protocol followed by a Wingate test at 5 (T5) or 10 (T10) minutes, post-PAP protocol...
January 4, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29304768/long-term-lactobacillus-rhamnosus-bmx-54-application-to-restore-a-balanced-vaginal-ecosystem-a-promising-solution-against-hpv-infection
#6
Ettore Palma, Nadia Recine, Lavinia Domenici, Margherita Giorgini, Alessandra Pierangeli, Pierluigi Benedetti Panici
BACKGROUND: Over recent years, a growing interest has developed in microbiota and in the concept of maintaining a special balance between Lactobacillus and other bacteria species in order to promote women's well-being. The aim of our study was to confirm that vaginal Lactobacilli long-lasting implementation in women with HPV-infections and concomitant bacterial vaginosis or vaginitis might be able to help in solving the viral infection, by re-establishing the original eubiosis. METHODS: A total of 117 women affected by bacterial vaginosis or vaginitis with concomitant HPV-infections were enrolled at Department of Gynecological Obstetrics and Urological Sciences, La Sapienza University, Rome, Italy between February 2015 and March 2016...
January 5, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29301476/the-cutaneous-manifestations-are-significantly-related-to-cerebrovascular-in-a-serbian-cohort-of-patients-with-hughes-syndrome
#7
L Stojanovich, A Djokovic, N Stanisavljevic, M Zdravkovic
Objectives To investigate a possible relationship between cerebrovascular, such as stroke and transient ischaemic attack, and various cutaneous manifestations (livedo reticularis, skin ulcerations, pseudovasculitis lesions, superficial cutaneous necrosis and digital gangrene) in antiphospholipid syndrome (APS). This report is based on a Serbian cohort of APS patients. Methods A total of 508 antiphospholipid syndrome APS patients were assessed: 360 with primary (PAPS) and 148 with APS associated with SLE (SAPS)...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29298124/inhaled-budesonide-does-not-affect-hypoxic-pulmonary-vasoconstriction-at-4559-meter-of-altitude
#8
Marc Moritz Berger, Franziska Macholz, Peter Schmidt, Sebastian Fried, Tabea Perz, Daniel Dankl, Josef Niebauer, Peter Bärtsch, Heimo Mairbäurl, Mahdi Sareban
Berger, Marc Moritz, Franziska Macholz, Peter Schmidt, Sebastian Fried, Tabea Perz, Daniel Dankl, Josef Niebauer, Peter Bärtsch, Heimo Mairbäurl, and Mahdi Sareban. Inhaled budesonide does not affect hypoxic pulmonary vasoconstriction at 4559 m of altitude. High Alt Med Biol 00:000-000, 2017.-Oral intake of the corticosteroid dexamethasone has been shown to lower pulmonary artery pressure (PAP) and to prevent high-altitude pulmonary edema. This study tested whether inhalation of the corticosteroid budesonide attenuates PAP and right ventricular (RV) function after rapid ascent to 4559 m...
January 3, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29297754/impact-of-patient-reminders-on-papanicolaou-test-completion-for-high-risk-patients-identified-by-a-clinical-decision-support-system
#9
Kathy L MacLaughlin, Maya E Kessler, Ravikumar Komandur Elayavilli, Branden C Hickey, Marianne R Scheitel, Kavishwar B Wagholikar, Hongfang Liu, Walter K Kremers, Rajeev Chaudhry
BACKGROUND: A clinical decision support system (CDSS) for cervical cancer screening identifies patients due for routine cervical cancer screening. Yet, high-risk patients who require more frequent screening or earlier follow-up to address past abnormal results are not identified. We aimed to assess the effect of a complex CDSS, incorporating national guidelines for high-risk patient screening and abnormal result management, its implementation to identify patients overdue for testing, and the outcome of sending a targeted recommendation for follow-up...
January 3, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29295775/-antibiotics-prescription-and-complementary-tests-based-on-frequency-of-use-and-loyalty-in-primary-care
#10
Josep Vicent Balaguer Martínez, Guadalupe Del Castillo Aguas, Ana Gallego Iborra
OBJECTIVE: To assess whether there is a relationship between the prescription of antibiotics and the performance of complementary tests with frequency of use and loyalty in Primary Care. METHODS: Analytical descriptive study performed through a network of Primary Care sentinel paediatricians (PAPenRed). Each paediatrician reviewed the spontaneous visits (in Primary Care and in Emergency Departments) of 15 patients for 12 months, randomly chosen from their quota...
December 30, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29286607/limited-understanding-of-pap-smear-testing-among-women-a-barrier-to-cervical-cancer-screening-in-the-united-arab-emirates
#11
Fatima Ahmed AL-Hammadi, Fatema Al-Tahri, Asma Al-Ali, Satish C Nair, Mahera Abdulrahman
Global data indicate that cervical cancer is the fourth most common cancer among women worldwide. Important factors that affect interventions for early diagnosis of cervical cancer include social beliefs and values and poor knowledge. These may contribute to women’s participation in screening for cervical cancer and have a significant impact on decisions to take preventive action. The present study was conducted with 599 women in the UAE between September 2016 and March 2017. A cross-sectional survey was conducted to determine knowledge about cervical cancer and screening, demographic characteristics and perceived barriers...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29284236/attitudes-of-women-after-the-age-of-50-towards-preventive-screening
#12
Hanna Skórzyńska, Marlena Krawczyk-Suszek, Teresa B Kulik, Anna Pacian, Agata Stefanowicz, Anna Skowronek
INTRODUCTION: Prevention is one of the major branches of the health sector. The National Health Programme encompasses main risk factors, elimination of which may lead to a reduced incidence of illnesses in the society. At the same time, the criteria of selecting people eligible for preventive screening are established according to risk groups determined by sex, as well as age in the population of women. The perimenopausal and menopausal period contributes to occurrence of numerous systemic diseases and to an increased risk of illnesses, especially cancers...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29281865/cancer-screening-awareness-and-practice-in-a-middle-income-country-a-systematic-review-from-ira
#13
Azam Majidi, Somayye Majidi, Somayye Salimzadeh, Maryam Khazaee- Pool, Alireza Sadjadi, Hamideh Salimzadeh, Alireza Delavari
Objective: Ageing population and noticeable changes in lifestyle in developing countries like Iran caused an increase in cancer incidence. This requires organized cancer prevention and screening programs in population level, but most importantly community should be aware of these programs and willing to use them. This study explored existing evidence on public awareness and practice, as well as, adherence to cancer screening in Iranian population. Methods: Major English databases including Web of Science, PubMed, Scopus, and domestic Persian databases i...
December 28, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29277629/patterns-and-correlates-of-cervical-cancer-screening-initiation-in-a-large-integrated-healthcare-system
#14
Tracy A Becerra-Culqui, Neal M Lonky, Qiaoling Chen, Chun R Chao
BACKGROUND: The latest 2012 United States Preventive Services Task Force cervical cancer screening guidelines recommended screening initiation at age 21 years. Little is known about the cervical cancer screening initiation practices in the community, and whether there are critical gaps with respect to adherence to current clinical guidelines. Despite an overall decline in cervical cancer incidence across women of all ages, the incidence rate has not declined among 24-25 year-olds between 2000 (2...
December 22, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29277414/primary-hpv-testing-u-s-women-s-awareness-and-acceptance-of-an-emerging-screening-modality
#15
Mona Saraiya, Albert Kwan, Crystale Purvis Cooper
BACKGROUND: Primary HPV testing (without the Pap test) has recently been recommended as a cervical cancer screening option in the United States. U.S. women's awareness and acceptance of primary HPV testing were evaluated. METHODS: Data from a 2015 web-based survey of U.S. adults was examined. Analyses were limited to women who were ≥18years old, had not undergone a hysterectomy, had not been diagnosed with cervical cancer, and would accept cervical cancer screening (N=1309)...
December 22, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29276057/racial-ethnic-differences-in-hpv-16-18-genotypes-and-integration-status-among-women-with-a-history-of-cytological-abnormalities
#16
J R Montealegre, E C Peckham-Gregory, D Marquez-Do, L Dillon, M Guillaud, K Adler-Storthz, M Follen, M E Scheurer
OBJECTIVE: HPV genotype distribution varies by race/ethnicity, but is unclear whether there are racial/ethnic variations in HPV 16/18 integration in the host genome. We describe HPV16/18 infection and integration status in a racially/ethnically diverse sample of women with a recent abnormal Pap test. METHODS: Patients (n=640) represent a subset of women participating in a clinical trial. Cervical swabs were tested for HPV16/18 DNA using type-specific polymerase chain reaction assays...
December 21, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29259388/genital-tract-infections-in-an-isolated-community-100-women-of-the-pr%C3%A3-ncipe-island
#17
Pedro Vieira-Baptista, Svitrigaile Grinceviciene, Gert Bellen, Carlos Sousa, Conceição Saldanha, Davy Vanden Broeck, John-Paul Bogers, Gilbert Donders
Objective: To characterize the vaginal microbiome and the rate of sexually transmitted infections (STIs) in the women of Príncipe (São Tomé and Príncipe). Methods: Cross-sectional study of 100 consecutive women, invited for a free appointment and cervical cancer screening. A vaginal slide (wet mount microscopy) and a cervical sample (ThinPrep®) (Pap test, high risk human papillomavirus [HR-HPV], N. gonorrhea [NG], T. vaginalis [TV], and C. trachomatis [CT]) were obtained...
2017: Infectious Diseases in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29251578/risk-factors-for-abnormal-cervical-cytology-in-women-undergoing-kidney-transplant-evaluation
#18
Kevin V Chaung, Yu Zheng, Anthony T Martella, Jordan B Stoecker, Devan R Cote, Joshua J Augustine, Edmund Q Sanchez, Vanessa R Humphreville, John B Ammori, Kenneth J Woodside
OBJECTIVES: Cervical cytology screening has been successful in reducing deaths from cervical cancer. We sought to determine risk factors for abnormal Pap test results in women undergoing kidney transplant evaluation. MATERILAS AND METHODS: We retrospectively examined women undergoing kidney transplant evaluations from 2008 to 2011. Patients were stratified based on normal cytology and atypical/malignant cytology. RESULTS: Of 404 patients, 293 patients (72...
December 18, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29249573/cervical-cancer-screening-among-lebanese-women
#19
I R Bou-Orm, R E Sakr, S M Adib
BACKGROUND: Cervical cancer is a very common malignancy amongst women worldwide. Pap smear is an effective and inexpensive screening test in asymptomatic women. The aim of this paper was to assess the prevalence of Pap smear screening for cervical cancer among Lebanese women and to determine associated sociodemographic and psychosocial characteristics. METHODS: This national survey included 2255 women, selected by multi-stage random cluster sampling across Lebanon...
December 14, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/29245055/high-proportion-of-abnormal-pap-smear-tests-and-cervical-dysplasia-in-women-with-cystic-fibrosis
#20
Christine Rousset-Jablonski, Quitterie Reynaud, Raphaëlle Nove-Josserand, Isabelle Ray-Coquard, Yahia Mekki, François Golfier, Isabelle Durieu
OBJECTIVES: Insufficient gynecological follow-up and cervical screening has been reported in women with cystic fibrosis (CF). Some of these patients will require a pulmonary transplantation, known to be associated with a higher risk of cervical dysplasia. The aim of this study was to explore the results of cervical screening in adult women with CF, and to report the prevalence of abnormal pap smear tests in this population. STUDY DESIGN: We retrospectively analyzed medical records of sexually active women with CF who attended a gynecological consultation in Lyon University CF referral center between June 2014 and December 2015...
December 9, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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