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Epicardial adipose tissue measurement

Kyoung Im Cho, Jung Ho Heo, Hyun Soo Kim, Sung Il Im, Tae Joon Cha
OBJECTIVE: Epicardial fat tissue reflects visceral adiposity and inflammation, and neutrophil to lymphocyte ratio (NLR) has been investigated as important inflammatory marker in cardiovascular disease. We aimed to investigate the relationship of echocardiographic epicardial fat thickness (EFT) and NLR with diurnal blood pressure (BP) changes in patients with recently diagnosed essential hypertension. DESIGN AND METHOD: A total of 647 hypertensive patients underwent echocardiography and 24-hours ambulatory BP monitoring...
September 2016: Journal of Hypertension
Arnold C T Ng, Shi Yi Goo, Nicole Roche, Rob J van der Geest, William Y S Wang
BACKGROUND: Although epicardial adipose tissue (EAT) volume is associated with increased incidence of coronary artery disease (CAD), its role in myocardial systolic dysfunction is unclear. The present study aimed to identify independent determinants of EAT volume in patients without obstructive CAD, and to evaluate the association between EAT volume (vs other measures of obesity) and myocardial systolic strain analysis. METHODS: We prospectively recruited 130 patients without obstructive CAD on contrast-enhanced cardiac computed tomography imaging and normal left ventricular ejection fraction on 3-dimensional (3D) echocardiography...
June 23, 2016: Canadian Journal of Cardiology
Mustafa Topuz, Ali Dogan
BACKGROUND: The aim of this study is to evaluate the effect of epicardial adipose tissue (EAT) thickness on left ventricular diastolic functions in patients with normal coronary arteries (NCA) proven by angiography. METHODS: We selected study patients who were referred to coronary angiography due to typical chest pain or atypical chest pain with a positive pre-test result for coronary artery disease. After coronary angiography, 85 patients had significant coronary lesion (≥50% stenosis) served as coronary artery disease (CAD) group, 82 patients had non-significant coronary lesion (<50% stenosis) and/or a coronary plaque served as non-significant CAD group and 83 patients had normal coronary arteries served as normal coronary artery (NCA) group...
October 7, 2016: Kardiologia Polska
Murat Ziyrek, Sinan Şahin, Emrah Özdemir, Zeydin Acar, Serkan Kahraman
OBJECTIVE: Atherosclerotic coronary artery disease is a leading cause of death, worldwide. Diagonal earlobe crease (DELC) has been suggested as a simple, noninvasive marker of cardiovascular disease. Although epicardial adipose tissue (EAT) thickness and carotid intima media thickness (CIMT) are closely related to atherosclerosis, the relation between EAT, CIMT, and DELC had yet to be studied. The present objective was to analyze this association. METHODS: Subjects were apparently healthy individuals referred to the cardiology outpatient clinic...
September 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Alexander Norlén, Jennifer Alvén, David Molnar, Olof Enqvist, Rauni Rossi Norrlund, John Brandberg, Göran Bergström, Fredrik Kahl
Recent findings indicate a strong correlation between the risk of future heart disease and the volume of adipose tissue inside of the pericardium. So far, large-scale studies have been hindered by the fact that manual delineation of the pericardium is extremely time-consuming and that existing methods for automatic delineation lack accuracy. An efficient and fully automatic approach to pericardium segmentation and epicardial fat volume (EFV) estimation is presented, based on a variant of multi-atlas segmentation for spatial initialization and a random forest classifier for accurate pericardium detection...
July 2016: Journal of Medical Imaging
Kyoung Im Cho, Jung Ho Heo, Hyun Soo Kim, Sung Il Im, Tae Joon Cha
OBJECTIVE: Epicardial fat tissue reflects visceral adiposity and inflammation, and neutrophil to lymphocyte ratio (NLR) has been investigated as important inflammatory marker in cardiovascular disease. We aimed to investigate the relationship of echocardiographic epicardial fat thickness (EFT) and NLR with diurnal blood pressure (BP) changes in patients with recently diagnosed essential hypertension. DESIGN AND METHOD: A total of 647 hypertensive patients underwent echocardiography and 24-hours ambulatory BP monitoring...
September 2016: Journal of Hypertension
Cihan Altin, Leyla Elif Sade, Esin Gezmis, Mustafa Yilmaz, Necmi Ozen, Haldun Muderrisoglu
BACKGROUND: Metabolic syndrome is a combination of multiple cardiovascular (CV) risk factors including insulin resistance (IR). Carotid, femoral intima media thickness (IMT), and epicardial fat thickness (EFT) are considered as novel cardiometabolic risk factors. We aimed to test the hypothesis that carotid, femoral IMT, and EFT are increased in patients with IR. METHODS: We enrolled consecutively and prospectively 113 patients with IR. Then we collected data from an age- and sex-matched control group of 112 individuals without IR...
September 6, 2016: Journal of Cardiology
Sinan Altan Kocaman, Oben Baysan, Mustafa Çetin, Tuğba Kayhan Altuner, Ezgi Polat Ocaklı, Murtaza Emre Durakoğlugil, Turan Erdoğan, Mustafa Remzi Karaoğuz
OBJECTIVE: Carotid intima-media thickness (CIMT) is reliable marker of subclinical atherosclerosis and cardiovascular events. Until today, there was no study that investigated whether epicardial adipose tissue (EAT), which is a surrogate for lipid depot in a special visceral tissue or circulating lipids, is more important for CIMT and atherosclerotic plaque. METHODS: Our study, having cross-sectional and prospective observational design, included 252 patients who were admitted to our outpatient clinic...
August 23, 2016: Anatolian Journal of Cardiology
Inmaculada Moreno-Santos, Luis Miguel Pérez-Belmonte, Manuel Macías-González, María José Mataró, Daniel Castellano, Miguel López-Garrido, Carlos Porras-Martín, Pedro L Sánchez-Fernández, Juan José Gómez-Doblas, Fernando Cardona, Eduardo de Teresa-Galván, Manuel Jiménez-Navarro
BACKGROUND: Although recent studies indicate that epicardial adipose tissue expresses brown fat-like genes, such as PGC1α, UCP1 and PRDM16, the association of these genes with type 2 diabetes mellitus (DM2) in coronary artery disease (CAD) remains unknown. METHODS: PGC1α, UCP1, and PRDM16 mRNAs expression levels were measured by real-time PCR in epicardial and thoracic subcutaneous adipose tissue from 44 CAD patients (22 with DM2 [CAD-DM2] and 22 without DM2 [CAD-NDM2]) and 23 non-CAD patients (NCAD)...
2016: Journal of Translational Medicine
Elena Dozio, Silvia Briganti, Alessandra Delnevo, Elena Vianello, Federica Ermetici, Francesco Secchi, Francesco Sardanelli, Lelio Morricone, Alexis E Malavazos, Massimiliano M Corsi Romanelli
PURPOSE: Soluble receptor for advanced glycation end products (sRAGE) is a decoy receptor which sequesters RAGE ligands and acts as a cytoprotective agent. To date, it is unclear whether the lower sRAGE levels observed in obesity are a marker of increased overall adiposity or reflect increases in particular fat depots. Therefore, we evaluated in healthy women the relationship among sRAGE and indicators of adiposity, including abdominal visceral (VAT) and epicardial visceral (EAT) adipose tissues, to explore the potential role of sRAGE as an earlier biomarker of cardiometabolic risk...
August 13, 2016: European Journal of Nutrition
Talal S Alnabelsi, Yaser Alhamshari, Ramzi H Mulki, Jose N Codolosa, Nikoloz Koshkelashvili, Igor Goykhman, Gregg S Pressman, Abel Romero-Corral
Epicardial adipose tissue (EAT) has been linked to coronary artery calcium deposits and atherosclerotic disease. Mitral annular (MAC) and aortic valve calcium (AVC) have also been associated with atherosclerosis. This study examined the possible relation between EAT thickness and valvular calcium deposits. We included 294 patients aged ≥65 years who had noncontrast computed tomography scans of the chest. Mean age was 76 ± 7 years; 47% were men. Using reconstructed images, EAT thickness was measured at various locations...
October 1, 2016: American Journal of Cardiology
Juan Serrano-Ferrer, Edward Crendal, Guillaume Walther, Agnes Vinet, Frédéric Dutheil, Geraldine Naughton, Bruno Lesourd, Robert Chapier, Daniel Courteix, Philippe Obert
AIMS: The purpose of our study was to determine the effect of lifestyle intervention on left ventricular (LV) regional myocardial function in patients with metabolic syndrome (MetS) and investigate the relationships of the changes in myocardial function to changes in epicardial adipose tissue (EAT), inflammatory profile and MetS components. METHODS: Eighty-seven MetS patients were enrolled in a 6month lifestyle intervention program based on dietary management and increased physical activity, and compared with 44 aged and sex-matched healthy controls...
September 2016: Metabolism: Clinical and Experimental
Sirous Darabian, Jye-Yu C Backlund, Patricia A Cleary, Nasim Sheidaee, Ionut Bebu, John M Lachin, Matthew J Budoff
INTRODUCTION: Type 1 diabetes (T1DM) patients are at increased risk of coronary artery disease (CAD). This pilot study sought to evaluate the relationship between epicardial adipose tissue (EAT) and intra-thoracic adipose tissue (IAT) volumes and cardio-metabolic risk factors in T1DM. METHOD: EAT/IAT volumes in 100 patients, underwent non-contrast cardiac computed tomography in the Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study were measured by a certified reader...
2016: PloS One
Amir A Mahabadi, Nils Lehmann, Stefan Möhlenkamp, Noreen Pundt, Iryna Dykun, Ulla Roggenbuck, Susanne Moebus, Karl-Heinz Jöckel, Raimund Erbel, Hagen Kälsch
OBJECTIVES: The aim of this study was to determine whether noncoronary measures from cardiac computed tomography (CT) may enhance the prognostic value of this imaging technology. BACKGROUND: When cardiac CT is performed for quantification of coronary artery calcium (CAC) score, information on other cardiac and thoracic structures is available. METHODS: Participants without known cardiovascular disease from the prospective population based Heinz Nixdorf Recall study underwent noncontrast cardiac CT for CAC score quantification...
October 2016: JACC. Cardiovascular Imaging
Ken Harada, Rei Shibata, Noriyuki Ouchi, Yoshiyuki Tokuda, Hiroshi Funakubo, Mayu Suzuki, Takashi Kataoka, Tomoyuki Nagao, Satoshi Okumura, Norihiro Shinoda, Bunichi Kato, Shinichi Sakai, Masataka Kato, Nobuyuki Marui, Hideki Ishii, Tetsuya Amano, Tatsuaki Matsubara, Toyoaki Murohara
BACKGROUND AND AIMS: Omentin, an adipocytokine secreted by visceral adipose tissue, protects against obesity-linked cardiovascular complications. However, little is known about its role in epicardial adipose tissue (EAT) and coronary artery disease (CAD). We investigated the expression of omentin in EAT from CAD subjects. METHODS: EAT, subcutaneous adipose tissue (SCAT), and plasma samples were collected from CAD (n = 15; 23.3 ± 3.1 kg/m(2)) and non-CAD patients (n = 10; 20...
August 2016: Atherosclerosis
Tsuyoshi Ito, Hiroshi Fujita, Taku Ichihashi, Nobuyuki Ohte
OBJECTIVE: Endothelial dysfunction of the coronary artery is thought to lead to the development of coronary spasms. Epicardial adipose tissue may be a marker of coronary atherosclerosis. This study investigated the diagnostic impact of epicardial fat volume (EFV), quantified with non-contrast electrocardiogram (ECG)-gated computed tomography (CT), on ergonovine-induced coronary spasms. METHODS: We included 97 patients with suspected coronary spastic angina who underwent ECG-gated CT and an ergonovine provocation test...
October 15, 2016: International Journal of Cardiology
Fatma Uysal, Erdem Akbal, Ayla Akbal, Sibel Cevizci, Kasım Arık, Emine Gazi
OBJECTIVES: Patients with inflammatory bowel disease (IBD) have high cardiovascular morbidity, and, in general, epicardial adipose tissue thickness is related to atherosclerotic vascular disease. This study aimed to investigate the association between epicardial adipose tissue thickness and carotid intima-media thickness as markers of early atherosclerosis in patients with IBD. METHODS: The study comprised 47 patients with IBD (25 with Crohn disease and 22 with ulcerative colitis) and 35 control participants...
September 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Yu Du, Qingwei Ji, Lun Cai, Fangjiong Huang, Yongqiang Lai, Yue Liu, Jianbo Yu, Bo Han, Enjun Zhu, Jinwei Zhang, Yujie Zhou, Zhijian Wang, Yingxin Zhao
BACKGROUND: Omentin-1, a novel adipocytokine mainly expressed in visceral adipose tissue, has been found to inhibit the inflammatory response and improve insulin resistance as well as other obesity-related disorders. This study investigated the association between omentin-1 expression in human epicardial adipose tissue (EAT) and coronary atherosclerosis. METHODS: Serum samples, and paired biopsies from EAT and subcutaneous adipose tissue (SAT), were obtained from patients with and without coronary artery disease (CAD, n = 28 and NCAD, n = 12, respectively) during elective cardiac surgery...
2016: Cardiovascular Diabetology
Bai-Chin Lee, Wen-Jeng Lee, Shyh-Chyi Lo, Hsiu-Ching Hsu, Kuo-Liong Chien, Yeun-Chung Chang, Ming-Fong Chen
The association between epicardial fat and coronary artery disease (CAD) might be affected by general adiposity. We aimed to determine whether the percentage of epicardial adipose tissue (%EAT), defined as the mass ratio of epicardial fat to body fat, could improve prediction of asymptomatic CAD. We consecutively enrolled 846 adults who underwent coronary computed tomography angiography as part of a health check-up and assessed their coronary stenosis severity and epicardial fat mass. Body fat mass was measured by bioelectrical impedance analysis...
June 2016: International Journal of Cardiovascular Imaging
Michael T Lu, Jakob Park, Khristine Ghemigian, Thomas Mayrhofer, Stefan B Puchner, Ting Liu, Jerome L Fleg, James E Udelson, Quynh A Truong, Maros Ferencik, Udo Hoffmann
BACKGROUND AND AIMS: To determine whether epicardial (EAT) and paracardial adipose tissue (PAT) volume and attenuation are associated with high-risk coronary plaque features. METHODS: In subjects with suspected acute coronary syndrome (ACS) enrolled in the ROMICAT II trial, EAT and PAT volumes indexed to body surface area (BSA) and attenuation were measured on non-contrast coronary artery calcium score (CACS) CT. High-risk plaque features (napkin-ring sign, positive remodeling, low density plaque, spotty calcium) and stenosis were assessed on coronary CT angiography (CTA)...
August 2016: Atherosclerosis
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