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https://www.readbyqxmd.com/read/28923693/novel-paclitaxel-coated-scoring-ballon-for-de-novo-complex-coronary-lesions-first-report
#1
Gaetano di Palma, Bernardo Cortese
Drug-coated balloons (DCB) are being used for in-stent restenosis treatment and there is some preliminary experience in other coronary settings, including small vessels and side branches. Scoring balloons (SB) are a useful tool for the preparation of fibro-calcific lesions. Because of the controlled micro-dissections that SB induce, it has been hypothesized that they may have a role in helping paclitaxel deliverability inside the vessel wall. The AngioSculpt®X (Spectranetics) is a novel paclitaxel-coated SB with encouraging preliminary data for the treatment of in-stent restenosis...
August 12, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28916599/directional-atherectomy-followed-by-a-paclitaxel-coated-balloon-to-inhibit-restenosis-and-maintain-vessel-patency-twelve-month-results-of-the-definitive-ar-study
#2
Thomas Zeller, Ralf Langhoff, Krishna J Rocha-Singh, Michael R Jaff, Erwin Blessing, Beatrice Amann-Vesti, Marek Krzanowski, Patrick Peeters, Dierk Scheinert, Giovanni Torsello, Sebastian Sixt, Gunnar Tepe
BACKGROUND: Studies assessing drug-coated balloons (DCB) for the treatment of femoropopliteal artery disease are encouraging. However, challenging lesions, such as severely calcified, remain difficult to treat with DCB alone. Vessel preparation with directional atherectomy (DA) potentially improves outcomes of DCB. METHODS AND RESULTS: DEFINITIVE AR study (Directional Atherectomy Followed by a Paclitaxel-Coated Balloon to Inhibit Restenosis and Maintain Vessel Patency-A Pilot Study of Anti-Restenosis Treatment) was a multicenter randomized trial designed to estimate the effect of DA before DCB to facilitate the development of future end point-driven randomized studies...
September 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28916429/incidence-and-predictors-of-recurrent-restenosis-after-drug-coated-balloon-angioplasty-for-restenosis-of-a-drug-eluting-stent-the-icarus-cooperation
#3
Salvatore Cassese, Bo Xu, Seiji Habara, Harald Rittger, Robert A Byrne, Matthias Waliszewski, María José Pérez-Vizcayno, Runlin Gao, Adnan Kastrati, Fernando Alfonso
INTRODUCTION AND OBJECTIVES: The incidence and predictors of recurrent restenosis after drug-coated balloon (DCB) angioplasty for drug-eluting stent (DES) restenosis remain poorly studied. We sought to evaluate the incidence and predictors of recurrent restenosis among participants in randomized controlled trials receiving DCB angioplasty for DES restenosis. METHODS: The clinical and lesion data of individuals enrolled in 6 randomized controlled trials of DCB angioplasty for DES restenosis were pooled...
September 12, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28902718/effect-of-drug-coated-balloon-on-stent-restenosis-neointimal-proliferation-and-coronary-dissection-an-optical-coherence-tomography-analysis
#4
Taku Fukushima, Takashi Ashikaga, Shunji Yoshikawa, Yu Hatano, Daisuke Ueshima, Takanobu Yamamoto, Maejima Yasuhiro, Mitsuaki Isobe
AIM: The aim of this study was to assess the acute and mid-term effects of drug-coated balloon (DCB) in terms of the healing process of non-flow-limiting dissections and changes in the neointimal area after DCB treatment using frequency domain optical coherence tomography (FD-OCT). PATIENTS AND METHODS: Thirty-six consecutive patients with in-stent restenosis pretreated with a scoring balloon were evaluated (19 and 17 patients with and without a DCB, respectively)...
September 11, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28891165/drug-coated-balloons-do-they-still-have-a-role-in-treating-coronary-artery-disease
#5
EDITORIAL
Wassim Shatila, Zvonimir Krajcer
Small vessels with coronary artery disease (CAD) are at high risk of restenosis, despite the use of drug-eluting stents (DESs). Drug-coated balloon (DCB) therapy offers a viable alternative to DESs for the management of small vessel CAD. The literature regarding the use of DCBs in lieu of the newer generation DESs to treat small vessel CAD is controversial.
September 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28844032/state-of-the-art-coronary-artery-stents-past-present-and-future
#6
Giulio G Stefanini, Robert A Byrne, Stephan Windecker, Adnan Kastrati
The first percutaneous coronary intervention (PCI) was performed in September 1977 by Andreas Grüntzig using a rudimentary balloon angioplasty catheter mounted on a fixed wire. PCI was immediately recognised as a potential breakthrough in cardiovascular medicine, but uptake in clinical practice was limited by unpredictable acute outcomes and a need for surgical standby. The introduction of bare metal stents (BMS) in the 1980s improved procedure reproducibility and clinical outcomes through a permanent scaffolding of the coronary vessel, preventing abrupt occlusion and acute recoil...
August 25, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28844030/state-of-the-art-balloon-catheter-technologies-drug-coated-balloon
#7
Fernando Alfonso, Bruno Scheller
Four decades after its introduction into clinical practice, coronary balloon angioplasty is still used during most coronary interventions. Conventional balloon angioplasty is frequently used to predilate complex or severe lesions and remains of major value to optimise the results of stent implantation. Plain balloon angioplasty is still used alone in some anatomic scenarios where stent implantation is not desirable (very small vessels or diffuse lesions, large resistant thrombus burden, side branches of bifurcations)...
August 25, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28843789/in%C3%A2-vitro-particulate-and-in%C3%A2-vivo-drug-retention-study-of-a-novel-polyethylene-oxide-formulation-for-drug-coated-balloons
#8
Jordan A Anderson, Sujan Lamichhane, Thomas Vierhout, Andrea Sherman, Daniel Engebretson, Kathryn Pohlson, Tyler Remund, Patrick Kelly
OBJECTIVE: The purpose of this study was to investigate the newly developed drug-coated balloon (DCB) using polyethylene oxide (PEO) as a platform and to compare it directly with a commercially available DCB in a preclinical experimental setting. METHODS: The PEO balloon was characterized for coating morphology and degree of paclitaxel (PAT) crystallinity. PAT tissue levels were then measured up to 30 days in a healthy porcine model (10 swine, 20 vessels) after treatment with either a PEO balloon or a commercially available DCB...
August 23, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28840466/advances-in-percutaneous-therapies-for-peripheral-artery-disease-drug-coated-balloons
#9
REVIEW
Rasha F Al-Bawardy, Stephen W Waldo, Kenneth Rosenfield
PURPOSE OF REVIEW: This review paper provides a summary on the use of drug-coated balloons in peripheral artery disease. It covers the main drug-coated balloon (DCB) trials. It is divided into categories of lesions: superficial femoral artery and popliteal lesions, infra-popliteal lesions and in-stent restenosis. It also includes an overview of the future of DCBs, highlighting the main ongoing trials. RECENT FINDINGS: The latest research on DCB focuses on newer types of DCBs, mainly paclitaxel-coated but with lower doses...
August 24, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28837370/drug-delivering-endovascular-treatment-versus-angioplasty-in-artery-occlusion-diseases-a-systematic-review-and-meta-analysis
#10
Xudong Chen, Jianhui Li, Chengfei Zheng, Yunjun He, Junjun Jia, Xiaohui Wang, Donglin Li, Tao Shang, Ming Li
OBJECTIVE: The best management of patients with femoropopliteal and infrapopliteal artery occlusion disease is not clear. This study aimed to compare the efficacy of drug-coated balloons (DCB) and drug-eluting stents (DES) with percutaneous transluminal angioplasty (PTA) in patients with femoropopliteal or infrapopliteal arterial occlusive disease. METHODS: Medline, Cochrane, EMBASE, and Google Scholar databases were searched for randomized controlled trials from January 1, 2000 until June 30, 2016...
August 24, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28830751/treatment-of-de-novo-coronary-artery-bifurcation-lesions-with-drug-coated-balloons-a-reappraisal-according-to-the-available-scientific-data
#11
REVIEW
Marco Zuin, Gianluca Rigatelli
The treatment of coronary artery bifurcation often represents a challenge for interventional cardiologist. Although several stenting techniques are available for the treatment of de novo coronary bifurcation lesions, over the last years, different studies have proposed and analysed the use of drug-coated balloon (DCB) in the treatment of coronary artery bifurcation lesions as an alternative treatment. To date, even considering those studies which have analysed a combined strategy (DCB+stenting) or a DCB-only approach, the evidences are scant and the results debatable...
July 11, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28808934/a-drug-coated-balloon-effectively-treated-in-stent-restenosis-due-to-a-stent-fracture
#12
Yusuke Oba, Hiroshi Funayama, Motoki Fukutomi, Kazuomi Kario
No abstract text is available yet for this article.
August 14, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28780037/drug-coated-balloons-for-treatment-of-femoropopliteal-disease-a-step-toward-an-elusive-goal
#13
EDITORIAL
Ivan P Casserly
No abstract text is available yet for this article.
July 27, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28780030/the-24-month-results-of-the-lutonix%C3%A2-global-sfa-registry-worldwide-experience-with%C3%A2-lutonix%C3%A2-drug-coated-balloon
#14
Marcus Thieme, Peter Von Bilderling, Christian Paetzel, Dimitrios Karnabatidis, Julio Perez Delgado, Michael Lichtenberg
OBJECTIVES: The Global SFA Registry sought to assess safety, clinical benefit, and outcomes of the Lutonix 035 drug-coated balloon (DCB) in a heterogeneous, real-world patient population at 12 and 24 months. BACKGROUND: Numerous clinical studies have evaluated the use of angioplasty for revascularization of femoropopliteal arteries in peripheral arterial disease with restenosis rates of 40% to 60% at 6 to 12 months. Data from recent studies document decreased restenosis rates and improvement in patency in patients receiving angioplasty of femoropopliteal arteries with DCBs...
August 28, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28779784/drug-coated-balloon-angioplasty-for-dialysis-access-fistula-stenosis
#15
REVIEW
Auréline Boitet, Ziad A Massy, Olivier Goeau-Brissonniere, Isabelle Javerliat, Marc Coggia, Raphaël Coscas
Maintaining vascular access patency represents a tremendous challenge in hemodialysis patients. Although "native" arteriovenous fistula (AVF) is currently recommended as primary vascular access, neointimal hyperplasia stenoses frequently develop, with a risk for AVF thrombosis and vascular access loss. For years, first-line treatment of AVFs stenoses has been percutaneous transluminal angioplasty, generally with high-pressure or cutting uncoated balloons. However, restenosis and reintervention rates remain incredibly high and occur, according to recent studies, in up to 60% and 70% of patients at 6 and 12 months, respectively...
December 2016: Seminars in Vascular Surgery
https://www.readbyqxmd.com/read/28763816/-drug-coated-balloons-and-stents-for-the-treatment-of-femoro-popliteal-lesions
#16
Wulf D Ito
No abstract text is available yet for this article.
August 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28735251/drug-coated-balloons-and-in-stent-restenosis-a-new-tale-of-an-old-story
#17
Roberto Nerla, Antonio Micari, Alberto Cremonesi
No abstract text is available yet for this article.
July 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28729250/stellarex-drug-coated-balloon-for-treatment-of-femoropopliteal-disease-12-month-outcomes-from-the-randomized-illumenate-pivotal-and-pharmacokinetic-studies
#18
Prakash Krishnan, Peter Faries, Khusrow Niazi, Ash Jain, Ravish Sachar, William B Bachinsky, Joseph A Cardenas, Martin Werner, Marianne Brodmann, J A Mustapha, Carlos I Mena-Hurtado, Michael R Jaff, Andrew H Holden, Sean P Lyden
Background -Drug-coated balloons (DCB) are a predominant revascularization therapy for symptomatic femoropopliteal artery disease. Due to differences in excipients, paclitaxel dose and coating morphologies, varying clinical outcomes have been observed with different DCBs. We report the results of two studies investigating the pharmacokinetic (PK) and clinical outcomes of a new DCB to treat femoropopliteal disease. Methods -In the ILLUMENATE Pivotal Study, 300 symptomatic patients (Rutherford class 2-4), were randomized to DCB (N=200) or standard angioplasty (PTA) (N=100)...
July 20, 2017: Circulation
https://www.readbyqxmd.com/read/28722253/late-lumen-enlargement-induced-by-drug-coated-balloon-in-the-patient-with-ptfe-covered-stent-restenosis
#19
Takayuki Warisawa, Toru Naganuma, Sunao Nakamura
We report a case of percutaneous coronary intervention with drug coated balloon (DCB) for the in-stent restenosis of polytetrafluoroethylene-covered stent. One year follow-up angiography was excellent and in-stent lumen enlargement compared with the postprocedure and 6-months follow-up was demonstrated by optical coherent tomography. This case suggested the utility of DCB as a therapeutic option for covered-stent restenosis.
July 19, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28715513/percutaneous-endovascular-treatment-of-infrainguinal-paod-results-of-the-psi-register-study-in-74%C3%A2-german-vascular-centers
#20
C-A Behrendt, F Heidemann, K Haustein, R T Grundmann, E S Debus
BACKGROUND: The percutaneous infrainguinal stent (PSI) register study aimed to collate all percutaneous endovascular procedures for infrainguinal peripheral arterial occlusive disease (PAOD) conducted in 74 German vascular centers between September and November 2015 (3 months). In order to obtain representative results all consecutive treatment procedures had to be submitted by the participating trial centers. MATERIAL AND METHODS: This was a prospective, nonrandomized multicenter study design...
2017: Gefässchirurgie: Zeitschrift Für Vaskuläre und Endovaskuläre Chirurgie
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