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https://www.readbyqxmd.com/read/29765419/low-magnitude-of-compression-enhances-biosynthesis-of-mesenchymal-stem-cells-towards-nucleus-pulposus-cells-via-the-trpv4-dependent-pathway
#1
Yibo Gan, Bing Tu, Pei Li, Jixing Ye, Chen Zhao, Lei Luo, Chengmin Zhang, Zetong Zhang, Linyong Zhu, Qiang Zhou
Mesenchymal stem cell- (MSC-) based therapy is regarded as a promising tissue engineering strategy to achieve nucleus pulposus (NP) regeneration for the treatment of intervertebral disc degeneration (IDD). However, it is still a challenge to promote the biosynthesis of MSC to meet the requirement of NP regeneration. The purpose of this study was to optimize the compressive magnitude to enhance the extracellular matrix (ECM) deposition towards discogenesis of MSCs. Thus, we constructed a 3D culture model for MSCs to bear different magnitudes of compression for 7 days (5%, 10%, and 20% at the frequency of 1...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29765022/tissue-and-cellular-rigidity-and-mechanosensitive-signaling-activation-in-alexander-disease
#2
Liqun Wang, Jing Xia, Jonathan Li, Tracy L Hagemann, Jeffrey R Jones, Ernest Fraenkel, David A Weitz, Su-Chun Zhang, Albee Messing, Mel B Feany
Glial cells have increasingly been implicated as active participants in the pathogenesis of neurological diseases, but critical pathways and mechanisms controlling glial function and secondary non-cell autonomous neuronal injury remain incompletely defined. Here we use models of Alexander disease, a severe brain disorder caused by gain-of-function mutations in GFAP, to demonstrate that misregulation of GFAP leads to activation of a mechanosensitive signaling cascade characterized by activation of the Hippo pathway and consequent increased expression of A-type lamin...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29764867/3d-fibrin-stiffness-mediates-dormancy-of-tumor-repopulating-cells-via-a-cdc42-driven-tet2-epigenetic-program
#3
Yuying Liu, Jiadi Lv, Xiaoyu Liang, Xiaonan Yin, Le Zhang, Degao Chen, Xun Jin, Roland Fiskesund, Ke Tang, Jingwei Ma, Huafeng Zhang, Wenqian Dong, Siqi Mo, Tianzhen Zhang, Feiran Cheng, Yabo Zhou, Jing Xie, Ning Wang, Bo Huang
Dormancy is recognized as a critical biological event for tumorigenic cells surviving in an extremely harsh environment. Understanding the molecular process of dormancy can unlock novel approaches to tackle cancers. We recently reported that stem-like tumor-repopulating cells (TRC) sense mechanical signals and rapidly proliferate in a 90 Pa soft fibrin matrix. Here we show that a stiff mechanical environment induces TRC dormancy via an epigenetic program initiated by translocation of Cdc42, a cytosolic regulator of mechanotransduction, into the nucleus, where it promotes transcription of hydroxymethylating enzyme Tet2...
May 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29761955/-effect-of-artery-pulse-on-the-osteonal-interstitial-fluid-flow-behavior
#4
Xiaogang Wu, Ningning Wang, Haipeng Cen, Zhaowei Wang, Weilun Yu, Kuijun Chen, Yanan Xue, Yanqin Wang, Yuan Guo, Weiyi Chen
There are two main types of fluid in bone tissue: blood and interstitial fluid. The metabolism of cells mainly relies on the microenvironment of the interstitial fluid. Researches of osteonal fluid seepage behavior based on the microstructure of bone tissue have become a hot point. The aim of the present research work is to assess the effect of blood pressure oscillation on the osteonal interstitial fluid seepage behavior. We established finite element osteon models for a hollow and that considering blood pressure oscillation, respectively, with COMSOL Multiphysics software in order to compare their fluid flow behavior under the axial loading...
August 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29755320/mechanically-gated-ion-channels-in-mammalian-hair-cells
#5
REVIEW
Xufeng Qiu, Ulrich Müller
Hair cells in the inner ear convert mechanical stimuli provided by sound waves and head movements into electrical signal. Several mechanically evoked ionic currents with different properties have been recorded in hair cells. The search for the proteins that form the underlying ion channels is still in progress. The mechanoelectrical transduction (MET) channel near the tips of stereociliary in hair cells, which is responsible for sensory transduction, has been studied most extensively. Several components of the sensory mechanotransduction machinery in stereocilia have been identified, including the multi-transmembrane proteins tetraspan membrane protein in hair cell stereocilia (TMHS)/LHFPL5, transmembrane inner ear (TMIE) and transmembrane channel-like proteins 1 and 2 (TMC1/2)...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29751274/engineering-mesenchymal-stem-cell-spheroids-by-incorporation-of-mechanoregulator-microparticles
#6
Fatemeh Abbasi, Mohammad Hossein Ghanian, Hossein Baharvand, Bahman Vahidi, Mohamadreza Baghaban Eslaminejad
Mechanical forces throughout human mesenchymal stem cell (hMSC) spheroids (mesenspheres) play a predominant role in determining cellular functions of cell growth, proliferation, and differentiation through mechanotransductional mechanisms. Here, we introduce microparticle (MP) incorporation as a mechanical intervention method to alter tensional homeostasis of the mesensphere and explore MSC differentiation in response to MP stiffness. The microparticulate mechanoregulators with different elastic modulus (34 kPa, 0...
May 3, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29740652/novel-ss-31-modified-liposomes-for-improved-protective-efficacy-of-minocycline-against-drug-induced-hearing-loss
#7
Shanshan Hou, Yang Yang, Shuang Zhou, Xiao Kuang, YinXian Yang, Hailing Gao, Zhenjie Wang, Hongzhuo Liu
Hearing loss, which is regarded as a worldwide public health concern, lacks approved therapeutic strategies. Current drug candidates used to treat hearing loss commonly have low efficacy. To achieve the optimum drug efficacy, we designed a liposome system to preload a clinically approved, water-soluble drug, minocycline. Inspired by our previous research, we used a mitochondria-targeting tetrapeptide, SS-31, to modify the surface of liposomes. The results revealed that SS-31 modified, minocycline-loaded liposomes significantly increased hair cell survival against chronic exposure to gentamicin in a zebrafish model...
May 9, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29740072/the-mechanical-microenvironment-regulates-ovarian-cancer-cell-morphology-migration-and-spheroid-disaggregation
#8
Andrew J McKenzie, Stephanie R Hicks, Kathryn V Svec, Hannah Naughton, Zöe L Edmunds, Alan K Howe
There is growing appreciation of the importance of the mechanical properties of the tumor microenvironment on disease progression. However, the role of extracellular matrix (ECM) stiffness and cellular mechanotransduction in epithelial ovarian cancer (EOC) is largely unknown. Here, we investigated the effect of substrate rigidity on various aspects of SKOV3 human EOC cell morphology and migration. Young's modulus values of normal mouse peritoneum, a principal target tissue for EOC metastasis, were determined by atomic force microscopy (AFM) and hydrogels were fabricated to mimic these values...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29740060/osm-9-and-an-amiloride-sensitive-channel-but-not-pkd-2-are-involved-in-mechanosensation-in-c-elegans-male-ray-neurons
#9
Hu Zhang, Xiaomin Yue, Hankui Cheng, Xiaoyan Zhang, Yang Cai, Wenjuan Zou, Guifang Huang, Lufeng Cheng, Fang Ye, Lijun Kang
Mechanotransduction is crucial for touch sensation, hearing, proprioception, and pain sensing. In C. elegans, male ray neurons have been implicated to be involved in the mechanosensation required for mating behavior. However, whether ray neurons directly sense mechanical stimulation is not yet known, and the underlying molecular mechanisms have not been identified. Using in vivo calcium imaging, we recorded the touch-induced calcium responses in male ray neurons. Our data demonstrated that ray neurons are sensitive to mechanical stimulation in a neurotransmitter-independent manner...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29735991/increased-piezo1-channel-activity-in-interstitial-cajal-like-cells-induces-bladder-hyperactivity-by-functionally-interacting-with-ncx1-in-rats-with-cyclophosphamide-induced-cystitis
#10
Qian Liu, Bishao Sun, Jiang Zhao, Qingqing Wang, Fan An, Xiaoyan Hu, Zhenxing Yang, Jie Xu, Mingjia Tan, Longkun Li
The Piezo1 channel is a mechanotransduction mediator, and Piezo1 abnormalities have been linked to several clinical disorders. However, the role of the Piezo1 channel in cystitis-associated bladder dysfunction has not been documented. The current study aimed to discover the functional role of this channel in regulating bladder activity during cyclophosphamide (CYP)-induced cystitis. One hundred four female rats were randomly assigned to the control, CYP-4h, CYP-48h and CYP-8d groups. CYP successfully induced acute or chronic cystitis in these rats...
May 7, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29720241/cross-talk-between-microtubules-and-the-linker-of-nucleoskeleton-complex-plays-a-critical-role-in-the-adipogenesis-of-human-adipose-derived-stem-cells
#11
Yiting Yang, Rongmei Qu, Tingyu Fan, Xi Zhu, Yanting Feng, Yuchao Yang, Ting Deng, Yan Peng, Wenhua Huang, Jun Ouyang, Jingxing Dai
BACKGROUND: Adipose-derived stem cells (ASCs) that show multidifferentiation and anti-immune rejection capacities have been widely used in plastic and reconstructive surgery. Previous studies have indicated that mechanical and biophysical interactions between cells and their surrounding environment regulate essential processes, such as growth, survival, and differentiation, and the cytoskeleton system plays an important role in the mechanotransduction. However, the role of mechanical force in the determination of lineage fate is still unclear...
May 2, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29719271/sticking-steering-squeezing-and-shearing-cell-movements-driven-by-heterotypic-mechanical-forces
#12
REVIEW
Anna Labernadie, Xavier Trepat
During development, the immune response and cancer, cells of different types interact mechanically. Here we review how such heterotypic mechanical interactions enable cell movements. We begin by analyzing the heterotypic forces that single cells use to adhere and squeeze through tight barriers, as in the case of leucocyte extravasation and cancer metastasis. We next focus on the different mechanisms by which adjacent tissues influence each other's movements, with particular emphasis on dragging forces during dorsal closure in Drosophila and shearing forces during gastrulation in zebrafish...
April 29, 2018: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/29714090/substrate-stiffness-dependent-exacerbation-of-endothelial-permeability-and-inflammation-mechanisms-and-potential-implications-in-ali-and-ph-2017-grover-conference-series
#13
Pratap Karki, Anna A Birukova
The maintenance of endothelial barrier integrity is absolutely essential to prevent the vascular leak associated with pneumonia, pulmonary edema resulting from inhalation of toxins, acute elevation to high altitude, traumatic and septic lung injury, acute lung injury (ALI), and its life-threatening complication, acute respiratory distress syndrome (ARDS). In addition to the long-known edemagenic and inflammatory agonists, emerging evidences suggest that factors of endothelial cell (EC) mechanical microenvironment such as blood flow, mechanical strain of the vessel, or extracellular matrix stiffness also play an essential role in the control of endothelial permeability and inflammation...
April 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/29712744/vascular-cell-glycocalyx-mediated-vascular-remodeling-induced-by-hemodynamic-environmental-alteration
#14
Jiajia Liu, Hongyan Kang, Xuejiao Ma, Anqiang Sun, Huiqin Luan, Xiaoyan Deng, Yubo Fan
Vascular remodeling induced by hemodynamic stimuli contributes to the pathophysiology of cardiovascular diseases. The importance of vascular cells (endothelial cells and smooth muscle cells) glycocalyx in the mechanotransduction of flow-induced shear stress at the cellular and molecular levels has been demonstrated over the past decade. However, its potential mechanotransduction role in vascular remodeling has triggered little attention. In the present study, a home-made apparatus was used to expose the rat abdominal aorta to sterile, flow or no flow, normal-pressure or high-pressure conditions for 4 days...
April 30, 2018: Hypertension
https://www.readbyqxmd.com/read/29709890/solo-and-keratin-filaments-regulate-epithelial-tubule-morphology
#15
Ryosuke Nishimura, Kagayaki Kato, Sachiko Fujiwara, Kazumasa Ohashi, Kensaku Mizuno
Epithelial tubules, consisting of the epithelial cell sheet with a central lumen, are the basic structure of many organs. Mechanical forces play an important role in epithelial tubulogenesis; however, little is known about the mechanisms controlling the mechanical forces during epithelial tubule morphogenesis. Solo (also known as ARHGEF40) is a RhoA-targeting guanine-nucleotide exchange factor that is involved in mechanical force-induced RhoA activation and stress fiber formation. Solo binds to keratin-8/keratin-18 (K8/K18) filaments, and this interaction plays a crucial role in mechanotransduction...
April 28, 2018: Cell Structure and Function
https://www.readbyqxmd.com/read/29691711/biomechanics-and-mechanical-signaling-in-the-ovary-a-systematic-review
#16
REVIEW
Jaimin S Shah, Reem Sabouni, Kamaria C Cayton Vaught, Carter M Owen, David F Albertini, James H Segars
PURPOSE: Mammalian oogenesis and folliculogenesis share a dynamic connection that is critical for gamete development. For maintenance of quiescence or follicular activation, follicles must respond to soluble signals (growth factors and hormones) and physical stresses, including mechanical forces and osmotic shifts. Likewise, mechanical processes are involved in cortical tension and cell polarity in oocytes. Our objective was to examine the contribution and influence of biomechanical signaling in female mammalian gametogenesis...
April 24, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29690743/-advances-in-the-research-of-biomechanical-effects-of-negative-pressure-wound-therapy-in-promoting-wound-healing
#17
X Q Chen, W Zhang, X Y Li
Recently, researchers have focused on the micro-mechano-environment and the resulting mechanical cues which can regulate the morphology, structure, and function of cells. As a novel mechanotherapy, negative-pressure wound therapy (NPWT) has revolutionized the treatment of acute and chronic wounds. The effects of mechanics in use of NPWT has been noticed by researchers, and sporadic results have been reported, while the mechanisms of mechanosensitivity and mechanotransduction in affecting cell behaviors and promoting wound healing haven't been elucidated yet...
April 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29689229/tensile-forces-and-mechanotransduction-at-cell-cell-junctions
#18
REVIEW
Guillaume Charras, Alpha S Yap
Cell-cell junctions are specializations of the plasma membrane responsible for physically integrating cells into tissues. We are now beginning to appreciate the diverse impacts that mechanical forces exert upon the integrity and function of these junctions. Currently, this is best understood for cadherin-based adherens junctions in epithelia and endothelia, where cell-cell adhesion couples the contractile cytoskeletons of cells together to generate tissue-scale tension. Junctional tension participates in morphogenesis and tissue homeostasis...
April 23, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29689211/structural-biology-piezo-senses-tension-through-curvature
#19
Xin Liang, Jonathon Howard
The sensations of sound, touch and pressure are mediated by mechanotransduction channels - transmembrane proteins whose ionic permeabilities are gated by mechanical forces. New structures of Piezo1 by cryoEM lead to the suggestion that this channel might sense membrane tension through changes in the local curvature of the membrane.
April 23, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29684675/fak-and-yap-taz-dependent-mechanotransduction-pathways-are-required-for-enhanced-immunomodulatory-properties-of-adipose-derived-mesenchymal-stem-cells-induced-by-aligned-fibrous-scaffolds
#20
S Wan, X Fu, Y Ji, M Li, X Shi, Y Wang
Adipose-derived mesenchymal stem cells (ASCs) represent an excellent candidate for tissue engineering due to their multipotency and paracrine functions. Physical cues provided by the scaffolds have been shown to direct a variety of cellular behaviors of ASCs; however, their effects on the paracrine functions of ASCs, especially immunomodulatory functions, remain largely unexplored. Thus, PLLA electrospun fibrous scaffolds, with fibers oriented either randomly or aligned, were used as a model to investigate the effects of fiber orientation on the immunomodulatory paracrine secretion of ASCs...
April 16, 2018: Biomaterials
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