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mechanotransduction

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https://www.readbyqxmd.com/read/28817244/key-developments-that-impacted-the-field-of-mechanobiology-and-mechanotransduction
#1
Michelle Wall, David Butler, Alicia El Haj, Josephine C Bodle, Elizabeth G Loboa, Albert J Banes
Advances in mechanobiology have evolved through insights from multiple disciplines including structural engineering, biomechanics, vascular biology, and orthopaedics. In this paper, we reviewed the impact of key reports related to the study of applied loads on tissues and cells and the resulting signal transduction pathways. We addressed how technology has helped advance the burgeoning field of mechanobiology (over 33,600 publications from 1970-2016). We analyzed the impact of critical ideas and then determined how these concepts influenced the mechanobiology field by looking at the citation frequency of these reports as well as tracking how the overall number of citations within the field changed over time...
August 17, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28813684/mimicking-mechanical-response-of-natural-tissues-strain-hardening-induced-by-transient-reticulation-in-lactose-modified-chitosan-chitlac
#2
Michela Cok, Pasquale Sacco, Davide Porrelli, Andrea Travan, Massimiliano Borgogna, Eleonora Marsich, Sergio Paoletti, Ivan Donati
The effect of transient cross-links has been explored on a lactose-modified chitosan, which previously had shown interesting biological features. The presence of galactose side chains and of the polyol spacer resulted particularly appealing for the reticulation by borate ions. The interaction between chitlac and borax was investigated by means of (11)B-NMR while rheology pointed to a marked non-linear behavior depending on the amount of borax added to the system. The presence of limited amount of cross-linking ion led to dilatant behavior when the steady flow curve was measured...
August 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28811304/selectin-catch-bonds-mechanotransduce-integrin-activation-and-neutrophil-arrest-on-inflamed-endothelium-under-shear-flow
#3
Vasilios A Morikis, Shannon Chase, Ted Wun, Elliot L Chaikof, John L Magnani, Scott I Simon
E-selectin extends from the plasma membrane of inflamed endothelium and serves to capture leukocytes from flowing blood via long-lived catch-bonds that support slow leukocyte rolling under shear stress. Its ligands are glycosylated with the tetrasaccharide sialyl Lewis(x) (sLe(x)), which contributes to bond affinity and specificity. E-selectin mediated rolling transmits signals into neutrophils that triggers activation of high-affinity β2-integrins necessary for transition to shear resistant adhesion and transendothelial migration...
August 15, 2017: Blood
https://www.readbyqxmd.com/read/28809511/vascular-stiffness-and-mechanotransduction-back-in-the-limelight
#4
Swati Dabral, Soni Savai Pullamsetti
No abstract text is available yet for this article.
August 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28799603/the-culture-of-hacat-cells-on-liquid-substrates-is-mediated-by-a-mechanically-strong-liquid-liquid-interface
#5
D Kong, K D Q Nguyen, W Megone, L Peng, J E Gautrot
The mechanical properties of naturally-derived matrices and biomaterials are thought to play an important role in directing cell adhesion, spreading, motility, proliferation and differentiation. However, recent reports have indicated that cells may respond to local nanoscale physical cues, rather than bulk mechanical properties. We had previously reported that primary keratinocytes and mesenchymal stem cells did not seem to respond to the bulk mechanical properties of poly(dimethyl siloxane) (PDMS) substrates...
August 11, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28792683/mechanotransduction-and-growth-factor-signalling-to-engineer-cellular-microenvironments
#6
REVIEW
Amaia Cipitria, Manuel Salmeron-Sanchez
Engineering cellular microenvironments involves biochemical factors, the extracellular matrix (ECM) and the interaction with neighbouring cells. This progress report provides a critical overview of key studies that incorporate growth factor (GF) signalling and mechanotransduction into the design of advanced microenvironments. Materials systems have been developed for surface-bound presentation of GFs, either covalently tethered or sequestered through physico-chemical affinity to the matrix, as an alternative to soluble GFs...
August 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28782645/marfan-syndrome-a-connective-tissue-disease-at-the-crossroads-of-mechanotransduction-tgf%C3%AE-signaling-and-cell-stemness
#7
REVIEW
Francesco Ramirez, Cristina Caescu, Elisabeth Wondimu, Josephine Galatioto
Mutations in fibrillin-1 cause Marfan syndrome (MFS), the most common heritable disorder of connective tissue. Fibrillin-1 assemblies (microfibrils and elastic fibers) represent a unique dual-function component of the architectural matrix. The first role is structural for they endow tissues with tensile strength and elasticity, transmit forces across them and demarcate functionally discrete areas within them. The second role is instructive in that these macroaggregates modulate a large variety of sub-cellular processes by interacting with mechanosensors, and integrin and syndecan receptors, and by modulating the bioavailability of local TGFβ signals...
August 4, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/28776271/do-metabolites-that-are-produced-during-resistance-exercise-enhance-muscle-hypertrophy
#8
REVIEW
Scott J Dankel, Kevin T Mattocks, Matthew B Jessee, Samuel L Buckner, J Grant Mouser, Jeremy P Loenneke
Many reviews conclude that metabolites play an important role with respect to muscle hypertrophy during resistance exercise, but their actual physiologic contribution remains unknown. Some have suggested that metabolites may work independently of muscle contraction, while others have suggested that metabolites may play a secondary role in their ability to augment muscle activation via inducing fatigue. Interestingly, the studies used as support for an anabolic role of metabolites use protocols that are not actually designed to test the importance of metabolites independent of muscle contraction...
August 3, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28771965/contribution-of-the-cytoskeleton-to-mechanosensitivity-reported-by-dinoflagellate-bioluminescence
#9
J C Stires, M I Latz
The cytoskeleton is crucial to cell mechanics and sensing the extracellular physical environment. The objective of this study was to examine the role of the cortical cytoskeleton in mechanosensitivity in a unicellular protist, the marine dinoflagellate Lingulodinium polyedra, using its intrinsic bioluminescence as a rapid reporter of mechanotransduction. Pharmacological treatments resolved effects due to immediate cytoskeleton disruption from those due to cytoskeletal remodeling during the light to dark phase transition...
August 3, 2017: Cytoskeleton
https://www.readbyqxmd.com/read/28767718/zygotic-vinculin-is-not-essential-for-embryonic-development-in-zebrafish
#10
Mitchell K L Han, Gerard N M van der Krogt, Johan de Rooij
The formation of multicellular tissues during development is governed by mechanical forces that drive cell shape and tissue architecture. Protein complexes at sites of adhesion to the extracellular matrix (ECM) and cell neighbors, not only transmit these mechanical forces, but also allow cells to respond to changes in force by inducing biochemical feedback pathways. Such force-induced signaling processes are termed mechanotransduction. Vinculin is a central protein in mechanotransduction that in both integrin-mediated cell-ECM and cadherin-mediated cell-cell adhesions mediates force-induced cytoskeletal remodeling and adhesion strengthening...
2017: PloS One
https://www.readbyqxmd.com/read/28760815/endothelial-cells-respond-to-the-direction-of-mechanical-stimuli-through-smad-signaling-to-regulate-coronary-artery-size
#11
Aruna Poduri, Brian Raftrey, Andrew H Chang, Siyeon Rhee, Mike Van, Kristy Red-Horse
How mechanotransduction intersects with chemical and transcriptional factors to shape organogenesis is an important question in developmental biology. This is particularly relevant to the cardiovascular system, which uses mechanical signals from flowing blood to stimulate cytoskeletal and transcriptional responses that form a highly efficient vascular network. Using this system, artery size and structure are tightly regulated, but the underlying mechanisms are poorly understood. Here, we demonstrate that deletion of Smad4 increased the diameter of coronary arteries during embryonic development, a phenotype that followed the initiation of blood flow...
July 31, 2017: Development
https://www.readbyqxmd.com/read/28757237/ultrasound-induced-strain-cytoskeleton-rearrangement-an-experimental-and-simulation-study
#12
Mohamadmahdi Samandari, Karen Abrinia, Manijhe Mokhtari-Dizaji, Ali Tamayol
Cytoskeleton and specially actin filaments are responsible for mechanical modulation of cellular behavior. These structures could be fluidized in response to transient mechanical cues. Ultrasound devices have been widely used in medicine which their generated ultrasonic waves could disrupt/fluidize actin filaments in cytoskeleton and thus could affect cellular organization. Present research aims at revealing the mechanism of fluidization caused by ultrasound induced strains. First, a numerical simulation was performed to reveal the effect of oscillating ultrasonic pressure on induced deformation in the cell with respect to different cell geometries and exposure conditions...
June 20, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28755471/mechanical-loading-disrupts-osteocyte-plasma-membranes-which-initiates-mechanosensation-events-in-bone
#13
Kanglun Yu, David P Sellman, Anoosh Bahraini, Mackenzie L Hagan, Ahmed Elsherbini, Kayce T Vanpelt, Peyton L Marshall, Mark W Hamrick, Anna McNeil, Paul L McNeil, Meghan E McGee-Lawrence
Osteocytes sense loading in bone, but their mechanosensation mechanisms remain poorly understood. Plasma membrane disruptions (PMD) develop with loading under physiological conditions in many cell types (e.g., myocytes, endothelial cells). These PMD foster molecular flux across cell membranes that promotes tissue adaptation, but this mechanosensation mechanism had not been explored in osteocytes. Our goal was to investigate whether PMD occur and initiate consequent mechanotransduction in osteocytes during physiological loading...
July 29, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28754555/elastin-insufficiency-causes-hypertension-structural%C3%A2-defects-and-abnormal-remodeling-of%C3%A2-renal-vascular-signaling
#14
Elizabeth A Owens, Li Jie, Beverly A S Reyes, Elisabeth J Van Bockstaele, Patrick Osei-Owusu
Elastin deficiency causes vascular stiffening, a leading risk for hypertension and chronic kidney disease (CKD). The mechanisms mediating hypertension and/or CKD pathogenesis due to elastin deficiency are poorly understood. Using the elastin heterozygous (Eln+/-) mouse model, we tested whether renal dysfunction due to elastin deficiency occurs independently of and precedes the development of hypertension. We assessed blood pressure and renal hemodynamics in 30-day and 12-week-old male and female mice. At P30, blood pressure of Eln+/- mice was similar to wild-type controls; however, renal blood flow was lower, whereas renal vascular resistance was augmented at baseline in Eln+/- mice...
July 26, 2017: Kidney International
https://www.readbyqxmd.com/read/28754442/mechanotransduction-at-the-cell-matrix-interface
#15
REVIEW
K A Jansen, P Atherton, C Ballestrem
The ability of cells to sense and respond to mechanical signals is vital in development and healthy tissue functioning. Many diseases are related to either changing mechanical properties of the tissue, or changes in the ability of cells to sense mechanical signals. This sensing occurs, in part, at integrin-associated complexes (IACs) that form sites of attachment between the cell and the extracellular matrix (ECM). In this review, we discuss the complex mechanical signals of the ECM. We will also outline how IACs are involved in cellular sensing of these mechanical properties, focussing on the molecular mechanisms of key adhesion molecules...
July 25, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28750602/mechanical-induction-of-bi-directional-orientation-of-primary-porcine-bladder-smooth-muscle-cells-in-tubular-fibrin-poly-vinylidene-fluoride-scaffolds-for-ureteral-and-urethral-repair-using-cyclic-and-focal-balloon-catheter-stimulation
#16
Volker Seifarth, Joachim O Grosse, Matthias Gossmann, Heinz Peter Janke, Patrick Arndt, Sabine Koch, Matthias Epple, Gerhard M Artmann, Aysegül Temiz Artmann
To restore damaged organ function or to investigate organ mechanisms, it is necessary to prepare replicates that follow the biological role model as faithfully as possible. The interdisciplinary field of tissue engineering has great potential in regenerative medicine and might overcome negative side effects in the replacement of damaged organs. In particular, tubular organ structures of the genitourinary tract, such as the ureter and urethra, are challenging because of their complexity and special milieu that gives rise to incrustation, inflammation and stricture formation...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28744841/cell-mechanosensors-and-the-possibilities-of-using-magnetic-nanoparticles-to-study-them-and-to-modify-cell-fate
#17
REVIEW
Yajing Shen, Yu Cheng, Taro Q P Uyeda, Gustavo R Plaza
The use of magnetic nanoparticles (MNPs) is a promising technique for future advances in biomedical applications. This idea is supported by the availability of MNPs that can target specific cell components, the variety of shapes of MNPs and the possibility of finely controlling the applied magnetic forces. To examine this opportunity, here we review the current developments in the use of MNPs to mechanically stimulate cells and, specifically, the cell mechanotransduction systems. We analyze the cell components that may act as mechanosensors and their effect on cell fate and we focus on the promising possibilities of controlling stem-cell differentiation, inducing cancer-cell death and treating nervous-system diseases...
July 25, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28744783/towards-the-identification-of-hemodynamic-parameters-involved-in-arteriovenous-fistula-maturation-and-failure-a-review
#18
Marco Franzoni, Michael T Walsh
Native arteriovenous fistulas have a high failure rate mainly due to the lack of maturation and uncontrolled neo-intimal hyperplasia development. Newly established hemodynamics is thought to be central in driving the fistula fate, after surgical creation. To investigate the effects of realistic wall shear stress stimuli on endothelial cells, an in vitro approach is necessary in order to reduce the complexity of the in vivo environment. After a systematic review, realistic WSS waveforms were selected and analysed in terms of magnitude, temporal gradient, presence of reversing phases (oscillatory shear index, OSI) and frequency content (hemodynamics index, HI)...
July 25, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28741418/focal-adhesion-kinase-activation-is-necessary-for-stretch-induced-alignment-and-enhanced-differentiation-of-myogenic-precursor-cells
#19
Jens Isak Andersen, Cristian Pablo Pennisi, Trine Fink, Vladimir Zachar
Myogenic precursors sense and dynamically respond to mechanical stimulation through complex integrin-mediated mechanotransduction, in which focal adhesion kinase (FAK) is a fundamental intracellular signaling mediator. When skeletal myoblasts are exposed to uniaxial cyclic tensile strain (UCTS) they display uniform alignment and an enhanced rate of differentiation. In this work, we explored the role of FAK activation using C2C12 myoblasts that were grown on flexible culture plates and exposed to UCTS during the early differentiation phase...
July 25, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28732675/substrate-stiffness-regulates-arterial-venous-differentiation-of-endothelial-progenitor-cells-via-the-ras-mek-pathway
#20
Changyue Xue, Tao Zhang, Xueping Xie, Qi Zhang, Shu Zhang, Bofeng Zhu, Yunfeng Lin, Xiaoxiao Cai
Cells sense and respond to the biophysical properties of their surrounding environment by interacting with the extracellular matrix (ECM). Therefore, the optimization of these cell-matrix interactions is critical in tissue engineering. The vascular system is adapted to specific functions in diverse tissues and organs. Appropriate arterial-venous differentiation is vital for the establishment of functional vasculature in angiogenesis. Here, we have developed a polydimethylsiloxane (PDMS)-based substrate capable of simulating the physiologically relevant stiffness of both venous (7kPa) and arterial (128kPa) tissues...
July 18, 2017: Biochimica et Biophysica Acta
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