keyword
https://read.qxmd.com/read/38534466/transcriptomic-and-metabolomic-analyses-reveal-the-response-mechanism-of-ophiopogon-japonicus-to-waterlogging-stress
#21
JOURNAL ARTICLE
Tingting Cheng, Xia Zhou, Juan Lin, Xianjian Zhou, Hongsu Wang, Tiezhu Chen
Ophiopogon japonicus , a plant that thrives in river alluvial dams, often faces waterlogging stress due to sustained rainfall and flood seasons, which significantly impacts its growth and development. Currently, the mechanisms of waterlogging tolerance in Ophiopogon japonicus are still unclear. This study analyzed the transcriptome and metabolome data for Ophiopogon japonicus in the Sichuan region (referred to as CMD) under varying degrees of waterlogging stress: mild, moderate, and severe. The results indicate that the group exposed to flooding stress exhibited a higher number of differentially expressed genes (DEGs) compared to the control group...
March 20, 2024: Biology
https://read.qxmd.com/read/38533085/membrane-trafficking-alterations-in-breast-cancer-progression
#22
REVIEW
Andreia Ferreira, Pedro Castanheira, Cristina Escrevente, Duarte C Barral, Teresa Barona
Breast cancer (BC) is the most common type of cancer in women, and remains one of the major causes of death in women worldwide. It is now well established that alterations in membrane trafficking are implicated in BC progression. Indeed, membrane trafficking pathways regulate BC cell proliferation, migration, invasion, and metastasis. The 22 members of the ADP-ribosylation factor (ARF) and the >60 members of the rat sarcoma (RAS)-related in brain (RAB) families of small GTP-binding proteins (GTPases), which belong to the RAS superfamily, are master regulators of membrane trafficking pathways...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38532930/targeting-of-lysosomal-bound-protein-meak-7-for-cancer-therapy
#23
REVIEW
Insoon Chang, Yi-Ling Loo, Jay Patel, Joe Truong Nguyen, Jin Koo Kim, Paul H Krebsbach
mEAK-7 (mammalian EAK-7 or MTOR-associated protein, eak-7 homolog), is an evolutionarily conserved lysosomal membrane protein that is highly expressed in several cancer cells. Multiple recent studies have identified mEAK-7 as a positive activator of mTOR (mammalian/mechanistic target of rapamycin) signaling via an alternative mTOR complex, implying that mEAK-7 plays an important role in the promotion of cancer proliferation and migration. In addition, structural analyses investigating interactions between mEAK-7 and V-ATPase, a protein complex responsible for regulating pH homeostasis in cellular compartments, have suggested that mEAK-7 may contribute to V-ATPase-mediated mTORC1 activation...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38531882/rna-modifications-in-cellular-metabolism-implications-for-metabolism-targeted-therapy-and-immunotherapy
#24
REVIEW
Wei-Wei Liu, Si-Qing Zheng, Tian Li, Yun-Fei Fei, Chen Wang, Shuang Zhang, Fei Wang, Guan-Min Jiang, Hao Wang
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells. Relevant studies have been constantly making inroads in our understanding of pathophysiology, and inspiring development of therapeutics. As a crucial component of epigenetics at post-transcription level, RNA modification significantly determines RNA fates, further affecting various biological processes and cellular phenotypes. To be noted, immunometabolism defines the metabolic alterations occur on immune cells in different stages and immunological contexts...
March 27, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38531660/role-of-wnt5b-ror1-signaling-in-the-proliferation-of-pancreatic-ductal-adenocarcinoma-cells
#25
JOURNAL ARTICLE
Natsuko Yamauchi, Mako Otsuka, Tomohiro Ishikawa, Yoshihiro Kakeji, Akira Kikuchi, Atsuhiro Masuda, Yuzo Kodama, Yasuhiro Minami, Koki Kamizaki
Pancreatic ductal adenocarcinoma (PDAC) is one of the most refractory cancers with the worst prognosis. Although several molecules are known to be associated with the progression of PDAC, the molecular mechanisms underlying the progression of PDAC remain largely elusive. The Ror-family receptors, Ror1 and Ror2, which act as a receptor(s) for Wnt-family ligands, particularly Wnt5a, are involved in the progression of various types of cancers. Here, we show that higher expression of Ror1 and Wnt5b, but not Ror2, are associated with poorer prognosis of PDAC patients, and that Ror1 and Wnt5b are expressed highly in a type of PDAC cell lines, PANC-1 cells...
March 26, 2024: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://read.qxmd.com/read/38530880/glucosylceramide-accumulation-in-microglia-triggers-sting-dependent-neuroinflammation-and-neurodegeneration-in-mice
#26
JOURNAL ARTICLE
Rui Wang, Hongyang Sun, Yifan Cao, Zhixiong Zhang, Yajing Chen, Xiying Wang, Lele Liu, Jin Wu, Hao Xu, Dan Wu, Chenchen Mu, Zongbing Hao, Song Qin, Haigang Ren, Junhai Han, Ming Fang, Guanghui Wang
Mutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GCase) are responsible for Gaucher disease (GD) and are considered the strongest genetic risk factor for Parkinson's disease (PD) and Lewy body dementia (LBD). GCase deficiency leads to extensive accumulation of glucosylceramides (GCs) in cells and contributes to the neuropathology of GD, PD, and LBD by triggering chronic neuroinflammation. Here, we investigated the mechanisms by which GC accumulation induces neuroinflammation. We found that GC accumulation within microglia induced by pharmacological inhibition of GCase triggered STING-dependent inflammation, which contributed to neuronal loss both in vitro and in vivo...
March 26, 2024: Science Signaling
https://read.qxmd.com/read/38529481/osteocyte-mediated-mechanical-response-controls-osteoblast-differentiation-and-function
#27
REVIEW
Heather VerValin Buck, Joseph Paul Stains
Low bone mass is a pervasive global health concern, with implications for osteoporosis, frailty, disability, and mortality. Lifestyle factors, including sedentary habits, metabolic dysfunction, and an aging population, contribute to the escalating prevalence of osteopenia and osteoporosis. The application of mechanical load to bone through physical activity and exercise prevents bone loss, while sufficient mechanical load stimulates new bone mass acquisition. Osteocytes, cells embedded within the bone, receive mechanical signals and translate these mechanical cues into biological signals, termed mechano-transduction...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38529291/connexin-43-in-the-function-and-homeostasis-of-osteocytes-a-narrative-review
#28
REVIEW
Liang Ma, Wenzhao Wang, Guixuan Xu, Hao Li, Fei Liu, Huarong Shao, Xiuhua Zhang, Yuxia Ma, Gang Li, Hui Li, Shuzhong Gao, Peixue Ling
BACKGROUND AND OBJECTIVE: Connexin 43 (Cx43) is the main gap junction (GJ) protein and hemichannel protein in bone tissue. It is involved in the formation of hemichannels and GJs and establishes channels that can communicate directly to exchange substances and signals, affecting the structure and function of osteocytes. CX43 is very important for the normal development of bone tissue and the establishment and balance of bone reconstruction. However, the molecular mechanisms by which CX43 regulates osteoblast function and homeostasis have been less well studied, and this article provides a review of research in this area...
2024: Annals of joint
https://read.qxmd.com/read/38529010/nanofabricated-high-turn-density-spiral-coils-for-on-chip-electromagneto-optical-conversion
#29
JOURNAL ARTICLE
Ilhan Bok, Alireza Ashtiani, Yash Gokhale, Jack Phillips, Tianxiang Zhu, Aviad Hai
Circuit-integrated electromagnets are fundamental building blocks for on-chip signal transduction, modulation, and tunability, with specific applications in environmental and biomedical micromagnetometry. A primary challenge for improving performance is pushing quality limitations while minimizing size and fabrication complexity and retaining spatial capabilities. Recent efforts have exploited highly involved three-dimensional synthesis, advanced insulation, and exotic material compositions. Here, we present a rapid nanofabrication process that employs electron beam dose control for high-turn-density diamond-embedded flat spiral coils; these coils achieve efficient on-chip electromagnetic-to-optical signal conversion...
2024: Microsystems & Nanoengineering
https://read.qxmd.com/read/38528683/changes-in-brain-proteasome-dynamics-associated-with-aging
#30
JOURNAL ARTICLE
Nodoka Nago, Shigeo Murata, Keiji Tanaka, Nobuyuki Tanahashi
In the nervous system, proteasomes are important for proteolysis and cellular homeostasis of neurons and glial cells and for brain health. Proteasome function declines with age in many tissues, including the nervous system, and this decline affects many of the nervous system processes important to brain health and may be related to age-related cognitive decline. Therefore, we analyzed the factors that contribute to this decline in function using the brain of mice from different months of life. Peptidase activity of proteasomes in crude extracts decreased with aging, while ubiquitinated proteins increased with aging...
March 25, 2024: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://read.qxmd.com/read/38527572/polyamine-release-and-vesicular-polyamine-transporter-expression-in-megakaryoblastic-cells-and-platelets
#31
JOURNAL ARTICLE
Mizuki Uehara, Ayaka Fukumoto, Hiroshi Omote, Miki Hiasa
Polyamines not only play essential roles in cell growth and function of living organisms but are also released into the extracellular space and function as regulators of chemical transduction, although the cells from which they are released and their mode of release are not well understood. The vesicular polyamine transporter (VPAT), encoded by the SLC18B1 is responsible for the vesicular storage of spermine and spermidine, followed by their vesicular release from secretory cells. Focusing on VPAT will help identify polyamine-secreting cells and new polyamine functions...
March 23, 2024: Biochimica et Biophysica Acta. General Subjects
https://read.qxmd.com/read/38527068/quasi-targeted-metabolomics-revealed-isoliquiritigenin-and-lauric-acid-associated-with-resistance-to-tobacco-black-shank
#32
JOURNAL ARTICLE
Shiwen Peng, Fangling Shu, Yanhui Lu, Dongsheng Fan, Dehong Zheng, Gaoqing Yuan
Tobacco black shank (TBS), caused by Phytophthora nicotianae , is a severe disease. Plant root exudates play a crucial role in mediating plant-pathogen interactions in the rhizosphere. However, the specific interaction between key secondary metabolites present in root exudates and the mechanisms of disease resistance remains poorly understood. This study conducted a comprehensive comparison via quasi-targeted metabolomic analysis on the root exudate metabolites from the tobacco cultivar Yunyan87 and K326, both before and after inoculation with P...
December 31, 2024: Plant Signaling & Behavior
https://read.qxmd.com/read/38526224/metal-tolerant-morganella-morganii-isolates-can-potentially-mediate-nickel-stress-tolerance-in-arabidopsis-by-upregulating-antioxidative-enzyme-activities
#33
JOURNAL ARTICLE
Tahir Naqqash, Aeman Aziz, Muhammad Baber, Muhammad Shahid, Muhammad Sajid, Radicetti Emanuele, Abdel-Rhman Z Gaafar, Mohamed S Hodhod, Ghulam Haider
Plant growth-promoting rhizobacteria (PGPRs) have been utilized to immobilize heavy metals, limiting their translocation in metal contaminated settings. However, studies on the mechanisms and interactions that elucidate how PGPRs mediate Nickel (Ni) tolerance in plants are rare. Thus, in this study we investigated how two pre-characterized heavy metal tolerant isolates of Morganella morganii (ABT9 and ABT3) improve Ni stress tolerance in Arabidopsis while enhancing its growth and yield. Arabidopsis seedlings were grown for five weeks in control/Ni contaminated (control, 1...
December 31, 2024: Plant Signaling & Behavior
https://read.qxmd.com/read/38525112/cgas-sting-an-important-signaling-pathway-in-diseases-and-their-therapy
#34
REVIEW
Qijie Li, Ping Wu, Qiujing Du, Ullah Hanif, Hongbo Hu, Ka Li
Since cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway was discovered in 2013, great progress has been made to elucidate the origin, function, and regulating mechanism of cGAS-STING signaling pathway in the past decade. Meanwhile, the triggering and transduction mechanisms have been continuously illuminated. cGAS-STING plays a key role in human diseases, particularly DNA-triggered inflammatory diseases, making it a potentially effective therapeutic target for inflammation-related diseases...
April 2024: MedComm
https://read.qxmd.com/read/38525006/molecular-mechanisms-underlying-the-signal-perception-and-transduction-during-seed-germination
#35
REVIEW
Huibin Xu, Fuxiang Wang, Rebecca Njeri Damari, Xiaofeng Chen, Zhongyuan Lin
QuerySeed germination is a vital step in the life cycle of a plant, playing a significant role in seedling establishment and crop yield potential. It is also an important factor in the conservation of plant germplasm resources. This complex process is influenced by a myriad of factors, including environmental conditions, the genetic makeup of the seed, and endogenous hormones. The perception of these environmental signals triggers a cascade of intricate signal transduction events that determine whether a seed germinates or remains dormant...
April 2024: Molecular Breeding
https://read.qxmd.com/read/38523746/shining-light-in-mechanobiology-optical-tweezers-scissors-and-beyond
#36
REVIEW
Alexander B Stilgoe, Itia A Favre-Bulle, Mark L Watson, Veronica Gomez-Godinez, Michael W Berns, Daryl Preece, Halina Rubinsztein-Dunlop
Mechanobiology helps us to decipher cell and tissue functions by looking at changes in their mechanical properties that contribute to development, cell differentiation, physiology, and disease. Mechanobiology sits at the interface of biology, physics and engineering. One of the key technologies that enables characterization of properties of cells and tissue is microscopy. Combining microscopy with other quantitative measurement techniques such as optical tweezers and scissors, gives a very powerful tool for unraveling the intricacies of mechanobiology enabling measurement of forces, torques and displacements at play...
March 20, 2024: ACS Photonics
https://read.qxmd.com/read/38523655/near-zero-stiffness-accelerometer-with-buckling-of-tunable-electrothermal-microbeams
#37
JOURNAL ARTICLE
Hussein Hussein, Chen Wang, Rui Amendoeira Esteves, Michael Kraft, Hossein Fariborzi
Pre-shaped microbeams, curved or inclined, are widely used in MEMS for their interesting stiffness properties. These mechanisms allow a wide range of positive and negative stiffness tuning in their direction of motion. A mechanism of pre-shaped beams with opposite curvature, connected in a parallel configuration, can be electrothermally tuned to reach a near-zero or negative stiffness behavior at the as-fabricated position. The simple structure helps incorporate the tunable spring mechanism in different designs for accelerometers, even with different transduction technologies...
2024: Microsystems & Nanoengineering
https://read.qxmd.com/read/38523645/dysregulation-of-sphingolipid-metabolism-in-pain
#38
REVIEW
Jianfeng Wang, Guangda Zheng, Linfeng Wang, Linghan Meng, Juanxia Ren, Lu Shang, Dongtao Li, Yanju Bao
Pain is a clinical condition that is currently of great concern and is often caused by tissue or nerve damage or occurs as a concomitant symptom of a variety of diseases such as cancer. Severe pain seriously affects the functional status of the body. However, existing pain management programs are not fully satisfactory. Therefore, there is a need to delve deeper into the pathological mechanisms underlying pain generation and to find new targets for drug therapy. Sphingolipids (SLs), as a major component of the bilayer structure of eukaryotic cell membranes, also have powerful signal transduction functions...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38523237/fucosyltransferase-8-regulates-adult-neurogenesis-and-cognition-of-mice-by-modulating-the-itga6-pi3k-akt-signaling-pathway
#39
JOURNAL ARTICLE
Hongfeng Guo, Qihang Sun, Xiaoli Huang, Xiaohao Wang, Feng Zhang, Wenzheng Qu, Jinling Liu, Xuejun Cheng, Qiang Zhu, Wen Yi, Qiang Shu, Xuekun Li
Fucosyltransferase 8 (Fut8) and core fucosylation play critical roles in regulating various biological processes, including immune response, signal transduction, proteasomal degradation, and energy metabolism. However, the function and underlying mechanism of Fut8 and core fucosylation in regulating adult neurogenesis remains unknown. We have shown that Fut8 and core fucosylation display dynamic features during the differentiation of adult neural stem/progenitor cells (aNSPCs) and postnatal brain development...
March 22, 2024: Science China. Life Sciences
https://read.qxmd.com/read/38522807/e2f8-cenpl-pathway-contributes-to-homologous-recombination-repair-and-chemoresistance-in-breast-cancer
#40
JOURNAL ARTICLE
Shan Wang, Yuhong Xia, Yu Sun, Wei Wang, Lianfeng Shan, Zhongbo Zhang, Chenghai Zhao
Chemoresistance poses a significant obstacle to the treatment of breast cancer patients. The increased capacity of DNA damage repair is one of the mechanisms underlying chemoresistance. Bioinformatic analyses showed that E2F8 was associated with cell cycle progression and homologous recombination (HR) repair of DNA double-strand breaks (DSBs) in breast cancer. E2F8 knockdown suppressed cell growth and attenuated HR repair. Accordingly, E2F8 knockdown sensitized cancer cells to Adriamycin and Cisplatin. Centromere protein L (CENPL) is a transcriptional target by E2F8...
March 22, 2024: Cellular Signalling
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