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https://www.readbyqxmd.com/read/28793336/a-systematic-review-of-adverse-drug-events-associated-with-administration-of-common-asthma-medications-in-children
#1
James S Leung, David W Johnson, Arissa J Sperou, Jennifer Crotts, Erik Saude, Lisa Hartling, Antonia Stang
OBJECTIVE: To systematically review the literature and determine frequencies of adverse drug events (ADE) associated with pediatric asthma medications. METHODS: Following PRISMA guidelines, we systematically searched six bibliographic databases between January 1991 and January 2017. Study eligibility, data extraction and quality assessment were independently completed and verified by two reviewers. We included randomized control trials (RCT), case-control, cohort, or quasi-experimental studies where the primary objective was identifying ADE in children 1 month- 18 years old exposed to commercial asthma medications...
2017: PloS One
https://www.readbyqxmd.com/read/28777929/human-germline-genome-editing
#2
REVIEW
Kelly E Ormond, Douglas P Mortlock, Derek T Scholes, Yvonne Bombard, Lawrence C Brody, W Andrew Faucett, Nanibaa' A Garrison, Laura Hercher, Rosario Isasi, Anna Middleton, Kiran Musunuru, Daniel Shriner, Alice Virani, Caroline E Young
With CRISPR/Cas9 and other genome-editing technologies, successful somatic and germline genome editing are becoming feasible. To respond, an American Society of Human Genetics (ASHG) workgroup developed this position statement, which was approved by the ASHG Board in March 2017. The workgroup included representatives from the UK Association of Genetic Nurses and Counsellors, Canadian Association of Genetic Counsellors, International Genetic Epidemiology Society, and US National Society of Genetic Counselors...
August 3, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28768613/medicine-goes-female-protocol-for-improving-career-options-of-females-and-working-conditions-for-researching-physicians-in-clinical-medical-research-by-organizational-transformation-and-participatory-design
#3
Joachim Hasebrook, Klaus Hahnenkamp, Wolfgang F F A Buhre, Dianne de Korte-de Boer, Ankie E W Hamaekers, Bibiana Metelmann, Camila Metelmann, Marina Bortul, Silvia Palmisano, Jannicke Mellin-Olsen, Andrius Macas, Janusz Andres, Anna Prokop-Dorner, Tomáš Vymazal, Juergen Hinkelmann, Sibyll Rodde, Bettina Pfleiderer
BACKGROUND: All European countries need to increase the number of health professionals in the near future. Most efforts have not brought the expected results so far. The current notion is that this is mainly related to the fact that female physicians will clearly outnumber their male colleagues within a few years in nearly all European countries. Still, women are underrepresented in leadership and research positions throughout Europe. OBJECTIVES: The MedGoFem project addresses multiple perspectives with the participation of multiple stakeholders...
August 2, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28767499/clinician-investigator-training-and-the-need-to-pilot-new-approaches-to-recruiting-and-retaining-this-workforce
#4
Alison K Hall, Sherry L Mills, P Kay Lund
Clinician-investigators, also called physician-scientists, offer critical knowledge and perspectives that benefit research on basic science mechanisms, improved diagnostic and therapeutic approaches, population and outcomes medicine, health policy, and health services, yet few clinically trained health professionals pursue a research career. Sustaining this workforce requires attention to the unique challenges faced by investigators who must achieve clinical and research competence during training and their careers...
August 1, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28756037/value-of-a-national-administrative-database-to-guide-public-decisions-from-the-syst%C3%A3-me-national-d-information-interr%C3%A3-gimes-de-l-assurance-maladie-sniiram-to-the-syst%C3%A3-me-national-des-donn%C3%A3-es-de-sant%C3%A3-snds-in-france
#5
REVIEW
P Tuppin, J Rudant, P Constantinou, C Gastaldi-Ménager, A Rachas, L de Roquefeuil, G Maura, H Caillol, A Tajahmady, J Coste, C Gissot, A Weill, A Fagot-Campagna
In 1999, French legislators asked health insurance funds to develop a système national d'information interrégimes de l'Assurance Maladie (SNIIRAM) [national health insurance information system] in order to more precisely determine and evaluate health care utilization and health care expenditure of beneficiaries. These data, based on almost 66 million inhabitants in 2015, have already been the subject of numerous international publications on various topics: prevalence and incidence of diseases, patient care pathways, health status and health care utilization of specific populations, real-life use of drugs, assessment of adverse effects of drugs or other health care procedures, monitoring of national health insurance expenditure, etc...
July 26, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28755961/patient-engagement-in-the-design-and-execution-of-urologic-oncology-research
#6
REVIEW
Daniel J Lee, Svetlana Avulova, Ralph Conwill, Daniel A Barocas
INTRODUCTION: There have been significant effort and financial support to engage patients in the design and execution of medical research. However, little is known about the relative benefits or potential impact of involving patients in research, most efficient practices and systems to enhance their involvement, and potential barriers and challenges that are involved with engaging patients. In this review, we will discuss the value of patient centered research, review the challenges that many of these studies faced, and highlight potential future opportunities to enhance patient involvement in urologic research...
July 26, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28737989/incremental-effect-of-the-addition-of-prescriber-restrictions-on-a-state-medicaid-s-pharmacy-only-patient-review-and-restriction-program
#7
Shellie L Keast, Timothy Pham, Ashley Teel, Nancy J Nesser
BACKGROUND: Patient review and restriction programs (PRRPs), used by state Medicaid programs to limit potential abuse and misuse of opioids and related controlled medications, often restrict members to a single pharmacy for controlled medications. While most states use a restricted pharmacy access model, not all states include restricted prescriber access. Oklahoma Medicaid (MOK) added a restricted prescriber access feature to its PRRP in July 2014. OBJECTIVE: To evaluate the incremental effect that the addition of a prescriber restriction to MOK's pharmacy-only PRRP had on the pharmacy and resource utilization of the enrolled members...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28729776/expenditure-of-hospital-care-on-cancer-in-china-from-2011-to-2015
#8
Yue Cai, Ming Xue, Wanqing Chen, Maogui Hu, Zhiwen Miao, Lan Lan, Rongshou Zheng, Qun Meng
OBJECTIVE: A solid understanding of levels and trends of spending on cancer is important to evaluate whether our healthcare resources were wisely spent and to prioritize future resources for cancer treatment and prevention. However, studies on economic burden of cancers in China are scant and the results are inconsistent. METHODS: The Chinese hospital information database and nearly 350 million inpatient medical record data were used. As the ratios of cancer inpatient payments to total inpatient payments were mainly influenced by the grades and sites of hospitals, the estimates of payments of cancer inpatients in this study were stratified by hospital grades and provinces...
June 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28707476/clinical-research-and-the-medical-research-future-fund
#9
Michael Berk, Rob Ramsay
No abstract text is available yet for this article.
July 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28693492/barriers-to-publishing-in-biomedical-journals-perceived-by-a-sample-of-french-researchers-results-of-the-diazepam-study
#10
Martin Duracinsky, Christophe Lalanne, Laurence Rous, Aichata Fofana Dara, Lesya Baudoin, Claire Pellet, Alexandre Descamps, Fabienne Péretz, Olivier Chassany
BACKGROUND: As publishing is essential but competitive for researchers, difficulties in writing and submitting medical articles to biomedical journals are disabling. The DIAzePAM (Difficultés des Auteurs à la Publication d'Articles Médicaux) survey aimed to assess the difficulties experienced by researchers in the AP-HP (Assistance Publique - Hôpitaux de Paris, i.e., Paris Hospitals Board, France), the largest public health institution in Europe, when preparing articles for biomedical journals...
July 10, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28692018/the-state-of-gene-therapy-research-in-africa-its-significance-and-implications-for-the-future
#11
REVIEW
P Arbuthnot, M B Maepa, A Ely, M S Pepper
Gene therapy has made impressive recent progress and has potential for treating a wide range of diseases, many of which are important to Africa. However, as a result of lack of direct public funding and skilled personnel, direct research on gene therapy in Africa is currently limited and resources to support the endeavor are modest. A strength of the technology is that it is based on principles of rational design, and the tools of gene therapy are now highly versatile. For example gene silencing and gene editing may be used to disable viral genes for therapeutic purposes...
July 10, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28673355/what-do-young-people-with-rheumatic-disease-believe-to-be-important-to-research-about-their-condition-a-uk-wide-study
#12
Suzanne Parsons, Wendy Thomson, Katharine Cresswell, Bella Starling, Janet E McDonagh
BACKGROUND: The involvement of people of all ages including young people in research is now widely advocated but prioritisation of research topics is still driven largely by professional agendas. Evidence from adult literature has reported a mismatch between a researcher and patient generated list of research topics. There have been no studies to date exploring the priorities of young people with long term conditions other than in SLE. The study aimed to explore the research priorities of young people across the UK with respect to rheumatic conditions...
July 3, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28663854/the-ecosystem-that-powered-the-translation-of-oct-from-fundamental-research-to-clinical-and-commercial-impact-invited
#13
Eric A Swanson, James G Fujimoto
25 years is a relatively short period of time for a medical technology to become a standard of care impacting the treatment of millions of people every year. Yet 25 years ago there were no OCT companies, no OCT products, no OCT markets, and only one journal article published using the term OCT (optical coherence tomography). OCT has had a tremendous scientific, clinical, and economic impact on society. Today, it is estimated that there are ~30 Million OCT imaging procedures performed worldwide every year and the OCT system market is approaching $1B per year...
March 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28660593/is-obesity-the-new-hypertension-parallels-in-the-evolution-of-obesity-and-hypertension-as-recognized-disease-states
#14
REVIEW
Devika Umashanker, Alpana P Shukla, Katherine H Saunders, Louis J Aronne
Obesity and hypertension are recognized disease states that share many similarities including complex physiology, therapeutic response to both lifestyle modification and pharmacotherapy, and the need for long-term management. Both were initially believed to be disorders of lifestyle rather than true disease entities, and initial efforts at developing medical and surgical therapies were criticized. Ultimately, both have proven to be amenable to treatments that control their underlying physiology. Both hypertension and obesity have complex pathophysiology involving multiple regulatory pathways that may require combination therapies in addition to lifestyle modification to reach therapeutic goals...
August 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28637441/impact-of-tobacco-industry-and-other-corporations-in-the-defeat-of-the-1994-clinton-health-care-plan
#15
Michael Givel
BACKGROUND: The primary reason cited by many scholars for the defeat of the Clinton Administration's 1994 health care reform bill has long been identified as Health Insurance Association of America and National Federation of Independent Businesses opposition to the bill. Given this predominant consensus combined with sizeable proposed funding for the bill by a large tobacco product tax, this manuscript examined what the tobacco industry's role was in whole or part in defeating the Clinton health care bill...
June 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28629438/an-output-evaluation-of-a-health-research-foundation-s-enhanced-grant-review-process-for-new-investigators
#16
Gregory W Hammond, Mê-Linh Lê, Tannis Novotny, Stephanie P B Caligiuri, Grant N Pierce, John Wade
BACKGROUND: We assessed the ability of the Manitoba Medical Service Foundation (MMSF, a small not-for-profit foundation affiliated with Manitoba Blue Cross) to determine the best candidates for selection to receive research funding support among new researchers applying to the Research Operating Grants Programme (ROGP). METHODS: Using bibliometric and grants funding analyses, we retrospectively compared indices of academic outputs from five cohorts of MMSF-funded and not MMSF-funded applicants to the annual MMSF ROGP over 2008 to 2012, from 1 to 5 years after having received evaluation decisions from the MMSF enhanced grant review process...
June 19, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28611976/a-sustained-partnership-between-a-haitian-children-s-hospital-and-north-american-academic-medical-centers
#17
Michael P Koster, Jackson H Williams, Jacqueline Gautier, Renee Alce, Bernard E Trappey
Global health initiatives from academic medical centers have rapidly proliferated over the last decade. This paper endeavors to describe our 5-year experience as an academic medical collaborative supporting healthcare delivery, medical training, and research at Hôpital Saint Damien-Nos Petits Frères et Soeurs, the only freestanding children's hospital in Haiti. Descriptions of the history and current activities of our academic medical collaborative, its partnership and communication structure, its evolution to fill the expressed needs of our host site, its funding mechanisms, and its challenges and opportunities for the future are included...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28589001/multisite-prospective-investigation-of-psychological-outcomes-following-cataract-surgery-in-vietnam
#18
David Berle, Zachary Steel, Beverley M Essue, Lisa Keay, Stephen Jan, Huynh Tan Phuc, Maree L Hackett
BACKGROUND: Cataract surgery is a low-cost and effective intervention. There is increasing evidence to suggest that cataract surgery is associated with improvements in mobility, overall functioning and reductions in psychological distress. Within low-income and middle-income countries, cataract surgery has also been documented to lead to reductions in psychological distress; however, differences in economic activity and engagement in paid and domestic work in these countries may moderate such reductions...
January 2017: BMJ Global Health
https://www.readbyqxmd.com/read/28584129/future-of-fundamental-discovery-in-us-biomedical-research
#19
Michael Levitt, Jonathan M Levitt
Young researchers are crucially important for basic science as they make unexpected, fundamental discoveries. Since 1982, we find a steady drop in the number of grant-eligible basic-science faculty [principal investigators (PIs)] younger than 46. This fall occurred over a 32-y period when inflation-corrected congressional funds for NIH almost tripled. During this time, the PI success ratio (fraction of basic-science PIs who are R01 grantees) dropped for younger PIs (below 46) and increased for older PIs (above 55)...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28562450/considerations-for-residency-programs-regarding-accepting-undocumented-students-who-are-daca-recipients
#20
Sunny Nakae, Denisse Rojas Marquez, Isha Marina Di Bartolo, Raquel Rodriguez
The Deferred Action for Childhood Arrivals (DACA) initiative provides for the temporary deferral of enforcement of immigration laws for certain undocumented individuals brought to the United States before age 16. More than 50 medical schools now consider applicants who are DACA recipients, and medical school graduates with DACA are eligible to continue their training in graduate medical education. In this article, the authors summarize current policy and provide data on DACA recipients in medical school. They then review the implications for considering DACA recipients in graduate medical education, including employment guidelines, employer responsibilities, training at Veterans Affairs facilities, research funding, and professional licensure...
May 30, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
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