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https://www.readbyqxmd.com/read/29750955/the-comparing-options-for-management-patient-centered-results-for-uterine-fibroids-compare-uf-registry-rationale-and-design
#1
Elizabeth A Stewart, Barbara L Lytle, Laine Thomas, Ganesa R Wegienka, Vanessa Jacoby, Michael P Diamond, Wanda K Nicholson, Raymond M Anchan, Sateria Venable, Kedra Wallace, Erica E Marsh, George L Maxwell, Bijan J Borah, William H Catherino, Evan R Myers
OBJECTIVE: To design and establish a uterine fibroid (UF) registry based in the United States (US) to provide comparative effectiveness data regarding UF treatment. STUDY DESIGN: We report here the design and initial recruitment for the Comparing Options for Management: Patient-centered Results for Uterine Fibroids (COMPARE-UF) registry (Clinicaltrials.gov, NCT02260752), funded by the Agency for Healthcare Research and Quality (AHRQ) in collaboration with the-Patient-Centered Outcomes Research Institute (PCORI)...
May 8, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29739461/clinical-providers-experiences-with-returning-results-from-genomic-sequencing-an-interview-study
#2
Julia Wynn, Katie Lewis, Laura M Amendola, Barbara A Bernhardt, Sawona Biswas, Manasi Joshi, Carmit McMullen, Sarah Scollon
BACKGROUND: Current medical practice includes the application of genomic sequencing (GS) in clinical and research settings. Despite expanded use of this technology, the process of disclosure of genomic results to patients and research participants has not been thoroughly examined and there are no established best practices. METHODS: We conducted semi-structured interviews with 21 genetic and non-genetic clinicians returning results of GS as part of the NIH funded Clinical Sequencing Exploratory Research (CSER) Consortium projects...
May 8, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/29731951/advanced-computational-methods-in-bio-mechanics
#3
REVIEW
Waleed M S Al Qahtani, Mohamed I El-Anwar
A novel partnership between surgeons and machines, made possible by advances in computing and engineering technology, could overcome many of the limitations of traditional surgery. By extending surgeons' ability to plan and carry out surgical interventions more accurately and with fewer traumas, computer-integrated surgery (CIS) systems could help to improve clinical outcomes and the efficiency of healthcare delivery. CIS systems could have a similar impact on surgery to that long since realised in computer-integrated manufacturing...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29731369/tailored-frequency-escalated-primary-prophylaxis-for-severe-haemophilia-a-results-of-the-16-year-canadian-hemophilia-prophylaxis-study-longitudinal-cohort
#4
Brian M Feldman, Georges E Rivard, Paul Babyn, John K M Wu, MacGregor Steele, Man-Chiu Poon, Robert T Card, Sara J Israels, Nicole Laferriere, Kulwant Gill, Anthony K Chan, Manuel Carcao, Robert J Klaassen, Stephanie Cloutier, Victoria E Price, Saunya Dover, Victor S Blanchette
BACKGROUND: Severe haemophilia A has high morbidity, and treatment, while effective, is very expensive. We report the 16-year follow-up of the Canadian Hemophilia Prophylaxis Study, which examined the effectiveness of tailored frequency-escalated primary prophylaxis with a focus on health outcomes within the domains of body structures and functions, and activities and participation (according to the WHO International Classification of Functioning, Disability and Health [WHO-ICF] framework) and a view to reducing consumption of costly clotting factor, which accounts for more than 90% of the cost of care of severe haemophilia...
May 3, 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29727316/gun-violence-two-medical-students-hometown-connection-to-this-public-health-crisis
#5
Nicholas O Kuhl, Monica P Lieberman
The school shooting in Parkland, Florida in February 2018 left 17 people dead and countless other children and teachers with physical and psychological trauma that will require decades of healing. As Marjory Stoneman Douglas High School alumni and current medical students, the authors of this Invited Commentary contend that they are in a unique position to advocate on behalf of their neighbors, classmates, and future patients. Since the authors began medical school in 2015, there have been 19 mass shootings in the United States resulting in 253 deaths...
May 2, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29698120/use-of-free-libre-open-source-software-in-sepsis-omics-research-a-bibliometric-comparative-analysis-among-the-united-states-eu-28-member-states-and-china
#6
Nikolaos Evangelatos, Kapaettu Satyamourthy, Georgia Levidou, Helmut Brand, Pia Bauer, Christina Kouskouti, Angela Brand
"-Omics" systems sciences are at the epicenter of personalized medicine and public health, and drivers of knowledge-based biotechnology innovation. Bioinformatics, a core component of omics research, is one of the disciplines that first employed Free/Libre Open Source Software (FLOSS), and thus provided a fertile ground for its further development. Understanding the use and characteristics of FLOSS deployed in the omics field is valuable for future innovation strategies, policy and funding priorities...
April 26, 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29693501/improving-research-in-radiation-oncology-through-interdisciplinary-collaboration
#7
Jay W Burmeister, Monica W Tracey, Sara E Kacin, Michael M Dominello, Michael C Joiner
The contribution of radiation oncology to the future of cancer treatment depends significantly on our continued clinical progress and future research advancements. Such progress relies on multidisciplinary collaboration among radiation oncologists, medical physicists and radiobiologists. Cultivating collaborative educational and research opportunities among these three disciplines and further investing in the infrastructure used to train both clinicians and researchers will therefore help us improve the future of cancer care...
April 25, 2018: Radiation Research
https://www.readbyqxmd.com/read/29674514/pharmacokinetic-studies-in-children-recommendations-for-practice-and-research
#8
REVIEW
Charlotte I S Barker, Joseph F Standing, Lauren E Kelly, Lauren Hanly Faught, Allison C Needham, Michael J Rieder, Saskia N de Wildt, Martin Offringa
Optimising the dosing of medicines for neonates and children remains a challenge. The importance of pharmacokinetic (PK) and pharmacodynamic (PD) research is recognised both in medicines regulation and paediatric clinical pharmacology, yet there remain barriers to undertaking high-quality PK and PD studies. While these studies are essential in understanding the dose-concentration-effect relationship and should underpin dosing recommendations, this review examines how challenges affecting the design and conduct of paediatric pharmacological studies can be overcome using targeted pharmacometric strategies...
April 19, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29669934/divergent-responses-to-kisspeptin-in-children-with-delayed-puberty
#9
Yee-Ming Chan, Margaret F Lippincott, Temitope O Kusa, Stephanie B Seminara
BACKGROUND: The neuropeptide kisspeptin stimulates luteinizing hormone (LH) secretion in healthy adults but not in adults with idiopathic hypogonadotropic hypogonadism. We hypothesized that, in children presenting with delayed or stalled puberty, kisspeptin would elicit LH secretion in those children found on detailed nighttime neuroendocrine profiling to have evidence of emerging reproductive endocrine function. METHODS: Eleven boys and four girls were admitted overnight to assess LH secretion at baseline, after a single intravenous bolus of kisspeptin, and after a single intravenous bolus of gonadotropin-releasing hormone (GnRH)...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29663405/a-career-path-for-pure-academic-medical-physicists-in-radiation-oncology-should-be-established
#10
Ke Sheng, Todd Pawlicki, Jing Cai
Medical physics research has led to many advanced radiation oncology technologies in the past decades, such as intensity modulated radiation therapy (IMRT), stereotactic body radiation therapy (SBRT), and proton therapy. These have fundamentally shaped the current landscape of cancer treatment. It is believed that medical physics research will continue to play an essential role in advancing radiation oncology in the future. However, sustaining a healthy medical physics research workforce is facing substantial challenges, such as limited funding support and lack of protected research time...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29658296/medical-and-health-surveillance-in-postaccident-recovery-experience-after-fukushima
#11
K Tanigawa
The accident at Fukushima Daiichi nuclear power plant occurred following the huge tsunami and earthquake of 11 March 2011. After the accident, there was considerable uncertainty and concern about the health effects of radiation. In this difficult situation, emergency responses, including large-scale evacuation, were implemented. The Fukushima Health Management Survey (FHMS) was initiated 3 months after the accident. The primary purposes of FHMS were to monitor the long-term health of residents, promote their well-being, and monitor any health effects related to long-term, low-dose radiation exposure...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29651981/lamotrigine-for-people-with-borderline-personality-disorder-a-rct
#12
Mike J Crawford, Rahil Sanatinia, Barbara Barrett, Gillian Cunningham, Oliver Dale, Poushali Ganguli, Geoff Lawrence-Smith, Verity C Leeson, Fenella Lemonsky, Georgia Lykomitrou-Matthews, Alan Montgomery, Richard Morriss, Jasna Munjiza, Carol Paton, Iwona Skorodzien, Vineet Singh, Wei Tan, Peter Tyrer, Joseph G Reilly
BACKGROUND: No drug treatments are currently licensed for the treatment of borderline personality disorder (BPD). Despite this, people with this condition are frequently prescribed psychotropic medications and often with considerable polypharmacy. Preliminary studies have indicated that mood stabilisers may be of benefit to people with BPD. OBJECTIVE: To examine the clinical effectiveness and cost-effectiveness of lamotrigine for people with BPD. DESIGN: A two-arm, double-blind, placebo-controlled individually randomised trial of lamotrigine versus placebo...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29644567/how-accurate-is-the-data-provided-to-the-irish-hip-fracture-database
#13
Andrew J Hughes, Orla Hennessy, Louise Brennan, Abdullah Rana, Colin G Murphy
National databases, such as the Irish Hip Fracture Database (IHFD), are known to contain inaccuracies. The coordination of services, national funding and future research rely on the integrity of the IHFD so as to avoid policy and budget planning being based on misrepresentative data. An audit was performed to assess the accuracy of the 2016 IHFD data collected in our trauma unit. The Hospital In-Patient Enquiry (HIPE)-recorded fracture classification, IHFD-recorded fracture classification and IHFD-recorded operation performed for each hip fracture patient was identified...
April 11, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29625810/enlight-european-network-for-light-ion-hadron-therapy
#14
REVIEW
Manjit Dosanjh, Ugo Amaldi, Ramona Mayer, Richard Poetter
The European Network for Light Ion Hadron Therapy (ENLIGHT) was established in 2002 following various European particle therapy network initiatives during the 1980s and 1990s (e.g. EORTC task group, EULIMA/PIMMS accelerator design). ENLIGHT started its work on major topics related to hadron therapy (HT), such as patient selection, clinical trials, technology, radiobiology, imaging and health economics. It was initiated through CERN and ESTRO and dealt with various disciplines such as (medical) physics and engineering, radiation biology and radiation oncology...
April 3, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29621583/a-review-of-the-traditional-use-of-southern-african-medicinal-plants-for-the-treatment-of-selected-parasite-infections-affecting-humans
#15
REVIEW
I E Cock, M I Selesho, S F van Vuuren
ETHNOPHARMACOLOGICAL RELEVANCE: Worldwide, more than three billion cases of parasitic disease are reported yearly and it is likely that this figure is substantially under-estimated. Approximately one in six people globally are estimated to be infected with at least one parasite species annually. In South Africa, the prevalence of Schistosoma haematobium (bilharzia) and intestinal worms and helminths are particularly high, especially in children and in crowded or poorer rural communities with inadequate sanitation and nutritional status...
April 2, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29599104/physical-trauma-patients-with-symptoms-of-an-acute-and-posttraumatic-stress-disorder-protocol-for-an-observational-prospective-cohort-study
#16
Eva Visser, Taco Gosens, Brenda Den Oudsten, Jolanda De Vries
BACKGROUND: Injury, medical treatment, and rehabilitation can have major impacts on patients' wellbeing. About 25-33% of the patients experience an acute stress disorder (ASD) or a posttraumatic stress disorder (PTSD) after injury. ASD is a relatively new diagnosis. Therefore, knowledge about patients' experiences, the course of ASD and PTSD, and who is at risk for developing ASD or PTSD is lacking. OBJECTIVE: The aims of this multi-method study are to explore patients' experiences with injury (and their care) using a focus group study...
March 29, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29588635/individualising-chronic-care-management-by-analysing-patients-needs-a-mixed-method-approach
#17
P Timpel, C Lang, J Wens, J C Contel, A Gilis-Januszewska, K Kemple, P E Schwarz
Background: Modern health systems are increasingly faced with the challenge to provide effective, affordable and accessible health care for people with chronic conditions. As evidence on the specific unmet needs and their impact on health outcomes is limited, practical research is needed to tailor chronic care to individual needs of patients with diabetes. Qualitative approaches to describe professional and informal caregiving will support understanding the complexity of chronic care...
November 13, 2017: International Journal of Integrated Care
https://www.readbyqxmd.com/read/29581093/evolution-of-cognitive-rehabilitation-after-stroke-from-traditional-techniques-to-smart-and-personalized-home-based-information-and-communication-technology-systems-literature-review
#18
REVIEW
José M Cogollor, Javier Rojo-Lacal, Joachim Hermsdörfer, Manuel Ferre, Maria Teresa Arredondo Waldmeyer, Christos Giachritsis, Alan Armstrong, Jose Manuel Breñosa Martinez, Doris Anabelle Bautista Loza, José María Sebastián
BACKGROUND: Neurological patients after stroke usually present cognitive deficits that cause dependencies in their daily living. These deficits mainly affect the performance of some of their daily activities. For that reason, stroke patients need long-term processes for their cognitive rehabilitation. Considering that classical techniques are focused on acting as guides and are dependent on help from therapists, significant efforts are being made to improve current methodologies and to use eHealth and Web-based architectures to implement information and communication technology (ICT) systems that achieve reliable, personalized, and home-based platforms to increase efficiency and level of attractiveness for patients and carers...
March 26, 2018: JMIR rehabilitation and assistive technologies
https://www.readbyqxmd.com/read/29571002/multiuser-virtual-worlds-in-healthcare-education-a-systematic-review
#19
REVIEW
Sok Ying Liaw, Guiller Augustin C Carpio, Ying Lau, Seng Chee Tan, Wee Shiong Lim, Poh Sun Goh
BACKGROUND: The use of multiuser virtual worlds (MUVWs) for collaborative learning has generated interest among healthcare educators. Published evidence to support its use is growing, but none has synthesized the evidence to guide future work. OBJECTIVE: This study sought to provide a comprehensive and systematic evaluation of MUVWs in healthcare education. DESIGN: A systematic review METHODS: A systematic search of five databases including CINAHL, Cochrane library, EMBASE, PubMed, and Scopus, was conducted from inception up to January 2017...
February 2, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29517535/the-institutional-development-award-states-pediatric-clinical-trials-network-building-research-capacity-among-the-rural-and-medically-underserved
#20
Jessica Snowden, Paul Darden, Paul Palumbo, Phil Saul, Jeannette Lee
PURPOSE OF REVIEW: The institutional development award (IDeA) program was created to increase the competitiveness of investigators in states with historically low success rates for National Institutes of Health (NIH) research funding applications. IDeA states have high numbers of rural and medically underserved residents with disproportionately high rates of infant mortality, obesity, and poverty. This program supports the development and expansion of research infrastructure and research activities in these states...
April 2018: Current Opinion in Pediatrics
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