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https://www.readbyqxmd.com/read/29683838/relationship-between-ventricular-arrhythmias-conduction-disorders-and-myocardial-fibrosis-in-patients-with-systemic-sclerosis-the-role-of-cardiac-magnetic-resonance
#1
Giacomo De Luca, Corrado Campochiaro, Giulio Cavalli, Lorenzo Dagna
No abstract text is available yet for this article.
April 16, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29683546/kappa-free-light-chains-in-cerebrospinal-fluid-to-identify-patients-with-oligoclonal-bands
#2
M Süße, M Hannich, A Petersmann, Stephanie Zylla, M Pietzner, M Nauck, A Dressel
OBJECTIVE: Gold standard for detection of intrathecal immunoglobulin synthesis is the measurement of oligoclonal bands (OCB). In the diagnosis of Multiple Sclerosis the kappa free light chains (KFLC) index has a similar sensitivity and specificity as OCB. This study investigated whether determination of the KFLC index could be used to predict the presence of OCB. METHODS: The KFLC index was determined prospectively from 295 paired serum and cerebrospinal fluid (CSF) samples...
April 23, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29683029/contrast-enhanced-fat-suppressed-flair-for-the-characterization-of-leptomeningeal-inflammation-in-optic-neuritis
#3
Luis Pino-Lopez, Holger Wenz, Johannes Böhme, Máté Maros, Frank Schlichtenbrede, Christoph Groden, Alex Förster
BACKGROUND: Leptomeningeal contrast enhancement on fluid-attenuated inversion recovery (FLAIR) images has been reported in patients with multiple sclerosis and interpreted as a biomarker of inflammation. In this study, we sought to evaluate this phenomenon in patients with optic neuritis (ON). METHODS: A total of 42 patients with suspected ON were included in this prospective study and underwent a dedicated study magnetic resonance imaging (MRI) protocol including native and contrast-enhanced fat-suppressed thin-section axial and coronal FLAIR images on an 1...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29682695/two-decades-long-journey-from-riluzole-to-edaravone-revisiting-the-clinical-pharmacokinetics-of-the-only-two-amyotrophic-lateral-sclerosis-therapeutics
#4
REVIEW
Ranjeet Prasad Dash, R Jayachandra Babu, Nuggehally R Srinivas
The recent approval of edaravone has provided an intravenous option to treat amyotrophic lateral sclerosis (ALS) in addition to the existing oral agent, riluzole. The present work was primarily undertaken to provide a comprehensive clinical pharmacokinetic summary of the two approved ALS therapeutics. The key objectives of the review were to (i) tabulate the clinical pharmacokinetics of riluzole and edaravone with emphasis on absorption, distribution, metabolism and excretion (ADME) properties; (ii) provide a comparative scenario of the pharmacokinetics of the two drugs wherever possible; and (iii) provide perspectives and introspection on the gathered clinical pharmacokinetic data of the two drugs with appropriate conjectures to quench scientific curiosity...
April 23, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29682587/therapeutic-potential-of-pien-tze-huang-on-experimental-autoimmune-encephalomyelitis-rat
#5
Xuemei Qiu, Hui Luo, Xue Liu, Qingqing Guo, Kang Zheng, Danping Fan, Jiawen Shen, Cheng Lu, Xiaojuan He, Ge Zhang, Aiping Lu
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). There is still lack of commercially viable treatment currently. Pien Tze Huang (PZH), a traditional Chinese medicine, has been proved to have anti-inflammatory, neuroprotective, and immunoregulatory effects. This study investigated the possible therapeutic effects of PZH on experimental autoimmune encephalomyelitis (EAE) rats, a classic animal model of MS. Male Lewis rats were immunized with myelin basic protein (MBP) peptide to establish an EAE model and then treated with three doses of PZH...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29682372/from-postural-orthostatic-tachycardia-syndrome-to-radiologically-isolated-syndrome
#6
Richa Tripathi, Evanthia Bernitsas
Background: Autonomic dysfunction is common in Multiple Sclerosis (MS) patients. Most spinal cord lesions entail some degree of autonomic nervous system dysfunction. MS patients may develop autonomic dysfunction later in their disease course. Methods: We report a patient with no prior history of MS presenting with orthostatic symptoms and diagnosed initially with postural orthostatic tachycardia syndrome (POTS). Four months later, she was diagnosed with radiologically isolated syndrome (RIS)...
2018: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29682349/multiple-sclerosis-patients-with-markedly-low-intrathecal-antibody-response-in-sri-lanka
#7
S M K Gamage, I Wijeweera, S B Adikari, Katharina Fink, Jan Hillert, Anna Fogdell-Hahn, H M A Sominanda
Multiple sclerosis (MS) is a heterogeneous disease which is poorly studied in Asia, where the disease is known to be rare with significant differences in clinical and radiological presentations and intrathecal antibody response. Therefore the objective of this study was to determine clinical presentation, radiological and neurophysiological characteristics, and oligoclonal band status in Sri Lankan MS patients, following careful exclusion of patients with neuromyelitis optica spectrum disorders and other conditions mimicking multiple sclerosis...
2018: Multiple Sclerosis International
https://www.readbyqxmd.com/read/29680223/dysregulation-of-micrornas-in-autoimmune-diseases-pathogenesis-biomarkers-and-potential-therapeutic-targets
#8
Hai Long, Xin Wang, Yongjian Chen, Ling Wang, Ming Zhao, Qianjin Lu
MicroRNAs (miRNAs) are small, single-stranded, endogenous non-coding RNAs that repress the expression of target genes via post-transcriptional mechanisms. Due to their broad regulatory effects, the precisely regulated, spatial-specific and temporal-specific expression of miRNAs is fundamentally important to various biological processes including the immune homeostasis and normal function of both innate and adaptive immune response. Aberrance of miRNAs is implicated in the development of various human diseases, especially cancers...
April 19, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29680130/-clinical-characteristics-of-patients-with-als-hospitalised-at-home
#9
REVIEW
Catherine Nativel, Odile Marquestaut
A study was carried out in 2013 in order to describe, using data from the programme for a medicalised information system, the population of patients with amyotrophic lateral sclerosis (ALS) cared for through the hospital at home service of the AP-HP Paris hospital group. This study highlights the highly technical nature of the care, in a context of palliative care and patient dependency. Patient care needs to be coordinated, preferably within a network.
April 2018: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/29679165/future-brain-and-spinal-cord-volumetric-imaging-in-the-clinic-for-monitoring-treatment-response-in-ms
#10
REVIEW
Tim Sinnecker, Cristina Granziera, Jens Wuerfel, Regina Schlaeger
PURPOSE OF REVIEW: Volumetric analysis of brain imaging has emerged as a standard approach used in clinical research, e.g., in the field of multiple sclerosis (MS), but its application in individual disease course monitoring is still hampered by biological and technical limitations. This review summarizes novel developments in volumetric imaging on the road towards clinical application to eventually monitor treatment response in patients with MS. RECENT FINDINGS: In addition to the assessment of whole-brain volume changes, recent work was focused on the volumetry of specific compartments and substructures of the central nervous system (CNS) in MS...
April 20, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29678847/diagnostic-value-of-vitamin-d-status-and-bone-turnover-markers-in-rheumatoid-arthritis-complicated-by-osteoporosis
#11
Li-Ming Tan, Ting-Ting Long, Xiao-Lin Guan, Si-Fan Wu, Wei Zheng, Hui-Ying Fu, Qiao-Hua Wang, Yi-Mei Meng, Yang Wu, Ting-Ting Zeng, Yong-Jian Tian, Jian-Lin Yu, Juan-Juan Chen, Hua Li, Li-Ping Cao
OBJECTIVE: To research the diagnostic performance of clinical potential bone turnover indexes in rheumatoid arthritis (RA) complicated with osteoporosis (OP). METHODS: This study involved 87 RA patients, 48 with OP, and 39 without OP, and 204 non-RA control patients, including those with systemic lupus erythematosus, ankylosing spondylitis, primary Sjogren's syndrome, systemic sclerosis, and healthy patients. The levels of 25-hydroxyvitamin D [25(OH)D], β-crosslaps (β-CROSSL), parathyroid hormone (PTH) were measured by electrochemiluminescence (ECLIA), and the level of bone alkaline phosphatase (BALP) was measured by lectin affinity method...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29678369/impaired-corticomuscular-and-interhemispheric-cortical-beta-oscillation-coupling-in-amyotrophic-lateral-sclerosis
#12
Malcolm Proudfoot, Freek van Ede, Andrew Quinn, Giles L Colclough, Joanne Wuu, Kevin Talbot, Michael Benatar, Mark W Woolrich, Anna C Nobre, Martin R Turner
OBJECTIVES: The neural activity of the primary motor cortex is variably synchronised with contralateral peripheral electromyographic signals, which is thought to facilitate long-range communication through the motor system. Such corticomuscular coherence (CMC) is typically observed in the beta-band (15-30 Hz) range during steady force production. We aimed to measure pathological alteration to CMC resulting from ALS. METHODS: CMC was appraised during a forearm grip task in 17 ALS patients contrasted against age-matched healthy controls...
April 6, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29676521/inhibitory-regulation-of-skin-fibrosis-in-systemic-sclerosis-by-apelin-apj-signaling
#13
Yoko Yokoyama, Akiko Sekiguchi, Chisako Fujiwara, Akihiko Uchiyama, Akihito Uehara, Sachiko Ogino, Ryoko Torii, Osamu Ishikawa, Sei-Ichiro Motegi
OBJECTIVE: Apelin/APJ signaling has been identified to regulate cardiac and arterial fibrosis and involved in the pathogenesis of pulmonary arterial hypertension. Objective was to elucidate the role of apelin in skin fibrosis in systemic sclerosis (SSc). METHODS: Expressions of apelin/APJ in normal and SSc fibroblasts were compared. Effects of siRNA depletion and the addition of apelin in fibroblasts were analyzed. Effect of apelin injections on bleomycin-induced dermal fibrosis in mice was investigated...
April 20, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29676479/sulfatide-isoform-pattern-in-cerebrospinal-fluid-discriminates-progressive-ms-from-relapsing-remitting-ms
#14
Lenka Novakova, Avadhesh Kumar Singh, Clas Malmeström, Henrik Zetterberg, Marcus Ståhlman, Markus Axelsson, Martin Adiels, Jan Borén, Jan Lycke, Susanna L Cardell, Maria Blomqvist
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Several biomarkers including proteins and lipids have been reported in MS cerebrospinal fluid (CSF), reflecting different aspects of the pathophysiology particularly of relapsing-remitting MS (RRMS). Sulfatide, abundant in the myelin sheath and a proposed target for autoimmune attack in MS, has been reported altered in MS CSF. Here, we investigated the potential of CSF sulfatide and its isoforms as biomarkers in MS...
April 20, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29676287/electrophysiological-correlates-of-neurodegeneration-in-motor-and-non-motor-brain-regions-in-amyotrophic-lateral-sclerosis-implications-for-brain-computer-interfacing
#15
Philipp Kellmeyer, Moritz Grosse-Wentrup, Andreas Schulze-Bonhage, Ulf Ziemann, Tonio Ball
For patients with amyotrophic lateral sclerosis (ALS) who are suffering from severe communication or motor problems, brain-computer interfaces (BCIs) can improve the quality of life and patient autonomy. However, current BCI systems are not as widely used as their potential and patient demand would let assume. This underutilization is a result of technological as well as user-based limitations but also of the comparatively poor performance of currently existing BCIs in patients with late-stage ALS, particularly in the locked-in state...
April 20, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29676181/identification-of-glia-phenotype-modulators-based-on-select-glial-function-regulatory-signaling-pathways
#16
Sun-Hwa Lee, Kyoungho Suk
Despite the considerable social and economic burden on the healthcare system worldwide due to neurodegenerative diseases, there are currently few disease-altering treatment options for many of these conditions. Therefore, new approaches for both prevention and intervention for neurodegenerative diseases are urgently required. Microglia-mediated neurotoxicity is one of the pathologic hallmarks common to Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Current therapeutic approaches to target microglia-mediated neurotoxicity are focused on the identification of glia phenotype modulators (GPMs), which can inhibit the 'classical' pro-inflammatory and neurotoxic phenotypes of microglia...
April 20, 2018: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29675203/lipid-biochemical-changes-detected-in-normal-appearing-white-matter-of-chronic-multiple-sclerosis-by-spectral-coherent-raman-imaging
#17
K W C Poon, C Brideau, R Klaver, G J Schenk, J J Geurts, P K Stys
Multiple sclerosis (MS) exhibits demyelination, inflammatory infiltration, axonal degeneration, and gliosis, affecting widespread regions of the central nervous system (CNS). While white matter MS lesions have been well characterized pathologically, evidence indicates that the MS brain may be globally altered, with subtle abnormalities found in grossly normal appearing white matter (NAWM). These subtle changes are difficult to investigate by common methods such as histochemical stains and conventional magnetic resonance imaging...
February 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29673738/tbk1-a-key-regulator-and-potential-treatment-target-for-interferon-positive-sj%C3%A3-gren-s-syndrome-systemic-lupus-erythematosus-and-systemic-sclerosis
#18
Iris L A Bodewes, Erika Huijser, Cornelia G van Helden-Meeuwsen, Liselotte Tas, Ruth Huizinga, Virgil A S H Dalm, P Martin van Hagen, Noortje Groot, Sylvia Kamphuis, Paul L A van Daele, Marjan A Versnel
OBJECTIVE: Upregulation of type I interferons (IFN-I) is a hallmark of systemic autoimmune diseases like primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). Expression of IFN-I is induced by three different receptor families: Toll-like receptors (TLRs), RIG-like receptors (RLRs) and DNA-sensing receptors (DSRs). TANK-binding kinase (TBK1) is an important signaling hub downstream of RLRs and DSRs. TBK1 activates IRF3 and IRF7, leading to IFN-I production and subsequent induction of interferon stimulated genes (ISGs)...
April 16, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29673575/classification-and-diagnostic-criteria-for-demyelinating-diseases-of-the-central-nervous-system-where-do-we-stand-today
#19
REVIEW
G Mathey, M Michaud, S Pittion-Vouyovitch, M Debouverie
The diagnosis of multiple sclerosis (MS) and other demyelinating diseases of the central nervous system is challenging, and although the currently available biological and imaging tools offer considerable support to physicians, these tools often fail to provide a simple and final answer at the time of a first event. Thus, sets of diagnostic criteria have been published and tested on patient cohorts, and are now used in clinical trials and in daily clinical practice. These criteria have evolved over time to take into account physicians' and patients' needs, along with emerging paraclinical tests...
April 16, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29673365/human-central-nervous-system-astrocytes-support-survival-and-activation-of-b-cells-implications-for-ms-pathogenesis
#20
Hanane Touil, Antonia Kobert, Nathalie Lebeurrier, Aja Rieger, Philippe Saikali, Caroline Lambert, Lama Fawaz, Craig S Moore, Alexandre Prat, Jennifer Gommerman, Jack P Antel, Yasuto Itoyama, Ichiro Nakashima, Amit Bar-Or
BACKGROUND: The success of clinical trials of selective B cell depletion in patients with relapsing multiple sclerosis (MS) indicates B cells are important contributors to peripheral immune responses involved in the development of new relapses. Such B cell contribution to peripheral inflammation likely involves antibody-independent mechanisms. Of growing interest is the potential that B cells, within the MS central nervous system (CNS), may also contribute to the propagation of CNS-compartmentalized inflammation in progressive (non-relapsing) disease...
April 19, 2018: Journal of Neuroinflammation
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