keyword
MENU ▼
Read by QxMD icon Read
search

Acute myeloid leukaemia

keyword
https://www.readbyqxmd.com/read/29147018/enforced-gfi1-expression-impedes-human-and-murine-leukemic-cell-growth
#1
Judith M Hönes, Aniththa Thivakaran, Lacramioara Botezatu, Pradeep Patnana, Symone Vitoriano da Conceição Castro, Yahya S Al-Matary, Judith Schütte, Karen B I Fischer, Lothar Vassen, André Görgens, Ulrich Dührsen, Bernd Giebel, Cyrus Khandanpour
The differentiation of haematopoietic cells is regulated by a plethora of so-called transcription factors (TFs). Mutations in genes encoding TFs or graded reduction in their expression levels can induce the development of various malignant diseases such as acute myeloid leukaemia (AML). Growth Factor Independence 1 (GFI1) is a transcriptional repressor with key roles in haematopoiesis, including regulating self-renewal of haematopoietic stem cells (HSCs) as well as myeloid and lymphoid differentiation. Analysis of AML patients and different AML mouse models with reduced GFI1 gene expression levels revealed a direct link between low GFI1 protein level and accelerated AML development and inferior prognosis...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29144447/bcat1-restricts-%C3%AE-kg-levels-in-aml-stem-cells-leading-to-idhmut-like-dna-hypermethylation
#2
Simon Raffel, Mattia Falcone, Niclas Kneisel, Jenny Hansson, Wei Wang, Christoph Lutz, Lars Bullinger, Gernot Poschet, Yannic Nonnenmacher, Andrea Barnert, Carsten Bahr, Petra Zeisberger, Adriana Przybylla, Markus Sohn, Martje Tönjes, Ayelet Erez, Lital Adler, Patrizia Jensen, Claudia Scholl, Stefan Fröhling, Sibylle Cocciardi, Patrick Wuchter, Christian Thiede, Anne Flörcken, Jörg Westermann, Gerhard Ehninger, Peter Lichter, Karsten Hiller, Rüdiger Hell, Carl Herrmann, Anthony D Ho, Jeroen Krijgsveld, Bernhard Radlwimmer, Andreas Trumpp
The branched-chain amino acid (BCAA) pathway and high levels of BCAA transaminase 1 (BCAT1) have recently been associated with aggressiveness in several cancer entities. However, the mechanistic role of BCAT1 in this process remains largely uncertain. Here, by performing high-resolution proteomic analysis of human acute myeloid leukaemia (AML) stem-cell and non-stem-cell populations, we find the BCAA pathway enriched and BCAT1 protein and transcripts overexpressed in leukaemia stem cells. We show that BCAT1, which transfers α-amino groups from BCAAs to α-ketoglutarate (αKG), is a critical regulator of intracellular αKG homeostasis...
November 16, 2017: Nature
https://www.readbyqxmd.com/read/29136959/alterations-of-biomechanics-in-cancer-and-normal-cells-induced-by-doxorubicin
#3
Kaja Fraczkowska, Marcin Bacia, Magda Przybyło, Dominik Drabik, Aleksandra Kaczorowska, Justyna Rybka, Ewa Stefanko, Slawomir Drobczynski, Jan Masajada, Halina Podbielska, Tomasz Wrobel, Marta Kopaczynska
Mechanical properties of biological structures play an important role in regulating cellular activities and are critical for understanding metabolic processes in cancerous cells and the effects of drugs. For some cancers, such as acute myeloid leukaemia, chemotherapy is one of preferential methods. However, due to the lack of selectivity to cancer cells, cytostatic agents cause toxicity to normal tissues. Here, we study the effect of doxorubicin (DOX) on the mechanical properties of DNA molecules, leukemic blast cells and erythrocytes, using optical tweezers...
November 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29129782/reactive-oxygen-species-production-triggers-green-tea-induced-anti-leukaemic-effects-on-acute-promyelocytic-leukaemia-model
#4
Cristiane Okuda Torello, Rodrigo Naoto Shiraishi, Fernanda Isabel Della Via, Tamara Cristina Lopes de Castro, Ana Leda Longhini, Irene Santos, André Luis Bombeiro, Cleide Lúcia Araujo Silva, Mary Luci de Souza Queiroz, Eduardo Magalhães Rego, Sara Teresinha Olalla Saad
Green tea (GT) has been consumed as a beverage for thousands of years because of its therapeutic properties observed over time. Because there is no sufficient evidence supporting the protective role of tea intake during the development of acute myeloid leukaemia, we herein study GT extract effects on an acute promyelocytic leukaemia model. Our results demonstrated that GT reduces leucocytosis and immature cells (blasts) in peripheral blood, bone marrow (BM), and spleen of leukaemic mice, parallel with an increase of mature cells in the BM...
November 9, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29120027/humanised-mouse-models-for-haematopoiesis-and-infectious-diseases
#5
Veronika Lysenko, Donal McHugh, Lena Behrmann, Mary-Aude Rochat, Christian Matthias Wilk, Larisa Kovtonyuk, Jean-Pierre Bourquin, Christian Münz, Markus Gabriel Manz, Roberto Speck, Alexandre Theocharides
"Humanised" mouse models have emerged over past years as powerful tools for investigating human haematopoiesis and immunity. They allowed the identification of key factors for the maintenance and function of normal and leukaemic human haematopoietic stem cells. These findings have been widely used to dissect the pathogenesis of multiple myeloid and lymphoid neoplasms, such as acute myeloid leukaemia and acute lymphoblastic leukaemia. Furthermore, these models can serve as a stepping-stone to clinical trials by testing novel drugs that target leukaemic stem cells...
November 9, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29113504/enhancement-of-chemosensitivity-by-simultaneously-silencing-of-mcl-1-and-survivin-genes-using-small-interfering-rna-in-human-myelomonocytic-leukaemia
#6
Mahdi Jafarlou, Dariush Shanehbandi, Parvin Dehghan, Behzad Mansoori, F Othman, Behzad Baradaran
Acute myeloid leukaemia (AML) is a genetically heterogeneous, severe and rapidly progressing disease triggered by blocking granulocyte or monocyte differentiation and maturation. Overexpression of myeloid cell leukaemia-1 (Mcl-1) and Survivin is associated with drug resistance, tumour progression and inhibition of apoptotic mechanisms in leukaemia and several cancers. In the present study, we examined the combined effect of etoposide and dual siRNA-mediated silencing of Mcl-1 and Survivin on U-937 AML cells...
November 7, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29098953/efficacy-of-clara-in-recurrent-refractory-acute-myeloid-leukaemia-patients-unresponsive-to-flag-chemotherapy
#7
Ali Hakan Kaya, Emre Tekgündüz, Kadir Ilkkiliç, Mehmet Sinan Dal, Alparslan Merdin, Abdullah Karakus, Sibel Kabukcu Hacioglu, Filiz Bekdemir, Merih Kızıl Çakar, Mehmet Hilmi Dogu, Mehmet Orhan Ayyildiz, Serdal Korkmaz, Fevzi Altuntaş
We hereby report our multicentre, retrospective experience with CLARA in patients with fludarabine/cytarabine/G-CSF (FLAG) refractory AML. The study included all consecutive R/R AML patients, who received CLARA salvage during October 2010-October 2015 period. All patients were unresponsive to FLAG salvage chemotherapy regimen and did not undergo previous allo-HCT. A total of 40 patients were included. Following CLARA 5 (12.5%) patients experienced induction mortality and 10 (25%) patients achieved CR. 25 (62...
November 3, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29076145/durable-graft-versus-leukaemia-effects-without-donor-lymphocyte-infusions-results-of-a-phase-ii-study-of-sequential-t-replete-allogeneic-transplantation-for-high-risk-acute-myeloid-leukaemia-and-myelodysplasia
#8
Jeff K Davies, Sandra Hassan, Shah-Jalal Sarker, Caroline Besley, Heather Oakervee, Matthew Smith, David Taussig, John G Gribben, Jamie D Cavenagh
Allogeneic haematopoietic stem-cell transplantation remains the only curative treatment for relapsed/refractory acute myeloid leukaemia (AML) and high-risk myelodysplasia but has previously been limited to patients who achieve remission before transplant. New sequential approaches employing T-cell depleted transplantation directly after chemotherapy show promise but are burdened by viral infection and require donor lymphocyte infusions (DLI) to augment donor chimerism and graft-versus-leukaemia effects. T-replete transplantation in sequential approaches could reduce both viral infection and DLI usage...
October 26, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29076133/effects-of-vascular-endothelial-growth-factors-and-their-receptors-on-megakaryocytes-and-platelets-and-related-diseases
#9
REVIEW
Jin-Gang Yang, Li-Li Wang, Dong-Chu Ma
It is well known that vascular endothelial growth factors (VEGFs) and their receptors (vascular endothelial growth factor receptors, VEGFRs) are expressed in different tissues, and VEGF-VEGFR loops regulate a wide range of responses, including metabolic homeostasis, cell proliferation, migration and tubuleogenesis. As ligands, VEGFs act on three structurally related VEGFRs (VEGFR1, VEGFR2 and VEGFR3 [also termed FLT1, KDR and FLT4, respectively]) that deliver downstream signals. Haematopoietic stem cells (HSCs), megakaryocytic cell lines, cultured megakaryocytes (MKs), primary MKs and abnormal MKs express and secrete VEGFs...
October 26, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29065396/cd34-cd38-cd123-cells-are-present-in-virtually-all-acute-myeloid-leukaemia-blasts-a-promising-single-unique-phenotype-for-minimal-residual-disease-detection
#10
Adhra Al-Mawali, Avinash Daniel Pinto, Shoaib Al-Zadjali
BACKGROUND/AIMS: In CD34-positive acute myeloid leukaemia (AML), the leukaemia-initiating event likely takes place in the CD34+CD38- cell compartment. CD123 has been shown to be a unique marker of leukaemic stem cells within the CD34+CD38- compartment. The aim of this study was to identify the percentage of CD34+CD38-CD123+ cells in AML blasts, AML CD34+CD38- stem cells, and normal and regenerating bone marrow CD34+CD38- stem cells from non-myeloid malignancies. METHODS: Thirty-eight adult de novo AML patients with intention to treat were enrolled after the application of inclusion criteria from February 2012 to February 2017...
October 25, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/29055209/long-term-survival-of-sorafenib-treated-flt3-itd-positive-acute-myeloid-leukaemia-patients-relapsing%C3%A2-after-allogeneic-stem-cell-transplantation
#11
S K Metzelder, T Schroeder, M Lübbert, M Ditschkowski, K Götze, S Scholl, R G Meyer, P Dreger, N Basara, M F Fey, H R Salih, A Finck, T Pabst, A Giagounidis, G Kobbe, E Wollmer, J Finke, A Neubauer, A Burchert
BACKGROUND: Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD)-positive acute myeloid leukaemia (AML) relapsing after allogeneic stem cell transplantation (allo-SCT) has a dismal prognosis with limited therapeutic options. FLT3-ITD kinase inhibition is a reasonable but palliative experimental treatment alternative in this situation. Information on long-term outcome is not available. METHODS: We performed a long-term follow-up analysis of a previously reported cohort of 29 FLT3-ITD-positive AML patients, which were treated in relapse after allo-SCT with sorafenib monotherapy...
October 18, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29051282/small-bone-marrow-adipocytes-predict-poor-prognosis-in-acute-myeloid-leukaemia
#12
Wei Lu, Wei Weng, Qi Zhu, Yuanmei Zhai, Yun Wan, Haiyan Liu, Shaoxin Yang, Yehua Yu, Yanyu Wei, Jun Shi
No abstract text is available yet for this article.
October 19, 2017: Haematologica
https://www.readbyqxmd.com/read/29048114/relapsing-polychondritis-as-a-presenting-feature-of-acute-myeloid-leukaemia
#13
Ya-Ting Hsu, Tsai-Yun Chen
No abstract text is available yet for this article.
October 19, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29048109/evaluation-of-a-disease-risk-index-for-adult-patients-undergoing-umbilical-cord-blood-transplantation-for-haematological-malignancies
#14
Annalisa Paviglianiti, Annalisa Ruggeri, Fernanda Volt, Guillermo Sanz, Noel Milpied, Sabine Furst, Albert Esquirol, William Arcese, Alessandra Picardi, Christelle Ferra, Norbert Ifrah, Jean H Bourhis, Kavita Raj, Peter A von dem Borne, Simona Sica, Anne-Lise Menard, Adrian Bloor, Chantal Kenzey, Eliane Gluckman, Vanderson Rocha
A disease risk index (DRI) has been defined for stratifying heterogeneous cohorts of patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT). This index defines 4 distinct groups with different outcomes, dividing patients by disease type and status and considering cytogenetics for acute myeloid leukaemia and myelodysplastic syndromes (MDS). Recently, the DRI has been refined to include rare diseases and improve MDS stratification by blast percentage and response to prior therapy. Previous reports on DRI include only a small number of UCBT recipients...
October 19, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29035359/acute-myeloid-leukaemia-disrupts-endogenous-myelo-erythropoiesis-by-compromising-the-adipocyte-bone-marrow-niche
#15
Allison L Boyd, Jennifer C Reid, Kyle R Salci, Lili Aslostovar, Yannick D Benoit, Zoya Shapovalova, Mio Nakanishi, Deanna P Porras, Mohammed Almakadi, Clinton J V Campbell, Michael F Jackson, Catherine A Ross, Ronan Foley, Brian Leber, David S Allan, Mitchell Sabloff, Anargyros Xenocostas, Tony J Collins, Mickie Bhatia
Acute myeloid leukaemia (AML) is distinguished by the generation of dysfunctional leukaemic blasts, and patients characteristically suffer from fatal infections and anaemia due to insufficient normal myelo-erythropoiesis. Direct physical crowding of bone marrow (BM) by accumulating leukaemic cells does not fully account for this haematopoietic failure. Here, analyses from AML patients were applied to both in vitro co-culture platforms and in vivo xenograft modelling, revealing that human AML disease specifically disrupts the adipocytic niche in BM...
November 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/29031126/artesunate-induces-apoptosis-via-inhibition-of-stat3-in-thp-1-cells
#16
Mei Tan, Ying Rong, Qiong Su, Yan Chen
OBJECTIVE: Our objective was to explore STAT3 expression in patients with acute myeloid leukaemia (AML), assess the anti-proliferative effects of artesunate (ART) on THP-1 cells in vivo and in vitro, and investigate the underlying mechanisms. METHODS: In this study, we examined 30 patients with acute myeloid leukaemia diagnosed in our hospital from January 2015 to January 2016. The 20 control group patients had non-haematological diseases and were hospitalized for the same period...
November 2017: Leukemia Research
https://www.readbyqxmd.com/read/29030252/sub-clonal-analysis-of-the-murine-c1498-acute-myeloid-leukaemia-cell-line-reveals-genomic-and-immunogenic-diversity
#17
Virginie Driss, Frédéric Leprêtre, Isabelle Briche, Alexia Mopin, Céline Villenet, Martin Figeac, Bruno Quesnel, Carine Brinster
BACKGROUND: In acute myeloid leukaemia (AML)-affected patients, the presence of heterogeneous sub-clones at diagnosis has been shown to be responsible for minimal residual disease and relapses. The role played by the immune system in this leukaemic sub-clonal hierarchy and maintenance remains unknown. As leukaemic sub-clone immunogenicity could not be evaluated in human AML xenograft models, we assessed the sub-clonal diversity of the murine C1498 AML cell line and the immunogenicity of its sub-clones in immune-competent syngeneic mice...
October 10, 2017: Immunology Letters
https://www.readbyqxmd.com/read/29017180/targeting-apoptosis-in-acute-myeloid-leukaemia
#18
REVIEW
Philippe A Cassier, Marie Castets, Amine Belhabri, Norbert Vey
Acute myeloid leukaemia (AML) is a molecularly and clinically heterogeneous disease, and its incidence is increasing as the populations in Western countries age. Despite major advances in understanding the genetic landscape of AML and its impact on the biology of the disease, standard therapy has not changed significantly in the last three decades. Allogeneic haematopoietic stem cell transplantation remains the best chance for cure, but can only be offered to a minority of younger fit patients. Molecularly targeted drugs aiming at restoring apoptosis in leukaemic cells have shown encouraging activity in early clinical trials and some of these drugs are currently being evaluated in randomised controlled trials...
October 10, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28993357/runx1-runx1t1-positive-acute-myeloid-leukaemia-presenting-as-bilateral-proptosis-and-multiple-cranial-nerve-palsy
#19
Sidharth Totadri, Prateek Bhatia, Sreejesh Sreedharanunni
We describe a unique presentation of acute myeloid leukaemia (AML) with myeloid sarcoma (MS), manifested as proptosis with multiple cranial nerve palsies in a 9-year-old boy. MRI of the brain revealed multiple enhancing lesions and bilateral mastoiditis, in addition to sagittal sinus thrombosis. Peripheral blood smear demonstrated blasts showing Auer rods. Bone marrow examination confirmed the diagnosis of AML. PCR was positive for RUNX1-RUNX1T1. Neurological deficits improved with induction chemotherapy for AML...
October 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28984348/acute-myeloid-leukaemia-with-gene-mutation-a-correlation-with-haematological-and-immunophenotypic-characteristics-and-our-experience-in-a-tertiary-care-cancer-center-in-south-india
#20
Rachna Khera, Faiq Ahmed, Manasi Mundada, Lavanya Nambaru, Sudha S Murthy, Sandhya Devig, Senthil J Rajappa, Krishna Mohan Mallavarapu, A Santa, Pavan Kumar
OBJECTIVE: Molecular genetic analysis of FLT3, NPM1, and CEBPA is already the standard of care in patients with acute myeloid leukaemia (AML) and represents the most frequent genetic alterations and important diagnostic and prognostic indicators. This study was undertaken to determine the frequency of FLT3 and NPM1 gene mutations in our institution and to characterize the association between gene mutations and haematological parameters as well as immunophenotypic features. MATERIAL AND METHOD: Morphological, haematological and immunophenotypic characteristics of NPM1 and FLT3 mutations in 126 patients of de novo AML including adults and children were studied...
October 6, 2017: Türk Patoloji Dergisi
keyword
keyword
25318
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"