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Acute lymphoblastic leukaemia

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https://www.readbyqxmd.com/read/29321348/influence-of-thiopurine-methyltransferase-gene-polymorphism-on-egyptian-children-with-acute-lymphoblastic-leukaemia
#1
Azza A G Tantawy, Fatma S E Ebeid, Amira A M Adly, Eman El-Ghoroury, Mai Mostafa
Thiopurine methyltransferase (TPMT) gene polymorphism regulates thiopurine therapeutic efficacy and toxicity. The aim of this study was to determine the influence of TPMT gene polymorphism in Egyptian children with acute lymphoblastic leukaemia (ALL). Sixty-four patients with ALL, T lineage (27%) and pre-B phenotype (73%), who were treated with BFM 90 or CCG 1991 standard risk protocol, and who also experiencedmyleosuppresion toxicity and required interruption and/ormodification of thiopurine chemotherapy were recruited over a year period...
December 2017: Journal of Genetics
https://www.readbyqxmd.com/read/29304322/epidemiological-patterns-of-leukaemia-in-184-countries-a-population-based-study
#2
Adalberto Miranda-Filho, Marion Piñeros, Jacques Ferlay, Isabelle Soerjomataram, Alain Monnereau, Freddie Bray
BACKGROUND: Leukaemia is a heterogeneous group of haemopoietic cancers that comprises a number of diverse and biologically distinct subgroups. We examine the leukaemia burden worldwide and highlight the distinct incidence patterns in order to elucidate explanatory factors that may support preventive measures and health resource planning. We aimed to estimate the global burden of leukaemia incidence according to the four major subtypes stratified by age and sex. METHODS: In this population-based study, we assessed leukaemia incidence for the major subtypes using the Cancer Incidence in Five Continents Volume X (CI5-X), which includes data from 290 cancer registries in 68 countries covering the diagnostic period 2003-07, for all ages and both sexes...
January 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29302068/autoimmunity-checkpoints-as-therapeutic-targets-in-b-cell-malignancies
#3
REVIEW
Markus Müschen
Targeted therapy of cancer typically focuses on inhibitors (for example, tyrosine kinase inhibitors) that suppress oncogenic signalling below a minimum threshold required for survival and proliferation of cancer cells. B cell acute lymphoblastic leukaemia and B cell lymphomas originate from various stages of development of B cells, which, unlike other cell types, are under intense selective pressure. The vast majority of newly generated B cells are autoreactive and die by negative selection at autoimmunity checkpoints (AICs)...
January 5, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29301507/incidence-socioeconomic-deprivation-volume-outcome-and-survival-in-adult-patients-with-acute-lymphoblastic-leukaemia-in-england
#4
Ravi Maheswaran, Nick Morley
BACKGROUND: We examined incidence and survival in relation to age, gender, socioeconomic deprivation, rurality and trends over time. We also examined the association between volume of patients treated by hospitals and survival. METHODS: Incident cases (2001-12) were identified using comprehensive National Health Service admissions data for England, with follow-up to March 2013. Socioeconomic deprivation was based on census area of residence. Volume was assessed in a three-year subset of the data with consistent hospital provider codes...
January 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29290986/the-effect-of-the-jak2-inhibitor-tg101209-against-t-cell-acute-lymphoblastic-leukemia-t-all-is-mediated-by-inhibition-of-jak-stat-signaling-and-activation-of-the-crosstalk-between-apoptosis-and-autophagy-signaling
#5
Zhao Cheng, Yifang Yi, Sisi Xie, Haizhi Yu, Hongling Peng, Guangsen Zhang
Previous reports have shown that active JAK2 contributes to T cell acute lymphoblastic leukaemia (T-ALL) development and that JAK inhibitors may be a potential treatment for T-ALL. In the current study, the JAK2 inhibitor TG101209 was used to treat T-ALL cell lines and primary T-ALL cells. The effects of TG101209 on T-ALL cells were determined, and the signaling proteins related to cell growth, apoptosis and autophagy were analysed. The results indicated that TG101209 significantly inhibited T-ALL cell proliferation and induced cell apoptosis in a dose-dependent manner...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29288188/efficacy-and-safety-of-chimeric-antigen-receptor-t-cell-car-t-therapy-in-patients-with-haematological-and-solid-malignancies-protocol-for-a-systematic-review-and-meta-analysis
#6
Emma J M Grigor, Dean A Fergusson, Fatima Haggar, Natasha Kekre, Harold Atkins, Risa Shorr, Robert A Holt, Brian Hutton, Tim Ramsay, Matthew Seftel, Derek Jonker, Mads Daugaard, Kednapa Thavorn, Justin Presseau, Manoj M Lalu
INTRODUCTION: Patients with relapsed or refractory malignancies have a poor prognosis. Immunotherapy with chimeric antigen receptor T (CAR-T) cells redirects a patient's immune cells against the tumour antigen. CAR-T cell therapy has demonstrated promise in treating patients with several haematological malignancies, including acute B-cell lymphoblastic leukaemia and B-cell lymphomas. CAR-T cell therapy for patients with other solid tumours is also being tested. Safety is an important consideration in CAR-T cell therapy given the potential for serious adverse events, including death...
December 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/29285342/a-study-on-the-predictability-of-acute-lymphoblastic-leukaemia-response-to-treatment-using-a-hybrid-oncosimulator
#7
Eleftherios Ouzounoglou, Eleni Kolokotroni, Martin Stanulla, Georgios S Stamatakos
Efficient use of Virtual Physiological Human (VPH)-type models for personalized treatment response prediction purposes requires a precise model parameterization. In the case where the available personalized data are not sufficient to fully determine the parameter values, an appropriate prediction task may be followed. This study, a hybrid combination of computational optimization and machine learning methods with an already developed mechanistic model called the acute lymphoblastic leukaemia (ALL) Oncosimulator which simulates ALL progression and treatment response is presented...
February 6, 2018: Interface Focus
https://www.readbyqxmd.com/read/29279597/severe-asymptomatic-hypophosphataemia-in-a-child-with-t-acute-lymphoblastic-leukaemia
#8
N H Zakaria, P Sthaneshwar, H Shanmugam
Hypophosphataemia is a metabolic disorder that is commonly encountered in critically ill patients. Phosphate has many roles in physiological functions, thus the depletion of serum phosphate could lead to impairment in multiple organ systems, which include the respiratory, cardiovascular, neurological and muscular systems and haematological and metabolic functions. Hypophosphataemia is defined as plasma phosphate level below 0.80 mmol per litre (mmol/L) and can be further divided into subgroups of mild (plasma phosphate of 0...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29258294/senescence-associated-reprogramming-promotes-cancer-stemness
#9
Maja Milanovic, Dorothy N Y Fan, Dimitri Belenki, J Henry M Däbritz, Zhen Zhao, Yong Yu, Jan R Dörr, Lora Dimitrova, Dido Lenze, Ines A Monteiro Barbosa, Marco A Mendoza-Parra, Tamara Kanashova, Marlen Metzner, Katharina Pardon, Maurice Reimann, Andreas Trumpp, Bernd Dörken, Johannes Zuber, Hinrich Gronemeyer, Michael Hummel, Gunnar Dittmar, Soyoung Lee, Clemens A Schmitt
Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the further expansion of (pre-)malignant cells. Key signalling components of the senescence machinery, such as p16INK4a, p21CIP1 and p53, as well as trimethylation of lysine 9 at histone H3 (H3K9me3), also operate as critical regulators of stem-cell functions (which are collectively termed 'stemness'). In cancer cells, a gain of stemness may have profound implications for tumour aggressiveness and clinical outcome. Here we investigated whether chemotherapy-induced senescence could change stem-cell-related properties of malignant cells...
December 20, 2017: Nature
https://www.readbyqxmd.com/read/29236998/extensive-myocardial-calcification-in-septic-shock-and-precursor-b-cell-acute-lymphoblastic-leukaemia
#10
Rena Ng, David Ferreira, Allan Davies, Elizabeth Hesketh, Bruce Bastian
No abstract text is available yet for this article.
December 11, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29235187/the-clinical-utility-of-fluorodeoxyglucose-positron-emission-tomography-for-investigation-of-fever-in-immunocompromised-children
#11
Shiqi Stacie Wang, Francoise Mechinaud, Karin Thursky, Timothy Cain, Eddie Lau, Gabrielle M Haeusler
AIM: Fever in immunocompromised children presents significant challenges. We aimed to determine the clinical impact of fluorodeoxyglucose-positron emission tomography (FDG-PET) in combination with computed tomography (CT) in children with malignancy or following haematopoietic stem cell transplantation with prolonged or recurrent fever. METHODS: Immunocompromised children who underwent FDG-PET/CT for investigation of prolonged or recurrent fever were identified from hospital databases...
December 13, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29226354/liquid-chromatographic-methods-for-the-therapeutic-drug-monitoring-of-methotrexate-as-clinical-decision-support-for-personalized-medicine-a-brief-review
#12
REVIEW
Mónica Francisco Silva, Cláudia Ribeiro, Virgínia M F Gonçalves, Maria Elizabeth Tiritan, Áurea Lima
Methotrexate (MTX) is an antifolate drug used for several diseases. Depending on the disease, MTX can be administered at low-dose (LDMTX) in some autoimmune diseases, like rheumatoid arthritis, or at high-dose (HDMTX) in some cancers, such as acute lymphoblastic leukaemia. After absorption, MTX is metabolized in the liver to 7-hydroxymethotrexate (7-OH-MTX) and in the intestine to 2,4-diamino-N10-methylpteroic acid (DAMPA). Moreover, inside red blood cells (RBCs), MTX is converted to active metabolites, MTX polyglutamates (MTXPGs), contributing to its pharmacodynamics...
December 11, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29222892/benefit-of-oral-nutritional-supplements-for-children-with-acute-lymphoblastic-leukaemia-during-remission-induction-chemotherapy-a-quasi-experimental-study
#13
Rui Liang, Gai-Yun Chen, San-Xian Fu, Jie Zhong, Yan Ma
BACKGROUND AND OBJECTIVES: To determine the effect of oral nutritional supplements (ONS) on children with acute lymphoblastic leukaemia undergoing remission-induction chemotherapy. METHODS AND STUDY DESIGN: We included 127 paediatric patients who were diagnosed with acute lymphoblastic leukaemia and undergoing remission- induction chemotherapy in the First Affiliated Hospital of Zhengzhou University. Children from two paediatric wards who met the inclusion criteria were enrolled...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29218389/primary-prophylaxis-of-invasive-fungal-infections-in-patients-with-haematological-malignancies-2017-update-of-the-recommendations-of-the-infectious-diseases-working-party-agiho-of-the-german-society-for-haematology-and-medical-oncology-dgho
#14
REVIEW
Sibylle C Mellinghoff, Jens Panse, Nael Alakel, Gerhard Behre, Dieter Buchheidt, Maximilian Christopeit, Justin Hasenkamp, Michael Kiehl, Michael Koldehoff, Stefan W Krause, Nicola Lehners, Marie von Lilienfeld-Toal, Annika Y Löhnert, Georg Maschmeyer, Daniel Teschner, Andrew J Ullmann, Olaf Penack, Markus Ruhnke, Karin Mayer, Helmut Ostermann, Hans-H Wolf, Oliver A Cornely
Immunocompromised patients are at high risk of invasive fungal infections (IFI), in particular those with haematological malignancies undergoing remission-induction chemotherapy for acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS) and recipients of allogeneic haematopoietic stem cell transplants (HSCT). Despite the development of new treatment options in the past decades, IFI remains a concern due to substantial morbidity and mortality in these patient populations. In addition, the increasing use of new immune modulating drugs in cancer therapy has opened an entirely new spectrum of at risk periods...
December 7, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29200702/affordable-and-safe-health-care-for-all-children-lessons-learned-from-the-use-of-peg-asparaginase-in-a-developing-country
#15
Dhaarani Jayaraman, Ramya Uppuluri, Venkateswaran Vellaichamy Swaminathan, Meena Sivasankaran, Shivani Patel, Revathi Raj
Peg-asparaginase has widely replaced the use of conventional asparaginase in treatment of children with acute lymphoblastic leukaemia in developed countries. In developing countries like India, with financial constraints being a part of clinical challenge to the treatment of cancers, uniform use of Peg-asparaginase in all children is not practically possible. However, we found by a retrospective analysis of 211 children treated for acute lymphoblastic leukaemia, uniform use of this drug was feasible with indigenous techniques like storing the drug with strict cold chain maintenance and sharing the drug amongst 2 or 3 patients to reduce the burden on each family...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29197892/relapse-of-b-cell-acute-lymphoblastic-leukaemia-presenting-as-right-aural-polyp-with-facial-and-mandibular-nerves-palsy
#16
C Shiun Chuen, M K Md Daud, N A Che Jalil, H Hazmi
A patient presenting with an ear polyp is a common finding in otorhinolaryngology practice. The common causes include chronic otitis media and cholesteatoma. We report an adult female patient with a history of acute leukaemia presenting with chronic otitis media symptoms and right ear polyp. She was subsequently diagnosed as relapse of B-cell acute lymphoblastic leukaemia based on histopathological examination. The presentation may be similar to an inflammatory pathology of the middle ear, making it misleading...
October 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/29194562/a-risk-score-including-microdeletions-improves-relapse-prediction-for-standard-and-medium-risk-precursor-b-cell-acute-lymphoblastic-leukaemia-in-children
#17
Rosemary Sutton, Nicola C Venn, Tamara Law, Judith M Boer, Toby N Trahair, Anthea Ng, Monique L Den Boer, Anuruddhika Dissanayake, Jodie E Giles, Pauline Dalzell, Chelsea Mayoh, Draga Barbaric, Tamas Revesz, Frank Alvaro, Rob Pieters, Michelle Haber, Murray D Norris, Martin Schrappe, Luciano Dalla Pozza, Glenn M Marshall
To prevent relapse, high risk paediatric acute lymphoblastic leukaemia (ALL) is treated very intensively. However, most patients who eventually relapse have standard or medium risk ALL with low minimal residual disease (MRD) levels. We analysed recurrent microdeletions and other clinical prognostic factors in a cohort of 475 uniformly treated non-high risk precursor B-cell ALL patients with the aim of better predicting relapse and refining risk stratification. Lower relapse-free survival at 7 years (RFS) was associated with IKZF1 intragenic deletions (P < 0·0001); P2RY8-CRLF2 gene fusion (P < 0·0004); Day 33 MRD>5 × 10-5 (P < 0·0001) and High National Cancer Institute (NCI) risk (P < 0·0001)...
November 30, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29193007/outcome-of-relapse-after-allogeneic-hsct-in-children-with-all-enrolled-in-the-all-sct-2003-2007-trial
#18
Michaela Kuhlen, Andre M Willasch, Jean-Hugues Dalle, Jacek Wachowiak, Isaac Yaniv, Marianne Ifversen, Petr Sedlacek, Tayfun Guengoer, Peter Lang, Peter Bader, Sabina Sufliarska, Adriana Balduzzi, Brigitte Strahm, Irene von Luettichau, Jessica I Hoell, Arndt Borkhardt, Thomas Klingebiel, Martin Schrappe, Arend von Stackelberg, Evgenia Glogova, Ulrike Poetschger, Roland Meisel, Christina Peters
Relapse remains the major cause of treatment failure in children with high-risk acute lymphoblastic leukaemia (ALL) undergoing allogeneic haematopoietic stem-cell transplantation (allo-SCT). Prognosis is considered dismal but data on risk factors and outcome are lacking from prospective studies. We analysed 242 children with recurrence of ALL after first allo-SCT enrolled in the Berlin-Frankfurt-Munster (BFM) ALL-SCT-BFM 2003 and ALL-SCT-BFM international 2007 studies. Median time from allo-SCT to relapse was 7·7 months; median follow-up from relapse after allo-SCT until last follow-up was 3·4 years...
November 28, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29183344/oral-verruciform-xanthoma-and-erythroplakia-associated-with-chronic-graft-versus-host-disease-a-rare-case-report-and-review-of-the-literature
#19
Giorgia Capocasale, Vera Panzarella, Pietro Tozzo, Rodolfo Mauceri, Vito Rodolico, Dorina Lauritano, Giuseppina Campisi
BACKGROUND: Oral verruciform xanthoma is an uncommon benign lesion. Although oral verruciform xanthoma occurs in healthy individuals, it has been also reported in association with some inflammatory conditions. The aim of this study is to report a case of oral verruciform xanthoma associated with chronic graft-versus-host disease and to review the literature on this topic. CASE PRESENTATION: A 47-year-old Caucasian male presented to the Sector of Oral Medicine "V...
November 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29171575/a-case-of-hypotriploid-chromosome-in-a-patient-with-acute-lymphoblastic-leukaemia
#20
Bilal Ahmed Khan, Mirza Faris Ali Baig, Nadir Siddiqui
TA 58-61, XXXX, hypotriploid chromosome was detected in the cytogenetics report of a 28 years old female patient, known case of B-cell Acute Lymphoblastic Leukaemia. On admission, the patient had normal physical examination findings and mental status, except history of fever spikes and generalized bone pains. The patient was admitted for induction of chemotherapy. Bone Marrow/Trephine biopsy report showed diffuse infiltration with blast cells with overall cellularity around 80-85% and suppressed normal haematopoiesis...
November 2017: JPMA. the Journal of the Pakistan Medical Association
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