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Spondyloarthritides

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https://www.readbyqxmd.com/read/27749140/biologic-therapy-for-hla-b27-associated-ocular-disorders
#1
Julie Gueudry, Jennifer E Thorne, Rakesh Bansie, Juergen Braun, P Martin van Hagen, Bahram Bodaghi
The treatment of articular and extra-articular manifestations associated with HLA-B27 has undergone dramatic changes over the past two decades, mainly as a consequence of the introduction of biologic agents and in particular anti-tumor necrosis factor α (anti-TNFα) agents. Uveitis is known to be the most frequent extra-articular feature in HLA-B27-associated spondyloarthritides. Topical corticosteroids and cycloplegic agents remain the cornerstones of treatment. However, biologic therapy may be effective in the management of refractory or recurrent forms of uveitis...
October 17, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27747518/secukinumab-a-new-treatment-option-for-psoriatic-arthritis
#2
Philip Mease, Iain B McInnes
INTRODUCTION: Psoriatic arthritis (PsA) is an immune-mediated chronic inflammatory arthropathy associated with impaired physical function and reduced quality of life. Biologic therapies that target tumor necrosis factor (anti-TNF) have significantly improved clinical outcomes. Partial, non- and transient responses remain common comprising significant unmet clinical need. New therapies with novel modes of action are urgently required. OBJECTIVES: The interleukin (IL)-17 pathway has recently been attributed a critical role in the pathogenesis of spondyloarthritides...
June 2016: Rheumatology and Therapy
https://www.readbyqxmd.com/read/27726745/adult-inflammatory-arthritides-what-the-radiologist-should-know
#3
Eric Y Chang, Karen C Chen, Brady K Huang, Arthur Kavanaugh
Developments and improvements in knowledge are rapid and ongoing in both the radiologic and rheumatologic fields. During the past decade, the roles of imaging and the radiologist in the assessment and management of many inflammatory rheumatologic diseases have undergone several changes. To remain effective in patient care, the radiologist needs to be aware of these changes when recommending and interpreting imaging examinations for the referring physician. The goal of contemporary rheumatoid arthritis (RA) management is to redefine RA as a disease that is no longer characterized by erosions, which reflect established or long-standing untreated disease...
October 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27701693/-evidence-based-physical-therapy-of-rheumatic-diseases
#4
Wilfried Mau
New studies increase the evidence, that different applications of physical therapy are effective. In patients with rheumatoid arthritis (RA) physiotherapy of the hands improve strength, joint mobility and activity without increased risk of pain nor inflammation. A theory-based physiotherapy of the hands shows clinical effectiveness and cost-utility. In patients with spondyloarthritides supervised group exercise training is more effective than home exercise programs. Compared with biologics only combined exercise training and tumour necrosis factor alpha inhibitor therapy improve mobility and disease activity more effectively...
September 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27627085/-adverse-effects-of-biological-therapy-in-rheumatology
#5
Marta Olejárová
UNLABELLED: The biological treatment which is the most effective type of therapy for inflammatory rheumatic diseases, has become part of a standard clinical rheumatology practice in recent years. Thousands of patients in the Czech Republic with rheumatoid arthritis, different forms of spondyloarthritides and with psoriatic arthritis are now successfully treated in this way. The following medications are registered in the Czech Republic for the treatment of rheumatic diseases: infliximab, adalimumab, golimumab, certolizumab pegol, etanercept, abatacept, rituximab, tocilizumab and belimumab, newly also secukinumab...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27423748/hla-b27-allele-frequency-in-sri-lankan-patients-with-spondyloarthritides
#6
S Kidnapillai, N D Sirisena, V H Dissanayake
This preliminary study aims to describe the HLA-B27 allele frequency in Sri Lankan patients with spondyloarthritides (SA). An anonymised database of 373 Sri Lankan patients with SA referred for HLA-B27 testing was retrospectively analysed. Eighty five (22.8%) patients were positive for the HLA-B27 allele. A male preponderance was observed among the positives. The HLA-B27 allele frequency in this sample of patients with SA was relatively low compared to published studies in other populations. Further research is needed to identify the predominant subtypes of the allele to determine which subtypes are the most prevalent in a larger sample of Sri Lankan patients with SA, and to define their association with the specific types of SA...
June 2016: Ceylon Medical Journal
https://www.readbyqxmd.com/read/27417564/improved-clinical-functional-and-work-outcomes-in-spondyloarthritides-during-real-life-adalimumab-treatment-in-central-eastern-europe
#7
Sándor Szántó, Gyula Poór, Daniela Opris, Oleg Iaremenko, Leona Procházková, Reet Kuuse, Orsolya Nagy, Valentyn Chernyshov, Pál Géher
AIM: Adalimumab effectiveness on clinical, functional and work-related outcomes was evaluated in patients with active ankylosing spondylitis or psoriatic arthritis treated in routine clinical practice in central-eastern Europe. METHODS: Patients (n = 555) were followed for 12 months. Primary end point was percentage of patients with a treatment response (≥50% decrease from baseline in Bath Ankylosing Spondylitis Disease Activity Index or ≥1.2 point decrease from baseline in Disease Activity Index-28 joint for axial or peripheral symptoms, respectively)...
August 2016: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/27089636/-general-concepts-and-pathogenesis-of-the-spondyloarthropathies
#8
Michael J Nissen
The spondyloarthritides are a group of interrelated diseases with a close association with the HLA-B27 antigen that share many common articular and extra-articular features. This paper summarizes the different classification criteria that are currently in use. While the exact pathogenesis of these diseases is not yet clearly elucidated, there are a number of hypotheses relating to HLA-B27, modifications of the microbiome and biomechanical stresses. This in turn leads to upregulation of various proinflammatory cytokines such as TNF-alpha, IL-17, IL-22 and IL-23, which results in further inflammation and osteoproliferation...
March 9, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/27067900/an-hla-b27-homodimer-specific-antibody-recognizes-a-discontinuous-mixed-disulfide-epitope-as-identified-by-affinity-mass-spectrometry
#9
Marius-Ionuţ Iuraşcu, Osiris Marroquin Belaunzanar, Claudia Cozma, Ulf Petrausch, Christoph Renner, Michael Przybylski
HLA-B27 homodimer formation is believed to be a hallmark of HLA-B27 associated spondyloarthritides. Recently, we have generated a homodimer-specific monoclonal antibody (HD6) and have demonstrated that HLA-B27 homodimer complexes are present on monocytes of healthy HLA-B27 gene carriers at low levels, with significantly increased levels at active disease. The capability of the HD6 antibody to discriminate between correctly formed HLA-B27 heterotrimers and pathology-associated homodimers is striking and cannot be explained by the primary structure of HLA-B27...
June 2016: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/26962559/concepts-in-monitoring-enthesitis-in-patients-with-spondylarthritis-the-role-of-musculoskeletal-ultrasound
#10
REVIEW
Mihaela Cosmina Micu, Daniela Fodor
Enthesitis is the key pathological lesion in the spondyloarthritides group and an important element for early diagnosis with a predictive and prognostic value. The recognition of enthesitis on a clinical basis alone remains a challenge and creates unnecessary delays in diagnosis and adequate treatment commencement. Musculoskeletal ultrasound is a valid, reliable, and feasible imaging tool valuable for identifying inflammatory and structural lesions at enthesis level, helpful in establishing a diagnosis, evaluating disease activity and therapy monitoring...
March 2016: Medical Ultrasonography
https://www.readbyqxmd.com/read/26908249/rheumatic-diseases-of-the-spine-imaging-diagnosis
#11
J A Narváez, J Hernández-Gañán, J Isern, J J Sánchez-Fernández
Spinal involvement is common both in the spondyloarthritides and in rheumatoid arthritis, in which the cervical segment is selectively affected. Rheumatoid involvement of the cervical spine has characteristic radiologic manifestations, fundamentally different patterns of atlantoaxial instability. Magnetic resonance imaging (MRI) is the technique of choice for evaluating the possible repercussions of atlantoaxial instability on the spinal cord and/or nerve roots in patients with rheumatoid arthritis as well as for evaluating parameters indicative of active inflammation, such as bone edema and synovitis...
April 2016: Radiología
https://www.readbyqxmd.com/read/26575013/ankylosis-of-the-wrist-bones-in-patients-with-rheumatoid-arthritis-a-study-with-extremity-dedicated-mri
#12
Francesca Barbieri, Giuseppe Zampogna, Dario Camellino, Francesco Paparo, Maurizio Cutolo, Giacomo Garlaschi, Marco A Cimmino
OBJECTIVES: Ankylosis, or spontaneous bone fusion, of the small joints of the hand is a rare event in patients with rheumatoid arthritis (RA), being observed in 0.8% of them on conventional radiographs. It is associated with long-lasting and severe disease. In other settings, such as fracture healing, bone fusion is a reparative process. The aim of this paper is the study of the frequency of wrist ankylosis in patients with RA in comparison with other arthritides; to correlate ankylosis with disease activity...
January 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/26557375/non-radiographic-axial-spondyloarthritis-and-ankylosing-spondylitis-what-are-the-similarities-and-differences
#13
REVIEW
X Baraliakos, J Braun
The development of the axial spondyloarthritis and ankylosing spondylitis (ASAS) classification criteria has had several implications for our understanding of the entire spectrum of spondyloarthritides (SpA). Going beyond the modified New York criteria, which concentrate on conventional radiographs of the sacroiliac joints (SIJ) for the classification of ankylosing spondylitis, the ASAS criteria add active inflammation of the SIJ as obtained by MRI and human leucocyte antigen (HLA) B27 to classify patients with chronic back pain starting at a young age as axial SpA (axSpA)...
2015: RMD Open
https://www.readbyqxmd.com/read/26523053/relationship-of-psoriatic-arthritis-to-other-spondyloarthritides
#14
Ignazio Olivieri, Salvatore D'Angelo, Michele Gilio, Carlo Palazzi, Ennio Lubrano, Angela Padula
In the early 1970s, Moll and co-workers formulated the unified concept of spondyloarthritides, a group of conditions sharing similar clinical features. Subsequently, criteria for their classification have been proposed by Amor and coworkers, the European Spondylarthropathy Study Group, and the Assessment in SpondyloArthritis international Society. Opinion, however, is divided between those who believe that the different entities of the complex represent the variable expression of the same disease ("lumpers") and those who think that these should be considered separately but under the same umbrella ("splitters")...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26125554/hla-b27-homodimer-specific-antibody-modulates-the-expansion-of-pro-inflammatory-t-cells-in-hla-b27-transgenic-rats
#15
Osiris Marroquin Belaunzaran, Sascha Kleber, Stefan Schauer, Martin Hausmann, Flora Nicholls, Maries Van den Broek, Sravan Payeli, Adrian Ciurea, Simon Milling, Frank Stenner, Jackie Shaw, Simon Kollnberger, Paul Bowness, Ulf Petrausch, Christoph Renner
OBJECTIVES: HLA-B27 is a common genetic risk factor for the development of Spondyloarthritides (SpA). HLA-B27 can misfold to form cell-surface heavy chain homodimers (B272) and induce pro-inflammatory responses that may lead to SpA pathogenesis. The presence of B272 can be detected on leukocytes of HLA-B27+ Ankylosing spondylitis (AS) patients and HLA-B27 transgenic rats. We characterized a novel B272-specific monoclonal antibody to study its therapeutic use in HLA-B27 associated disorders...
2015: PloS One
https://www.readbyqxmd.com/read/26096090/how-to-investigate-chronic-pain
#16
REVIEW
Matthew Hague, Nicholas Shenker
Chronic pain is defined as an unpleasant sensory and emotional experience persisting longer than the normal process of healing, usually longer than 3 months. About a fifth of the world's population is believed to suffer from chronic pain. In Europe, chronic pain accounts for nearly 500 m lost working days, and it costs the European economy >€34 billion (£28 billion) every year. Establishing a reliable diagnosis is the primary challenge in evaluating a patient with chronic pain. Common diagnoses not to miss include seronegative spondyloarthritides, endocrine abnormalities including severe vitamin D deficiency and polymyalgia rheumatica...
December 2014: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/26054442/-safe-use-of-biological-therapies-for-the-treatment-of-rheumatoid-arthritis-and-spondyloarthritides
#17
Licia Maria Henrique da Mota, Bóris Afonso Cruz, Claiton Viegas Brenol, Daniel Feldman Pollak, Geraldo da Rocha Castelar Pinheiro, Ieda Maria Magalhães Laurindo, Ivânio Alves Pereira, Jozélio Freire de Carvalho, Manoel Barros Bertolo, Marcelo de Medeiros Pinheiro, Max Victor Carioca Freitas, Nilzio Antônio da Silva, Paulo Louzada-Júnior, Percival Degrava Sampaio-Barros, Rina Dalva Neubarth Giorgi, Rodrigo Aires Corrêa Lima, Luis Eduardo Coelho Andrade
The treatment of autoimmune rheumatic diseases has gradually improved over the last half century, which has been expanded with the contribution of biological therapies or immunobiopharmaceuticals. However, we must be alert to the possibilities of undesirable effects from the use of this class of medications. The Brazilian Society of Rheumatology (Sociedade Brasileira de Reumatologia/SBR) produced a document based on a comprehensive literature review on the safety aspects of this class of drugs, specifically with regard to the treatment of rheumatoid arthritis (RA) and spondyloarthritides...
May 2015: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/25928402/in-situ-analysis-of-interleukin-6-expression-at-different-sites-of-zygapophyseal-joints-from-patients-with-ankylosing-spondylitis-in-comparison-to-controls
#18
J Bleil, R Maier, U Syrbe, J Sieper, H Appel
OBJECTIVES: Analysis of interleukin (IL)-6 serum levels in patients with ankylosing spondylitis (AS) has indicated that IL-6 might be a pro-inflammatory cytokine involved in AS. However, two placebo-controlled trials with monoclonal antibodies directed against the IL-6 receptor have failed to demonstrate the efficacy of the monoclonal humanized anti-human IL-6 receptor antibody over placebo for the treatment of symptoms of AS. In this study we conducted an in situ analysis of IL-6 expression at different sites of inflammation in zygapophyseal joints of patients with AS in comparison to osteoarthritis autopsy controls (CO)...
2015: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/25896337/whole-body-mri-of-juvenile-spondyloarthritis-protocols-and-pictorial-review-of-characteristic-patterns
#19
REVIEW
Michael R Aquino, Shirley M L Tse, Sumeet Gupta, Alisa C Rachlis, Jennifer Stimec
Spondyloarthritides are a group of inflammatory rheumatological diseases that cause arthritis with a predilection for spinal or sacroiliac involvement in addition to a high association with HLA-B27. Juvenile spondyloarthritis is distinct from adult spondyloarthritis and manifests more frequently as peripheral arthritis and enthesitis. Consequently juvenile spondyloarthritis is often referred to as enthesitis-related arthritis (ERA) subtype under the juvenile idiopathic arthritis (JIA) classification criteria...
April 2015: Pediatric Radiology
https://www.readbyqxmd.com/read/25834238/analysis-of-bone-samples-from-patients-with-spondyloarthritides-identifying-causes-of-new-bone-formation-in-axial-spondyloarthritis
#20
EDITORIAL
Heiner Appel, Joachim Sieper
No abstract text is available yet for this article.
April 2015: Journal of Rheumatology
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