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https://www.readbyqxmd.com/read/28108103/respiratory-support-for-very-low-birth-weight-infants-receiving-dexamethasone
#1
Yamini V Virkud, Christoph P Hornik, Daniel K Benjamin, Matthew M Laughon, Reese H Clark, Rachel G Greenberg, P Brian Smith
OBJECTIVE: To assess how neonatal intensive care units followed the American Academy of Pediatrics guidelines for use of dexamethasone in preterm infants by evaluating respiratory support at the time of dexamethasone administration. STUDY DESIGN: This is an observational study of infants discharged from one of 290 neonatal intensive care units from 2003 to 2010. The cohort included very low birth weight (<1500 g birth weight) infants born at ≤32 weeks gestational age...
January 18, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28105101/urinary-neutrophil-gelatinase-associated-lipocalin-is-an-early-predictor-of-acute-kidney-injury-in-premature-infants
#2
Ryota Kuribayashi, Hiroshi Suzumura, Toshimi Sairenchi, Yoshiyuki Watabe, Yayoi Tsuboi, George Imataka, Hidemitsu Kurosawa, Osamu Arisaka
Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is produced in response to tubular epithelial injury and is a biomarker of tubulointerstitial injury. The aim of the present study was to examine whether acute kidney injury (AKI) could be predicted by measuring uNGAL in very low-birth weight (VLBW) infants. Forty VLBW infants with birthweight below 1,500 g were enrolled in the present study. uNGAL and serum creatinine (sCre) were measured daily from postnatal days 0 to 8. Infants with sCre ≥1.2 mg/dl were diagnosed with AKI...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28100335/-methods-for-establishing-animal-model-of-bronchopulmonary-dysplasia-and-their-evaluation
#3
Zeng Xiong, Xia Zhou, Shao-Jie Yue
With the development of treatment, the survival rate of premature infants has significantly increased, especially extremely premature infants and very low birth weight infants. This has led to an increase in incidence of bronchopulmonary dysplasia (BPD) year by year. BPD has been one of the most common respiratory system diseases in premature infants, especially the small premature infants. Arrested alveolar development is an important cause of BPD. Therefore, the mechanism of arrested alveolar development and the intervention measures for promoting alveolar development are the focuses of research on BPD...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28099450/advanced-neonatal-medicine-in-china-a-national-baseline-database
#4
Xiang-Peng Liao, Selma Chipenda-Dansokho, Antoine Lewin, Nadia Abdelouahab, Shu-Qin Wei
Previous surveys of neonatal medicine in China have not collected comprehensive information on workforce, investment, health care practice, and disease expenditure. The goal of the present study was to develop a national database of neonatal care units and compare present outcomes data in conjunction with health care practices and costs. We summarized the above components by extracting data from the databases of the national key clinical subspecialty proposals issued by national health authority in China, as well as publicly accessible databases...
2017: PloS One
https://www.readbyqxmd.com/read/28099428/biomarkers-of-adiposity-are-elevated-in-preterm-very-low-birth-weight-infants-at-1-2-and-3-years-of-age
#5
Andrea F Duncan, Joshua A Frankfurt, Roy J Heyne, Charles R Rosenfeld
BACKGROUND: Preterm, very-low-birth-weight (PT-VLBW) neonates are at-risk for metabolic syndrome later in life. At 1-3yrs, they exhibit excessive weight-for-length z-scores (Wt-LZ) and elevated systolic blood pressures (SBP). Serum adipokines are biomarkers of adiposity, but expression in PT-VLBW infants is unclear. We examined the correlation between serum adipokine levels, anthropometric measures and SBP in PT-VLBW neonates at follow-up. METHODS: This was a cross-sectional cohort study of PT-VLBW infants at 1, 2 and 3yrs of age (40/cohort)...
January 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28099421/estimation-of-adult-and-neonatal-rbc-lifespans-in-anemic-neonates-using-rbcs-labeled-at-several-discrete-biotin-densities
#6
Denison J Kuruvilla, John A Widness, Demet Nalbant, Robert L Schmidt, Donald M Mock, Guohua An, Peter Veng-Pedersen
BACKGROUND: Prior conclusions that autologous neonatal red blood cells (RBC) have substantially shorter lifespans than allogeneic adult RBCs were not based on direct comparison of autologous neonatal vs. allogeneic adult RBCs performed concurrently in the same infant. Biotin labeling of autologous neonatal RBCs and allogeneic adult donor RBCs permits concurrent direct comparison of autologous vs. allogeneic RBC lifespan. METHODS: RBCs from 15 allogeneic adult donors and from 15 very low birth weight (VLBW) neonates were labeled at separate biotin densities and transfused simultaneously into the 15 neonates...
January 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28097444/obstetric-outcome-of-vanishing-twins-syndrome-a-systematic-review-and-meta-analysis
#7
REVIEW
Ling Sun, Ling X Jiang, Heng Z Chen
PURPOSE: Due to the high number of multiple embryo transfers into the uterus performed in assisted reproductive technology treatment (ART), the incidences of twin pregnancy and of vanishing twin syndrome (VTS) are correspondingly high. A number of studies have described the obstetric outcomes of the remaining fetus produced after the other twin had vanished compared with a singleton at the start following ART, but the results are mixed and contradictory. We performed a systematic review of the existing studies to explore the actual obstetric outcome of VTS to allow physicians to adequately advise their patients...
January 17, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28096129/current-knowledge-of-necrotizing-enterocolitis-in-preterm-infants-and-the-impact-of-different-types-of-enteral-nutrition-products
#8
REVIEW
Jocelyn Shulhan, Bryan Dicken, Lisa Hartling, Bodil Mk Larsen
Preterm infants are extremely vulnerable to a range of morbidities and mortality. Underdeveloped cardiac, respiratory, gastrointestinal, and immune systems in the preterm period increase the risk of necrotizing enterocolitis (NEC), a serious disease of the gut. NEC affects 5-12% of very-low birth-weight infants, leads to surgery in 20-40% of cases, and is fatal in 25-50% of cases. There are multiple factors that may contribute to NEC, but the exact cause is not yet fully understood. Severe cases can result in intestinal resection or death, and the health care costs average >$300,000/infant when surgical management is required...
January 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28086969/multicenter-neonatal-databases-trends-in-research-uses
#9
Liza M Creel, Sean Gregory, Catherine J McNeal, Madhava R Beeram, David R Krauss
BACKGROUND: In the US, approximately 12.7% of all live births are preterm, 8.2% of live births were low birth weight (LBW), and 1.5% are very low birth weight (VLBW). Although technological advances have improved mortality rates among preterm and LBW infants, improving overall rates of prematurity and LBW remains a national priority. Monitoring short- and long-term outcomes is critical for advancing medical treatment and minimizing morbidities associated with prematurity or LBW; however, studying these infants can be challenging...
January 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28081574/gstp1-and-cyp2b6-genetic-polymorphisms-and-the-risk-of-bronchopulmonary-dysplasia-in-preterm-neonates
#10
Sophia Zachaki, Aggeliki Daraki, Elena Polycarpou, Chrysa Stavropoulou, Kalliopi N Manola, Stavroula Gavrili
Objectives Antioxidant response plays a key role in bronchopulmonary dysplasia (BPD) pathogenesis. The glutathione-S-tranferases pi 1 (GSTP1) and cytochrome P450 (CYP) detoxification enzymes protect cells from oxidative damage. The aim of the study was to investigate whether the A(313)G GSTP1 and G(516)T CYP2B6 inactivating polymorphisms could be associated with BPD susceptibility. Study Design To test this hypothesis, we conducted a case-control study enrolled 138 premature neonates ≤32 weeks of gestational age; of the 138, 46 developed BPD and 92 did not develop BPD...
January 12, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28081048/a-prospective-cohort-study-of-common-childhood-infections-in-south-african-hiv-exposed-uninfected-and-hiv-unexposed-infants
#11
Amy L Slogrove, Monika M Esser, Mark F Cotton, David P Speert, Tobias R Kollmann, Joel Singer, Julie A Bettinger
BACKGROUND: Much evidence of HIV-exposed uninfected (HEU) infant infectious morbidity predates availability of maternal combination antiretroviral therapy and does not control for universal risk factors (preterm birth, low birth weight, suboptimal breastfeeding and poverty). METHODS: This prospective cohort study identified HIV-infected and HIV-uninfected mothers and their newborns from South African community midwife unit. The primary outcome, infectious cause hospitalization or death before 6 months of age, was compared between HEU and HIV-unexposed (HU) infants and classified for type and severity using validated study-specific case definitions...
February 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28077516/early-onset-invasive-candidiasis-in-extremely-low-birth-weight-infants-perinatal-acquisition-predicts-poor-outcome
#12
Michelle Barton, Alex Shen, Karel O'Brien, Joan L Robinson, H Dele Davies, Kim Simpson, Elizabeth Asztalos, Joanne Langley, Nicole Le Saux, Reginald Sauve, Anne Synnes, Ben Tan, Louis de Repentigny, Earl Rubin, Chuck Hui, Lajos Kovacs, Yvonne Cw Yau, Susan E Richardson
BACKGROUND: Neonatal invasive candidiasis (IC)presenting in the first week of life is less common and less well described than later onset IC. Risk factors, clinical features and disease outcomeshave not been studied in early onset disease (EOD, ≤7d) or compared to late onset disease (LOD, >7d). METHODS: All extremely low birth weight (ELBW, <1000g) cases with IC and controls froma multicentre study of neonatal candidiasisenrolledfrom 2001 to 2003were included in this study...
January 11, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28068533/the-weight-of-inequalities-duration-of-residence-and-offspring-s-birthweight-among-migrant-mothers-in-sweden
#13
Sol P Juárez, Anders Hjern
In this study we assessed the effect duration of residence on the association between maternal origin and birthweight in Sweden. Considering sibling information, we also investigated how far the presence or lack of such an effect could be biased by the use of cross-sectional data, since there may be a selection among those mothers who decide to have a child soon after moving to the country (e.g. those with a more stable family situation). Using the Swedish Medical Birth Register for the period 1992-2012, we performed linear and multinomial regressions, multilevel linear regressions, and random effect meta-analysis...
December 30, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/28063822/-hospital-discharge-criteria-for-very-low-birth-weight-newborns
#14
Isabel Benavente Fernández, María Dolores Sánchez Redondo, Jose Luis Leante Castellanos, Alejandro Pérez Muñuzuri, Segundo Rite Gracia, Cèsar W Ruiz Campillo, Ester Sanz López, Manuel Sánchez Luna
Hospital discharge criteria for the pre-term newborn are mainly based on physiological competences (thermoregulation, respiratory stability, and feeding skills), although family support and ability to care for the baby, as well as a well-planned discharge are also cornerstones to ensure a successful discharge. In this article, the Committee of Standards of the Spanish Society of Neonatology reviews the current hospital discharge criteria in order for it to be useful as a clinical guide in Spanish neonatal units...
January 4, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28063717/half-life-of-plasma-phytosterols-in-very-low-birth-weight-preterm-infants-on-routine-parenteral-nutrition-with-vegetable-oil-based-lipid-emulsions
#15
Daniele Pupillo, Alessio Correani, Chiara Biagetti, Rita D'Ascenzo, Manuela Simonato, Giovanna Verlato, Paola Cogo, Marco B L Rocchi, Virgilio P Carnielli
BACKGROUND: Phytosterols in vegetable oil (VO)-based lipid emulsions (LE) likely contribute to parenteral nutrition-associated cholestasis (PNAC) in preterm infants. No characterization of plasma phytosterol half-lives has been done in very low birth weight (VLBW) preterm infants receiving parenteral nutrition (PN) with LE. METHODS: In a prospective cohort study, 45 VLBW preterm infants who received PN underwent serial blood sample measurements of sitosterol (SITO), campesterol (CAMP), and stigmasterol (STIGM)...
December 30, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28057383/reference-values-for-nucleated-red-blood-cells-and-serum-lactate-in-very-and-extremely-low-birth-weight-infants-in-the-first-week-of-life
#16
Martin Poryo, Antonia Wissing, Aylin Aygün, Jürgen Geisel, Stefan Wagenpfeil, Michael Zemlin, Sascha Meyer
STUDY PURPOSE: To provide reference values for nucleated red blood cells and serum lactate concentrations in very and extremely low birth weight (VLBW/ELBW) infants in the first week of life. PATIENTS AND METHODS: Retrospective data analysis of serial, daily measurements of NRBC counts and serum lactate during the first 6days of life in VLBW and ELBW infants. RESULTS: In total, 250 infants<1500g were included in this study. Intrauterine growth retardation (IUGR) was seen in 87 (34...
January 2, 2017: Early Human Development
https://www.readbyqxmd.com/read/28056907/lung-function-in-very-low-birth-weight-infants-after-pharmacological-and-surgical-treatment-of-patent-ductus-arteriosus-a-retrospective-analysis
#17
Payman Barikbin, Hannes Sallmon, Silke Wilitzki, Joachim Photiadis, Christoph Bührer, Petra Koehne, Gerd Schmalisch
BACKGROUND: The indications and strategies for treatment of patent ductus arteriosus (PDA) are controversial, and the safety and long-term benefits of surgical PDA closure remain uncertain. The aim of this study was to compare the lung function of very low birth weight (VLBW) infants after successful PDA treatment with a cyclooxygenase inhibitor or secondary surgical ligation. METHODS: A total of 114 VLBW infants (birth weight < 1500 g), including 94 infants (82%) with a birth weight < 1000 g, who received treatment for hemodynamically significant PDA (hsPDA), were examined at a median postmenstrual age of 48 weeks...
January 6, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28052714/efficacy-and-safety-of-rectal-ibuprofen-for-patent-ductus-arteriosus-closure-in-very-low-birth-weight-preterm-infants
#18
Nihat Demir, Erdal Peker, İbrahim Ece, Ragıp Balahoroğlu, Oğuz Tuncer
BACKGROUND: To compare rectal ibuprofen with oral ibuprofen for closure of hemodynamically significant patent ductus arteriosus (hsPDA) in very low birth weight (VLBW) preterm infants. STUDY DESIGN AND SUBJECTS: In a prospective, randomized study, 72 VLBW infants who had hsPDA received either rectal or oral ibuprofen. The plasma concentration of ibuprofen and renal functions were determined in both groups by high performance liquid chromatography (HPLC) method and cystatin-C (cys-C), respectively...
January 4, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28052185/early-administration-of-inhaled-corticosteroids-for-preventing-chronic-lung-disease-in-very-low-birth-weight-preterm-neonates
#19
REVIEW
Vibhuti S Shah, Arne Ohlsson, Henry L Halliday, Michael Dunn
BACKGROUND: Chronic lung disease (CLD) remains a common complication among preterm infants. There is increasing evidence that inflammation plays an important role in the pathogenesis of CLD. Due to their strong anti-inflammatory properties, corticosteroids are an attractive intervention strategy. However, there are growing concerns regarding short- and long-term effects of systemic corticosteroids. Theoretically, administration of inhaled corticosteroids may allow for beneficial effects on the pulmonary system with a lower risk of undesirable systemic side effects...
January 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28050019/survey-and-evidence-based-review-of-probiotics-used-in-very-low-birth-weight-preterm-infants-within-the-united-states
#20
S Viswanathan, C Lau, H Akbari, C Hoyen, M C Walsh
No abstract text is available yet for this article.
January 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
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