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https://www.readbyqxmd.com/read/28443531/probiotics-to-prevent-necrotising-enterocolitis-and-nosocomial-infection-in-very-low-birth-weight-preterm-infants
#1
J Uberos, E Aguilera-Rodríguez, A Jerez-Calero, M Molina-Oya, A Molina-Carballo, E Narbona-López
The aim of the study was to determine whether routine probiotic supplementation (RPS) with Lactobacillus rhamnosus GG (LGG) or Lactobacillus acidophilus +Lactobacillus bifidum is associated with reduced risk of necrotising enterocolitis (NEC)≥Stage II in preterm neonates born at ≤32 weeks' gestation. We conducted a retrospective cohort study on the effect of probiotic supplementation in very low birth weight infants in our neonatal unit by comparing two periods: before and after supplementation. The incidence of NEC≥Stage II, late-onset sepsis and all-cause mortality was compared for an equal period 'before' (Period I) and 'after' (Period II) RPS with LGG or L...
April 26, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28437783/evacuation-of-a-tertiary-neonatal-centre-lessons-from-the-2016-kumamoto-earthquakes
#2
Osuke Iwata, Akihiko Kawase, Masanori Iwai, Kazuko Wada
BACKGROUND: Newborn infants hospitalised in the neonatal intensive care unit (NICU) are vulnerable to natural disasters. However, publications on evacuation from NICUs are sparse. The 2016 Kumamoto Earthquakes caused serious damage to Kumamoto City Hospital and its level III regional core NICU. Local/neighbour NICU teams and the disaster-communication team of a neonatal academic society cooperated to evacuate 38 newborn infants from the ward. OBJECTIVE: The aim of this paper was to highlight potential key factors to improve emergency NICU evacuation and coordination of hospital transportation following natural disasters...
April 25, 2017: Neonatology
https://www.readbyqxmd.com/read/28437520/academic-performance-motor-function-and-behavior-11-years-after-neonatal-caffeine-citrate-therapy-for-apnea-of-prematurity-an-11-year-follow-up-of-the-cap-randomized-clinical-trial
#3
Barbara Schmidt, Robin S Roberts, Peter J Anderson, Elizabeth V Asztalos, Lorrie Costantini, Peter G Davis, Deborah Dewey, Judy D'Ilario, Lex W Doyle, Ruth E Grunau, Diane Moddemann, Harvey Nelson, Arne Ohlsson, Alfonso Solimano, Win Tin
Importance: Caffeine citrate therapy for apnea of prematurity reduces the rates of bronchopulmonary dysplasia, severe retinopathy, and neurodevelopmental disability at 18 months and may improve motor function at 5 years. Objective: To evaluate whether neonatal caffeine therapy is associated with improved functional outcomes 11 years later. Design, Setting, and Participants: A follow-up study was conducted at 14 academic hospitals in Canada, Australia, and the United Kingdom from May 7, 2011, to May 27, 2016, of English- or French-speaking children who had been enrolled in the randomized, placebo-controlled Caffeine for Apnea of Prematurity trial between October 11, 1999, and October 22, 2004...
April 24, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28433797/development-of-comorbid-crying-sleeping-feeding-problems-across-infancy-neurodevelopmental-vulnerability-and-parenting
#4
Ayten Bilgin, Dieter Wolke
BACKGROUND: Regulatory problems (excessive crying, feeding, and sleeping difficulties), specifically their comorbidity, are early warning signs of future problems. Insensitive parenting and neurodevelopmental vulnerabilities have been suggested as factors explaining development or maintenance of regulatory problems. Nevertheless, none of the previous studies investigated these factors within the same sample across infancy, taking into account the reciprocal influences between maternal sensitivity and regulatory problems...
April 19, 2017: Early Human Development
https://www.readbyqxmd.com/read/28431170/early-total-enteral-feeding-in-stable-very-low-birth-weight-infants-a-before-and-after-study
#5
Sushma Nangia, Amit Bishnoi, Ankita Goel, Piali Mandal, Soumya Tiwari, Arvind Saili
Background: Fear of necrotizing enterocolitis (NEC) has perpetuated delayed initiation and slow advancement of enteral feeding in very low birth weight (VLBW) infants with inherent risks of parenteral alimentation. The objective of this study was to assess effect of early total enteral feeding (ETEF) on day of achievement of full enteral feeds, feed intolerance, NEC and sepsis. Methods: In total, 208 stable VLBW neonates (28-34 weeks) admitted during 6 month periods of three consecutive years were enrolled...
April 18, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28428111/reproductive-healthcare-experiences-of-women-with-cerebral-palsy
#6
Katharine Hayward, Angela Y Chen, Elizabeth Forbes, Rachel Byrne, Marcia B Greenberg, Eileen G Fowler
BACKGROUND: Little is known about pregnancy rates in women with disabilities in general and even less is known about women with child-onset disabilities such as cerebral palsy (CP). HYPOTHESIS: We hypothesized that discussions about pregnancy with healthcare providers and pregnancy rates for woman with CP would be related to their functional levels. METHODS: Survey methodology was used to gather information about demographics, function, whether women were asked about their desire for children, pregnancy outcomes, and services offered during pregnancy and postpartum...
April 5, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28422947/factors-affecting-the-cognitive-profile-of-11-year-old-children-born-very-preterm
#7
Anna Nyman, Tapio Korhonen, Petriina Munck, Riitta Parkkola, Liisa Lehtonen, Leena Haataja
BACKGROUND: Preterm birth is a risk for cognitive development. This study assessed the cognitive profile of children born very preterm at the age of 11 years as well as associated risk factors. METHODS: A total of 128 children born very preterm were included. MRI was performed at term age. Cognitive development was assessed using the full-scale intelligence quotient (IQ) and four domains of the Wechsler Intelligence Scale for Children, fourth edition (WISC-IV), Finnish translation...
April 19, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28422945/growth-pattern-and-final-height-of-very-preterm-versus-very-low-birth-weight-infants
#8
Jonneke J Hollanders, Sylvia M van der Pal, Paula van Dommelen, Joost Rotteveel, Martijn Jj Finken
BACKGROUND: Both very preterm (VP; i.e., gestational age <32 weeks) and very low birth weight (VLBW; i.e., birth weight <1,500 grams) are used as inclusion criteria by studies on preterm birth. We aimed to quantify the impact of these entities on postnatal growth until final height. METHODS: Subjects born VP and/or with VLBW from the Project On Preterm and Small-for-gestational-age infants cohort were classified as: (1) VP+/VLBW+ (n=495), (2) VP+/VLBW- (n=207) or (3) VP-/VLBW+ (n=296) infants...
April 19, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28418793/wide-variability-in-caloric-density-of-expressed-human-milk-can-lead-to-major-underestimation-or-overestimation-of-nutrient-content
#9
Charles W Sauer, Mallory A Boutin, Jae H Kim
BACKGROUND: Very-low-birth-weight infants continue to face significant difficulties with postnatal growth. Human milk is the optimal form of nutrition for infants but may exhibit variation in nutrient content. OBJECTIVE: This study aimed to perform macronutrient analysis on expressed human milk from mothers whose babies are hospitalized in the neonatal intensive care unit. METHODS: Up to five human milk samples per participant were analyzed for protein, carbohydrate, and fat content using reference chemical analyses (Kjeldahl for protein, high pressure liquid chromatography for carbohydrates, and Mojonnier for fat)...
May 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28412957/pattern-of-drug-use-among-preterm-neonates-results-from-an-italian-neonatal-intensive-care-unit
#10
A Girardi, S Galletti, E Raschi, A Koci, E Poluzzi, G Faldella, F De Ponti
BACKGROUND: Drug use in preterm neonates admitted to Neonatal Intensive Care Unit (NICU) has been investigated, so far, in terms of unauthorized or off-label use; very little is known on the use of combinations of different active substances, which is frequently required in this population (prophylaxis of infections, treatment of concomitant diseases). The aim of this study was to describe the most common patterns of drug use in an Italian NICU, focusing on those with nephrotoxic potential...
April 17, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28410788/independence-of-gut-bacterial-content-and-neonatal-necrotizing-enterocolitis-severity
#11
Lauren K Barron, Barbara B Warner, Phillip I Tarr, William D Shannon, Elena Deych, Brad W Warner
INTRODUCTION: Necrotizing enterocolitis (NEC) is a common and devastating gastrointestinal disease of premature infants. NEC severity varies widely. Recent data have demonstrated a strong link between gut microbial dysbiosis and development of NEC. We tested the hypothesis that alterations in the gut microbiome at the time of diagnosis predict the severity of NEC. METHODS: We used prospectively collected fecal samples from very low birth weight infants who developed NEC, stratifying by NEC severity...
April 5, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28410276/hiv-transmission-to-premature-very-low-birth-weight-infants
#12
Candyce Levin, David Le Roux, Michael Harrison, Lloyd Tooke
There is sparse literature about HIV transmission in preterm infants. 82 HIV exposed preterm infants received birth PCRs. Five (6.1%) were HIV positive with all 5 mothers receiving inadequate antiretrovirals. Of the PCR negative infants, 9 died and 87% of the survivors received further PCR testing which remained negative. With correct care, intrapartum transmission of HIV can virtually be eliminated.
April 13, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28409751/early-extubation-failure-in-very-low-birth-weight-infants-clinical-outcomes-and-predictive-factors
#13
K Al-Hathlol, N Bin Saleem, M Khawaji, S Al Saif, I Abdelhakim, B Al-Hathlol, E Bazbouz, Q Al Anzi, A Al-Essa
OBJECTIVE: To identify the clinical outcomes and the potential predictive factors of early extubation failure (EEF) in very low birth weight (VLBW) infants. METHODS: A retrospective study of VLBW infants admitted to the neonatal intensive care unit (NICU) over five years. Neonates were intubated and mechanically ventilated on the first day of life, and early extubated within the first 3 days. EEF was defined as the need for re-intubation within 3 days of the first extubation...
April 8, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28407825/-effect-of-pregnancy-induced-hypertension-syndrome-on-complications-in-very-low-birth-weight-preterm-infants
#14
Song-Zhou Xu, Xiao-Yan Hu, Fang Zhao, Yu-Xin Zhou, Shuang-Chuan Zhang
OBJECTIVE: To study the effect of pregnancy-induced hypertension syndrome (PIH) on complications in very low birth weight (VLBW) preterm infants. METHODS: The VLBW preterm infants were enrolled as research subjects, and according to the presence or absence of PIH in their mothers, they were divided into PIH group and non- PIH group. The incidence of major complications and length of hospital stay were compared between the two groups. RESULTS: There were no significant differences between the two groups in gestational age, birth weight, sex, incidence rate of maternal diabetes, and use of antepartum hormone...
April 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28407656/high-blood-pressure-during-pregnancy-is-not-a-protective-factor-for-preterm-infants-with-very-low-birth-weight-a-case-control-study
#15
Annibal Tagliaferri Sabino, Eduardo de Souza, Ana Lucia Goulart, Adriana Martins de Lima, Nelson Sass
Objective To evaluate whether the presence of maternal blood pressure reduces the risks of morbidity, perinatal mortality and morbidity at 24 months of age in very low birth weight infants (VLBWIs) compared with a control group. Methods A retrospective, observational, case-control study. Total 49 VLBWIs were allocated to the study group, called the maternal arterial hypertension group (AHG), and matched with 44 in the control group (CG). The infants were assessed during hospitalization and at 12 and 24 months corrected age at a specialized clinic...
April 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28404230/birth-outcomes-among-us-women-with-intellectual-and-developmental-disabilities
#16
Ilhom Akobirshoev, Susan L Parish, Monika Mitra, Eliana Rosenthal
BACKGROUND: Women with intellectual and developmental disabilities (IDD) are bearing children at increasing rates. However, there is very little research about pregnancy experiences and birth outcomes among women with IDD. No studies to date have examined birth outcomes with a US population-based sample. OBJECTIVE: The main objective was to estimate the national occurrence of deliveries in women with IDD and to compare their birth outcomes to women without IDD. METHODS: We examined the 2007-2011 Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project to compare birth outcomes in women with and without IDD...
April 6, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28403049/clinical-and-microbiologic-characteristics-of-early-onset-sepsis-among-very-low-birth-weight-infants-opportunities-for-antibiotic-stewardship
#17
Sagori Mukhopadhyay, Karen M Puopolo
BACKGROUND: Most very low birth weight (VLBW, birth weight <1500 g) infants receive empiric antibiotics for risk of early-onset sepsis (EOS). The objective of this study was to determine the characteristics of VLBW infants with culture-confirmed EOS at a single center during 25 years and to identify opportunities for antibiotic stewardship. METHODS: Retrospective cohort study includes VLBW infants admitted from 1990 to 2015. EOS was defined as isolation of a pathogen in blood or cerebrospinal fluid culture obtained at <72 hours of age...
May 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28399640/associations-of-maternal-testosterone-and-cortisol-levels-with-health-outcomes-of-mothers-and-their-very-low-birth-weight-infants
#18
June Cho, Xiaogang Su, Diane Holditch-Davis
OBJECTIVE: Although the roles of testosterone and cortisol in various health problems have been extensively investigated, little is known about their associations with health outcomes in mothers and their very-low-birth weight (VLBW) infants when maternal testosterone and cortisol are examined together during the postpartum period. METHOD: The 101 mother-VLBW infant pairs were recruited from the neonatal intensive care unit of a tertiary medical center in the southeastern United States...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28399439/maternal-and-pregnancy-related-factors-affecting-human-milk-cytokines-among-peruvian-mothers-bearing-low-birth-weight-neonates
#19
Mara Zambruni, Alex Villalobos, Anoma Somasunderam, Sarah Westergaard, Maitreyee Nigalye, Christie G Turin, Jaime Zegarra, Sicilia Bellomo, Erik Mercado, Theresa J Ochoa, Netanya S Utay
Several cytokines have been detected in human milk but their relative concentrations differ among women and vary over time in the same person. The drivers of such differences have been only partially identified, while the effect of luminal cytokines in the fine-regulation of the intestinal immune system is increasingly appreciated. The aim of this study was to investigate the associations between obstetrical complications and human milk cytokine profiles in a cohort of Peruvian women giving birth to Low Birth Weight (LBW) infants...
April 6, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28398697/effects-of-targeting-lower-versus-higher-arterial-oxygen-saturations-on-death-or-disability-in-preterm-infants
#20
REVIEW
Lisa M Askie, Brian A Darlow, Peter G Davis, Neil Finer, Ben Stenson, Maximo Vento, Robin Whyte
BACKGROUND: The use of supplemental oxygen in the care of extremely preterm infants has been common practice since the 1940s. Despite this, there is little agreement regarding which oxygen saturation (SpO₂) ranges to target to maximise short- or long-term growth and development, while minimising harms. There are two opposing concerns. Lower oxygen levels (targeting SpO₂ at 90% or less) may impair neurodevelopment or result in death. Higher oxygen levels (targeting SpO₂ greater than 90%) may increase severe retinopathy of prematurity or chronic lung disease...
April 11, 2017: Cochrane Database of Systematic Reviews
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