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Bipolar 2

Amy R McDowell, Susan C Shelmerdine, David W Carmichael, Owen J Arthurs
OBJECTIVE: To investigate the potential of advanced diffusion imaging in Post-Mortem MRI (PMMR) at 3T.  Methods: We acquired PMMR brain and body imaging in 12 neonates, mean gestational age 33.4 weeks (range 29-37 weeks) at 3T and 1.5T. Head and body diffusion imaging at 1.5T using bipolar diffusion encoding and single-shot echo-planar imaging (EPI) for acquisition (TE 96ms; TR 2700ms; voxel size 1.8x1.8mm in-plane with slice thickness 5mm; b values of 500 and 1000 s/mm2 applied in three orthogonal directions; total acquisition time 2:12)...
July 13, 2018: British Journal of Radiology
Chen-Ya Yang, Muh-Lii Liang, Hsin-Hung Chen, Jan-Wei Chiu, Kwong-Kum Liao, Tsui-Fen Yang
OBJECTIVE The aim of this study was to investigate the feasibility of using subdural strip electrodes, placed just rostral to the surgical field, to record sensory evoked potentials (SEPs) from the lumbosacral sensory nerves and define the most inferior functional portion of the conus medullaris during detethering surgery for spinal dysraphism and/or tethered cord syndrome (TCS). METHODS Six patients, 2 boys and 4 girls, aged 0.5 to 16 years, were enrolled in this study. One patient had lipomyelomeningocele-related, 4 had myelomeningocele-related, and 1 had diastematomyelia and lipomyelomeningocele-related TCS...
July 13, 2018: Journal of Neurosurgery. Spine
Jonathan Channing, Mary Mitchell, Samuele Cortese
OBJECTIVE: To perform a systematic review of studies of lurasidone in children and/or adolescents and to present a case report aimed to add further insights into its use in clinical practice with youth. METHODS: We searched the following databases for empirical studies, of any design, focusing on the pharmacokinetics, efficacy, or safety of lurasidone in children and/or adolescents: Pubmed (Medline), OVID (PsycInfo, EMBASE+EMBASE classic, OVID Medline), Web of Knowledge, and ClinicalTrials...
July 13, 2018: Journal of Child and Adolescent Psychopharmacology
Carina Kelbsch, Archana Jalligampala, Torsten Strasser, Paul Richter, Katarina Stingl, Christoph Braun, Daniel L Rathbun, Eberhart Zrenner, Helmut Wilhelm, Barbara Wilhelm, Tobias Peters, Krunoslav Stingl
The purpose was to evaluate retinal function by measuring pupillary responses to sinusoidal transcorneal electrostimulation in healthy young human subjects. This work also translates data from analogous in vitro experiments and connects it to the pupillary responses obtained in human experiments. 14 healthy human subjects participated (4 males, 10 females); for the in vitro experiments two male healthy mouse retinas (adult wild-type C57B/6J) were used. Pupillary responses to sinusoidal transcorneal electrostimulation of varying stimulus carrier frequencies (10, 20 Hz; envelope frequency constantly kept at 1...
July 9, 2018: Experimental Eye Research
Kathryn Fletcher, Fiona Foley, Neil Thomas, Erin Michalak, Lesley Berk, Michael Berk, Steve Bowe, Sue Cotton, Lidia Engel, Sheri L Johnson, Steven Jones, Michael Kyrios, Sara Lapsley, Cathrine Mihalopoulos, Tania Perich, Greg Murray
BACKGROUND: The primary objective of this randomised controlled trial (RCT) is to establish the effectiveness of a novel online quality of life (QoL) intervention tailored for people with late stage (≥ 10 episodes) bipolar disorder (BD) compared with psychoeducation. Relative to early stage individuals, this late stage group may not benefit as much from existing psychosocial treatments. The intervention is a guided self-help, mindfulness based intervention (MBI) developed in consultation with consumers, designed specifically for web-based delivery, with email coaching support...
July 13, 2018: BMC Psychiatry
Olav Rohof, Chee Kean Chen
Background and aims The evidence for interventional treatment of thoracic facet joint pain remains limited. This is partly due to inconsistency of the path of thoracic medial branches and a lower incidence of thoracic facet pain among spine pain patients. The purpose of this study is to evaluate the efficacy of bipolar radiofrequency (RF) neurotomy of medial branches for treating chronic thoracic facet joint pain. Methods This is a retrospective record review of all patients diagnosed to have thoracic facet pain with diagnostic block and subsequently treated with bipolar RF neurotomy of medial branch between January 2012 and December 2015...
July 12, 2018: Scandinavian Journal of Pain
Lu Wang, Weiqing Liu, Xingxing Li, Xiao Xiao, Lingyi Li, Fang Liu, Yuanfang He, Yan Bai, Hong Chang, Dong-Sheng Zhou, Ming Li
Genome-wide association studies suggest that rs1064395 in the neurocan gene ( NCAN ) is a potential risk factor for bipolar disorder (BPD), and further replication analyses in larger independent samples are needed. We herein analyzed rs1064395 in a Han Chinese sample of 1,146 BPD cases and 2,031 controls, followed by a meta-analysis of BPD samples from worldwide populations including a total of 15,318 cases and 91,990 controls. The meta-analysis found that rs1064395 showed a genome-wide significant association with BPD ( p = 4...
June 2018: Molecular Neuropsychiatry
Clement C Zai, Arun K Tiwari, Gwyneth C Zai, Vincenzo de Luca, Sajid A Shaikh, Nicole King, John Strauss, James L Kennedy, John B Vincent
Background: A number of genes have been implicated in recent genome-wide association studies of suicide attempt in bipolar disorder. More focused investigation of genes coding for protein targets of existing drugs may lead to drug repurposing for the treatment and/or prevention of suicide. Methods: We analyzed 2,457 DNA variants across 197 genes of interest to GlaxoSmithKline across the pipeline in our sample of European patients suffering from bipolar disorder ( N = 219)...
June 2018: Molecular Neuropsychiatry
Malihe Farahani, Seyyed Salman Alavi, Mahmood Mirzamani Bafghi, Sudeh Esmaili Alamuti, Zohreh Taghavi, Mohammadreza Mohammadi
Objective: Problematic internet use is an important social problem among adolescents and has become a global health issue. This study identified predictors and patterns of problematic internet use among adult students. Method : In this study, 401 students were recruited using stratified sampling technique. Participants were selected among students from 4 universities in Tehran and Karaj, Iran, during 2016 and 2017. Internet Addiction Test (IAT), Millon Clinical Multiaxial Inventory - Third Edition (MCMI-III), Structured Clinical Interview for DSM (SCID-I), and semi-structured interview were used to diagnose internet addiction...
April 2018: Iranian Journal of Psychiatry
Xiong Liu, Shi Shu, Edward D Korn
The three mammalian nonmuscle myosin 2 (NM2) monomers, like all class 2 myosin monomers, are hexamers of two identical heavy (long) chains and two pairs of light (short) chains bound to the heavy chains. The heavy chains have an N-terminal globular motor domain (head) with actin-activated ATPase activity, a lever arm (neck) to which the two light chains bind, and a coiled-coil helical tail. Monomers polymerize into bipolar filaments, with globular heads at each end separated by a bare zone, by antiparallel association of their coiled-coil tails...
July 11, 2018: Proceedings of the National Academy of Sciences of the United States of America
Jonathan M Platt, Katherine M Keyes, Katie A McLaughlin, Alan S Kaufman
BACKGROUND: Most research on the prevalence, distribution, and psychiatric comorbidity of intellectual disability (ID) relies on clinical samples, limiting the generalizability and utility of ID assessment in a legal context. This study assessed ID prevalence in a population-representative sample of US adolescents and examined associations of ID with socio-demographic factors and mental disorders. METHODS: Data were drawn from the National Comorbidity Survey Adolescent Supplement (N = 6256)...
July 12, 2018: Psychological Medicine
Meha Qassem, Loukas Constantinou, Iasonas Triantis, Michelle Hickey, Eleni Palazidou, Panayiotis A Kyriacou
GOAL: Lithium preparations are considered the most reliable mood stabilizers for patients with Bipolar Disorder (BD), and are the most effective at reducing the risk of suicide. However, maintaining blood lithium concentration within the narrow therapeutic range of 0.4-1.2 mEq is crucial but extremely difficult. The aim of this work is to develop a personal lithium blood level analyzer using a novel method of combined optical and electrical impedance spectroscopy to test micro volumes of spiked samples of human blood...
May 14, 2018: IEEE Transactions on Bio-medical Engineering
Mohammad Hassan Shariat, Javad Hashemi, Saeed Gazor, Damian P Redfearn
Cardiac mapping systems are based on the time/frequency feature analyses of intracardiac electrograms recorded from individual bipolar/unipolar electrodes. Signals from each electrode are processed independently. Such approaches fail to investigate the interrelationship between simultaneously recorded channels of any given mapping catheter during atrial fibrillation (AF). We introduce a novel signal processing technique that reflects regional dominant frequency (RDF) components. We show that RDF can be used to identify and characterize variation and disorganization in wavefront propagation- wave breaks...
2018: Frontiers in Cardiovascular Medicine
Charles N Bernstein, Carol A Hitchon, Randy Walld, James M Bolton, Jitender Sareen, John R Walker, Lesley A Graff, Scott B Patten, Alexander Singer, Lisa M Lix, Renée El-Gabalawy, Alan Katz, John D Fisk, Ruth Ann Marrie
Background: Psychiatric comorbidity in inflammatory bowel disease (IBD) is well known; however, data from a truly representative sample are sparse. We aimed to estimate the incidence and prevalence of psychiatric disorders in an IBD cohort compared with a matched cohort without IBD. Methods: Using population-based administrative health data from Manitoba, Canada, we identified all persons with incident IBD from 1989 to 2012 and a general population matched cohort (5:1)...
July 7, 2018: Inflammatory Bowel Diseases
Dylan J Jester, Kathryn Hyer, Victor Molinari, Ross Andel, Ellen Rozek
OBJECTIVES: To assess factors related to antipsychotic (AP) use in skilled nursing facilities for newly admitted residents aged 18 to 49, 50 to 64, 65 to 84, and 85 years or older. METHODS: Retrospective, population-level, Minimum Data Set (MDS) 2.0 data from the United States during the year of 2009 were used. Over 1 million residents were included. Fourteen clinically relevant variables were identified through a literature search. Antipsychotic use was defined as APs dispensed daily for the prior 7 days...
July 8, 2018: International Journal of Geriatric Psychiatry
V Lequimener-de Lorgeril, M Chirio-Espitalier, M Grall-Bronnec
INTRODUCTION: Bipolar disorder is a mental illness that is associated with a long-term impairment in psychosocial functioning and quality of life. The objective of this study was to evaluate the influence of a therapeutic education program on the quality of life of patients with bipolar disorder (type 1 or 2). METHOD: This study included 18 patients with bipolar disorder (type 1 or 2) following the therapeutic education program on bipolar disorder which includes 8 sessions of 2hours each...
July 5, 2018: L'Encéphale
Jason A Varzaly, Darius Chapman, Dennis H Lau, Suzanne Edwards, Jennie Louise, James Edwards, Rajiv Mahajan, Michael Worthington, Prashanthan Sanders
OBJECTIVES: Atrial fibrillation is treated surgically by creating conduction block lesions. Radiofrequency (RF) lesions have reduced efficacy compared to 'cut-and-sew'. Catheter ablation studies demonstrate a relationship between lesion depth and contact force. We hypothesized that contact force and lesion depth are dependent on design of the bipolar surgical RF clamps. METHODS: Hinged and parallel jaw style RF clamps were studied. Muscle samples were clamped with pressure-sensitive film at increasing tissue thicknesses...
June 29, 2018: Interactive Cardiovascular and Thoracic Surgery
Van Quang Nguyen, Thi Huong Nguyen, Van Thiet Duong, Ji Eun Lee, Su-Dong Park, Jae Yong Song, Hyun-Min Park, Anh Tuan Duong, Sunglae Cho
ᅟ: We report on the successful preparation of Bi-doped n-type polycrystalline SnSe by hot-press method. We observed anisotropic transport properties due to the (h00) preferred orientation of grains along the pressing direction. The electrical conductivity perpendicular to the pressing direction is higher than that parallel to the pressing direction, 12.85 and 6.46 S cm-1 at 773 K for SnSe:Bi 8% sample, respectively, while thermal conductivity perpendicular to the pressing direction is higher than that parallel to the pressing direction, 0...
July 6, 2018: Nanoscale Research Letters
Tong Sun, Dengchao Wang, Michael V Mirkin
This paper is concerned with long-distance interactions between an unbiased metal nanoparticle (NP) and a nanoelectrode employed as a tip in the scanning electrochemical microscope (SECM). A NP immobilized on the inert substrate acts as a bipolar electrode, producing positive SECM feedback. The tip current magnitude depends strongly on the ratio of the particle and tip radii and the heterogeneous charge-transfer kinetics. The onset of electron tunneling was observed at very short separation distances (<2-3 nm) at which the NP behaves as a part of the tip electrode...
July 6, 2018: Faraday Discussions
Jérémy Lambert, Michael Chekroun, Hélène Gilet, Catherine Acquadro, Benoit Arnould
BACKGROUND: Patients with chronic conditions are required to take long-term treatments for their disease itself or to prevent any potential health risks. Measuring patient acceptance of their medication should help to better understand and predict patients' behavior toward treatment. This study aimed to describe the level of patient acceptance toward various long-term treatments in real life using an online patient community. METHODS: This was an observational, cross-sectional study conducted through the French Carenity platform...
July 6, 2018: Health and Quality of Life Outcomes
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