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Immunohistochemistry to distinguish pancreatic adenocarcinoma from poorly differentiated pancreatic neuroendocrine carcinoma

Jussuf T Kaifi, Sina Heidtmann, Paulus G Schurr, Uta Reichelt, Oliver Mann, Emre F Yekebas, Robin Wachowiak, Tim Strate, Melitta Schachner, Jakob R Izbicki
BACKGROUND: Pancreatic adenocarcinoma is a tumor with fatal outcome. Cell adhesion molecules, such as L1 (CD171), have an essential function in tumor progression. L1 has been shown to be specifically expressed in poorly differentiated neuroendocrine carcinomas of the pancreas. The aim of this study was to determine the expression of L1 in pancreatic adenocarcinomas to evaluate whether L1 might differentiate between pancreatic carcinomas of neuroendocrine and ductal origin. MATERIALS AND METHODS: L1 expression was retrospectively analyzed in 111 cases of pancreatic adenocarcinomas by immunohistochemistry on paraffin sections of primary tumors...
March 2006: Anticancer Research
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