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https://www.readbyqxmd.com/read/28346921/bacterial-colonization-of-the-newborn-gut-immune-development-and-prevention-of-disease
#1
W Allan Walker
We now know that the fetus does not reside in a sterile intrauterine environment but is exposed to commensal bacteria from the maternal gut which cross the placenta and infiltrate the amniotic fluid. This exposure to colonizing bacteria continues at birth and during the first year of life, and it has a profound influence on lifelong health. Why is this important? Cross talk with colonizing bacteria in the developing neonatal intestine helps in the initial adaptation of the infant to extrauterine life, particularly in acquiring immune homeostasis, and provides protection against disease expression (e...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28346263/minimally-invasive-aortic-valve-replacement-via-right-anterior-minithoracotomy-and-central-aortic-cannulation-a-13-year-experience
#2
Daniel M Bethencourt, Jennifer Le, Gabriela Rodriguez, Robert W Kalayjian, Gregory S Thomas
OBJECTIVE: This study reports the evolution of a minimally invasive aortic valve replacement (mini-AVR) technique that uses a right anterior minithoracotomy approach with central cannulation, for a 13-year period. This technique has become our standard approach for isolated primary AVR in nearly all patients. METHODS: This observational study evaluated perioperative clinical outcomes of patients 18 years or older who underwent mini-AVR from November 2003 to June 2015...
March 25, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/28343928/endodontics-endodontic-retreatment-and-apical-surgery-versus-tooth-extraction-and-implant-placement-a-systematic-review
#3
REVIEW
Anna Chércoles-Ruiz, Alba Sánchez-Torres, Cosme Gay-Escoda
INTRODUCTION: The aim of this systematic review was to answer the following clinical question: Which is the best treatment option for a pulpally involved tooth? METHODS: An electronic search was conducted in the Cochrane, PubMed (MEDLINE), and ScienceDirect databases between December 2015 and February 2016. A manual search was also performed. The inclusion criteria were randomized clinical trials, prospective or retrospective cohort studies, and cross-sectional studies performed on humans with at least 1 year of follow-up and published within the last 10 years...
March 23, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28343280/relationships-between-work-related-factors-and-musculoskeletal-health-with-current-and-future-work-ability-among-male-workers
#4
J S Boschman, A Noor, R Lundström, T Nilsson, J K Sluiter, M Hagberg
PURPOSE: The purpose was to increase job-specific knowledge about individual and work-related factors and their relationship with current and future work ability (WA). We studied cross-sectional relationships between mental demands, physical exertion during work, grip strength, musculoskeletal pain in the upper extremities and WA and the relationships between these variables and WA 11 years later. METHODS: We used a dataset of a prospective cohort study (1997-2008) among employees of an engineering plant (n = 157)...
March 25, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28343124/effects-of-acute-alcohol-consumption-on-measures-of-simulated-driving-a-systematic-review-and-meta-analysis
#5
Christopher Irwin, Elizaveta Iudakhina, Ben Desbrow, Danielle McCartney
Driving simulators are used in a wide range of research settings to help develop an understanding of driver behavior in complex environments. Acute alcohol impairment is an important research topic for traffic safety and a large number of studies have indicated levels of simulated driving impairment imposed by alcohol across a range of performance outcome variables. The aim of the present study was to examine the impact of acute alcohol consumption on simulated driving performance by conducting a systematic review and meta-analysis of the available evidence...
March 23, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28342750/mutation-of-the-caspase-3-cleavage-site-in-the-astroglial-glutamate-transporter-eaat2-delays-disease-progression-and-extends-lifespan-in-the-sod1-g93a-mouse-model-of-als
#6
Lauren Taylor Rosenblum, Shashirekha Shamamandri-Markandaiah, Biswarup Ghosh, Emily Foran, Angelo C Lepore, Piera Pasinelli, Davide Trotti
Downregulation in the astroglial glutamate transporter EAAT2 in amyotrophic lateral sclerosis (ALS) patients and mutant SOD1 mouse models of ALS is believed to contribute to the death of motor neurons by excitotoxicity. We previously reported that caspase-3 cleaves EAAT2 at a unique cleavage consensus site located in its c-terminus domain, a proteolytic cleavage that also occurs in vivo in the mutant SOD1 mouse model of ALS and leads to accumulation of a sumoylated EAAT2 C-Terminus fragment (CTE-SUMO1) beginning around onset of disease...
March 22, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28341725/paraneoplastic-endocrine-syndromes
#7
Georgios K Dimitriadis, Anna Angelousi, Martin O Weickert, Harpal S Randeva, Gregory A Kaltsas, Ashley B Grossman
The majority of neoplasms produce symptoms related to mass effects to surrounding tissues and/or through the development of metastases. However, occasionally neoplasms, with or without endocrine differentiation, acquire the ability to secrete a variety of bioactive substances or induce immune cross-reactivity with the normal tissues that can lead to the development of characteristic clinical syndromes. These syndromes are named endocrine paraneoplastic when the specific secretory components (hormones, peptides or cytokines) are unrelated to the anticipated tissue or organ of origin...
March 24, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28340863/serum-cytokine-profiles-as-predictors-of-asthma-control-in-adults-from-the-egea-study
#8
Zeina Akiki, Marta Rava, Oscar Diaz Gil, Isabelle Pin, Nicole le Moual, Valérie Siroux, Stefano Guerra, Soulaima Chamat, Regis Matran, Montserrat Fitó, Pascale Salameh, Rachel Nadif
BACKGROUND: To which extent serum cytokines may predict asthma control in adults remains understudied. OBJECTIVES: We investigated cross-sectional and longitudinal associations between cytokine profiles and asthma outcomes. METHODS: Serum interleukin (IL)-1Ra, IL-5, IL-7, IL-8, IL-10, IL-13 and TNF-α levels were determined in 283 adults with current asthma from the 2nd survey of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA2)...
April 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28340178/morphometric-covariation-between-palatal-shape-and-skeletal-pattern-in-class-ii-growing-subjects
#9
Valeria Paoloni, Roberta Lione, Francesca Farisco, Demetrios J Halazonetis, Lorenzo Franchi, Paola Cozza
Objectives: To evaluate the patterns of covariation between palatal and craniofacial morphology in Class II subjects in the early mixed dentition by means of geometric morphometrics. Methods: A cross-sectional sample of 85 Class II subjects (44 females, 41 males; mean age 8.7 years ± 0.8) was collected retrospectively according to the following inclusion criteria: European ancestry (white), Class II skeletal relationship, Class II division 1 dental relationship, early mixed dentition, and prepubertal skeletal maturation...
March 14, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28340134/primary-motor-cortex-organization-is-altered-in-persistent-patellofemoral-pain
#10
Maxine Te, Abrahão F Baptista, Lucy S Chipchase, Siobhan M Schabrun
Objective.:  Reorganization of the primary motor cortex (M1) may be a feature of persistent patellofemoral pain (PFP), but no studies have investigated M1 organization in this condition. Here we aimed to examine the organization of the M1 representation of the quadriceps muscles in people with PFP and healthy controls. Design.:  Using a cross-sectional design, the M1 representation of the rectus femoris, vastus lateralis, and vastus medialis was mapped using transcranial magnetic stimulation in 11 individuals with PFP and 11 controls...
March 14, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339560/temporal-trends-in-renal-function-and-birthweight-in-japanese-adolescent-males-1998-2015
#11
Takeshi Kanda, Ayano Takeda, Hiroshi Hirose, Takayuki Abe, Hidenori Urai, Mikako Inokuchi, Shu Wakino, Mitsuaki Tokumura, Hiroshi Itoh, Hiroshi Kawabe
Background.: Low birthweight (LBW) is a worldwide public health problem, demonstrating an increasing incidence in developed countries, including Japan. LBW is also a risk factor for later development of chronic kidney disease (CKD). To date, studies have not evaluated the population impacts of increasing LBW rates on renal function. Methods.: Estimated glomerular filtration rate (eGFR) was evaluated in 3737 Japanese adolescent males (15-16 years old) using annual cross-sectional data over an 18-year period (1998-2015)...
January 17, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28339441/the-role-of-the-ligamentum-flavum-area-as-a-morphological-parameter-of-lumbar-central-spinal-stenosis
#12
Young Uk Kim, Jun Young Park, Doo Hwan Kim, Myung-Hwan Karm, Jae-Young Lee, Jee In Yoo, Sung Won Chon, Jeong Hun Suh
BACKGROUND: Hypertrophy of the ligamentum flavum (LF) has been considered as a major cause of lumbar central spinal stenosis (LCSS). Previous studies have found that ligamentum flavum thickness (LFT) is correlated with aging, disc degeneration, and lumbar spinal stenosis. However, hypertrophy is different from thickness. Thus, to evaluate hypertrophy of the whole LF, we devised a new morphological parameter, called the ligamentum flavum area (LFA). OBJECTIVES: We hypothesized that the LFA is a key morphologic parameter in the diagnosis of LCSS...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28338524/chronic-boutonniere-deformities-supple-or-stiff-a-new-surgical-technique-with-early-mobilization-in-11-cases
#13
Elodie Dubois, Frederic Teboul, Thomas Bihel, Jean-N Goubier
Injuries to the central slip of the extensor mechanism can lead to a Boutonniere deformity with important functional consequences. We report a series of 11 patients treated by lengthening-dorsalizing the lateral bands and tightening the central slip with early mobilization. The average age of the patients was 42 years (14;52). The extension defect of the proximal interphalangeal (PIP) joint was 64 degrees (80;55) and the hyperextension of the distal interphalangeal joint was 10 degrees (15;5). The surgery was performed with peripheral nerve block (sensitive), allowing dynamic adjustment of the tendinous sutures...
March 23, 2017: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/28337172/bone-marrow-derived-cell-accumulation-in-the-spinal-cord-is-independent-of-peripheral-mobilization-in-a-mouse-model-of-amyotrophic-lateral-sclerosis
#14
Kyle Peake, John Manning, Coral-Ann Lewis, Kevin Tran, Fabio Rossi, Charles Krieger
Bone marrow-derived cells (BMDCs) are capable of migrating across the blood-brain barrier (BBB) and accumulating in the central nervous system (CNS) when transplanted into recipients conditioned with whole-body irradiation or chemotherapy. We used the chemotherapeutic agents busulfan and treosulfan to condition recipient mice for transplantation with bone marrow (BM) cells isolated from donor mice ubiquitously expressing green fluorescent protein. We attempted to increase the accumulation of BMDCs in the CNS by mobilization of BMDCs using either, or both, granulocyte colony-stimulating factor (GCSF) or plerixafor (AMD3100)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28335879/are-social-and-communication-difficulties-a-risk-factor-for-the-development-of-social-anxiety
#15
Hannah Pickard, Fruhling Rijsdijk, Francesca Happé, William Mandy
OBJECTIVE: Social anxiety (SA) is a common condition associated with social and communication (SC) difficulties in typically developing young people, as well as those with autism spectrum disorder (ASD). Whether SC difficulties place children at risk for developing SA is unclear. Using a longitudinal design, the present study aimed to disentangle the relationship between SA symptoms and SC difficulties using a population-based sample of 9,491 children from the Avon Longitudinal Study of Parents and Children (ALSPAC)...
April 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28335875/age-at-first-identification-of-autism-spectrum-disorder-an-analysis-of-two-us-surveys
#16
R Christopher Sheldrick, Melissa P Maye, Alice S Carter
OBJECTIVE: Evidence regarding the age at which autism spectrum disorder (ASD) is identified is essential for improving early detection, yet many extant studies have not applied time-to-event analyses, which account for statistical biases that arise from sampling in cross-sectional surveys by adjusting for child age at time of parental report. Our objective was to estimate age distributions for first identification of ASD in national parent surveys using time-to-event analyses. METHOD: We conducted time-to-event analyses of responses to identical questions in the 2011 to 2012 National Survey of Children's Health (n = 95,677) and the 2009 to 2010 National Survey of Children with Special Health Care Needs (n = 371,617)...
April 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28333916/genetic-susceptibility-to-bilateral-tinnitus-in-a-swedish-twin-cohort
#17
Iris Lianne Maas, Petra Brüggemann, Teresa Requena, Jan Bulla, Niklas K Edvall, Jacob V B Hjelmborg, Agnieszka J Szczepek, Barbara Canlon, Birgit Mazurek, Jose A Lopez-Escamez, Christopher R Cederroth
PURPOSE: Genetic contributions to tinnitus have been difficult to determine due to the heterogeneity of the condition and its broad etiology. Here, we evaluated the genetic and nongenetic influences on self-reported tinnitus from the Swedish Twin Registry (STR). METHODS: Cross-sectional data from the STR was obtained. Casewise concordance rates (the risk of one twin being affected given that his/her twin partner has tinnitus) were compared for monozygotic (MZ) and dizygotic (DZ) twin pairs (N = 10,464 concordant and discordant twin pairs) and heritability coefficients (the proportion of the total variance attributable to genetic factors) were calculated using biometrical model fitting procedures...
March 23, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28333527/reading-self-perceived-ability-enjoyment-and-achievement-a-genetically-informative-study-of-their-reciprocal-links-over-time
#18
Margherita Malanchini, Zhe Wang, Ivan Voronin, Victoria J Schenker, Robert Plomin, Stephen A Petrill, Yulia Kovas
Extant literature has established a consistent association between aspects of reading motivation, such as enjoyment and self-perceived ability, and reading achievement, in that more motivated readers are generally more skilled readers. However, the developmental etiology of this relation is yet to be investigated. The present study explores the development of the motivation-achievement association and its genetic and environmental underpinnings. Applying cross-lagged design in a sample of 13,825 twins, we examined the relative contribution of genetic and environmental factors to the association between reading enjoyment and self-perceived ability and reading achievement...
April 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28333321/preconception-and-early-pregnancy-maternal-haemodynamic-changes-in-healthy-women-in-relation-to-pregnancy-viability
#19
F L Foo, A Collins, C M McEniery, P R Bennett, I B Wilkinson, C C Lees
STUDY QUESTION: Are there differences in preconception cardiovascular function between women who have a viable pregnancy and those who have a first trimester miscarriage? SUMMARY ANSWER: Preconception cardiovascular function of central haemodynamics and arterial function are similar between women who have a viable pregnancy and those who have a first trimester miscarriage. WHAT IS KNOWN ALREADY: Miscarriages have been associated with increased long-term cardiovascular disease risk, and arterial and cardiovascular dysfunction has been hypothesised as the common link...
March 16, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28332849/can-we-determine-sasang-constitutional-body-type-merely-by-facial-inspection
#20
Seung Chul Rhee, Hyo-Sang Bae, Yung-Seop Lee, Rahil Hwang
OBJECTIVES: This study aimed to assess the inter-observer concordance rate of anthroscopic examination on facial features among experts in Sasang constitutional medicine (SCM) in order to evaluate the presence of statistical differences in facial structural characteristics among different body types of Sasang constitution (SC), and to develop an objective method for facial analysis for diagnosing SC types to prevent SCM experts from misdiagnosis by their perceptional errors about faces...
February 22, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
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