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https://www.readbyqxmd.com/read/28738414/impact-of-amyotrophic-lateral-sclerosis-on-slow-tonic-myofiber-composition-in-human-extraocular-muscles
#1
Anton E Tjust, Adam Danielsson, Peter M Andersen, Thomas Brännström, Fatima Pedrosa Domellöf
Purpose: To analyze the proportion and cross-sectional area of myofibers containing myosin heavy chain slow-twitch (MyHCI) and myosin heavy chain slow tonic (MyHCsto) in extraocular muscles of autopsied amyotrophic lateral sclerosis (ALS) patients with either spinal or bulbar site of disease onset. Methods: Whole-muscle cross sections from the middle portion of the medial rectus were labeled with antibodies against MyHCI or MyHCsto and laminin. Myofibers labeled with the MyHC antibodies (MyHCI+sto) and the total number of myofibers were quantified in the orbital and global layer of 6 control individuals and 18 ALS patients...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28738312/habitual-sleep-quality-and-diurnal-rhythms-of-salivary-cortisol-and-dehydroepiandrosterone-in-postmenopausal-women
#2
Tianyi Huang, Elizabeth M Poole, Celine Vetter, Kathryn M Rexrode, Laura D Kubzansky, Eva Schernhammer, Nicolas Rohleder, Frank B Hu, Susan Redline, Shelley S Tworoger
Dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis has been suggested as a potential mechanism linking sleep and cardiometabolic disorders. However, the associations of two primary outputs of the HPA axis, cortisol and its antagonist dehydroepiandrosterone (DHEA), with sleep are less well studied. In the Nurses' Health Study II, 233 postmenopausal women provided five timed saliva samples over one day (immediately upon waking, 45min, 4h, and 10h after waking, and prior to going to sleep) to measure cortisol and DHEA...
July 19, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28735917/mother-father-agreement-and-one-year-stability-of-children-s-sleep-functioning
#3
Stephen P Becker, Paul A Isaacson, Mateu Servera, Belén Sáez, G Leonard Burns
OBJECTIVES: To (1) evaluate mother-father agreement of total sleep problems and specific sleep problem domains and (2) examine the one-year stability of children's sleep functioning, including cross-rater stability. METHODS: A community-based sample of 519 children (51% boys) in Spain was assessed in third grade and again 1 year later. At each time-point, both mothers and fathers provided ratings of sleep functioning using the Children's Sleep Habits Questionnaire (CSHQ)...
August 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28734940/role-of-orbitofrontal-sulcogyral-pattern-on-lifetime-cannabis-use-and-depressive-symptoms
#4
Yann Chye, Nadia Solowij, Eleni P Ganella, Chao Suo, Murat Yücel, Albert Batalla, Janna Cousijn, Anna E Goudriaan, Rocio Martin-Santos, Sarah Whittle, Cali F Bartholomeusz, Valentina Lorenzetti
Orbitofrontal cortex (OFC) sulcogyral patterns are stable morphological variations established early in life. They consist of three distinct pattern types, with Type III in particular being associated with poor regulatory control (e.g., high sensation seeking and negative emotionality, low constraint), which may confer risk for earlier onset of cannabis (CB) use and greater use in later life. The OFC sulcogyral pattern may therefore be a stable trait marker in understanding individual differences in substance-use vulnerability and associated affective disturbances in users...
July 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28733927/nut-intake-and-5-year-changes-in-body-weight-and-obesity-risk-in-adults-results-from-the-epic-panacea-study
#5
Heinz Freisling, Hwayoung Noh, Nadia Slimani, Véronique Chajès, Anne M May, Petra H Peeters, Elisabete Weiderpass, Amanda J Cross, Guri Skeie, Mazda Jenab, Francesca R Mancini, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Verena A Katzke, Tilman Kühn, Annika Steffen, Heiner Boeing, Anne Tjønneland, Cecilie Kyrø, Camilla P Hansen, Kim Overvad, Eric J Duell, Daniel Redondo-Sánchez, Pilar Amiano, Carmen Navarro, Aurelio Barricarte, Aurora Perez-Cornago, Konstantinos K Tsilidis, Dagfinn Aune, Heather Ward, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Giovanna Masala, Claudia Agnoli, Franco Berrino, Rosario Tumino, Carlotta Sacerdote, Amalia Mattiello, H Bas Bueno-de-Mesquita, Ulrika Ericson, Emily Sonestedt, Anna Winkvist, Tonje Braaten, Isabelle Romieu, Joan Sabaté
PURPOSE: There is inconsistent evidence regarding the relationship between higher intake of nuts, being an energy-dense food, and weight gain. We investigated the relationship between nut intake and changes in weight over 5 years. METHODS: This study includes 373,293 men and women, 25-70 years old, recruited between 1992 and 2000 from 10 European countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Habitual intake of nuts including peanuts, together defined as nut intake, was estimated from country-specific validated dietary questionnaires...
July 21, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28733739/variation-and-treatment-of-vessels-in-laparoscopic-right-hemicolectomy
#6
Kai Ye, Jianan Lin, Yafeng Sun, Yiyang Wu, Jianhua Xu, Songbing He
BACKGROUND: With the introduction of complete mesocolic excision (CME) and the application of laparoscopic technique, surgery for colon cancer has become more standardized and the curative effect has improved [1]. The key points in laparoscopic right hemicolectomy are high ligation of main vessels and root dissection of lymph nodes. The wide range of variations in vascular architecture and intraoperative bleeding are common causes of prolonged surgical time, wound hemorrhage, and even transfer to the opening operation...
July 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28732689/defining-coronary-artery-calcium-concordance-and-repeatability-implications-for-development-and-change-the-dallas-heart-study
#7
Andre R M Paixao, Ian J Neeland, Colby R Ayers, Frank Xing, Jarett D Berry, James A de Lemos, Suhny Abbara, Ronald M Peshock, Amit Khera
BACKGROUND: Development and change of coronary artery calcium (CAC) are associated with coronary heart disease. Interpretation of serial CAC measurements will require better understanding of changes in CAC beyond the variability in the test itself. METHODS: Dallas Heart Study participants (2888) with duplicate CAC scans obtained minutes apart were analyzed to determine interscan concordance and 95% confidence bounds (ie: repeatability limits) for each discrete CAC value...
July 3, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28732496/accuracy-and-determinants-of-perceived-hiv-risk-among-young-women-in-south-africa
#8
Brendan Maughan-Brown, Atheendar S Venkataramani
BACKGROUND: HIV risk perceptions are a key determinant of HIV testing. The success of efforts to achieve an AIDS-free generation - including reaching the UNAIDS 90-90-90 target - thus depends critically on the content of these perceptions. We examined the accuracy of HIV-risk perceptions and their correlates among young black women in South Africa, a group with one of the highest HIV incidence rates worldwide. METHODS: We used individual-level longitudinal data from the Cape Area Panel Study (CAPS) from 2005 to 2009 on black African women (20-30 years old in 2009) to assess the association between perceived HIV-risk in 2005 and the probability of testing HIV-positive four years later...
July 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28732208/longitudinal-investigation-of-the-parietal-lobe-anatomy-in-bipolar-disorder-and-its-association-with-general-functioning
#9
Adele Ferro, Carolina Bonivento, Giuseppe Delvecchio, Marcella Bellani, Cinzia Perlini, Nicola Dusi, Veronica Marinelli, Mirella Ruggeri, A Carlo Altamura, Benedicto Crespo-Facorro, Paolo Brambilla
The parietal lobe (PL) supports cognitive domains, including attention and memory, which are impaired in bipolar disorder (BD). Although cross-sectional voxel-based morphometry studies found reduced PL grey matter (GM) in BD, none has longitudinally focused on PL anatomy in BD, relating it to patients' functioning. Thirty-eight right-handed BD patients and 42 matched healthy subjects (HS) underwent a Magnetic Resonance Imaging (MRI) scan at baseline. Seventeen BD patients and 16 matched HS underwent a follow-up MRI...
June 20, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28732089/cx47-fine-tunes-the-handling-of-serum-lipids-but-is-dispensable-for-lymphatic-vascular-function
#10
Merlijn J Meens, Issa Kutkut, Viviane Rochemont, Juan Dubrot, Fouad R Kaladji, Amélie Sabine, Oliver Lyons, Stefanie Hendrikx, Jeremiah Bernier-Latmani, Friedemann Kiefer, Alberto Smith, Stéphanie Hugues, Tatiana V Petrova, Brenda R Kwak
Mutations in the gap junction protein connexin47 (Cx47) are associated with lymphedema. However, the role of Cx47 in lymphatic pathophysiology is unknown. We demonstrate that Cx47 is expressed in lymphatic endothelial cells by whole-mount immunostaining and qPCR. To determine if Cx47 plays a role in lymphatic vessel function we analysed Cx47-/- mice. Cx47-deficiency did not affect lymphatic contractility (contractile amplitude or frequency) or lymphatic morphology (vessel diameter or number of valves). Interstitial fluid drainage or dendritic cell migration through lymphatic vessels was also not affected by Cx47-deficiency...
2017: PloS One
https://www.readbyqxmd.com/read/28731802/neurovascular-structures-at-risk-with-curved-retrograde-ttc-fusion-nails
#11
Cesar de Cesar Netto, David Johannesmeyer, Brent Cone, Ibukunoluwa Araoye, Parke William Hudson, Bahman Sahranavard, Michael Johnson, Ashish Shah
BACKGROUND: The purpose of this study was to assess the risk of iatrogenic injury to plantar neurovascular structures of the foot during insertion of a curved retrograde tibiotalocalcaneal (TTC) fusion nail. MATERIAL AND METHODS: Ten below-knee thawed fresh-frozen cadaveric specimens underwent curved retrograde nailing of the ankle. The shortest distance between the nail and the main plantar neurovascular branches and injured structures were recorded during dissection...
July 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28729617/the-effect-of-electrical-stimulation-of-the-calf-muscle-on-leg-fluid-accumulation-over-a-long-period-of-sitting
#12
Daniel Vena, Jonathan Rubianto, Milos R Popovic, Geoff R Fernie, Azadeh Yadollahi
Leg fluid accumulation during sedentary behaviours such as sitting can lead to leg edema and associated adverse health consequences. This study investigates the use calf muscle electrical stimulation (ES) to reduce seated leg fluid accumulation. Thirteen non-obese, normotensive men (mean age 51 yr.) with sleep apnea were enrolled in the study. Participants first lay supine for 30 minutes to equalize fluid distribution and then sat for 150 minutes. While seated, participants received either active or sham ES of the calf muscles, according to random assignment...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729221/sensitivity-to-cocaine-in-adult-mice-is-due-to-interplay-between-genetic-makeup-early-environment-and-later-experience
#13
Matteo Di Segni, Diego Andolina, Alessandra Coassin, Alessandra Accoto, Alessandra Luchetti, Tiziana Pascucci, Carla Luzi, Anna Rita Lizzi, Francesca R D'Amato, Rossella Ventura
Although early aversive postnatal events are known to increase the risk to develop psychiatric disorders later in life, rarely they determine alone the nature and outcome of the psychopathology, indicating that interaction with genetic factors is crucial for expression of psychopathologies in adulthood. Moreover, it has been suggested that early life experiences could have negative consequences or confer adaptive value in different individuals. Here we suggest that resilience or vulnerability to adult cocaine sensitivity depends on a "triple interaction" between genetic makeup x early environment x later experience...
July 17, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28729059/ultrasonographic-assessment-of-femoral-cartilage-thickness-in-patients-with-cerebral-palsy
#14
Emre Adigüzel, Fatih Tok, Emre Ata, Evren Yaşar, Bilge Yilmaz
BACKGROUND: Cerebral palsy (CP) is one of the most disabling syndromes of children. To our knowledge, there has not yet been any reported evaluation of the effect of CP on distal femoral cartilage by ultrasonography. The value of understanding this effect on cartilage is that sonographic evaluation of cartilage thickness may help physician to predict the joint health of these children. OBJECTIVE: To determine whether femoral cartilage thickness in patients with CP is different from that of healthy control subjects...
July 17, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28728640/hangover-symptoms-heavy-episodic-drinking-and-depression-in-young-adults-a-cross-lagged-analysis
#15
Thomas M Piasecki, Constantine J Trela, Robin J Mermelstein
OBJECTIVE: The objective of this study was to examine associations between symptoms of alcohol hangover and depression, both cross-sectionally and prospectively. METHOD: Data were from a survey of young adults (N = 986, 60% female) initially recruited as part of an observational study of youth smoking. Participants reported past-year hangover symptoms, past-year frequency of heavy episodic drinking (HED), and past-week depression symptoms on two occasions separated by 1 year...
July 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28727778/in-vitro-study-of-accuracy-of-subaxial-cervical-pedicle-screw-insertion-using-calipers-based-on-the-gravity-line
#16
Xiang Yao, Shiqing Liu
OBJECT: There is a high probability of iatrogenic perforation of the vertebral pedicle wall during the application of subaxial cervical pedicle screw (CPS). The goal of this study was to evaluate the accuracy of CPS insertion at C3-C7 in vitro using novel calipers based on the gravity line. METHODS: Nine cadaveric cervical spines underwent computed tomography scanning and preoperative design. A lateral fluoroscopic view was taken to measure the intra-operative sagittal angle by C-arm with hanging cross structured K-wires...
2017: PloS One
https://www.readbyqxmd.com/read/28727611/formula-feeding-as-a-risk-factor-for-attention-deficit-hyperactivity-disorder-is-bisphenol-a-exposure-a-smoking-gun
#17
Andrew Adesman, Derek Soled, Lisa Rosen
OBJECTIVE: Breastfeeding during infancy is associated with a lower risk of attention-deficit/hyperactivity disorder (ADHD). Although this is presumably due to breast milk's nutritional advantages, formula-fed infants have, until recently, also been exposed to bisphenol A (BPA), a neurotoxic chemical previously used to manufacture baby bottles and formula cans. Our goal was to examine the association between formula feeding and preschool ADHD in 2 comparable, serial cohorts of preschool children who differ in BPA exposure during infancy...
July 14, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28726468/longitudinal-trajectories-of-benefit-finding-in-adolescents-with-type-1-diabetes
#18
Jessica Rassart, Koen Luyckx, Cynthia A Berg, Leen Oris, Deborah J Wiebe
OBJECTIVES: Benefit finding, which refers to perceiving positive life changes resulting from adversity, has been associated with better psychosocial well-being in different chronic illnesses. However, little research to date has examined how benefit finding develops in the context of Type 1 diabetes (T1D). The present study aimed to identify trajectories of benefit finding across adolescence and to investigate prospective associations with depressive symptoms, self-care, and metabolic control...
July 20, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28724650/dynamic-relation-of-changes-in-weight-and-indices-of-fat-distribution-with-cardiac-structure-and-function-the-dallas-heart-study
#19
Bryan Wilner, Sonia Garg, Colby R Ayers, Christopher D Maroules, Roderick McColl, Susan A Matulevicius, James A de Lemos, Mark H Drazner, Ronald Peshock, Ian J Neeland
BACKGROUND: Obesity may increase heart failure risk through cardiac remodeling. Cross-sectional associations between adiposity and cardiac structure and function have been elucidated, but the impact of longitudinal changes in adiposity on cardiac remodeling is less well understood. METHODS AND RESULTS: Participants in the Dallas Heart Study without cardiovascular disease or left ventricular dysfunction underwent assessment of body weight, anthropometrics, and cardiac magnetic resonance imaging at baseline and 7 years later...
July 19, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28724457/the-association-between-food-insecurity-and-academic-achievement-in-canadian-school-aged-children
#20
Erin L Faught, Patty L Williams, Noreen D Willows, Mark Asbridge, Paul J Veugelers
OBJECTIVE: Education is a crucial social determinant of health. Food insecurity can be detrimental to children's academic achievement, potentially perpetuating a cycle of poverty and food insecurity. We aimed to assess the relationship between food insecurity and academic achievement in Canadian school-aged children. DESIGN: Cross-sectional study of children and parents. Parents completed the short-form Household Food Security Survey Module and questions about income and education level (socio-economic status)...
July 20, 2017: Public Health Nutrition
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