keyword
MENU ▼
Read by QxMD icon Read
search

Ovarian ablation

keyword
https://www.readbyqxmd.com/read/29401296/changes-in-keratin-8-18-expression-in-human-granulosa-cell-lineage-are-associated-to-cell-death-survival-events-potential-implications-for-the-maintenance-of-the-ovarian-reserve
#1
F Gaytan, C Morales, J Roa, M Tena-Sempere
STUDY QUESTION: Is keratin 8/18 (K8/K18) expression linked to cell death/survival events in the human granulosa cell lineage? SUMMARY ANSWER: A close association exists between changes in K8/K18 expression and cell death/survival events along the human granulosa cell lineage lifespan. WHAT IS KNOWN ALREADY: In addition to their structural and mechanical functions, K8/K18 play essential roles regulating cell death, survival and differentiation in several non-gonadal epithelial tissues...
February 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29394693/-combination-treatments-to-the-huge-ovarian-cancer-with-liver-metastases
#2
Yasunori Hasuike, Yasushi Kanaoka, Ichiro Higuchi, Hirosumi Imoto, Sanae Hosomi, Akira Ishikawa, Yosuke Akiyama, Takahiko Tanigawa, Makoto Miyamoto
We report a CR case of huge ovarian cancer with peritoneal and liver metastases who was operated bilateral ovaries, uterus and peritoneal metastases at first, followed by systemic chemotherapy and performed 4 times of radiofrequency ablation (RFA)and 2 times of liver resection(LR). The case was a 50-year-old woman. She suffered with bowel enlargement from over 1 year ago. Preoperative MRI finding was huge ovarian serous cyst with partial solid tumor inside. The major axis was about 30 cm. CA125 and CA19-9 levels were elevated...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29360538/ccrk-is-a-novel-signalling-hub-exploitable-in-cancer-immunotherapy
#3
REVIEW
Myth T S Mok, Jingying Zhou, Wenshu Tang, Xuezhen Zeng, Antony W Oliver, Simon E Ward, Alfred S L Cheng
Cyclin-dependent kinase 20 (CDK20), or more commonly referred to as cell cycle-related kinase (CCRK), is the latest member of CDK family with strong linkage to human cancers. Accumulating studies have reported the consistent overexpression of CCRK in cancers arising from brain, colon, liver, lung and ovary. Such aberrant up-regulation of CCRK is clinically significant as it correlates with tumor staging, shorter patient survival and poor prognosis. Intriguingly, the signalling molecules perturbed by CCRK are divergent and cancer-specific, including the cell cycle regulators CDK2, cyclin D1, cyclin E and RB in glioblastoma, ovarian carcinoma and colorectal cancer, and KEAP1-NRF2 cytoprotective pathway in lung cancer...
January 21, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29329412/lhx8-ablation-leads-to-massive-autophagy-of-mouse-oocytes-associated-with-dna-damage
#4
Emanuele Pelosi, Laura D'Ignazio, Marc Michel, Melissa Beyer, Kassimier Thompson, Antonino Forabosco, David Schlessinger
Following proliferation of oogonia in mammals, great numbers of germ cells are discarded, primarily by apoptosis, while the remainder form primordial follicles (the ovarian reserve) that determine fertility and reproductive lifespan. More massive, rapid, and essentially total loss of oocytes, however, occurs when the transcription factor Lhx8 is ablated-though the cause and mechanism of germ cell loss from the Lhx8-/- ovaries has been unknown. We found that Lhx8-/- ovaries maintain the same number of germ cells throughout embryonic development; rapid decrease in the pool of oocytes starts shortly before birth...
January 10, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29324540/metastatic-involvement-of-lesser-sac-in-advanced-epithelial-ovarian-cancer
#5
Asima Mukhopadhyay, Nicolò Bizzarri, Melissa Bradbury, Subir Sinha, Jaydip Bhaumik, C William Helm
OBJECTIVES: In advanced epithelial ovarian cancer (AOC), lesser sac (LS) metastasis particularly to the supragastric LS (SGLS) may be overlooked, resulting in unrecognized residual disease. We aimed to identify the frequency, distribution, and predictors of LS metastasis using laparoscopic evaluation at laparotomy and perioperative surgical complications associated with evaluation and resection/ablation. METHODS: Prospective observational study in consecutive patients with AOC undergoing laparotomy for primary or interval cytoreductive surgery in 2 centers between November 2013 and December 2016...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29302874/anti-m%C3%A3-llerian-hormone-in-pre-menopausal-females-after-ablative-radioiodine-treatment-for-differentiated-thyroid-cancer
#6
Massimo Giusti, Miranda Mittica, Paola Comite, Claudia Campana, Stefano Gay, Michele Mussap
PURPOSE: In recent years, anti-Mullerian hormone (AMH) has been considered a reliable index of ovarian reserve. There are few data on AMH values in thyroid cancer. The aim of this study was to evaluate AMH levels in pre-menopausal women with a history of low-risk thyroid cancer. METHODS: Thirty-four women (aged 40.7 ± 6.7 years) were studied 7.1 ± 0.9 years after surgery and at least one RAI treatment. A group of 23 thyroid cancer women (41.6 ± 7...
January 4, 2018: Endocrine
https://www.readbyqxmd.com/read/29285022/recommendations-for-the-surgical-treatment-of-endometriosis-part-1-ovarian-endometrioma
#7
Ertan Saridogan, Christian M Becker, Anis Feki, Grigoris F Grimbizis, Lone Hummelshoj, Joerg Keckstein, Michelle Nisolle, Vasilios Tanos, Uwe A Ulrich, Nathalie Vermeulen, Rudy Leon De Wilde
Study question: What does this document on the surgical treatment of endometriosis jointly prepared by the European Society for Gynaecological Endoscopy (ESGE), ESHRE, and the World Endometriosis Society (WES) provide? Summary answer: This document provides recommendations covering technical aspects of different methods of surgery for endometriomas in women of reproductive age. What is already known: Endometriomas (ovarian endometriotic cysts) are a commonly diagnosed form of endometriosis, owing to the relative ease and accuracy of ultrasound diagnosis...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/29279355/gadd45%C3%AE-loss-ablates-innate-immunosuppression-in-cancer
#8
Daniela Verzella, Jason Bennett, Mariafausta Fischietti, Anil Kumar Thotakura, Camilla Recordati, Fabio Pasqualini, Daria Capece, Davide Vecchiotti, Daniel D'Andrea, Barbara Di Francesco, Marcella De Maglie, Federica Begalli, Laura Tornatore, Salvatore Papa, Toby Lawrence, Stuart Forbes, Antonio Sica, Edoardo Alesse, Francesca Zazzeroni, Guido Franzoso
T cell exclusion from the tumour microenvironment (TME) is a major barrier to overcoming immune escape. Here we identify a myeloid-intrinsic mechanism governed by the NF-κB effector molecule GADD45β that restricts tumour-associated inflammation and T cell trafficking into tumors. In various models of solid cancers refractory to immunotherapies, including hepatocellular carcinoma (HCC) and ovarian adenocarcinoma, Gadd45b inhibition in myeloid cells restored activation of pro-inflammatory tumour-associated macrophages (TAM) and intratumoural immune infiltration, thereby diminishing oncogenesis...
December 26, 2017: Cancer Research
https://www.readbyqxmd.com/read/29274928/optimal-adjuvant-endocrine-treatment-of-er-her2-breast-cancer-patients-by-age-at-diagnosis-a-population-based-cohort-study
#9
G M H E Dackus, K Jóźwiak, G S Sonke, E van der Wall, P J van Diest, M Hauptmann, S Siesling, S C Linn
BACKGROUND: Prior randomised controlled trials on adjuvant hormonal therapy included HER2any patients; however, a differential effect of aromatase inhibitors (AIs) versus tamoxifen (TAM) may have been missed in ER+/HER2+ patients that comprise 7-15% of all breast cancer patients. In addition, a woman's hormonal microenvironment may influence sensitivity to TAM and AIs in the adjuvant setting, which changes during menopausal transition, a process that takes years. We studied the efficacy of AIs versus TAM in ER+/HER2+ breast cancer patients grouped by age at diagnosis as a proxy for menopausal status using treatment and outcome data from the nationwide population-based Netherlands Cancer Registry (NCR)...
December 21, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29261681/decreased-expression-of-lethal-giant-larvae-causes-ovarian-follicle-cell-outgrowth-in-the-drosophila-scutoid-mutant
#10
Chen-Yuan Tseng, Hwei-Jan Hsu
Snail, a zinc-finger transcription factor, controls the process of epithelial-mesenchymal transition, and ectopic expression of this protein may produce cells with stem cell properties. Because the effect of Snail expression in ovarian epithelial cells remains unclear, we generated Drosophila ovarian follicle stem cells (FSCs) with homozygous Scutoid (Sco) mutation. The Sco mutation is a reciprocal transposition that is known to induce ectopic Snail activity. We found that Sco mutant FSCs showed excess proliferation and high competitiveness for niche occupancy, and the descendants of this lineage formed outgrowths that failed to enter the endocycle...
2017: PloS One
https://www.readbyqxmd.com/read/29208899/in-vivo-transplantation-of-3d-encapsulated-ovarian-constructs-in-rats-corrects-abnormalities-of-ovarian-failure
#11
Sivanandane Sittadjody, Justin M Saul, John P McQuilling, Sunyoung Joo, Thomas C Register, James J Yoo, Anthony Atala, Emmanuel C Opara
Safe clinical hormone replacement (HR) will likely become increasingly important in the growing populations of aged women and cancer patients undergoing treatments that ablate the ovaries. Cell-based HRT (cHRT) is an alternative approach that may allow certain physiological outcomes to be achieved with lower circulating hormone levels than pharmacological means due to participation of cells in the hypothalamus-pituitary-ovary feedback control loop. Here we describe the in vivo performance of 3D bioengineered ovarian constructs that recapitulate native cell-cell interactions between ovarian granulosa and theca cells as an approach to cHRT...
December 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/29208873/correlation-between-seropositivity-of-chlamydia-trachomatis-and-tubal-and-or-pelvic-pathology-detected-by-diagnostic-laparoscopy-in-subfertile-women
#12
N Begum, S A Anwary, M Alfazzaman, Z Mahzabin, F Deeba, M A Mostafa, M Akhter, M M Rahman
This prospective observational study was carried out in the Infertility Unit, Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from February 2011 to December 2013. Sixty-nine (69) subfertile women who were seropositive for Chlamydia Trachomatis were included in this study. Inclusion criteria was patients with sub-fertility having age between 22 and 40 years, seeking infertility treatment, normal ovarian function, all normozoospermic male partner, duration of infertility ranged from 1...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29172851/intrinsic-subtypes-and-benefit-from-postmastectomy-radiotherapy-in-node-positive-premenopausal-breast-cancer-patients-who-received-adjuvant-chemotherapy-results-from-two-independent-randomized-trials
#13
Tinne Laurberg, Trine Tramm, Torsten Nielsen, Jan Alsner, Silje Nord, Simen Myhre, Therese Sørlie, Samuel Leung, Cheng Fan, Charles Perou, Karen Gelmon, Jens Overgaard, David Voduc, Aleix Prat, Maggie Chon U Cheang
BACKGROUND: The study of the intrinsic molecular subtypes of breast cancer has revealed differences among them in terms of prognosis and response to chemotherapy and endocrine therapy. However, the ability of intrinsic subtypes to predict benefit from adjuvant radiotherapy has only been examined in few studies. METHODS: Gene expression-based intrinsic subtyping was performed in 228 breast tumors collected from two independent post-mastectomy clinical trials (British Columbia and the Danish Breast Cancer Cooperative Group 82b trials), where pre-menopausal patients with node-positive disease were randomized to adjuvant radiotherapy or not...
January 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29162714/ablation-of-an-ovarian-tumor-family-deubiquitinase-exposes-the-underlying-regulation-governing-the-plasticity-of-cell-cycle-progression-in-toxoplasma-gondii
#14
Animesh Dhara, Rodrigo de Paula Baptista, Jessica C Kissinger, E Charles Snow, Anthony P Sinai
The Toxoplasma genome encodes the capacity for distinct architectures underlying cell cycle progression in a life cycle stage-dependent manner. Replication in intermediate hosts occurs by endodyogeny, whereas a hybrid of schizogony and endopolygeny occurs in the gut of the definitive feline host. Here, we characterize the consequence of the loss of a cell cycle-regulated ovarian tumor (OTU family) deubiquitinase, OTUD3A of Toxoplasma gondii (TgOTUD3A; TGGT1_258780), in T. gondii tachyzoites. Rather than the mutation being detrimental, mutant parasites exhibited a fitness advantage, outcompeting the wild type...
November 21, 2017: MBio
https://www.readbyqxmd.com/read/29126187/med12-regulates-ovarian-steroidogenesis-uterine-development-and-maternal-effects-in-the-mammalian-egg
#15
Xinye Wang, Priya Mittal, Carlos A Castro, Gabriel Rajkovic, Aleksandar Rajkovic
The transcriptional factor MED12 is part of the essential mediator transcriptional complex that acts as a transcriptional coactivator in all eukaryotes. Missense gain of function mutations in human MED12 are associated with uterine leiomyomas, yet the role of MED12 deficiency in tumorigenesis and reproductive biology has not been fully explored. We generated a Med12 reproductive conditional knockout mouse model to evaluate its role in uterine mesenchyme, granulosa cells, and oocytes. Mice heterozygous for Med12 deficiency in granulosa cells and uterus (Med12fl/+ Amhr2-Cre) were subfertile, while mice homozygous for Med12 deficiency in granulosa cells and uterus (Med12fl/fl Amhr2-Cre) were infertile...
November 8, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29073540/uterine-endometrial-vascularization-during-ovarian-follicular-growth-in-llamas-the-effect-of-estradiol-plasma-concentration
#16
Mauricio Silva, Felipe Urra, Marcelo Ratto
The aim of this study was to evaluated changes in endometrial vascularization area (EVA) between the left and right uterine horn: a) during the ovarian follicular growth in intact llamas, and b) after exogenous estradiol administration of estradiol benzoate in ovariectomized (OVX) llamas. In experiment 1 follicle wave emergence was synchronized (n = 5 llamas) by follicle ablation (Day 0). Females were examined every other day from Day 1 to Day 27, using B mode ultrasonography to evaluate dominant follicle growth profile...
October 17, 2017: Theriogenology
https://www.readbyqxmd.com/read/29030300/gold-nanocage-decorated-ph-sensitive-micelle-for-highly-effective-photothermo-chemotherapy-and-photoacoustic-imaging
#17
Guoyong Zhou, Hong Xiao, Xiaoxia Li, Yi Huang, Wei Song, Liang Song, Meiwan Chen, Du Cheng, Xintao Shuai
A pH-sensitive copolymer PAsp(DIP)-b-PAsp(MEA) (PDPM) was synthesized and self-assembled to micelle loading chemotherapeutic drug doxorubicin (DOX) and introducing a gold nanocage structure for photothermo-chemotherapy and photoacoustic imaging. After further surface modification with polyethylene glycol (PEG), the DOX-loaded pH-sensitive gold nanocage (D-PGNC) around 100 nm possessed a uniform spherical structure with a pH-sensitive core of PAsp(DIP) incorporating DOX, an interlayer crosslinked via disulfide bonds and decorated with discontinuous gold shell, and a PEG corona...
December 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28938467/testis-determination-requires-a-specific-fgfr2-isoform-to-repress-foxl2
#18
Stefan Bagheri-Fam, Anthony D Bird, Liang Zhao, Janelle M Ryan, Meiyun Yong, Dagmar Wilhelm, Peter Koopman, Veraragavan P Eswarakumar, Vincent R Harley
Male sex determination in mammals relies on sex determining region Y-mediated upregulation of sex determining region-box 9 (SOX9) expression in XY gonads, whereas Wnt family member (WNT)/R-spondin 1 signaling and forkhead box L2 (FOXL2) drive female sex determination in XX gonads. Fibroblast growth factor (FGF) 9 signaling ensures sustained SOX9 expression through repression of one of the ovarian pathways (WNT signaling), whereas the significance of FGF-mediated repression of the FOXL2 pathway has not been studied...
November 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28895089/bilateral-salpingo-oophorectomy-versus-gnrh-analogue-in-the-adjuvant-treatment-of-premenopausal-breast-cancer-patients-cost-effectiveness-evaluation-of-breast-cancer-outcome-ovarian-cancer-prevention-and-treatment
#19
Gabriella Ferrandina, Giulia Amadio, Andrea Marcellusi, Elena Azzolini, Anna Puggina, Roberta Pastorino, Walter Ricciardi, Giovanni Scambia
BACKGROUND AND OBJECTIVE: There is no available evidence to recommend gonadotropin-releasing hormone (GnRH) analogue-based ovarian suppression versus bilateral salpingo-oophorectomy (BSO) in the adjuvant treatment of early breast cancer, since the two approaches are considered equivalent in terms of oncologic outcome. The role of surgical ovarian ablation has been revitalized based on the advances of minimally invasive surgery, and a better understanding of clinical and molecular basis of hereditary breast/ovarian cancer syndromes...
November 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28881798/role-of-a-kinase-anchor-protein-akap4-in-growth-and-survival-of-ovarian-cancer-cells
#20
Vikash Kumar, Nirmala Jagadish, Anil Suri
Ovarian cancer represents one of the most common malignancies among women with very high mortality rate worldwide. A-kinase anchor protein 4 (AKAP4), a unique cancer testis (CT) antigen has been shown to be associated with various malignant properties of cancer cells. However, its involvement in various molecular pathways in ovarian cancer remains unknown. In present investigation, employing gene silencing approach, we examined the role of AKAP4 in cell cycle, apoptosis and epithelial-mesenchymal transition (EMT)...
August 8, 2017: Oncotarget
keyword
keyword
2527
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"