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https://www.readbyqxmd.com/read/26457678/a-swi-snf-chromatin-remodelling-protein-controls-cytokinin-production-through-the-regulation-of-chromatin-architecture
#1
Teddy Jégu, Séverine Domenichini, Thomas Blein, Federico Ariel, Aurélie Christ, Soon-Kap Kim, Martin Crespi, Stéphanie Boutet-Mercey, Grégory Mouille, Mickaël Bourge, Heribert Hirt, Catherine Bergounioux, Cécile Raynaud, Moussa Benhamed
Chromatin architecture determines transcriptional accessibility to DNA and consequently gene expression levels in response to developmental and environmental stimuli. Recently, chromatin remodelers such as SWI/SNF complexes have been recognized as key regulators of chromatin architecture. To gain insight into the function of these complexes during root development, we have analyzed Arabidopsis knock-down lines for one sub-unit of SWI/SNF complexes: BAF60. Here, we show that BAF60 is a positive regulator of root development and cell cycle progression in the root meristem via its ability to down-regulate cytokinin production...
2015: PloS One
https://www.readbyqxmd.com/read/26106148/swp73-subunits-of-arabidopsis-swi-snf-chromatin-remodeling-complexes-play-distinct-roles-in-leaf-and-flower-development
#2
Sebastian P Sacharowski, Dominika M Gratkowska, Elzbieta A Sarnowska, Paulina Kondrak, Iga Jancewicz, Aimone Porri, Ernest Bucior, Anna T Rolicka, Rainer Franzen, Justyna Kowalczyk, Katarzyna Pawlikowska, Bruno Huettel, Stefano Torti, Elmon Schmelzer, George Coupland, Andrzej Jerzmanowski, Csaba Koncz, Tomasz J Sarnowski
Arabidopsis thaliana SWP73A and SWP73B are homologs of mammalian BRAHMA-associated factors (BAF60s) that tether SWITCH/SUCROSE NONFERMENTING chromatin remodeling complexes to transcription factors of genes regulating various cell differentiation pathways. Here, we show that Arabidopsis thaliana SWP73s modulate several important developmental pathways. While undergoing normal vegetative development, swp73a mutants display reduced expression of FLOWERING LOCUS C and early flowering in short days. By contrast, swp73b mutants are characterized by retarded growth, severe defects in leaf and flower development, delayed flowering, and male sterility...
July 2015: Plant Cell
https://www.readbyqxmd.com/read/25107474/akirin2-is-critical-for-inducing-inflammatory-genes-by-bridging-i%C3%AE%C2%BAb-%C3%AE-and-the-swi-snf-complex
#3
Sarang Tartey, Kazufumi Matsushita, Alexis Vandenbon, Daisuke Ori, Tomoko Imamura, Takashi Mino, Daron M Standley, Jules A Hoffmann, Jean-Marc Reichhart, Shizuo Akira, Osamu Takeuchi
Transcription of inflammatory genes in innate immune cells is coordinately regulated by transcription factors, including NF-κB, and chromatin modifiers. However, it remains unclear how microbial sensing initiates chromatin remodeling. Here, we show that Akirin2, an evolutionarily conserved nuclear protein, bridges NF-κB and the chromatin remodeling SWI/SNF complex by interacting with BRG1-Associated Factor 60 (BAF60) proteins as well as IκB-ζ, which forms a complex with the NF-κB p50 subunit. These interactions are essential for Toll-like receptor-, RIG-I-, and Listeria-mediated expression of proinflammatory genes including Il6 and Il12b in macrophages...
October 16, 2014: EMBO Journal
https://www.readbyqxmd.com/read/25078649/myomir-dependent-switching-of-baf60-variant-incorporation-into-brg1-chromatin-remodeling-complexes-during-embryo-myogenesis
#4
Katarzyna Goljanek-Whysall, Gi Fay Mok, Abdulmajeed Fahad Alrefaei, Niki Kennerley, Grant N Wheeler, Andrea Münsterberg
Myogenesis involves the stable commitment of progenitor cells followed by the execution of myogenic differentiation, processes that are coordinated by myogenic regulatory factors, microRNAs and BAF chromatin remodeling complexes. BAF60a, BAF60b and BAF60c are structural subunits of the BAF complex that bind to the core ATPase Brg1 to provide functional specificity. BAF60c is essential for myogenesis; however, the mechanisms regulating the subunit composition of BAF/Brg1 complexes, in particular the incorporation of different BAF60 variants, are not understood...
September 2014: Development
https://www.readbyqxmd.com/read/24682306/hdac-regulated-myomirs-control-baf60-variant-exchange-and-direct-the-functional-phenotype-of-fibro-adipogenic-progenitors-in-dystrophic-muscles
#5
Valentina Saccone, Silvia Consalvi, Lorenzo Giordani, Chiara Mozzetta, Iros Barozzi, Martina Sandoná, Tammy Ryan, Agustin Rojas-Muñoz, Luca Madaro, Pasquale Fasanaro, Giovanna Borsellino, Marco De Bardi, Gianmaria Frigè, Alberto Termanini, Xin Sun, Janet Rossant, Benoit G Bruneau, Mark Mercola, Saverio Minucci, Pier Lorenzo Puri
Fibro-adipogenic progenitors (FAPs) are important components of the skeletal muscle regenerative environment. Whether FAPs support muscle regeneration or promote fibro-adipogenic degeneration is emerging as a key determinant in the pathogenesis of muscular diseases, including Duchenne muscular dystrophy (DMD). However, the molecular mechanism that controls FAP lineage commitment and activity is currently unknown. We show here that an HDAC-myomiR-BAF60 variant network regulates the fate of FAPs in dystrophic muscles of mdx mice...
April 15, 2014: Genes & Development
https://www.readbyqxmd.com/read/24510722/the-baf60-subunit-of-the-swi-snf-chromatin-remodeling-complex-directly-controls-the-formation-of-a-gene-loop-at-flowering-locus-c-in-arabidopsis
#6
Teddy Jégu, David Latrasse, Marianne Delarue, Heribert Hirt, Séverine Domenichini, Federico Ariel, Martin Crespi, Catherine Bergounioux, Cécile Raynaud, Moussa Benhamed
SWI/SNF complexes mediate ATP-dependent chromatin remodeling to regulate gene expression. Many components of these complexes are evolutionarily conserved, and several subunits of Arabidopsis thaliana SWI/SNF complexes are involved in the control of flowering, a process that depends on the floral repressor FLOWERING LOCUS C (FLC). BAF60 is a SWI/SNF subunit, and in this work, we show that BAF60, via a direct targeting of the floral repressor FLC, induces a change at the high-order chromatin level and represses the photoperiod flowering pathway in Arabidopsis...
February 2014: Plant Cell
https://www.readbyqxmd.com/read/24186978/coordinate-nodal-and-bmp-inhibition-directs-baf60c-dependent-cardiomyocyte-commitment
#7
Wenqing Cai, Sonia Albini, Ke Wei, Erik Willems, Rosa M Guzzo, Masanao Tsuda, Lorenzo Giordani, Sean Spiering, Leo Kurian, Gene W Yeo, Pier Lorenzo Puri, Mark Mercola
A critical but molecularly uncharacterized step in heart formation and regeneration is the process that commits progenitor cells to differentiate into cardiomyocytes. Here, we show that the endoderm-derived dual Nodal/bone morphogenetic protein (BMP) antagonist Cerberus-1 (Cer1) in embryonic stem cell cultures orchestrates two signaling pathways that direct the SWI/SNF chromatin remodeling complex to cardiomyogenic loci in multipotent (KDR/Flk1+) progenitors, activating lineage-specific transcription. Transient inhibition of Nodal by Cer1 induces Brahma-associated factor 60c (Baf60c), one of three Baf60 variants (a, b, and c) that are mutually exclusively assembled into SWI/SNF...
November 1, 2013: Genes & Development
https://www.readbyqxmd.com/read/23457234/the-swi-snf-chromatin-remodeling-complex-selectively-affects-multiple-aspects-of-serotonergic-neuron-differentiation
#8
Peter Weinberg, Nuria Flames, Hitoshi Sawa, Gian Garriga, Oliver Hobert
Regulatory programs that control the specification of serotonergic neurons have been investigated by genetic mutant screens in the nematode Caenorhabditis elegans. Loss of a previously uncloned gene, ham-3, affects migration and serotonin antibody staining of the hermaphrodite-specific neuron (HSN) pair. We characterize these defects here in more detail, showing that the defects in serotonin antibody staining are paralleled by a loss of the transcription of all genes involved in serotonin synthesis and transport...
May 2013: Genetics
https://www.readbyqxmd.com/read/23222103/baf60-a-b-and-cs-of-muscle-determination-and-renewal
#9
REVIEW
Pier Lorenzo Puri, Mark Mercola
Developmental biologists have defined many of the diffusible and transcription factors that control muscle differentiation, yet we still have only rudimentary knowledge of the mechanisms that dictate whether a myogenic progenitor cell forms muscle versus alternate lineages, including those that can be pathological in a state of disease or degeneration. Clues about the molecular basis for lineage determination in muscle progenitors are only now emerging from studies of chromatin modifications that avail myogenic genes for transcription, together with analysis of the composition and activities of the chromatin-modifying complexes themselves...
December 15, 2012: Genes & Development
https://www.readbyqxmd.com/read/20148946/the-swi-snf-protein-baf60b-is-ubiquitinated-through-a-signalling-process-involving-rac-gtpase-and-the-ring-finger-protein-unkempt
#10
Patrick Lorès, Orane Visvikis, Rosa Luna, Emmanuel Lemichez, Gérard Gacon
The SWI/SNF chromatin remodelling complexes are important regulators of transcription; they consist of large multisubunit assemblies containing either Brm or Brg1 as the catalytic ATPase subunit and a variable subset of approximately 10 Brg/Brm-associated factors (BAF). Among these factors, BAF60 proteins (BAF60a, BAF60b or BAF60c), which are found in most complexes, are thought to bridge interactions between transcription factors and SWI/SNF complexes. We report here on a Rac-dependent process leading to BAF60b ubiquitination...
March 2010: FEBS Journal
https://www.readbyqxmd.com/read/19326447/interaction-of-estrogen-receptor-alpha-ligand-binding-domain-with-nuclear-proteins-of-aging-mouse-brain
#11
Swati Ghosh, M K Thakur
After the interaction of estrogen with the ligand binding domain (LBD) of mouse estrogen receptor-alpha (mERalpha) and hormone-responsive elements of target genes, many nuclear proteins are recruited to regulate the expression of specific genes. Because it is not known which brain proteins interact with LBD or whether these proteins vary with age and sex, we used pull-down assay and far Western blotting to detect five nuclear proteins of 160, 140, 87, 60, and 46 kD in the mouse brain. These interacting proteins were identified as PELP1, RIP140, PGC1alpha, BAF60, and ADA3, respectively...
August 15, 2009: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/16199878/regulating-swi-snf-subunit-levels-via-protein-protein-interactions-and-proteasomal-degradation-baf155-and-baf170-limit-expression-of-baf57
#12
Jianguang Chen, Trevor K Archer
The mammalian SWI/SNF chromatin remodeling complex, whose function is of critical importance in transcriptional regulation, contains approximately 10 protein components. The expression levels of the core SWI/SNF subunits, including BRG1/Brm, BAF155, BAF170, BAF60, hSNF/Ini1, and BAF57, are stoichiometric, with few to no unbound molecules in the cell. Here we report that exogenous expression of the wild type or certain deletion mutants of BAF57, a key subunit that mediates the interaction between the remodeling complex and transcription factors, results in diminished expression of endogenous BAF57...
October 2005: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/15208625/p38-pathway-targets-swi-snf-chromatin-remodeling-complex-to-muscle-specific-loci
#13
Cristiano Simone, Sonia Vanina Forcales, David A Hill, Anthony N Imbalzano, Lucia Latella, Pier Lorenzo Puri
During skeletal myogenesis, genomic reprogramming toward terminal differentiation is achieved by recruiting chromatin-modifying enzymes to muscle-specific loci. The relative contribution of extracellular signaling cascades in targeting these enzymes to individual genes is unknown. Here we show that the differentiation-activated p38 pathway targets the SWI-SNF chromatin-remodeling complex to myogenic loci. Upon differentiation, p38 kinases were recruited to the chromatin of muscle-regulatory elements. Blockade of p38 alpha/beta repressed the transcription of muscle genes by preventing recruitment of the SWI-SNF complex at these elements without affecting chromatin binding of muscle-regulatory factors and acetyltransferases...
July 2004: Nature Genetics
https://www.readbyqxmd.com/read/8804307/diversity-and-specialization-of-mammalian-swi-snf-complexes
#14
COMPARATIVE STUDY
W Wang, Y Xue, S Zhou, A Kuo, B R Cairns, G R Crabtree
The SWI/SNF complex in yeast facilitates the function of transcriptional activators by opposing chromatin-dependent repression of transcription. We demonstrate that in mammals SWI/SNF complexes are present in multiple forms made up of 9-12 proteins that we refer to as BRG1-associated factors (BAFs) ranging from 47 to 250 kD. We have isolated cDNAs for human BAF155, BAF170, and BAF60. BAF155 and BAF170 are encoded by separate genes that are both homologs of yeast SWI3. Both contain a region of similarity to the DNA binding domain of myb, but lack the basic residues known to be necessary for interaction with DNA...
September 1, 1996: Genes & Development
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