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https://www.readbyqxmd.com/read/28221368/no-evidence-for-the-presence-of-genetic-variants-predisposing-to-psychotic-disorders-on-the-non-deleted-22q11-2-allele-of-vcfs-patients
#1
M Guipponi, F Santoni, M Schneider, C Gehrig, X B Bustillo, W R Kates, B Morrow, M Armando, S Vicari, F Sloan-Béna, M Gagnebin, V Shashi, S R Hooper, S Eliez, S E Antonarakis
The velo-cardio-facial syndrome (VCFS) is caused by hemizygous deletions on chromosome 22q11.2. The VCFS phenotype is complex and characterized by frequent occurrence of neuropsychiatric symptoms with up to 25-30% of cases suffering from psychotic disorders compared with only ~1% in the general population (odds ratio≈20-25). This makes the 22q11.2 deletion one of the most prominent risk factors for schizophrenia. However, its penetrance for neuropsychiatric phenotypes is incomplete suggesting that additional risk factors are required for disease development...
February 21, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28216146/divergent-levels-of-marker-chromosomes-in-an-hipsc-based-model-of%C3%A2-psychosis
#2
Julia Tcw, Claudia M B Carvalho, Bo Yuan, Shen Gu, Alyssa N Altheimer, Shane McCarthy, Dheeraj Malhotra, Jonathan Sebat, Arthur J Siegel, Uwe Rudolph, James R Lupski, Deborah L Levy, Kristen J Brennand
In the process of generating presumably clonal human induced pluripotent stem cells (hiPSCs) from two carriers of a complex structural rearrangement, each having a psychotic disorder, we also serendipitously generated isogenic non-carrier control hiPSCs, finding that the rearrangement occurs as an extrachromosomal marker (mar) element. All confirmed carrier hiPSCs and differentiated neural progenitor cell lines were found to be mosaic. We caution that mar elements may be difficult to functionally evaluate in hiPSC cultures using currently available methods, as it is difficult to distinguish cells with and without mar elements in live mosaic cultures...
February 9, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28214436/impact-of-child-maltreatment-on-meaning-in-life-in-psychiatric-patients
#3
Sébastien Weibel, Sonia Vidal, Emilie Olié, Roland Hasler, Catherine Torriani, Paco Prada, Philippe Courtet, Sébastien Guillaume, Nader Perroud, Philippe Huguelet
Child maltreatment (CM) worsens prognosis and quality of life in several psychiatric conditions. Meaning in life is a construct which relates to the sense of purpose that one can perceive in life, and is a key aspect of recovery in psychiatric patients. The lasting impact of CM on meaning in life and its mediating variables have not been studied in patients with chronic persistent psychiatric conditions. One hundred and sixty-six patients with bipolar disorder (N=35), psychotic disorder (N=73), anorexia nervosa (N=30) or borderline personality disorder (N=28) were assessed for meaning in life (revised version of the Life Regard Index (LRI-R)), for CM (Childhood Trauma Questionnaire (CTQ)) and for internalized/externalized psychopathology...
February 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28214175/the-traumatic-experience-of-first-episode-psychosis-a-systematic-review-and-meta-analysis
#4
Rebecca Rodrigues, Kelly K Anderson
INTRODUCTION: A psychotic episode may be sufficiently traumatic to induce symptoms of post-traumatic stress disorder (PTSD), which could impact outcomes in first-episode psychosis (FEP). The objectives of this systematic review and meta-analysis were to estimate the prevalence of PTSD symptoms in relation to psychosis in FEP and to identify risk factors for the development of PTSD symptoms. METHODS: We searched electronic databases and conducted manual searching of reference lists and tables of contents to identify relevant studies...
February 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28213813/waiting-time-variation-in-early-intervention-psychosis-services-longitudinal-evidence-from-the-sepea-naturalistic-cohort-study
#5
James B Kirkbride, Y Hameed, L Wright, K Russell, C Knight, J Perez, P B Jones
PURPOSE: Early Intervention Psychosis [EIP] services have gained traction internationally, but are currently undergoing various forms of reconfiguration. In England, such services are now mandated to ensure 50% of accepted referrals commence care within 14 days, but no empirical evidence exists. We sought to estimate waiting times to EIP services in a large, representative epidemiological cohort in England, and investigate possible reasons for any variation. METHODS: We estimated median waiting time from referral to acceptance by EIP services and investigated whether this varied by clinical, demographic or neighbourhood-level factors, amongst 798 participants, 16-35 years old, presenting to six EIP services over 3...
February 18, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28212507/higher-severity-of-cocaine-addiction-is-associated-with-tactile-and-somatic-hallucinations
#6
C Roncero, L Grau-López, R F Palma-Álvarez, L Rodriguez-Cintas, E Ros-Cucurull, A Esojo, C Daigre
BACKGROUND: The aim of this study is to describe the features of cocaine-dependent patients who have had cocaine-induced tactile/somatic hallucinations (CITSH), and to analyze the association with addiction-related variables and psychiatric comorbidity, comparing patients with CITSH, patients with cocaine psychotic symptoms (CIP) and no CITSH, and patients without any psychotic symptom. METHOD: A cross-sectional study was conducted in 767 cocaine-dependent patients in an outpatient treatment center for addictions...
December 1, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28212505/long-term-validity-of-the-at-risk-mental-state-arms-for-predicting-psychotic-and-non-psychotic-mental-disorders
#7
P Fusar-Poli, G Rutigliano, D Stahl, C Davies, A De Micheli, V Ramella-Cravaro, I Bonoldi, P McGuire
BACKGROUND: The long-term clinical validity of the At Risk Mental State (ARMS) for the prediction of non-psychotic mental disorders is unknown. METHODS: Clinical register-based cohort study including all non-psychotic individuals assessed by the Outreach And Support in South London (OASIS) service (2002-2015). The primary outcome was risk of developing any mental disorder (psychotic or non-psychotic). Analyses included Cox proportional hazard models, Kaplan-Meier survival/failure function and C statistics...
December 6, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28210217/transcranial-direct-current-stimulation-over-the-dorsolateral-prefrontal-cortex-in-schizophrenia-a-quantitative-review-of-cognitive-outcomes
#8
REVIEW
Joshua E Mervis, Riley J Capizzi, Elias Boroda, Angus W MacDonald
Cognitive deficits are a core and disabling feature of psychotic disorders, specifically schizophrenia. Current treatments for impaired cognition in schizophrenia remain insufficient. Recent research suggests transcranial direct current stimulation (tDCS) targeting the dorsolateral prefrontal cortex can potentiate cognitive improvements in healthy individuals and those with psychiatric conditions, such as schizophrenia. However, this burgeoning literature has not been quantitatively evaluated. Through a literature search and quantitative review, we identified 194 papers on tDCS, psychosis, and cognition...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28203081/the-spectrum-of-psychosis-in-multiple-sclerosis-a-clinical-case-series
#9
Thomas G Gilberthorpe, Kara E O'Connell, Alison Carolan, Eli Silber, Peter A Brex, Naomi A Sibtain, Anthony S David
Psychosis in the context of multiple sclerosis (MS) has previously been reported as a rare occurrence. However, recent epidemiological studies have found prevalence rates of psychosis in MS that are two to three times higher than those in the general population. Untreated psychosis in patients with MS can adversely impact on adherence to MS medication, levels of disability, and quality of life. This retrospective case series describes the spectrum of psychotic disorders occurring in association with MS using demographic, clinical, and neuroimaging data...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28197002/an-exploratory-study-for-bladder-dysfunction-in-atypical-antipsychotic-emergent-urinary-incontinence
#10
Preeti Sinha, Anupam Gupta, V Senthil Kumar Reddi, Chittaranjan Andrade
INTRODUCTION: This is an exploratory study, which aimed to analyze urodynamic findings in patients who are on atypical antipsychotics and present with urinary incontinence (UI) in order to understand the mechanisms of antipsychotic-emergent UI. PATIENTS AND METHODS: Eight patients (34 ± 7.6 years; five males and three females) diagnosed with schizophrenia or other psychotic disorders, who were on risperidone, olanzapine, or clozapine monotherapy and having UI were recruited...
October 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28196698/-when-and-how-prescribe-antipsychotics
#11
S Tebeka, G Airagnes, F Limosin
Antipsychotics are commonly prescribed in the general population since they have many indications. They can be used in acute care such as agitation or behavior disorders, or to treat more characterized psychiatric disorders like psychotic or mood disorders. Consequently, any practitioner will have to prescribe or renew a prescription of antipsychotics. These treatments require a benefit/risk balance assessment taking into account the specific context of each patient. Indeed, antipsychotics have many side effects, mainly neurological (extrapyramidal syndrome, dyskinesia, akathisia), metabolic and cardiac...
February 10, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28196549/mental-health-related-stigma-and-pathways-to-care-for-people-at-risk-of-psychotic-disorders-or-experiencing-first-episode-psychosis-a-systematic-review
#12
P C Gronholm, G Thornicroft, K R Laurens, S Evans-Lacko
BACKGROUND: Stigma associated with mental illness can delay or prevent help-seeking and service contact. Stigma-related influences on pathways to care in the early stages of psychotic disorders have not been systematically examined. METHOD: This review systematically assessed findings from qualitative, quantitative and mixed-methods research studies on the relationship between stigma and pathways to care (i.e. processes associated with help-seeking and health service contact) among people experiencing first-episode psychosis or at clinically defined increased risk of developing psychotic disorder...
February 15, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28195930/treatment-duration-with-long-acting-injectable-antipsychotics-after-in-hospital-initiation-a-retrospective-cohort-study
#13
Hans Rittmannsberger, Jan Rosenleitner, Gertraud Malsiner-Walli, Regina Werl, Barbara Rittmannsberger, Kurosch Yazdi
PURPOSE: Long-acting injectable (LAI) antipsychotics are recommended especially for patients with multiple admissions and poor adherence. The empirical basis of this strategy is a matter of debate. METHODS: In a retrospective cohort study extending over 6 years, all patients admitted for inpatient treatment with a diagnosis of psychotic disorders according to International Statistical Classification of Diseases and Related Health Problems, 10th Revision (F2) were screened for treatment episodes with a new start of an LAI...
February 13, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28192770/the-relationship-between-childhood-trauma-emotion-recognition-and-irritability-in-schizophrenia-patients
#14
Mustafa Melih Bilgi, Seval Taspinar, Burcu Aksoy, Kaya Oguz, Kerry Coburn, Ali Saffet Gonul
This study investigated the relationship between childhood trauma, irritability, and emotion recognition, in schizophrenia patients during a psychotic break. Thirty-six schizophrenia inpatients and 36 healthy controls were assessed with the Irritability Questionnaire (IRQ) and two facial emotion recognition tasks, the Emotion Discrimination Test (EDT) and Emotion Identification Test (EIT). Patients were further assessed with the Structured Clinical Interview for DSM III-R Axis II Disorders (SCID-II), the Positive and Negative Symptom Scale (PANSS), and the Childhood Trauma Questionnaire-28 (CTQ-28)...
February 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28188958/potassium-channel-gene-associations-with-joint-processing-speed-and-white-matter-impairments-in-schizophrenia
#15
Heather A Bruce, Peter Kochunov, Sara A Paciga, Craig L Hyde, Xing Chen, Zhiyong Xie, Baohong Zhang, Hualin S Xi, Patricio O'Donnell, Christopher Whelan, Christian R Schubert, Alfredo Bellon, Seth A Ament, Dinesh K Shukla, Xiaoming Du, Laura M Rowland, Hugh O'Neill, L Elliot Hong
Patients with schizophrenia show decreased processing speed on neuropsychological testing and decreased white matter integrity as measured by diffusion tensor imaging, two traits shown to be both heritable and genetically associated indicating that there may be genes that influence both traits as well as schizophrenia disease risk. The potassium channel gene family is a reasonable candidate to harbor such a gene given the prominent role potassium channels play in the central nervous system in signal transduction, particularly in myelinated axons...
February 11, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28187857/adaptive-and-behavioral-changes-in-kynurenine-3-monooxygenase-knockout-mice-relevance-to-psychotic-disorders
#16
Sophie Erhardt, Ana Pocivavsek, Mariaelena Repici, Xi-Cong Liu, Sophie Imbeault, Daniel C Maddison, Marian A R Thomas, Joshua L Smalley, Markus K Larsson, Paul J Muchowski, Flaviano Giorgini, Robert Schwarcz
BACKGROUND: Kynurenine 3-monooxygenase converts kynurenine to 3-hydroxykynurenine, and its inhibition shunts the kynurenine pathway-which is implicated as dysfunctional in various psychiatric disorders-toward enhanced synthesis of kynurenic acid, an antagonist of both α7 nicotinic acetylcholine and N-methyl-D-aspartate receptors. Possibly as a result of reduced kynurenine 3-monooxygenase activity, elevated central nervous system levels of kynurenic acid have been found in patients with psychotic disorders, including schizophrenia...
December 16, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28185872/neuronal-and-molecular-effects-of-cannabidiol-on-the-mesolimbic-dopamine-system-implications-for-novel-schizophrenia-treatments
#17
REVIEW
Justine Renard, Christopher Norris, Walter Rushlow, Steven R Laviolette
Growing clinical and pre-clinical evidence points to a critical role for cannabidiol (CBD), the largest phytochemical component of cannabis, as a potential pharmacotherapy for various neuropsychiatric disorders. In contrast to delta-9-tetrahydrocannabinol (THC), which is associated with acute and neurodevelopmental pro-psychotic side-effects, CBD possesses no known psychoactive or dependence-producing properties. However, evidence has demonstrated that CBD strongly modulates the mesolimbic dopamine (DA) system and may possess promising anti-psychotic properties...
February 7, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28185785/can-antibiotics-cause-a-psychosis-case-report-and-review-of-the-literature
#18
Duy Ly, Lynn E DeLisi
It is relatively unknown that some of the possible side effects of antibiotic treatment can be transient psychotic episodes and other encephalopathies such as seizure disorders. Since these are rare events, there have not been many studies about them, nor is there a clear understanding of the underlying basis for these symptoms. This phenomenon was recently brought to our attention by a patient whose case history is discussed here. For the past few years, he has been diagnosed at different times with schizophrenia, schizoaffective disorder, bipolar disorder with psychosis, temporal lobe epilepsy, and psychogenic nonepileptic seizures...
February 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28185269/psychotic-experiences-and-suicide-attempt-risk-in-common-mental-disorders-and-borderline-personality-disorder
#19
I Kelleher, H Ramsay, J DeVylder
OBJECTIVE: Recent research has demonstrated a strong relationship between psychotic experiences and suicidal behaviour. No research to date, however, has investigated the role of borderline personality disorder (BPD) in this relationship, despite the fact that BPD is highly comorbid with common mental disorders and is associated with both recurrent suicidal behaviour and psychotic experiences. This paper examined the relationship between psychotic experiences and suicide attempts, including interrelationships with BPD and common mental disorders...
March 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28185044/a-predictive-coding-account-of-psychotic-symptoms-in-autism-spectrum-disorder
#20
Gerrit I van Schalkwyk, Fred R Volkmar, Philip R Corlett
The co-occurrence of psychotic and autism spectrum disorder (ASD) symptoms represents an important clinical challenge. Here we consider this problem in the context of a computational psychiatry approach that has been applied to both conditions-predictive coding. Some symptoms of schizophrenia have been explained in terms of a failure of top-down predictions or an enhanced weighting of bottom-up prediction errors. Likewise, autism has been explained in terms of similar perturbations. We suggest that this theoretical overlap may explain overlapping symptomatology...
February 10, 2017: Journal of Autism and Developmental Disorders
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