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https://www.readbyqxmd.com/read/29150198/comparative-effectiveness-of-extended-release-naltrexone-versus-buprenorphine-naloxone-for-opioid-relapse-prevention-x-bot-a-multicentre-open-label-randomised-controlled-trial
#1
Joshua D Lee, Edward V Nunes, Patricia Novo, Ken Bachrach, Genie L Bailey, Snehal Bhatt, Sarah Farkas, Marc Fishman, Phoebe Gauthier, Candace C Hodgkins, Jacquie King, Robert Lindblad, David Liu, Abigail G Matthews, Jeanine May, K Michelle Peavy, Stephen Ross, Dagmar Salazar, Paul Schkolnik, Dikla Shmueli-Blumberg, Don Stablein, Geetha Subramaniam, John Rotrosen
BACKGROUND: Extended-release naltrexone (XR-NTX), an opioid antagonist, and sublingual buprenorphine-naloxone (BUP-NX), a partial opioid agonist, are pharmacologically and conceptually distinct interventions to prevent opioid relapse. We aimed to estimate the difference in opioid relapse-free survival between XR-NTX and BUP-NX. METHODS: We initiated this 24 week, open-label, randomised controlled, comparative effectiveness trial at eight US community-based inpatient services and followed up participants as outpatients...
November 14, 2017: Lancet
https://www.readbyqxmd.com/read/29149910/sodium-chloride-pica-causing-recurrent-nephrolithiasis-in-a-patient-with-iron-deficiency-anemia-a-case-report
#2
Brittany Rogers, Joshua Kramer, Stephanie Smith, Vincent Bird, Eric I Rosenberg
BACKGROUND: Iron deficiency anemia is a common finding in women of child-bearing age. Pica, or the ingestion of non-food or non-nutritive items, is a well-known manifestation of iron deficiency. A high sodium diet increases risk for nephrolithiasis. We describe the case of a 31-year-old woman with recurrent calcium nephrolithiasis and anemia who ate ice chips as well as spoons of salt daily. Treatment of pica may prove effective in preventing recurrent nephrolithiasis. CASE PRESENTATION: A 31-year-old white woman with a past medical history of menorrhagia, anemia, and recurrent calcium nephrolithiasis presented for preoperative evaluation prior to ureterolithotomy...
November 18, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29149636/examining-characteristics-associated-with-quitting-smoking-during-pregnancy-and-relapse-postpartum
#3
Farnaaz Kia, Nicole Tosun, Samantha Carlson, Sharon Allen
INTRODUCTION: Smoking during pregnancy is a significant public health concern that can cause adverse health outcomes for both the mother and fetus. Studies have shown only 40% of women quit smoking during pregnancy, with more than half relapsing within 6months, and up to 90% relapsing within one year. This study investigates differences in demographics and smoking-related symptomatology between pregnant smokers and pregnant quitters, as well as factors associated with postpartum relapse...
November 10, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29146290/sustained-opioid-antagonism-modulates-striatal-sensitivity-to-baby-schema-in-opioid-use-disorder
#4
An-Li Wang, Steven B Lowen, Igor Elman, Zhenhao Shi, Victoria P Fairchild, Alexander Bouril, Ruben C Gur, Daniel D Langleben
BACKGROUND: Chronic opioid misuse is associated with reduced sensitivity to natural rewards and social motivation deficits that include impaired caregiving. The neurobiological mechanisms underlying these deficits and their response to treatment are not well understood. Baby schema (Kindchenschema) is a set of juvenile physical features, which is perceived as "cute" and triggers motivation for caregiving. Recent studies suggest that the "baby schema effect" is mediated by the brain "reward" network...
October 18, 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29145640/craving-as-a-dsm-5-symptom-of-alcohol-use-disorder-in-non-treatment-seekers
#5
Emily E Hartwell, Lara A Ray
Aims: DSM-5 has added craving as a new criterion and changed the diagnostic structure of alcohol use disorder (AUD). Though craving has long been a target of intervention, less is known about the impact this addition will have on prevalence and factor structure of AUD, particularly in non-treatment seeker with alcohol problems. Methods: Non-treatment seeking individuals reporting alcohol-related problems (N = 296) completed a structured clinical interview and the Penn Alcohol Craving Scale (PACS)...
November 14, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29145077/stability-of-the-diagnosis-of-seasonal-affective-disorder-in-a-long-term-prospective-study
#6
Marie-Laure Cléry-Melin, Philip Gorwood, Serge Friedman, Christian Even
BACKGROUND: Seasonal affective disorder (SAD) is mainly characterized by a seasonal pattern of depressive recurrences over the years. However, few studies have been conducted on the long-term course of patients with SAD, whose findings raised questions about the diagnosis stability over time. This study aimed to better characterize the diagnosis evolution, and determine prognosis markers. METHODS: An initial cohort of 225 outpatients diagnosed as having a SAD, was assessed at baseline (T1) for clinical symptoms and response to bright light therapy...
November 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29143399/buprenorphine-naloxone-treatment-responses-differ-between-young-adults-with-heroin-and-prescription-opioid-use-disorders
#7
Mauricio Romero-Gonzalez, Abtin Shahanaghi, Gregory J DiGirolamo, Gerardo Gonzalez
BACKGROUND AND OBJECTIVES: Opioid use disorder among young adults is rising sharply with an increase in morbidity and mortality. This study examined differences in treatment response to a fixed dose of buprenorphine-naloxone between heroin (HU) and prescriptions opioids (POU) users. METHODS: Eighty opioid dependent young adults (M = 22 years) were treated with buprenorphine-naloxone 16-4 mg/day for 8 weeks. Differences between HU (N = 17) and POU (N = 63) on changes in weekly opioid use, opioid craving, withdrawal, and depression symptoms were analyzed with mixed-effects regression models...
November 16, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/29137841/using-ecological-momentary-assessment-to-assess-the-temporal-relationship-between-sleep-quality-and-cravings-in-individuals-recovering-from-substance-use-disorders
#8
Lindsey K Freeman, Nisha C Gottfredson
INTRODUCTION: The causal direction of the relationship between sleep disturbance and drug cravings is unknown. Based on resource depletion literature, we hypothesized that sleep difficulties lead to cravings. We tested whether sleep quality predicts craving at the within- or between-person level, with perceived willpower as a multilevel mediator. METHODS: We used ecological momentary assessments (EMA) to compare two models of temporal precedence. Participants in addiction treatment (N=122) were sent four surveys each day for three weeks...
November 11, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29136565/attentional-bias-toward-alcohol-stimuli-as-a-predictor-of-treatment-retention-in-cocaine-dependence-and-alcohol-user-patients
#9
Carmen Díaz-Batanero, Sara Domínguez-Salas, Enrique Moraleda, Fermín Fernández-Calderón, Oscar M Lozano
BACKGROUND: Attentional bias towards substance-related stimuli has shown to be involved in the development and maintenance of cocaine dependence. The relationship between alcohol use and cocaine dependence shown in literature justify the need of study these two substances jointly. METHODS: This paper analyzes patterns of attentional bias in 71 patients with cocaine dependence and compares these patterns according to whether occasional or problematic concurrent alcohol use is taken into account...
November 6, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29135112/symptom-triggered-alcohol-vapor-inhalation-for-postoperative-alcohol-withdrawal-syndrome-in-patients-with-gastroesophageal-carcinoma
#10
Fengwei Kong, Miao Zhang, Heng Wang, Dong Liu, Ying Wu, Ning Chai, Wenbin Wu
PURPOSE: The purpose of this study was to investigate the feasibility and efficacy of alcohol vapor inhalation during fasting time for cancer patients with alcohol withdrawal symptoms (AWS) after surgery. METHODS: The data of 51 patients after esophagectomy or gastrectomy for gastroesophageal carcinoma in two hospitals from January 2011 to December 2016 was retrospectively analyzed. These patients were diagnosed with AWS with Clinic Institute Alcohol Withdrawal Syndrome Scale (CIWA-Ar) score ≥ 9 in two hospitals during fasting time from January 2011 to December 2016, and they were accordingly divided into alcohol vapor group (n=25) and diazepam group (n=26)...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29134789/either-at-left-or-right-both-high-and-low-frequency-rtms-of-dorsolateral-prefrontal-cortex-decreases-cue-induced-craving-for-methamphetamine
#11
Qingming Liu, Ying Shen, Xinyu Cao, Yongqiang Li, Yijiang Chen, Wei Yang, Ti-Fei Yuan
BACKGROUND AND OBJECTIVES: The study is to investigate if left or right dorsolateral prefrontal cortex is important in modulating the craving to drug related cues. METHODS: The present investigation examined different combinations between left/right and high/low frequency rTMS on cue induced craving to methamphetamine, with active sham rTMS on P3 region on a total of 50 subjects. RESULTS: The results showed that either at left or right side, both high and low frequency rTMS are effective in decreasing the cue induced craving to methamphetamine...
November 14, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/29134058/a-test-of-four-evolutionary-hypotheses-of-pregnancy-food-cravings-evidence-for-the-social-bargaining-model
#12
Caitlyn Placek
The onset of cravings for items not typically desired is often considered a hallmark of pregnancy. Given the ubiquity of cravings, this phenomenon remains surprisingly understudied. The current study tested four hypotheses of pregnancy food cravings: behavioural immune system, nutrient seeking, resource scarcity and social bargaining. The research took place in Tamil Nadu, South India, with pregnant women residing in rural villages (N = 94). Methods included structured interviews and anthropometric measures...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29130147/callous-unemotional-traits-modulate-brain-drug-craving-response-in-high-risk-young-offenders
#13
Gina M Vincent, Lora M Cope, Jean King, Prashanth Nyalakanti, Kent A Kiehl
Adults with psychopathy have a high propensity for substance abuse, generally starting from a young age. This investigation tested hypotheses about differences in the neural responses associated with drug craving among high-risk young offenders with histories of abuse of stimulants and other drugs as a function of psychopathic traits. Fifty-four male adolescents (44 with a history of stimulant abuse and 10 controls) incarcerated at a maximum-security facility (M age = 17.08 years) completed a drug-cue exposure task while brain hemodynamic activity was monitored using functional magnetic resonance imaging (fMRI) with a mobile MRI scanner stationed at the facility...
November 13, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29129555/nicotine-delivery-efficiency-of-first-and-second-generation-e-cigarettes-and-its-impact-on-relief-of-craving-during-the-acute-phase-of-use
#14
Tobias Rüther, Dieter Hagedorn, Konstantin Schiela, Thomas Schettgen, Helga Osiander-Fuchs, Wolfgang Schober
Knowledge about the change in blood nicotine concentrations during the first five minutes (acute phase) of e-cigarette vaping is important to determine whether the used product has a dependence potential or may be an efficient nicotine replacement product. To address this issue, we monitored blood nicotine levels during the acute phase in volunteers using disposable cigalikes (CLs) and a tank model (TM) and compared them with blood nicotine levels in subjects using a tobacco cigarette (TC). In parallel, heart rate changes were continually measured and withdrawal symptoms and craving were assessed with the Questionnaire on Smoking Urges before and immediately after the vaping/smoking sessions...
October 28, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29129289/craving-for-the-future-the-brain-as-a-nutritional-prediction-system
#15
REVIEW
Samuel J Walker, Dennis Goldschmidt, Carlos Ribeiro
In the last decades, predictive coding has emerged as an important framework for understanding how the brain processes information. It states that the brain is constantly inferring and predicting sensory data from statistical regularities in its environment. While this framework has been largely applied to sensory processing and motor control, we argue here that it could also serve as framework for a better understanding of how animals regulate nutrient homeostasis. Mechanisms that underlie nutrient homeostasis are commonly described in terms of negative feedback control, which compares current states with a reference point, called setpoint, and counteracts any mismatches...
October 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/29129190/moderators-of-sudden-gains-after-sessions-addressing-emotion-regulation-among-women-in-treatment-for-alcohol-use
#16
Cathryn Glanton Holzhauer, Elizabeth E Epstein, Jumi Hayaki, James S Marinchak, Barbara S McCrady, Sharon M Cook
Sudden gains (SGs) are defined as abrupt and significant improvements in mental health symptoms that occur between two psychotherapy sessions. Preliminary evidence suggests that SGs may be an important pattern of symptom reduction in the treatment of alcohol use disorder (AUD) (i.e., a steep between-session reduction in drinking or alcohol craving frequency or intensity) (Drapkin, Epstein, McCrady, & Eddie, 2015). The current study examined SGs within two randomized clinical trials (RCTs) testing female-specific cognitive behavior therapy (CBT) protocol for AUD (n=146)...
December 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29128523/acute-effect-of-smoking-and-smoking-abstinence-on-energy-intake-and-appetite-related-hormones-blood-concentrations
#17
M Yannakoulia, C A Anastasiou, K Zachari, M Sidiropoulou, P Katsaounou, R Tenta
The effect of smoking on energy balance and the underlying mechanisms are not fully understood. The aim of the present study is to examine the acute effect of smoking and its abstinence on energy intake, subjective feelings of appetite and related hormones. Fourteen healthy smokers participated in a randomized, crossover study consisting of two trials: the Cigarette trial (participants smoked two cigarettes of their brand within 15min) and the Sham trial (they were asked to hold the cigarette as smoking, but without lighting it)...
November 8, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29126857/impact-of-endogenous-progesterone-on-reactivity-to-yohimbine-and-cocaine-cues-in-cocaine-dependent-women
#18
Megan M Moran-Santa Maria, Brian J Sherman, Kathleen T Brady, Nathaniel L Baker, J Madison Hyer, Chantelle Ferland, Aimee L McRae-Clark
BACKGROUND AND OBJECTIVE: Data from clinical and preclinical models of relapse suggest that progesterone attenuates cocaine-seeking behavior. In a recent study, we found that cocaine-dependent women reported greater subjective responses to cues that were preceded by a stressor than cocaine-dependent men. The objective of this study was to examine the impact of endogenous progesterone on the subjective and endocrine responses to a drug-paired cue that was preceded by a stressor in cocaine-dependent women...
November 7, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29126126/exposure-to-point-of-sale-marketing-of-cigarettes-and-e-cigarettes-as-predictors-of-smoking-cessation-behaviors
#19
Dale S Mantey, Keryn E Pasch, Alexandra Loukas, Cheryl L Perry
Introduction: Cue-reactivity theory suggests smoking-related visual cues such as point-of-sale (POS) marketing (e.g., advertising, product displays) may undermine cessation attempts by causing an increase in nicotine cravings among users. This study examined the relationship between recall of exposure to POS marketing and subsequent cessation behaviors among young adult cigarette smokers. Methods: Participants included 813 18-29 year old (m=21.1, sd=2.70) current cigarette smokers attending 24 Texas colleges...
November 6, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29126097/cue-induced-craving-among-inhalant-users-development-and-preliminary-validation-of-a-visual-cue-paradigm
#20
Shobhit Jain, Anju Dhawan, S Senthil Kumaran, Raman Deep Pattanayak, Raka Jain
INTRODUCTION: Cue-induced craving is known to be associated with a higher risk of relapse, wherein drug-specific cues become conditioned stimuli, eliciting conditioned responses. Cue-reactivity paradigm are important tools to study psychological responses and functional neuroimaging changes. However, till date, there has been no specific study or a validated paradigm for inhalant cue-induced craving research. The study aimed to develop and validate visual cue stimulus for inhalant cue-associated craving...
October 16, 2017: Asian Journal of Psychiatry
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