keyword
MENU ▼
Read by QxMD icon Read
search

Metabolic conditioning

keyword
https://www.readbyqxmd.com/read/29353457/fasting-and-fast-food-diet-play-an-opposite-role-in-mice-brain-aging
#1
Paola Castrogiovanni, Giovanni Li Volti, Cristina Sanfilippo, Daniele Tibullo, Fabio Galvano, Michele Vecchio, Roberto Avola, Ignazio Barbagallo, Lucia Malaguarnera, Sergio Castorina, Giuseppe Musumeci, Rosa Imbesi, Michelino Di Rosa
Fasting may be exploited as a possible strategy for prevention and treatment of several diseases such as diabetes, obesity, and aging. On the other hand, high-fat diet (HFD) represents a risk factor for several diseases and increased mortality. The aim of the present study was to evaluate the impact of fasting on mouse brain aging transcriptome and how HFD regulates such pathways. We used the NCBI Gene Expression Omnibus (GEO) database, in order to identify suitable microarray datasets comparing mouse brain transcriptome under fasting or HFD vs aged mouse brain transcriptome...
January 20, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29353425/natural-attenuation-of-petroleum-hydrocarbons-a-study-of-biodegradation-effects-in-groundwater-vitanovac-serbia
#2
Nenad Marić, Ivan Matić, Petar Papić, Vladimir P Beškoski, Mila Ilić, Gordana Gojgić-Cvijović, Srđan Miletić, Zoran Nikić, Miroslav M Vrvić
The role of natural attenuation processes in groundwater contamination by petroleum hydrocarbons is of intense scientific and practical interest. This study provides insight into the biodegradation effects in groundwater at a site contaminated by kerosene (jet fuel) in 1993 (Vitanovac, Serbia). Total petroleum hydrocarbons (TPH), hydrochemical indicators (O2, NO3-, Mn, Fe, SO42-, HCO3-), δ13C of dissolved inorganic carbon (DIC), and other parameters were measured to demonstrate biodegradation effects in groundwater at the contaminated site...
January 20, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29353275/endocrine-and-metabolic-disturbances-in-survivors-of-hematopoietic-stem-cell-transplantation-in-childhood-and-adolescence
#3
Shlomit Shalitin, Lihi Pertman, Michal Yackobovitch-Gavan, Isaac Yaniv, Yael Lebenthal, Moshe Phillip, Jerry Stein
BACKGROUND/AIMS: The objective was to evaluate endocrine complications in survivors of hematopoietic stem cell transplantation (HSCT) performed during childhood. METHODS: Endocrine dysfunction and metabolic syndrome parameters were assessed by chart review of 178 childhood HSCT survivors (median age at evaluation, 15.5 [range: 3.8-29.8] years; median follow-up, 8.5 [range: 2-23.4] years). RESULTS: The following statistically significant associations were identified (p < 0...
January 19, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29353241/inhibition-of-endothelial-notch-signaling-impairs-fatty-acid-transport-and-leads-to-metabolic-and-vascular-remodeling-of-the-adult-heart
#4
Markus Jabs, Adam J Rose, Lorenz H Lehmann, Jacqueline Taylor, Iris Moll, Tjeerd P Sijmonsma, Stefanie E Herberich, Sven W Sauer, Gernot Poschet, Giuseppina Federico, Carolin Mogler, Eva-Maria Weis, Hellmut G Augustin, Minhong Yan, Norbert Gretz, Roland M Schmid, Ralf H Adams, Hermann-Joseph Gröne, Rüdiger Hell, Jürgen G Okun, Johannes Backs, Peter P Nawroth, Stephan Herzig, Andreas Fischer
Background -Nutrients are transported through endothelial cells before being metabolized in muscle cells. However, little is known about the regulation of endothelial transport processes. Notch signaling is a critical regulator of metabolism and angiogenesis during development. Here, we studied how genetic and pharmacological manipulation of endothelial Notch signaling in adult mice affects endothelial fatty acid transport, cardiac angiogenesis, and heart function. Methods -Endothelial-specific Notch inhibition was achieved by conditional genetic inactivation of Rbp-jκ in adult mice to analyze fatty acid metabolism and heart function...
January 20, 2018: Circulation
https://www.readbyqxmd.com/read/29353097/genetics-of-immunoglobulin-a-vasculitis-henoch-sch%C3%A3-nlein-purpura-an-updated-review
#5
REVIEW
Raquel López-Mejías, Santos Castañeda, Fernanda Genre, Sara Remuzgo-Martínez, F David Carmona, Javier Llorca, Ricardo Blanco, Javier Martín, Miguel A González-Gay
Immunoglobulin-A vasculitis (IgAV) is classically a childhood small-sized blood vessel vasculitis with predominant involvement of the skin. Gastrointestinal and joint manifestations are common in patients diagnosed with this condition. Nephritis, which is more severe in adults, constitutes the most feared complication of this vasculitis. The molecular bases underlying the origin of IgAV have not been completely elucidated. Nevertheless, several pieces of evidence support the claim that genes play a crucial role in the pathogenesis of this disease...
January 15, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29353021/phosphoproteomics-unveils-stable-energy-supply-as-key-to-flooding-tolerance-in-kandelia-candel
#6
Dezhuo Pan, Lingxia Wang, Fanglin Tan, Si Lu, Xiaojie Lv, Madiha Zaynab, Chi-Lien Cheng, Yakubu Saddeeq Abubakar, Shipin Chen, Wei Chen
The mangrove Kandelia candel (L.) Druce experiences daily flooding cycles. To explore the molecular mechanism underlying the physiological adaptation of K. candel to flooding, the potential role of protein phosphorylation in flooding responses was investigated by a large-scale quantitative phosphoproteomic analysis using isobaric tag for relative and absolute quantitation. Total 2141 unique phosphopeptides and 2603 non-redundant phosphorylation sites were identified from 1516 phosphoproteins in K. candel leaves...
January 15, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29352810/ectopic-expression-of-the-apple-nucleus-encoded-thylakoid-protein-mdy3ip1-triggers-early-flowering-and-enhanced-salt-tolerance-in-arabidopsis-thaliana
#7
Jian-Qiang Yu, Jia-Hui Wang, Cui-Hui Sun, Quan-Yan Zhang, Da-Gang Hu, Yu-Jin Hao
BACKGROUND: The roles in photosystem I (PSI) assembly of the nucleus-encoded thylakoid protein Y3IP1 who interacts with the plastid-encoded Ycf3 protein that has been well-characterized in plants. However, its function and potential mechanisms in other aspects remain poorly understood. RESULTS: We identified the apple MdY3IP1 gene, which encodes a protein highly homologous to the Arabidopsis Y3IP1 (AtY3IP1). Ectopic expression of MdY3IP1 triggered early-flowering and enhanced salt tolerance in Arabidopsis plants...
January 20, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29352615/gene-circuits-for-dynamically-regulating-metabolism
#8
Xiulai Chen, Liming Liu
Gene circuits are a functional innovation in synthetic biology for engineering cellular behavior. Recent advances have demonstrated that gene circuits can be exploited for dynamically controlling pathway redirection and pathway balance to produce valuable chemicals. The next frontier is to engineer robust, sensitive, and efficient circuits that adapt to changing conditions.
January 15, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29352229/expression-dynamics-of-mirnas-and-their-targets-in-seed-germination-conditions-reveals-mirna-ta-sirna-crosstalk-as-regulator-of-seed-germination
#9
Shabari Sarkar Das, Sandeep Yadav, Archita Singh, Vibhav Gautam, Ananda K Sarkar, Asis K Nandi, Prakash Karmakar, Manoj Majee, Neeti Sanan-Mishra
Seed germination paves the way for the dormant embryo to establish itself as a new plant marking the first critical step in postembryonic plant growth and development. Germination starts with the uptake of water (imbibition), followed by induction of transcription, translation, energy metabolism, and cell division processes. Although small RNAs have been implicated in many developmental processes, their role during seed germination stages and conditions remained elusive. Here we show that seed germination conditions, like imbibition and temperature, dynamically regulate the expression of many developmentally important miRNAs and their targets...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352221/role-of-mettl20-in-regulating-%C3%AE-oxidation-and-heat-production-in-mice-under-fasting-or-ketogenic-conditions
#10
Tadahiro Shimazu, Tamio Furuse, Shabeesh Balan, Ikuko Yamada, Shuzo Okuno, Hiroko Iwanari, Takehiro Suzuki, Takao Hamakubo, Naoshi Dohmae, Takeo Yoshikawa, Shigeharu Wakana, Yoichi Shinkai
METTL20 is a seven-β-strand methyltransferase that is localised to the mitochondria and tri-methylates the electron transfer flavoprotein (ETF) β subunit (ETFB) at lysines 200 and 203. It has been shown that METTL20 decreases the ability of ETF to extract electrons from medium-chain acyl-coenzyme A (CoA) dehydrogenase (MCAD) and glutaryl-CoA dehydrogenase in vitro. METTL20-mediated methylation of ETFB influences the oxygen consumption rate in permeabilised mitochondria, suggesting that METTL20-mediated ETFB methylation may also play a regulatory role in mitochondrial metabolism...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352083/polyphosphate-accumulating-bacteria-potential-contributors-to-mineral-dissolution-in-the-oral-cavity
#11
Ashley A Breiland, Beverly E Flood, Julia Nikrad, John Bakarich, Matthew Husman, TaekHyun Rhee, Robert S Jones, Jake V Bailey
Bacteria that accumulate polyphosphate have previously been shown to dynamically influence the solubility of phosphatic minerals in marine settings and wastewater. Here we show that dental plaque, saliva, and carious lesions, all contain abundant polyphosphate-accumulating bacteria. Saturation state modeling results, informed by phosphate uptake experiments using the model organism Lactobacillus rhamnosus, which is known to inhabit advanced carious-lesions, suggest that polyphosphate accumulation can lead to undersaturated conditions with respect to hydroxyapatite under some oral cavity conditions...
January 19, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29352075/o-linked-%C3%AE-n-acetylglucosamine-o-glcnac-modification-a-new-pathway-to-decode-pathogenesis-of-diabetic-retinopathy
#12
REVIEW
Zafer Gurel, Nader Sheibani
The incidence of diabetes continues to rise among all ages and ethnic groups worldwide. Diabetic retinopathy (DR) is a complication of diabetes that affects the retinal neurovasculature causing serious vision problems, including blindness. Its pathogenesis and severity is directly linked to the chronic exposure to high glucose conditions. No treatments are currently available to stop the development and progression of DR. To develop new and effective therapeutic approaches, it is critical to better understand how hyperglycemia contributes to the pathogenesis of DR at the cellular and molecular levels...
January 31, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29351487/contribution-of-parasympathetic-muscarinic-augmentation-of-insulin-secretion-to-olanzapine-induced-hyperinsulinemia
#13
Michael R Rickels, Elys M Perez, Amy J Peleckis, Erica Alshehabi, Huong-Lan Nguyen, Darko Stefanovski, Karl Rickels, Karen L Teff
Atypical antipsychotic drugs have been associated with the development of obesity and diabetes. In particular, olanzapine can induce peripheral insulin resistance and compensatory hyperinsulinemia independent of weight gain or psychiatric disease. To determine if this compensatory increase in insulin is mediated by parasympathetic muscarinic stimulation, we randomized fifteen healthy subjects 2:1 to receive double-blind olanzapine or placebo for 9 days under diet and activity controlled inpatient conditions...
December 19, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29351429/removal-of-interscapular-brown-adipose-tissue-increases-aortic-stiffness-despite-normal-systemic-glucose-metabolism-in-mice
#14
Zachary Ian Grunewald, Nathan C Winn, Michelle L Gastecki, Makenzie L Woodford, James R Ball, Sarah A Hansen, Harold S Sacks, Victoria J Vieira-Potter, Jaume Padilla
Brown adipose tissue (BAT) is considered protective against obesity and related cardiometabolic dysfunction. Indeed, activation of BAT improves glucose homeostasis and attenuates cardiovascular disease development. However, whether a reduction in BAT mass perturbs metabolic function and increases risk for cardiovascular disease remains largely unknown. To address this question, C57BL/6J male mice underwent sham or surgical bilateral excision of interscapular BAT (iBATx) and were fed a normal chow or Western diet (WD) for 18 weeks, creating four groups (n=10/group)...
December 20, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29351361/pathways-of-nitric-oxide-metabolism-and-operation-of-phytoglobins-in-legume-nodules-missing-links-and-future-directions
#15
Antoine Berger, Renaud Brouquisse, Pradeep Kumar Pathak, Imène Hichri, Inderjit Singh, Sabhyata Bhatia, Alexandre Boscari, Abir U Igamberdiev, Kapuganti Jagadis Gupta
The interaction between legumes and rhizobia leads to the establishment of a beneficial symbiotic relationship. Recent advances in legume - rhizobium symbiosis revealed that various reactive oxygen and nitrogen species including nitric oxide (NO) play important roles during this process. Nodule development occurs with a transition from a normoxic environment during the establishment of symbiosis to a microoxic environment in functional nodules. Such oxygen dynamics are required for activation and repression of various NO production and scavenging pathways...
January 19, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29351285/wine-yeast-phenomics-a-standardized-fermentation-method-for-assessing-quantitative-traits-of-saccharomyces-cerevisiae-strains-in-enological-conditions
#16
Emilien Peltier, Margaux Bernard, Marine Trujillo, Duyên Prodhomme, Jean-Christophe Barbe, Yves Gibon, Philippe Marullo
This work describes the set up of a small scale fermentation methodology for measuring quantitative traits of hundreds of samples in an enological context. By using standardized screw cap vessels, the alcoholic fermentation kinetics of Saccharomyces cerevisiae strains were measured by following their weight loss over the time. This dispositive was coupled with robotized enzymatic assays for measuring metabolites of enological interest in natural grape juices. Despite the small volume used, kinetic parameters and fermentation end products measured are similar with those observed in larger scale vats...
2018: PloS One
https://www.readbyqxmd.com/read/29351204/mtor-cross-talk-in-cancer-and-potential-for-combination-therapy
#17
REVIEW
Fabiana Conciatori, Ludovica Ciuffreda, Chiara Bazzichetto, Italia Falcone, Sara Pilotto, Emilio Bria, Francesco Cognetti, Michele Milella
The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions. mTOR functions through two functionally and structurally distinct multi-component complexes, mTORC1 and mTORC2, which interact with each other and with several elements of other signaling pathways. In the past few years, many new insights into mTOR function and regulation have been gained and extensive genetic and pharmacological studies in mice have enhanced our understanding of how mTOR dysfunction contributes to several diseases, including cancer...
January 19, 2018: Cancers
https://www.readbyqxmd.com/read/29351144/cardiac-dysfunction-in-critical-illness
#18
Allison Dalton, Sajid Shahul
PURPOSE OF REVIEW: Sepsis and septic shock are prevalent conditions that are likely to increase in prevalence in the future. Given the high mortality and morbidity associated with sepsis and sepsis-induced cardiac dysfunction, we must continue to make advances in knowledge of the complex physiologic interactions and how we may target specific mediators for potential therapeutic options in the future. RECENT FINDINGS: Multiple biomarkers have been discovered, which when assayed in sepsis-induced cardiomyopathy predict morbidity and mortality...
January 17, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29351020/a-dynamic-state-model-of-migratory-behavior-and-physiology-to-assess-the-consequences-of-environmental-variation-and-anthropogenic-disturbance-on-marine-vertebrates
#19
Enrico Pirotta, Marc Mangel, Daniel P Costa, Bruce Mate, Jeremy A Goldbogen, Daniel M Palacios, Luis A Hückstädt, Elizabeth A McHuron, Lisa Schwarz, Leslie New
Integrating behavior and physiology is critical to formulating new hypotheses on the evolution of animal life-history strategies. Migratory capital breeders acquire most of the energy they need to sustain migration, gestation, and lactation before parturition. Therefore, when predicting the impact of environmental variation on such species, a mechanistic understanding of the physiology of their migratory behavior is required. Using baleen whales as a model system, we developed a dynamic state variable model that captures the interplay among behavioral decisions, energy, reproductive needs, and the environment...
February 2018: American Naturalist
https://www.readbyqxmd.com/read/29350673/glyphosate-ingestion-causing-multiple-organ-failure-a-near-fatal-case-report
#20
Edoardo Picetti, Michela Generali, Francesca Mensi, Giampaolo Neri, Roberta Damia, Giuseppe Lippi, Gianfranco Cervellin
A 55 years old man self-presented to our Emergency Department (ED) reporting an attempted suicide by cutting the left forearm veins and ingesting approximately 200 mL of an herbicide (Myrtos®, containing 36% of glyphosate as isopropylamine salt). Laboratory tests showed metabolic acidosis. Hydration with normal saline and alkalinization with sodium bicarbonate was started according to suggestion of the poison control center, since an antidote was unavailable. Cardiorespiratory condition gradually worsened, so that non-invasive positive pressure ventilation (NIPPV) was applied and infusion of fluids was established...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
keyword
keyword
25262
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"