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https://www.readbyqxmd.com/read/29454146/matching-trends-for-the-fellowship-in-minimally-invasive-gynecologic-surgery-fmigs-since-participation-in-the-national-residency-match-program-nrmp
#1
Maria V Vargas, Magdy P Milad
OBJECTIVE: To describe the level of interest in the fellowship in minimally invasive gynecologic surgery (FMIGS) using data from National Residency Match Program (NRMP) over the past 4 years. DESIGN: Retrospective report (Canadian Task Force Classification II-2) SETTING: Publically reported data from the NRMP PARTICIPANTS: Applicants using the NRMP to match into fellowship training. INTERVENTIONS: Reporting matching trends for the gynecologic surgical subspecialty programs starting in 2014, when the FMIGS programs started participating in the NRMP...
February 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29450147/lemongrass-cymbopogon-flexuosus-essential-oil-demonstrated-anti-inflammatory-effect-in-pre-inflamed-human-dermal-fibroblasts
#2
Xuesheng Han, Tory L Parker
Lemongrass ( Cymbopogon flexuosus ) essential oil (LEO), which has citral as its main component, has exhibited anti-inflammatory effect in both animal and human cells. In this study, we evaluated the anti-inflammatory activity of a commercially available LEO in pre-inflamed human dermal fibroblasts. We first studied the impact of LEO on 17 protein biomarkers that are critically associated with inflammation and tissue remodeling. LEO significantly inhibited production of the inflammatory biomarkers vascular cell adhesion molecule 1 (VCAM-1), interferon gamma-induced protein 10 (IP-10), interferon-inducible T-cell alpha chemoattractant (I-TAC), and monokine induced by gamma interferon (MIG); decreased levels of the tissue remodeling biomarkers collagen-I and III, epidermal growth factor receptor (EGFR), and plasminogen activator inhibitor (PAI-1); and inhibited the immunomodulatory biomarker macrophage colony-stimulating factor (M-CSF)...
June 2017: Biochimie Open
https://www.readbyqxmd.com/read/29450144/anti-inflammatory-tissue-remodeling-immunomodulatory-and-anticancer-activities-of-oregano-origanum-vulgare-essential-oil-in-a-human-skin-disease-model
#3
Xuesheng Han, Tory L Parker
The use of oregano ( Origanum vulgare ) essential oil (OEO) has become popular in skin care products. However, scientific research regarding its effects on human skin cells is scarce. In this study, we investigated the biological activity of a commercially available OEO, which is high in carvacrol content, in a human skin cell disease model. OEO induced marked antiproliferative effects and significantly inhibited several inflammatory biomarkers, including monocyte chemoattractant protein 1 (MCP-1), vascular cell adhesion molecule 1 (VCAM-1), intracellular cell adhesion molecule 1 (ICAM-1), interferon gamma-induced protein 10 (IP-10), interferon-inducible T-cell alpha chemoattractant (I-TAC), and monokine induced by gamma interferon (MIG)...
June 2017: Biochimie Open
https://www.readbyqxmd.com/read/29450142/arborvitae-thuja-plicata-essential-oil-significantly-inhibited-critical-inflammation-and-tissue-remodeling-related-proteins-and-genes-in-human-dermal-fibroblasts
#4
Xuesheng Han, Tory L Parker
Arborvitae ( Thuja plicata ) essential oil (AEO) is becoming increasingly popular in skincare, although its biological activity in human skin cells has not been investigated. Therefore, we sought to study AEO's effect on 17 important protein biomarkers that are closely related to inflammation and tissue remodeling by using a pre-inflamed human dermal fibroblast culture model. AEO significantly inhibited the expression of vascular cell adhesion molecule 1 (VCAM-1), intracellular cell adhesion molecule 1 (ICAM-1), interferon gamma-induced protein 10 (IP-10), interferon-inducible T-cell chemoattractant (I-TAC), monokine induced by interferon gamma (MIG), and macrophage colony-stimulating factor (M-CSF)...
June 2017: Biochimie Open
https://www.readbyqxmd.com/read/29448152/the-clinical-utility-of-qualitative-electroencephalography-during-tilt-table-testing-a-retrospective-study
#5
Srikanth Muppidi, Babak Razavi, Mitchell G Miglis, Safwan Jaradeh
OBJECTIVE: To assess electroencephalography (EEG) changes during tilt table testing in syncope and other orthostatic syndromes. METHODS: We retrospectively reviewed consecutive tilt table studies with simultaneous EEG from April 2014 to May 2016 at our center. All patients had video EEG during tilt table. All patients had at least 10 min of head up tilt unless they had syncope or did not tolerate the study. Video EEG was interpreted by epileptologists. RESULTS: Eighty-seven patients met the inclusion criteria...
February 3, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29440871/erratum-micro-invasive-glaucoma-surgery-migs-a-review-of-surgical-procedures-using-stents-corrigendum
#6
(no author information available yet)
[This corrects the article on p. 1583 in vol. 11, PMID: 28919702.].
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29432939/effect-of-elevated-imipenem-cilastatin-mics-on-patient-outcomes-in-gram-negative-bloodstream-infections
#7
Milena M McLaughlin, Cristina Miglis, Erik Skoglund, Jamie Wagner, Maria R Advincula, Marc H Scheetz
BACKGROUND: Carbapenem MICs are known to predict outcomes for patients with Gram-negative bacteremias. However, limited data exists on how MICs influence such outcomes when organisms are classified as carbapenem resistant. The purpose of this study was to evaluate the effect of increasing imipenem/cilastatin MICs on mortality. METHODS: Patients with an imipenem/cilastatin resistant (i.e. MIC>4mg/L), monomicrobial, Gram-negative bloodstream infection were eligible and assessed for baseline characteristics, organ function, microbiological data, timing and type of therapeutic treatment, and in-hospital mortality...
February 9, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29396486/in-vivo-microbiome-and-associated-immune-markers-new-insights-into-the-pathogenesis-of-vaginal-dysbiosis
#8
Giuseppina Campisciano, Nunzia Zanotta, Danilo Licastro, Francesco De Seta, Manola Comar
The microbiota fulfils a key role in the training and function of the immune system, which contributes to the symbiosis between the host and complex microbial communities. In this study, we characterized the interplay between vaginal bacteria and local immune mediators during dysbiosis in selected women of reproductive age who were grouped according to Nugent's criteria. The abundance of Gardnerella vaginalis and Bifidobacterium breve was increased in the intermediate dysbiotic status, while the presence of a plethora of non-resident bacteria characterized the group with overt vaginosis...
February 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29374213/cerebrospinal-fluid-chemokine-patterns-in-children-with-enterovirus-71-related-encephalitis
#9
Jinling Liu, Shuxian Li, Chunyan Cai, Yingchun Xu, Yuan Jiang, Zhimin Chen
Enterovirus 71 (EV71) is a major pathogen that causes hand, foot and mouth disease (HFMD) as well as neurological complications, such as encephalitis. The chemokines involved in the migration of leukocytes have increasingly been implicated in infectious diseases of the central nervous system. Few studies have evaluated the levels of chemokines in HMFD children with EV71-related encephalitis. In the present study, we evaluated the cerebrospinal fluid (CSF) levels of the chemokines IL-8, RANTES, MIG, MCP-1 and IP-10 in 99 children with EV71-related encephalitis and 22 children with febrile convulsion (FC)...
January 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29370021/the-role-of-minimally-invasive-glaucoma-surgery-devices-in-the-management-of-glaucoma
#10
Murray Fingeret, Jaime E Dickerson
Noncompliance is a problem affecting glaucoma patients. Approaches to improve adherence include the use of drug-delivery systems and safer forms of surgery. Minimally invasive glaucoma surgery (MIGS) has reduced complications, particularly in combination with cataract surgery, and with its good intraocular pressure (IOP) reduction may reduce or eliminate glaucoma medications.Glaucoma is a progressive disease and a leading cause of irreversible blindness. Elevated IOP is the most important risk factor, but effective medical management is dependent on patient adherence...
January 25, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29358109/deepaligner-deep-encoding-of-pathways-to-align-epigenetic-signatures
#11
R Visakh, K A Abdul Nazeer
BACKGROUND AND OBJECTIVE: Recently, differential DNA Methylation is known to affect the regulatory mechanism of biological pathways. A pathway encompasses a set of interacting genes or gene products that altogether perform a given biological function. Pathways often encode strong methylation signatures that are capable of distinguishing biologically distinct subtypes. Even though Next Generation Sequencing techniques such as MeDIP-seq and MBD-isolated genome sequencing (MiGS) allow for genome-wide identification of clinical and biological subtypes, there is a pressing need for computational methods to compare epigenetic signatures across pathways...
January 11, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29349644/does-statin-benefits-patients-with-heart-failure-undergoing-percutaneous-coronary-intervention-findings-from-the-melbourne-interventional-group-registry
#12
Ken Lee Chin, Rory Wolfe, Christopher M Reid, Andrew Tonkin, Ingrid Hopper, Angela Brennan, Nick Andrianopoulos, Stephen J Duffy, David Clark, Andrew Ajani, Danny Liew
PURPOSE: The effectiveness of statins in improving clinical outcomes among patients with heart failure (HF) undergoing percutaneous coronary intervention (PCI) is unclear. We examined the association between use of statins and clinical outcomes in patients with HF included in the Melbourne Interventional Group registry. METHODS: Patients were followed from 30 days to 1 year post-PCI for a primary composite outcome of all-cause mortality and hospitalisation for cardiovascular (CV) causes...
January 18, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29335776/migs-therapeutic-success-of-combined-xen-gel-stent-implantation-with-cataract-surgery
#13
Bettina Hohberger, Ulrich-Christoph Welge-Lüßen, Robert Lämmer
PURPOSE: Glaucoma, a common disease in the elderly population, is frequently coexistent with cataract. While the combination of filtration surgery and cataract surgery is a challenging topic with limited success, minimal invasive glaucoma surgery (MIGS), such as Xen Gel Stents, seems to provide promising results. The aim of this study was to investigate the complete and qualified therapeutic success of Xen Gel Stent implantation with (XenPhaco) and without cataract surgery. METHODS: One hundred and eleven open-angle glaucoma eyes underwent implantation of Xen45 Gel Stent (AqueSys, Inc...
January 15, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29316140/a-male-gametocyte-osmiophilic-body-and-microgamete-surface-protein-of-the-rodent-malaria-parasite-plasmodium-yoelii-pymigs-plays-a-critical-role-in-male-osmiophilic-body-formation-and-exflagellation
#14
Mayumi Tachibana, Tomoko Ishino, Eizo Takashima, Takafumi Tsuboi, Motomi Torii
Anopheles mosquitoes transmit Plasmodium parasites of mammals, including the species that cause malaria in humans. Malaria pathology is caused by rapid multiplication of parasites in asexual intraerythrocytic cycles. Sexual stage parasites are also produced during the intraerythrocytic cycle, and are ingested by the mosquito, initiating gametogenesis and subsequent sporogonic stage development. Here, we present a Plasmodium protein, termed microgamete surface protein (MiGS), which has an important role in male gametocyte osmiophilic body (MOB) formation and microgamete function...
January 5, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29311071/population-pharmacokinetics-of-polymyxin-b-in-acutely-ill-adult-patients
#15
Cristina Miglis, Nathaniel J Rhodes, Sean Avedissian, Christine J Kubin, Michael T Yin, Brian Nelson, Manjunath P Pai, Marc H Scheetz
Polymyxin B (PB) has reemerged as a common treatment against multidrug-resistant Gram-negative pathogens. However, nephrotoxicity remains a significant dose-limiting side effect and contemporary pharmacokinetic (PK) data is limited. This study sought to evaluate PB exposure differences in various load and non-loading strategies according to total body weight (TBW) and adjusted body weight (ABW). Patients treated with PB had plasma samples obtained for clinical care and analyzed using LC-MS/MS. Compartmental PK models with linear and allometric scaling of TBW were explored...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29311066/population-pharmacokinetics-of-intravenous-polymyxin-b-from-clinical-samples
#16
Christine J Kubin, Brian C Nelson, Cristina Miglis, Marc H Scheetz, Nathaniel Rhodes, Sean Avedissian, Serge Cremers, Michael T Yin
A retrospective study was conducted in hospitalized patients receiving intravenous polymyxin B who underwent therapeutic drug monitoring during treatment. The aim of this study was to assess the population pharmacokinetics (PK) of intravenous polymyxin B in patients with variable total body weights and create a population model for clinical use. Nonlinear mixed-effects modeling analyses were performed. A total of 43 patients were included: 70% were male with a median age of 58 years and a median weight of 78 kg...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29305815/autonomic-dysfunction-predicts-poor-outcome-in-stroke-updates-on-recent-autonomic-research
#17
EDITORIAL
Mitchell G Miglis, Srikanth Muppidi
No abstract text is available yet for this article.
January 5, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29284469/both-inflammatory-and-regulatory-cytokine-responses-to-malaria-are-blunted-with-increasing-age-in-highly-exposed-children
#18
Lila Farrington, Hilary Vance, John Rek, Mary Prahl, Prasanna Jagannathan, Agaba Katureebe, Emmanuel Arinaitwe, Moses R Kamya, Grant Dorsey, Margaret E Feeney
BACKGROUND: Young children are at greatest risk for malaria-associated morbidity and mortality. The immune response of young children differs in fundamental ways from that of adults, and these differences likely contribute to the increased susceptibility of children to severe malaria and to their delayed development of immunity. Elevated levels of pro-inflammatory cytokines and chemokines in the peripheral blood during acute infection contribute to the control of parasitaemia, but are also responsible for much of the immunopathology seen during symptomatic disease...
December 29, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29273450/helicobacter-pylori-depletes-cholesterol-in-gastric-glands-to-prevent-interferon-gamma-signaling-and-escape-the-inflammatory-response
#19
Pau Morey, Lennart Pfannkuch, Ervinna Pang, Francesco Boccellato, Michael Sigal, Aki Imai-Matsushima, Victoria Dyer, Manuel Koch, Hans-Joachim Mollenkopf, Philipp Schlaermann, Thomas F Meyer
BACKGROUND & AIMS: Despite inducing an inflammatory response, Helicobacter pylori can persist in the gastric mucosa for decades. H pylori expression of cholesterol-α-glucosyltransferase (encoded by cgt) is required for gastric colonization and T-cell activation. We investigated how cgt affects gastric epithelial cells and the host immune response. METHODS: MKN45 gastric epithelial cells, AGS cells, and human primary gastric epithelial cells (obtained from patients undergoing gastrectomy or sleeve resection or gastric antral organoids) were incubated with interferon gamma (IFNG) or IFNB and exposed to H pylori, including cagPAI and cgt mutant strains...
December 19, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29258450/serum-cytokine-profiles-predict-survival-benefits-in-patients-with-advanced-hepatocellular-carcinoma-treated-with-sorafenib-a-retrospective-cohort-study
#20
Tomoyuki Hayashi, Taro Yamashita, Takeshi Terashima, Tsuyoshi Suda, Hikari Okada, Yoshiro Asahina, Takehiro Hayashi, Yasumasa Hara, Kouki Nio, Hajime Sunagozaka, Hajime Takatori, Kuniaki Arai, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
BACKGROUND: Sorafenib is a multiple receptor tyrosine kinase inhibitor known to prolong overall survival in patients with advanced hepatocellular carcinoma (HCC). Predicting this drug's survival benefits is challenging because clinical responses are rarely measurable during treatment. In this study, we hypothesized that serum cytokines levels could predict the survival of advanced HCC patients, as sorafenib targets signaling pathways activated in the tumor stromal microenvironment and potentially affects serum cytokine profiles...
December 19, 2017: BMC Cancer
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