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https://www.readbyqxmd.com/read/29228003/a-mig-15-jnk-1-map-kinase-cascade-opposes-rpm-1-signaling-in-synapse-formation-and-learning
#1
Oliver Crawley, Andrew C Giles, Muriel Desbois, Sudhanva Kashyap, Rayna Birnbaum, Brock Grill
The Pam/Highwire/RPM-1 (PHR) proteins are conserved intracellular signaling hubs that regulate synapse formation and axon termination. The C. elegans PHR protein, called RPM-1, acts as a ubiquitin ligase to inhibit the DLK-1 and MLK-1 MAP kinase pathways. We have identified several kinases that are likely to form a new MAP kinase pathway that suppresses synapse formation defects, but not axon termination defects, in the mechanosensory neurons of rpm-1 mutants. This pathway includes: MIG-15 (MAP4K), NSY-1 (MAP3K), JKK-1 (MAP2K) and JNK-1 (MAPK)...
December 11, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29214172/migraine-and-complex-regional-pain-syndrome-a-case-referent-clinical-study
#2
Yohannes W Woldeamanuel, Corinne Cooley, Katharine Foley-Saldena, Robert P Cowan
We studied clinical phenotype differences between migraineurs with CRPS (Mig + CRPS) and those without (Mig - CRPS). Mig + CRPS cases and Mig - CRPS referents aged ≥18 years were enrolled. Diagnosis was made in accordance with International Classification of Headache Disorders-3 beta (ICHD-3 beta) for migraine and Budapest Criteria for CRPS. Migraines both with and without aura were included. A total of 70 Mig + CRPS cases (13% males, mean age 48 years) and 80 Mig - CRPS referents (17% males, mean age 51 years) were included...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29210411/graphene-integrated-circuits-new-prospects-towards-receiver-realisation
#3
Mohamed Saeed, Ahmed Hamed, Zhenxing Wang, Mehrdad Shaygan, Daniel Neumaier, Renato Negra
This work demonstrates a design approach which enables the fabrication of fully integrated radio frequency (RF) and millimetre-wave frequency direct-conversion graphene receivers by adapting the frontend architecture to exploit the state-of-the-art performance of the recently reported wafer-scale CVD metal-insulator-graphene (MIG) diodes. As a proof-of-concept, we built a fully integrated microwave receiver in the frequency range 2.1-2.7 GHz employing the strong nonlinearity and the high responsivity of MIG diodes to successfully receive and demodulate complex, digitally modulated communication signals at 2...
December 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/29192416/mig-7-expression-and-vasculogenic-mimicry-in-malignant-ovarian-tumors
#4
Artur Czekierdowski, Sylwia Czekierdowska, Norbert Stachowicz, Tomasz Łoziński, Grzegorz Gurynowicz
OBJECTIVES: To investigate the possible association of vasculogenic mimicry (VM), VE-cadherin and MIG-7 expression with clinicopathological features of women with malignant ovarian masses. MATERIAL AND METHODS: VM was studied with the PAS reaction and VE-cadherin was assessed with immunohistochemistry in 108 women with malignant ovarian tumors. Additionally, quantitative expression of MIG-7 mRNA was performed in 52 ovarian cancers with qRT-PCR. RESULTS: VM was found in 48/108 cases (44%), more often in higher FIGO stage tumors (83% cases; 40 vs...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/29191600/mig-6-deficiency-cooperates-with-oncogenic-kras-to-promote-mouse-lung-tumorigenesis
#5
Jian Liu, Sung-Nam Cho, San-Pin Wu, Nili Jin, Seyed Javad Moghaddam, Jennifer L Gilbert, Ignacio Wistuba, Francesco J DeMayo
OBJECTIVES: Lung cancer is the leading cause of cancer related deaths worldwide and mutation activating KRAS is one of the most frequent mutations found in lung adenocarcinoma. Identifying regulators of KRAS may aid in the development of therapies to treat this disease. The mitogen-induced gene 6, MIG-6, is a small adaptor protein modulating signaling in cells to regulate the growth and differentiation in multiple tissues. Here, we investigated the role of Mig-6 in regulating adenocarcinoma progression in the lungs of genetically engineered mice with activation of Kras...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29172005/cytokine-profiling-of-serum-allows-monitoring-of-disease-progression-in-inclusion-body-myositis
#6
Umesh A Badrising, Roula Tsonaka, Monika Hiller, Erik H Niks, Teresinha Evangelista, Hanns Lochmüller, Jan Jgm Verschuuren, Annemieke Aartsma-Rus, Pietro Spitali
BACKGROUND: Inclusion body myositis is a late onset inflammatory myopathy lacking reliable serum biomarkers for diagnosis and for disease progression. OBJECTIVE: To identify diagnostic and predictive biomarkers, cytokine profiling is used to assess the potential of cytokines to discriminate between cases and controls and to assess whether treatment with methotrexate can influence biomarkers associated with disease progression. METHODS: The diagnostic and follow-up potential of 48 cytokines was tested using Bioplex-assay and ELISA in sera of healthy individuals, IBM patients and patients with other neuromuscular disorders...
2017: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/29169938/correlation-between-hospital-level-antibiotic-consumption-and-incident-health-care-facility-onset-clostridium-difficile-infection
#7
Page E Crew, Nathaniel J Rhodes, J Nicholas O'Donnell, Cristina Miglis, Elise M Gilbert, Teresa R Zembower, Chao Qi, Christina Silkaitis, Sarah H Sutton, Marc H Scheetz
BACKGROUND: The purpose of this single-center, ecologic study is to characterize the relationship between facility-wide (FacWide) antibiotic consumption and incident health care facility-onset Clostridium difficile infection (HO-CDI). METHODS: FacWide antibiotic consumption and incident HO-CDI were tallied on a monthly basis and standardized, from January 2013 through April 2015. Spearman rank-order correlation coefficients were calculated using matched-months analysis and a 1-month delay...
November 21, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29161797/electromechanical-morcellators-black-box-warning-tribulations-expectations-and-solutions
#8
Papri Sarkar, Emad Mikhail, Lenox Hoyte, Shayne Plosker, Anthony Imudia
Laparoscopic minimally invasive gynecologic surgery (MIGS) for benign conditions results in decreased morbidity, and faster recovery, compared with laparotomy. Tissue fragmentation by electromechanical morcellation permits the removal of large specimens through small laparoscopic incisions. Since the US Food and Drug Administration (FDA) published its safety warning about the risk of power morcellators spreading cancer during fibroid surgery in 2014, power morcellation has become rare. MIGS for fibroids and other large tissue specimens has declined...
November 21, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/29139601/utility-of-the-acc-aha-lesion-classification-as-a-predictor-of-procedural-30-day-and-12-month-outcomes-in-the-contemporary-percutaneous-coronary-intervention-era
#9
James Theuerle, Matias B Yudi, Omar Farouque, Nick Andrianopoulos, Peter Scott, Andrew E Ajani, Angela Brennan, Stephen J Duffy, Christopher M Reid, David J Clark
BACKGROUND: Correlations between the ACC/AHA coronary lesion classification and clinical outcomes in the contemporary percutaneous coronary intervention (PCI) era are not well established. METHODS: We analyzed clinical characteristics and outcomes according to ACC/AHA lesion classification (A, B1, B2, C) in 13,701 consecutive patients from the Melbourne Interventional Group (MIG) registry. Patients presenting with STEMI, cardiogenic shock and out-of-hospital cardiac arrest were excluded...
November 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29131383/rational-optimization-of-tumor-suppressor-derived-peptide-inhibitor-selectivity-between-oncogene-tyrosine-kinases-erbb1-and-erbb2
#10
Yilin Deng, Jian Li
The tumor-suppressor protein Mig-6 has been found to directly target and inhibit the human ErbB receptor tyrosine kinases ErbB1 and ErbB2. Despite their highly homologous nature, these two kinases are separately involved in the development of different types of human cancer. Here, we utilized a rational strategy to iteratively optimize the interaction specificity of the two kinases with a Mig-6 derived peptide by exploiting structural diversity space. Instead of traditionally improving the peptide binding potency, the optimization attempts to maximize the affinity difference between peptides binding to ErbB1 and ErbB2...
November 13, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29126743/benign-and-malignant-pathology-of-the-uterus
#11
REVIEW
V Tanos, K E Berry
The diagnosis of a uterine myoma size and location can be very precise when a 3D sonograph and knowledge are available. The majority of fibroids are asymptomatic, and expectant management is recommended. In young patients, fibroids cause infertility and in middle-aged women, abnormal uterine bleedings. Laparoscopic myomectomy is the preferred way of surgery for IM and SS fibroids, versus hysteroscopy for SM fibroids. In both cases, the size, number of fibroids and the surgeon's experience determine the limitations of the MIGS...
October 16, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29117010/assessing-the-methodological-quality-of-glaucoma-clinical-practice-guidelines-and-their-recommendations-on-microinvasive-glaucoma-surgery-a-systematic-review
#12
Evan Michaelov, James J Armstrong, Mary Nguyen, Bridget Instrum, Tracey Lam, James Denstedt, Cindy M L Hutnik
INTRODUCTION: Clinical practice guidelines (CPG) are regarded by many as critical communications providing guidance within specific medical fields. Over a decade ago, the first microinvasive glaucoma surgical procedures (MIGS) were introduced. Since then, a number of these novel intraocular pressure (IOP) controlling surgical options have been approved worldwide. Governing bodies and healthcare administration often utilize CPGs when considering funding for newer technologies. This highlights the importance of well-written, accurate and up-to-date CPGs in the rapidly evolving field of MIGS...
November 7, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29102620/levels-of-cytokines-in-serum-associate-with-development-of-hepatocellular-carcinoma-in-patients-with-hcv-infection-treated-with-direct-acting-antivirals
#13
Jose D Debes, Marjolein van Tilborg, Zwier M A Groothuismink, Bettina E Hansen, Julian Schulze Zur Wiesch, Johann von Felden, Robert J de Knegt, Andre Boonstra
Concern has arisen about development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) infection treated with direct-acting antivirals (DAAs). To identify patients at risk for HCC, we evaluated serum levels of immune mediators before, during, and after DAA treatment of HCV infection. Our study included 13 patients who developed HCC within 18 months after treatment (3 with HCC recurrence and 10 with new HCC) and 10 patients who did not develop HCC (controls), within at least 24 months of treatment (median, 26 months)...
November 1, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29098133/multilobar-insular-involving-gliomas-results-with-hyperaggressive-resection
#14
Michael Sughrue, Phillip A Bonney, Joshua D Burks, Jad Othman, Cordell Baker, Chad A Glenn, Charles Teo
Objective Hyperaggressive resection refers to a philosophy that maximal resection should be pursued in gliomas, wherever possible. In this study, we provide a detailed report of the outcomes with hyperaggressive surgery for multilobar insular-involving gliomas (MIGs).  Methods We report outcomes in patients with MIGs undergoing surgery aiming at gross total resection in all cases. Risk factors for neurologic deficits and survival were modeled using logistic and Cox regression. Results There were 72 consecutive patients, of whom 53 (74%) had undergone previous surgery...
August 28, 2017: Curēus
https://www.readbyqxmd.com/read/29083540/incorporation-of-a-ligand-peptide-for-immune-inhibitory-receptor-lair-1-on-biomaterial-surfaces-inhibits-macrophage-inflammatory-responses
#15
Yoon Kyung Kim, Shu-Hui Chu, Jessica Y Hsieh, Cody M Kamoku, Andrea J Tenner, Wendy F Liu, Szu-Wen Wang
Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is an inhibitory receptor broadly expressed on immune cells, with its ligands residing within the extracellular matrix protein collagen. In this study, surfaces are modified with a LAIR-1 ligand peptide (LP), and it is observed that macrophages cultured on LAIR-1 LP-conjugated surfaces exhibit significantly reduced secretion of inflammatory cytokines in response to proinflammatory stimuli that reflect an injured environment. These downregulated mediators include TNF-α, MIP-1α, MIP-1β, MIP-2, RANTES, and MIG...
October 30, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29072695/glucocorticoid-mediates-prenatal-caffeine-exposure-induced-endochondral-ossification-retardation-and-its-molecular-mechanism-in-female-fetal-rats
#16
Yangfan Shangguan, Hongqiang Jiang, Zhengqi Pan, Hao Xiao, Yang Tan, Kai Tie, Jun Qin, Yu Deng, Liaobin Chen, Hui Wang
Our previous studies discovered that prenatal caffeine exposure (PCE) could induce intrauterine growth retardation (IUGR) and long-bone dysplasia in offspring rats, accompanied by maternal glucocorticoid over-exposure. This study is to explore whether intrauterine high glucocorticoid level can cause endochondral ossification retardation and clarify its molecular mechanism in PCE fetal rats. Pregnant Wistar rats were intragastrically administered 30 and 120 mg/kg day of caffeine during gestational days (GDs) 9-20, then collected fetal serum and femurs at GD20...
October 26, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29067597/factors-influencing-health-related-quality-of-life-after-gastrectomy-for-cancer
#17
Hylke J F Brenkman, Juul J W Tegels, Jelle P Ruurda, Misha D P Luyer, Ewout A Kouwenhoven, Werner A Draaisma, Donald L van der Peet, Bas P L Wijnhoven, Jan H M B Stoot, Richard van Hillegersberg
AIM: Insight in health-related quality of life (HRQoL) may improve clinical decision making and inform patients about the long-term effects of gastrectomy. This study aimed to evaluate and identify factors associated with HRQoL after gastrectomy. METHODS: This cross-sectional study used prospective databases from seven Dutch centers (2001-2015) including patients who underwent gastrectomy for cancer. Between July 2015 and November 2016, European Organization for Research and Treatment of Cancer HRQoL questionnaires QLQ-C30 and QLQ-STO22 were sent to all surviving patients without recurrence...
October 24, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29036290/comparative-genomics-of-apomictic-root-knot-nematodes-hybridization-ploidy-and-dynamic-genome-change
#18
Amir Szitenberg, Laura Salazar-Jaramillo, Vivian C Blok, Dominik R Laetsch, Soumi Joseph, Valerie M Williamson, Mark L Blaxter, David H Lunt
The Root-Knot Nematodes (RKN; genus Meloidogyne) are important plant parasites causing substantial agricultural losses. The Meloidogyne incognita group (MIG) of species, most of which are obligatory apomicts (mitotic parthenogens), are extremely polyphagous and important problems for global agriculture. While understanding the genomic basis for their variable success on different crops could benefit future agriculture, analyses of their genomes are challenging due to complex evolutionary histories that may incorporate hybridization, ploidy changes, and chromosomal fragmentation...
September 25, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29028986/a-new-haplotype-block-detection-method-for-dense-genome-sequencing-data-based-on-interval-graph-modeling-of-clusters-of-highly-correlated-snps
#19
Sun Ah Kim, Chang-Sung Cho, Suh-Ryung Kim, Shelley B Bull, Yun Joo Yoo
Motivation: Linkage disequilibrium (LD) block construction is required for research in population genetics and genetic epidemiology, including specification of sets of single nucleotide polymorphisms (SNPs) for analysis of multi-SNP based association and identification of haplotype blocks in high density sequencing data. Existing methods based on a narrow sense definition do not allow intermediate regions of low LD between strongly associated SNP pairs and tend to split high density SNP data into small blocks having high between-block correlation...
September 29, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29026937/-minimally-invasive-and-robotic-assisted-surgical-management-of-upper-gastrointestinal-cancer
#20
REVIEW
P P Grimminger, H F Fuchs
Total minimally invasive upper gastrointestinal resections are currently mainly performed in centers. The advantages include reduction of operative trauma, magnified enlargement of the operation field and the resulting improvement in operative precision. Robotic-assisted minimally invasive esophagectomy (RAMIE) and laparoscopic/thoracoscopic minimally invasive esophagectomy (MIE) are currently the most commonly performed strategies for esophageal cancer. Laparoscopic (MIG) and robotic-assisted gastrectomy (RAG) are the equivalent procedures for gastric cancer...
October 12, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
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