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https://www.readbyqxmd.com/read/29161722/the-impact-of-tumor-necrosis-factor-%C3%AE-and-interleukin-1%C3%AE-levels-and-polymorphisms-on-long-term-stroke-outcomes
#1
Ju-Wan Kim, Man-Seok Park, Joon-Tae Kim, Hee-Ju Kang, Kyung-Yeol Bae, Sung-Wan Kim, Myung-Geun Shin, Ki-Hyun Cho, Jae-Min Kim
BACKGROUND: The accuracy of predictions regarding disability that sets in after stroke could be improved by using blood biomarker measurements. This study aimed to investigate the roles of serum tumor necrosis factor alpha (TNF-α) and interleukin (IL)-1β concentrations and polymorphisms in stroke outcomes. METHODS: In total, 286 patients were evaluated at the time of admission and at 2 weeks after stroke, and 222 of these patients (78%) were followed up for 1 year to evaluate the consequences of stroke during both the acute and chronic stages...
November 21, 2017: European Neurology
https://www.readbyqxmd.com/read/29161682/socioeconomic-status-disparities-in-late-life-disability-based-on-age-period-and-cohort-in-japan
#2
Hidehiro Sugisawa, Ken Harada, Yoko Sugihara, Shizuko Yanagisawa, Masaya Shinmei
INTRODUCTION: Effects of disparities in socioeconomic status (SES) on late-life disabilities have been reported around the world. However, there are only a few studies that have examined age, period, and cohort dependent influences of SES disparities on late-life disabilities. We investigated associations between SES disparities and late-life disability based on the Age-Period-Cohort. We also investigated how macro-economic conditions unique to a period, or a cohort might explain the period or the cohort trends...
November 14, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29161628/stigma-accounts-for-depression-in-patients-with-epilepsy
#3
Zerrin Yıldırım, Devrimsel Harika Ertem, Ayten Ceyhan Dirican, Sevim Baybaş
OBJECTIVE: Epilepsy is a chronic disease with an increased risk of stigmatization due to psychosocial consequences of the seizures. Intuitively, one may well conclude that stigmatization would lead to depression in patients with epilepsy as well as in other patient groups with increased risk of stigmatization. Indeed, there are a few studies in support of this intuition. In this study, we aimed to investigate the relationship between level of stigmatization and the severity of the depressive symptoms in our patients with epilepsy...
November 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29161622/on-denny-brown-s-spastic-dystonia-what-is-it-and-what-causes-it
#4
REVIEW
Jakob Lorentzen, Maud Pradines, Jean-Michel Gracies, Jens Bo Nielsen
In this review, we will work around two simple definitions of two different entities, which most often co-exist in patients with lesions to central motor pathways: Spasticity is "Enhanced excitability of velocity-dependent responses to phasic stretch at rest", which will not be the subject of this review, while Spastic dystonia is tonic, chronic, involuntary muscle contraction in the absence of any stretch or any voluntary command (Gracies, 2005). Spastic dystonia is a much less well understood entity that will be the subject this review...
November 4, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29161536/multiple-health-conditions-and-barriers-to-healthcare-among-older-australians-prevalence-reasons-and-types-of-barriers
#5
Jeromey B Temple, Ruth Williams
Accompanying population ageing is an increase in the number of older Australians living with multiple health conditions and disabilities (Australian Institute of Health and Welfare 2014). This study sought to examine the barriers to accessing healthcare faced by older Australians. Utilising the 2014 Australian Bureau of Statistics General Social Survey, it was found that 6% of respondents aged 50 years and over reported experiencing a barrier to accessing healthcare within the previous 12 months. Those with multiple health conditions are at a considerably higher risk of experiencing a barrier to healthcare (21% with four or more disabilities) compared with people with no or fewer health conditions, and this risk persists once wide-ranging control variables are included...
November 22, 2017: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/29161342/oral-frailty-as-a-risk-factor-for-physical-frailty-and-mortality-in-community-dwelling-elderly
#6
Tomoki Tanaka, Kyo Takahashi, Hirohiko Hirano, Takeshi Kikutani, Yutaka Watanabe, Yuki Ohara, Hiroyasu Furuya, Tetsuo Tsuji, Masahiro Akishita, Katsuya Iijima
Background: Oral health is important for maintaining general health among the elderly. However, a longitudinal association between poor oral health and general health has not been reported. We investigated whether poor oral status can predict physical weakening (physical frailty, sarcopenia, subsequent disability) and identified the longitudinal impact of the accumulated poor oral health (i.e., oral frailty) on adverse health outcomes, including mortality. Methods: A total of 2,011 elderly individuals (aged ≥65 years) participated in the baseline survey of the Kashiwa study in 2012...
November 17, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29161336/efficacy-of-electrical-stimulation-of-the-occipital-nerve-in-intractable-primary-headache-disorders-a-systematic-review-with-meta-analyses
#7
Robert T Cadalso, John Daugherty, Caron Holmes, Saravanan Ram, Reyes Enciso
AIMS: To determine the efficacy of occipital nerve stimulation (ONS) in reducing the intensity, duration, and frequency of medically intractable primary headaches. METHODS: A systematic review was carried out by searching three electronic databases: the Cochrane Library, MEDLINE via PubMed, and Web of Science. Randomized controlled trials (RCTs) and case series were eligible for inclusion. RCTs were assessed for quality of evidence by using the Cochrane Risk of Bias and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tools...
November 21, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29161335/shoulder-complaints-in-wheelchair-athletes-a-systematic-review
#8
Omar W Heyward, Riemer J K Vegter, Sonja de Groot, Lucas H V van der Woude
BACKGROUND: In recent years the popularity of disabled sports and competition among disabled athletes has grown considerably. With this rise in exposure of, and participation in wheelchair sports comes an increase in related stressors, including musculoskeletal load. External mechanical loading may increase the risk of shoulder complaints. The objective of this literature review was to 1) identify and describe the prevalence and/or incidence of shoulder complaints in wheelchair athletes in the literature, to 2) examine the factors and underlying mechanisms that could be potentially involved, and 3) provide some insights into the development of preventative measures...
2017: PloS One
https://www.readbyqxmd.com/read/29161259/the-us-president-s-malaria-initiative-plasmodium-falciparum-transmission-and-mortality-a-modelling-study
#9
Peter Winskill, Hannah C Slater, Jamie T Griffin, Azra C Ghani, Patrick G T Walker
BACKGROUND: Although significant progress has been made in reducing malaria transmission globally in recent years, a large number of people remain at risk and hence the gains made are fragile. Funding lags well behind amounts needed to protect all those at risk and ongoing contributions from major donors, such as the President's Malaria Initiative (PMI), are vital to maintain progress and pursue further reductions in burden. We use a mathematical modelling approach to estimate the impact of PMI investments to date in reducing malaria burden and to explore the potential negative impact on malaria burden should a proposed 44% reduction in PMI funding occur...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29161137/pragmatic-competence-of-children-with-autism-spectrum-disorder-impact-of-theory-of-mind-verbal-working-memory-adhd-symptoms-and-structural-language
#10
Inmaculada Baixauli-Fortea, Ana Miranda Casas, Carmen Berenguer-Forner, Carla Colomer-Diago, Belén Roselló-Miranda
The primary aim of this study is to increase the existing knowledge about the pragmatic skills of children with autism spectrum disorders (ASD). Specifically, the study has two objectives. The first is to provide a profile of characteristics based on The Children's Communication Checklist (CCC-2) pragmatics scales (inappropriate initiation, stereotyped language, use of context, nonverbal communication, and general pragmatics) and narrative task indicators. To this end, children with ASD will be compared to children with typical development (TD), controlling the effects of sex and structural language (speech, syntax, semantics, coherence)...
November 21, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/29161073/evaluating-public-health-interventions-7-let-the-subject-matter-choose-the-effect-measure-ratio-difference-or-something-else-entirely
#11
Donna Spiegelman, Polyna Khudyakov, Molin Wang, Tyler J Vanderweele
We define measures of effect used in public health evaluations, which include the risk difference and the risk ratio, the population-attributable risk, years of life lost or gained, disability-adjusted life years, quality-adjusted life years, and the incremental cost-effectiveness ratio. Except for the risk ratio, all of these are absolute effect measures. For constructing externally generalizable absolute measures of effect when there is superior fit of the multiplicative model, we suggest using the multiplicative model to estimate relative risks, which will often be obtained in simple linear form with no interactions, and then converting these to the desired absolute measure...
November 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29160948/disability-social-functioning-and-school-inclusion-among-older-children-and-adolescents-living-with-hiv-in-zimbabwe
#12
Ruramayi Rukuni, Grace McHugh, Edith Majonga, Katharina Kranzer, Hilda Mujuru, Shungu Munyati, Kusum Nathoo, Celia L Gregson, Hannah Kuper, Rashida A Ferrand
OBJECTIVE: Increasing numbers of children with HIV are surviving to adolescence and encountering multiple clinical and social consequences of longstanding HIV infection. We aimed to investigate the association between HIV and disability, social functioning and school inclusion among 6 to 16 year-olds in Zimbabwe. METHODS: HIV-infected children receiving antiretroviral therapy from a public sector HIV clinic, and HIV-uninfected children attending primary care clinics in the same catchment area were recruited...
November 21, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29160926/electro-mechanical-response-of-a-3d-nerve-bundle-model-to-mechanical-loads-leading-to-axonal-injury
#13
I Cinelli, M Destrade, M Duffy, P McHugh
OBJECTIVE: Traumatic brain injuries and damage are major causes of death and disability. We propose a 3D fully coupled electro-mechanical model of a nerve bundle to investigate the electrophysiological impairments due to trauma at the cellular level. METHODS: The coupling is based on a thermal analogy of the neural electrical activity by using the finite element software Abaqus CAE 6.13-3. The model includes a real-time coupling, modulated threshold for spiking activation and independent alteration of the electrical properties for each 3-layer fibre within a nerve bundle as a function of strain...
November 21, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29160901/dietary-advanced-glycation-end-products-have-sex-and-age-dependent-effects-on-vertebral-bone-microstructure-and-mechanical-function-in-mice
#14
Svenja Illien-Jünger, Paolo Palacio-Mancheno, William F Kindschuh, Xue Chen, Grazyna E Sroga, Deepak Vashishth, James C Iatridis
Back pain is a leading cause of global disability that can arise from vertebral fracture and osteoporosis. While poor general health and obesity are among the strongest risk factors for back pain, there is remarkably little known about how diet influences spinal diseases. Advanced glycation endproducts (AGEs) are implicated in increased fracture risk, yet no studies investigated how dietary AGEs affect spinal health. We tested the hypothesis that high dietary AGE ingestion will diminish vertebral structure and function in a sex- and age-dependent manner...
November 21, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29160809/evaluation-of-dietary-intakes-and-supplement-use-in-paralympic-athletes
#15
Robyn F Madden, Jane Shearer, Jill A Parnell
Dietary intakes and supplement use in Paralympic athletes remains largely unexplored, and specialized recommendations are lacking. The aim of this study was to evaluate nutrient intakes and supplement use in high-performance athletes with physical disabilities using three-day food records and a validated dietary supplement use questionnaire. A secondary aim examined gender differences in nutrient and supplement intakes. Male (n = 18) and female (n = 22) athletes were recruited from nine Paralympic sports through sporting organizations, coaches, and social media...
November 21, 2017: Nutrients
https://www.readbyqxmd.com/read/29160606/the-relationship-between-hazardous-alcohol-use-and-violence-among-street-involved-youth
#16
Nadia Fairbairn, Evan Wood, Sabina Dobrer, Huiru Dong, Thomas Kerr, Kora Debeck
BACKGROUND AND OBJECTIVES: Alcohol is a major contributor to premature disability and death among youth, often due to physical trauma, violence, and suicide. The purpose of this study was to longitudinally examine the association between hazardous alcohol use and experiences of violence among a cohort of street-involved youth. METHODS: Data were derived from the At-Risk Youth Study (ARYS), a prospective cohort of street-involved youth who use illicit substances in Vancouver, Canada...
November 21, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/29160571/sacral-neuromodulation-and-pregnancy-results-of-a-national-survey-carried-out-for-the-neuro-urology-committee-of-the-french-association-of-urology-afu
#17
Pauline Roulette, Evelyne Castel-Lacanal, Sylvain Sanson, Romain Caremel, Véronique Phé, Stéphane Bart, Franck Duchêne, Marianne De Sèze, Alexia Even, Andréa Manunta, Maria C Scheiber-Nogueira, Pascal Mouracade, Catherine-Marie Loche, Emmanuel Chartier-Kastler, Alain Ruffion, Gilles Karsenty, Xavier Gamé
AIMS: To assess the impact of sacral neuromodulation (SNM) on pregnancy and vice-versa, by identifying women who had received SNM for lower-urinary tract symptoms (LUTS) and had become pregnant. METHODS: A cross-sectional descriptive study was carried out based on responses to an on-line questionnaire sent to practitioners listed on the InterStim enCaptureTM National Registry. Questions were related to pre-pregnancy health and SNM efficacy, deactivation of the device, its impact on LUTS, childbirth, the infant, its reactivation and postpartum effectiveness...
November 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29160551/effects-of-pilates-and-yoga-in-patients-with-chronic-neck-pain-a-sonographic-study
#18
Naime Uluğ, Öznur Tunca Yılmaz, Murat Kara, Levent Özçakar
BACKGROUND: Various studies have shown the efficacy of conventional isometric, Pilates and yoga exercises. However, data on the effects and comparison of these specific exercises on the cervical muscle morphology are insufficient or lacking. OBJECTIVE: To investigate the effects of different exercise treatments on neck muscles in patients with chronic neck pain. DESIGN: A randomized study. METHODS: Fifty-six patients with chronic neck pain were randomized into 3 groups as follows: Pilates group (n = 20), yoga group (n = 18) and isometric group (n = 18)...
November 16, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29160173/gene-delivery-to-joints-by-intra-articular-injection
#19
Christopher H Evans, Steven Craig Ghivizzani, Paul D Robbins
Most forms of arthritis are incurable, difficult to treat and a major cause of disability in western countries. Better local treatment of arthritis is impaired by the pharmacokinetics of the joint that make it very difficult to deliver drugs to joints at sustained, therapeutic concentrations. This is especially true of biologic drugs, such as proteins and RNA, many of which show great promise in pre-clinical studies. Gene transfer provides a strategy for overcoming this limitation. The basic concept is to deliver cDNAs encoding therapeutic products by direct intra-articular injection, leading to sustained, endogenous synthesis of the gene products within the joint...
November 21, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/29160168/cerebral-blood-volume-lesion-extent-predicts-functional-outcome-in-patients-with-vertebral-and-basilar-artery-occlusion
#20
Fana Alemseged, Darshan G Shah, Andrew Bivard, Timothy J Kleinig, Nawaf Yassi, Marina Diomedi, Francesca Di Giuliano, Gagan Sharma, Roy Drew, Bernard Yan, Richard J Dowling, Steven Bush, Fabrizio Sallustio, Carlo Caltagirone, Nicola B Mercuri, Roberto Floris, Mark W Parsons, Christopher R Levi, Peter J Mitchell, Stephen M Davis, Bruce Cv Campbell
Background CT perfusion may improve diagnostic accuracy in posterior circulation stroke. The posterior circulation Acute Stroke Prognosis Early CT score (pc-ASPECTS) on Computed Tomography Angiography source images (CTA-SI) predicts functional outcome in patients with basilar artery occlusion. Aims We assessed the prognostic value of pc-ASPECTS on CT perfusion in patients with vertebral and basilar artery occlusion (VBAO) in comparison with CTA-SI. Methods Whole-brain CT perfusion from consecutive stroke patients with VBAO at four stroke centers was retrospectively analyzed...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
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