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https://www.readbyqxmd.com/read/27272448/ovarian-function-after-hematopoietic-cell-transplantation-a-descriptive-study-following-the-use-of-gnrh-agonists-for-myeloablative-conditioning-and-observation-only-for-reduced-intensity-conditioning
#1
R Phelan, E Mann, C Napurski, T E DeFor, A Petryk, W P Miller, J E Wagner, M R Verneris, A R Smith
Gonadal failure is a health and quality-of-life concern in hematopoietic cell transplant (HCT) survivors. While ovarian dysfunction is nearly universal following myeloablative (MA) conditioning, the risk is unclear after reduced-intensity conditioning (RIC). Gonadotropin-releasing hormone agonists decrease ovarian failure rates following conventional chemotherapy, but little is known about its effectiveness with HCT. We investigated the impact of leuprolide on ovarian function after MA conditioning and monitored ovarian function after RIC in this descriptive pilot study...
October 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27123918/analysis-of-adherence-persistence-and-surgery-among-endometriosis-patients-treated-with-leuprolide-acetate-plus-norethindrone-acetate-add-back-therapy
#2
Ahmed M Soliman, Machaon Bonafede, Amanda M Farr, Jane Castelli-Haley, Craig Winkel
BACKGROUND: Endometriosis affects over 10 million women in the United States. Depot leuprolide acetate (LA), a gonadotropin-releasing hormone agonist, has been used extensively for the treatment of women with endometriosis but is associated with hypoestrogenic symptoms and bone mineral density loss. The concomitant use of add-back therapies, specifically norethindrone acetate (NETA), can alleviate these adverse effects. OBJECTIVE: To compare adherence to and persistence with LA treatment and time to endometriosis-related surgery among women treated with NETA and women treated with LA plus other add-back therapies or LA only...
May 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27003301/acute-female-hypogonadism-alters-adipose-tissue-fatty-acid-storage-factors-and-chylomicronemia
#3
Sylvia Santosa, Sara L Bonnes, Michael D Jensen
CONTEXT: Chronic sex steroid deficiency has effects on adipose fatty acid (FA) storage mechanisms and fat oxidation, but the chronology of events are not well understood. OBJECTIVE: The objective of the study was to examine the acute effects of female sex steroid suppression on cellular mechanisms affecting abdominal and femoral subcutaneous adipose tissue FA storage. DESIGN: This study had a randomized, longitudinal, parallel study design...
May 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26101682/postinjection-muscle-fibrosis-from-lupron
#4
Erica Everest, Laurie A Tsilianidis, Nouhad Raissouni, Tracy Ballock, Terra Blatnik, Anzar Haider, Douglas G Rogers, B Michelle Schweiger
We describe the case of a 6.5-year-old girl with central precocious puberty (CPP), which signifies the onset of secondary sexual characteristics before the age of eight in females and the age of nine in males as a result of stimulation of the hypothalamic-pituitary-gonadal axis. Her case is likely related to her adoption, as children who are adopted internationally have much higher rates of CPP. She had left breast development at Tanner Stage 2, adult body odor, and mildly advanced bone age. In order to halt puberty and maximize adult height, she was prescribed a gonadotropin releasing hormone analog, the first line treatment for CPP...
2015: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/25994435/unilateral-testicular-metastasis-of-low-psa-level-prostatic-adenocarcinoma
#5
Brianna Jeanette Shinn, David W Greenwald, Navid Ahmad
A 71-year-old man presented with a firm left testicle 15 years after being diagnosed with prostatic adenocarcinoma. After the initial diagnosis, the patient underwent a radical prostatectomy. He received radiation therapy 5 years after surgery for a slightly elevated prostate-specific antigen (PSA) level and a negative metastatic workup. Eight years later, the patient's PSA rose to 3.38 ng/mL and he was started on intermittent Lupron therapy. It was then 3 years later when the patient discovered the testicular mass...
2015: BMJ Case Reports
https://www.readbyqxmd.com/read/25310993/a-clinical-study-of-lupron-depot-in-the-treatment-of-women-with-alzheimer-s-disease-preservation-of-cognitive-function-in-patients-taking-an-acetylcholinesterase-inhibitor-and-treated-with-high-dose-lupron-over-48-weeks
#6
RANDOMIZED CONTROLLED TRIAL
Richard L Bowen, George Perry, Chengjie Xiong, Mark A Smith, Craig S Atwood
To test the efficacy and safety of leuprolide acetate (Lupron Depot) in the treatment of Alzheimer's disease (AD), we conducted a 48-week, double-blind, placebo-controlled, dose-ranging study in women aged 65 years or older with mild to moderate AD. A total of 109 women with mild to moderate AD and a Mini-Mental State Examination score between 12 and 24 inclusive were randomized to low dose Lupron Depot (11.25 mg leuprolide acetate), high dose Lupron Depot (22.5 mg leuprolide acetate), or placebo injections every 12 weeks...
2015: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/25308086/short-term-testosterone-manipulations-do-not-affect-cognition-or-motor-function-but-differentially-modulate-emotions-in-young-and-older-male-rhesus-monkeys
#7
Brian Kelly, Vanessa Maguire-Herring, Christian M Rose, Heather E Gore, Stephen Ferrigno, Melinda A Novak, Agnès Lacreuse
Human aging is characterized by declines in cognition and fine motor function as well as improved emotional regulation. In men, declining levels of testosterone (T) with age have been implicated in the development of these age-related changes. However, studies examining the effects of T replacement on cognition, emotion and fine motor function in older men have not provided consistent results. Rhesus monkeys (Macaca mulatta) are excellent models for human cognitive aging and may provide novel insights on this issue...
November 2014: Hormones and Behavior
https://www.readbyqxmd.com/read/25240733/the-rejuvenating-effects-of-leuprolide-acetate-on-the-aged-baboon-s-thymus
#8
Joseph R Scalea, Radbeh Torabi, Aseda Tena, Masayuki Tasaki, Bradford C Gillon, Shannon Moran, Taylor Cormack, Vincenzo Villani, Akira Shimizu, David H Sachs, Kazuhiko Yamada
BACKGROUND: We have previously demonstrated that the juvenile thymus plays an essential role in tolerance induced by both renal transplantation and a short course of calcineurin inhibitors. Aged thymi have a decreased ability to induce tolerance. Luteinizing hormone-releasing hormone (LHRH) is known to pharmacologically rejuvenate the thymus in rodents. In order to develop a clinically applicable regimen of transplantation tolerance in adults, we sought to determine if thymic rejuvenation would occur with LHRH agonism in non-human primates...
September 2014: Transplant Immunology
https://www.readbyqxmd.com/read/24105216/role-of-gonadal-steroids-in-mrmd
#9
Peter J Schmidt, David R Rubinow
We evaluated the efficacy of ovarian suppression with a GnRH agonist in the treatment of women with prospectively confirmed menstrual-related mood disorders (MRMD) during a double-blind, placebo-controlled, parallel design trial. All women (patients and controls) received either GnRH agonist (depot leuprolide acetate) or placebo (N saline) IM every four weeks for 24 weeks and received in random sequence estradiol and progesterone as "add back" hormones during the latter 12 weeks. ANOVA-R was employed to examine the effects of depot lupron in women with MRMD compared with placebo and compared to controls...
December 1994: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/23484560/novasure-as-a-mechanical-endometrial-preparation-agent-in-large-uteri
#10
COMPARATIVE STUDY
Sushma Potti, Shitanshu Uppal, Ashwin J Chatwani, Enrique Hernandez, Vani Dandolu
OBJECTIVE: We evaluated Novasure ablation as a mechanical endometrial preparation agent before Roller Ball endometrial ablation in lieu of GnRH agonists in large uteri. METHODS: A retrospective chart review of 20 consecutive patients undergoing Novasure ablation for mechanical endometrial preparation before Roller Ball ablation (RBNovasure group) was conducted and the results compared to that of 23 consecutive patients who received GnRH agonist (Leuprolide acetate) as a medical endometrial preparation before Roller Ball ablation (RB-Lupron group)...
October 2012: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/23333155/testosterone-modulation-of-anxiety-in-gonadally-suppressed-male-rhesus-monkeys-a-role-for-gonadotropins
#11
Benjamin Suarez-Jimenez, Heather E Gore, Julie Hachey, Hanna M King, Agnès Lacreuse
Testosterone (T) has repeatedly been shown to have anxiolytic properties in rodents, but findings in primates are more mixed. To examine the effects of exogenous T on anxiety, we tested pharmacologically-castrated adult male rhesus monkeys in a modified version of the Human Intruder Paradigm, which measured defensive responses to an unfamiliar human staring directly at them for 2 min. Monkeys were tested at 2 week intervals during 4 experimental conditions lasting 4 weeks each: at baseline, during treatment with the gonadotropin releasing hormone (GnRH) agonist leuprolide acetate (200 μg/kg; Lupron phase), during treatment with Lupron+T enanthate (TE, 5 mg/kg; TE phase) and during treatment with Lupron+oil vehicle (oil phase)...
March 2013: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/23188540/cognitive-performance-in-healthy-women-during-induced-hypogonadism-and-ovarian-steroid-addback
#12
Peter J Schmidt, P A Keenan, Linda A Schenkel, Kate Berlin, Carolyn Gibson, David R Rubinow
Gynecology clinic-based studies have consistently demonstrated that induced hypogonadism is accompanied by a decline in cognitive test performance. However, a recent study in healthy asymptomatic controls observed that neither induced hypogonadism nor estradiol replacement influenced cognitive performance. Thus, the effects of induced hypogonadism on cognition might not be uniformly experienced across individual women. Moreover, discrepancies in the effects of hypogonadism on cognition also could suggest the existence of specific risk phenotypes that predict a woman's symptomatic experience during menopause...
February 2013: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/22946397/chemical-and-surgical-interventions-to-alleviate-intraspecific-aggression-in-male-collared-lemurs-eulemur-collaris
#13
Gina M Ferrie, Kris K Becker, Catharine J Wheaton, Deidre Fontenot, Tammie Bettinger
To reduce male-male aggression in collared lemurs (Eulemur collaris) at Disney's Animal Kingdom, a clinical trial of leuprolide acetate (Depo-Lupron) injections through one breeding season (24 wk), followed by surgical castration after the breeding season was implemented. Daily behavioral observations to record occurrences of aggression were conducted before and during the injection period, as well as after castration. Fecal sample collection began 2 wk before the first injection and continued throughout the clinical trial to determine testosterone metabolite concentration...
June 2011: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/22466349/acth-and-cortisol-response-to-dex-crh-testing-in-women-with-and-without-premenstrual-dysphoria-during-gnrh-agonist-induced-hypogonadism-and-ovarian-steroid-replacement
#14
Ellen E Lee, Lynnette K Nieman, Pedro E Martinez, Veronica L Harsh, David R Rubinow, Peter J Schmidt
CONTEXT: During conditions of ovarian suppression, women with premenstrual dysphoria (PMD) experience abnormal behavioral responses to physiological levels of ovarian steroids. Although hypothalamic-pituitary-adrenal (HPA) axis dysregulation frequently accompanies depression, and ovarian steroids regulate HPA axis responsivity, the role of HPA axis dysregulation in PMD is not known. We hypothesized that women with PMD would show abnormalities of HPA axis function analogous to those reported in depressive illness, and that ovarian steroids would differentially regulate HPA axis function in women with PMD compared with asymptomatic controls (AC)...
June 2012: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/22396997/what-should-i-know-about-lupron-depot-for-treating-prostate-cancer
#15
(no author information available yet)
No abstract text is available yet for this article.
January 2012: Johns Hopkins Medical Letter Health After 50
https://www.readbyqxmd.com/read/21874658/effects-of-breast-cancer-treatment-on-the-hormonal-and-cognitive-consequences-of-acute-stress
#16
Joseph M Andreano, James Waisman, Lisa Donley, Larry Cahill
BACKGROUND: Cognitive difficulties following treatment for breast cancer are frequently reported. Breast cancer treatments also disrupt the function of ovarian and glucocorticoid hormone systems, both of which can affect cognition. METHODS: To assess the influence of glucocorticoid and ovarian disruption on cognitive dysfunction, survivors of breast cancer treated with the GnRH agonist Lupron were compared with healthy controls on their glucocorticoid response to a physiological stressor, and their performance on various measures of cognition including working memory, verbal paired associate memory, and narrative recall...
October 2012: Psycho-oncology
https://www.readbyqxmd.com/read/21820809/effects-of-testosterone-on-attention-and-memory-for-emotional-stimuli-in-male-rhesus-monkeys
#17
Hanna M King, Laura B Kurdziel, Jerrold S Meyer, Agnès Lacreuse
Increasing evidence in humans and other animals suggests that testosterone (T) plays an important role in modulating emotion. We previously reported that T treatment in rhesus monkeys undergoing chemically induced hypogonadism results in increased watching time of videos depicting fights between unfamiliar conspecifics (Lacreuse et al., 2010). In the current study, we aimed to further investigate the effect of T manipulations on attention and memory for emotional stimuli in male rhesus monkeys. Six males (7 years old) were administered Depot Lupron to suppress endogenous T levels and treated with either testosterone enanthate (TE, 5 mg/kg) or oil, before crossing over to the alternate treatment...
March 2012: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/21677198/inhibition-of-transplantation-tolerance-by-immune-senescence-is-reversed-by-endocrine-modulation
#18
Gaoping Zhao, Daniel J Moore, James I Kim, Kang Mi Lee, Matthew R O'Connor, Patrick E Duff, Maozhu Yang, Ji Lei, James F Markmann, Shaoping Deng
The senescent immune system responds poorly to new stimuli; thymic involution, accumulation of memory cells against other specificities, and general refractoriness to antigen signaling all may contribute to poor resistance to infection. These same changes may pose a significant clinical barrier to organ transplantation, as transplantation tolerance requires thymic participation and integrated, tolerance-promoting responses to novel antigens. We found that after the age of 12 months, mice became resistant to the tolerance-inducing capacity of the monoclonal antibody therapy anti-CD45RB...
June 15, 2011: Science Translational Medicine
https://www.readbyqxmd.com/read/21247854/hyperandrogenism-in-a-postmenopausal-woman-diagnostic-and-therapeutic-challenges
#19
Vicky Cheng, Krupa B Doshi, Tommaso Falcone, Charles Faiman
OBJECTIVE: To describe a postmenopausal woman with severe hyperandrogenism who responded dramatically to a gonadotropin-releasing hormone (GnRH) agonist. METHODS: Detailed clinical and laboratory findings are presented, and the pertinent literature is reviewed. RESULTS: A 53-year-old postmenopausal woman with end-stage renal disease, who had undergone kidney transplantation, was referred because of high serum testosterone levels. She presented with worsening acne and hirsutism for the previous 2 years...
March 2011: Endocrine Practice
https://www.readbyqxmd.com/read/20804760/testosterone-may-increase-selective-attention-to-threat-in-young-male-macaques
#20
Agnès Lacreuse, Hanna M King, Laura B Kurdziel, Sarah R Partan, Kaelyn M Caldwell, Margaret R Chiavetta, Matthew M Millette, Jerrold S Meyer, Daniel R Grow
Animal studies indicate that sex hormones have widespread effects on the brain, cognition and emotion, but findings in humans are inconsistent. Well-controlled studies in nonhuman primates are crucial to resolve these discrepancies. In this study, we examined the effects of testosterone (T) on emotion in male rhesus monkeys. Six young adult males were tested on two emotional tasks during three hormonal conditions in a crossover design: when intact at baseline and when pharmacologically hypogonadal with add-back of T or placebo...
November 2010: Hormones and Behavior
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