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Shon's complex

Keri J Fogle, J Ian Hertzler, Joy H Shon, Michael J Palladino
Effective therapies are lacking for mitochondrial encephalomyopathies (MEs). MEs are devastating diseases that predominantly affect the energy-demanding tissues of the nervous system and muscle, causing symptoms such as seizures, cardiomyopathy, and neuro- and muscular degeneration. Even common anti-epileptic drugs which are frequently successful in ameliorating seizures in other diseases tend to have a lower success rate in ME, highlighting the need for novel drug targets, especially those that may couple metabolic sensitivity to neuronal excitability...
September 2016: Journal of Neurogenetics
Amutha Boominathan, Shon Vanhoozer, Nathan Basisty, Kathleen Powers, Alexandra L Crampton, Xiaobin Wang, Natalie Friedricks, Birgit Schilling, Martin D Brand, Matthew S O'Connor
We explore the possibility of re-engineering mitochondrial genes and expressing them from the nucleus as an approach to rescue defects arising from mitochondrial DNA mutations. We have used a patient cybrid cell line with a single point mutation in the overlap region of the ATP8 and ATP6 genes of the human mitochondrial genome. These cells are null for the ATP8 protein, have significantly lowered ATP6 protein levels and no Complex V function. Nuclear expression of only the ATP8 gene with the ATP5G1 mitochondrial targeting sequence appended restored viability on Krebs cycle substrates and ATP synthesis capabilities but, failed to restore ATP hydrolysis and was insensitive to various inhibitors of oxidative phosphorylation...
September 4, 2016: Nucleic Acids Research
Kristen E Elstner, John W Read, Omar Rodriguez-Acevedo, Kevin Ho-Shon, John Magnussen, Nabeel Ibrahim
BACKGROUND: A rarely used technique for enabling closure of large ventral hernias with loss of domain is preoperative progressive pneumoperitoneum (PPP), which uses intermittent insufflation to gradually stretch the contracted abdominal wall muscles, increasing the capacity of the abdominal cavity. This allows the re-introduction of herniated viscera into the abdominal cavity and assists in closure of giant hernias which may otherwise be considered inoperable. METHODS: This was a prospective study assessing 16 patients between 2013 and 2015 with multi-recurrent ventral hernia...
August 29, 2016: Surgical Endoscopy
Hong Liu, Yiyang Xu, Jingyi Xiang, Li Long, Shon Green, Zhiyuan Yang, Bryan Zimdahl, Jingwei Lu, Neal Cheng, Lucas H Horan, Bin Liu, Su Yan, Pei Wang, Juan Diaz, Lu Jin, Yoko Nakano, Javier F Morales, Pengbo Zhang, Lian-Xing Liu, Binnaz K Staley, Saul J Priceman, Christine E Brown, Stephen J Forman, Vivien W Chan, Cheng Liu
PURPOSE: The majority of tumor-specific antigens are intracellular and/or secreted and therefore inaccessible by conventional chimeric antigen receptor (CAR) T-cell therapy. Given that all intracellular/secreted proteins are processed into peptides and presented by class I MHC on the surface of tumor cells, we used alpha-fetoprotein (AFP), a specific liver cancer marker, as an example to determine whether peptide-MHC complexes can be targets for CAR T-cell therapy against solid tumors...
August 17, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Jai Hyung Park, Yongkoo Lee, Oog-Jin Shon, Hyun Chul Shon, Ji Wan Kim
INTRODUCTION: The surgical management of atypical femoral fractures (AFFs) is complex in cases with severe bowing of the femur, being associated with a high rate of failure. Our first aim was to use preoperative templating and 3D printed model characterise the technical difficulties associated with use of current commercially available intramedullary nail (IMN) systems for the management of AFFs with severe bowing. Our second aim was to use outcomes of our 3D printing analysis to define technical criteria to overcome these problems...
June 2016: Injury
Hyeon Ah Park, Taewook Kim, Meijing Li, Ho Sun Shon, Jeong Seok Park, Keun Ho Ryu
OBJECTIVES: Predicting protein function from the protein-protein interaction network is challenging due to its complexity and huge scale of protein interaction process along with inconsistent pattern. Previously proposed methods such as neighbor counting, network analysis, and graph pattern mining has predicted functions by calculating the rules and probability of patterns inside network. Although these methods have shown good prediction, difficulty still exists in searching several functions that are exceptional from simple rules and patterns as a result of not considering the inconsistent aspect of the interaction network...
April 2015: Osong Public Health and Research Perspectives
L Chekli, S Phuntsho, L D Tijing, J L Zhou, J-H Kim, H K Shon
Manufactured nanoparticles (MNPs) are increasingly released into the environment and thus research on their fate and behaviour in complex environmental samples is urgently needed. The fate of MNPs in the aquatic environment will mainly depend on the physico-chemical characteristics of the medium. The presence and concentration of natural organic matter (NOM) will play a significant role on the stability of MNPs by either decreasing or exacerbating the aggregation phenomenon. In this study, we firstly investigated the effect of NOM concentration on the aggregation behaviour of manufactured Fe-oxide nanoparticles...
2014: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Behzad Rad, Thomas K Haxton, Albert Shon, Seong-Ho Shin, Stephen Whitelam, Caroline M Ajo-Franklin
Self-assembling proteins offer a potential means of creating nanostructures with complex structure and function. However, using self-assembly to create nanostructures with long-range order whose size is tunable is challenging, because the kinetics and thermodynamics of protein interactions depend sensitively on solution conditions. Here we systematically investigate the impact of varying solution conditions on the self-assembly of SbpA, a surface-layer protein from Lysinibacillus sphaericus that forms two-dimensional nanosheets...
January 27, 2015: ACS Nano
Maria F Ramirez, Di Ai, Maria Bauer, Jean-Nicolas Vauthey, Vijaya Gottumukkala, Spencer Kee, Daliah Shon, Mark Truty, Henry M Kuerer, Anrea Kurz, Mike Hernandez, Juan P Cata
BACKGROUND: The cytotoxic activity and count of natural killer (NK) cells appear to be reduced after surgery; however, it is unknown whether the magnitude of this immune suppression is similar among different types of oncological surgery. In this study, we compared the innate immune function of patients undergoing three different oncological surgeries. METHODS: We compared the number and function of NK cells obtained from patients who had undergone mastectomies (n = 17), thoracotomies (n = 21), or liver resections for cancer (n = 22)...
March 2015: Journal of Surgical Research
Chunrong Qu, Erqing Tang, Richard Loeppky, Zixin Deng, Shon R Pulley, Xuechuan Hong
The C-arylglycosides are available in enantiomerically pure form via the Dötz benzannulation reaction between Fischer alkenyl chromium carbene complexes and alkynes; it also could be converted to a precursor of medermycin by O-carbamate directed ipso bromination and nitrile substitution in good overall yields.
January 2015: Chirality
Seok-Bong Kang, Ho-Sang Shon, Soo-Jin Park, Chang-Hyun Song, Sae-Kwang Ku
For sufficient antihypertension with less adverse effects, numerous clinical trials have recommended combination therapy using two or more hypertensive drugs. Chungsinoryungsan (CSORS) is a polyherbal complex based on oriental medicine, which has shown therapeutic potentials for antihypertension and additional renal improvement. Therefore, the affect of CSORS on the pharmacokinetic profiles of perindopril, an antihypertensive drug, was analyzed as a novel combination of hypertensive drugs. Rats received perindopril with CSORS as the combination or distilled water as the control...
November 2014: Biomedical Reports
Seok Woo Chang, Young-Kyu Lee, Qiang Zhu, Won Jun Shon, Woo Cheol Lee, Kee Yeon Kum, Seung Ho Baek, In Bog Lee, Bum-Soon Lim, Kwang Shik Bae
The flowability of a root canal sealer is clinically important because it improves the penetration of the sealer into the complex root canal system. The purpose of this study was to compare the flowabilities of four root canal sealers, measured using the simple press method (ISO 6876), and their viscosities, measured using a strain-controlled rheometer. A newly developed, calcium phosphate-based root canal sealer (Capseal) and three commercial root canal sealers (AH Plus, Sealapex and Pulp Canal Sealer EWT) were used in this study...
March 2015: International Journal of Oral Science
Young-Pil Kim, Hyun Kyong Shon, Seung Koo Shin, Tae Geol Lee
Bio-conjugated nanoparticles have emerged as novel molecular probes in nano-biotechnology and nanomedicine and chemical analyses of their surfaces have become challenges. The time-of-flight (TOF) secondary ion mass spectrometry (SIMS) has been one of the most powerful surface characterization techniques for both nanoparticles and biomolecules. When combined with various nanoparticle-based signal enhancing strategies, TOF-SIMS can probe the functionalization of nanoparticles as well as their locations and interactions in biological systems...
March 2015: Mass Spectrometry Reviews
A Babinska, C C Clement, M Swiatkowska, J Szymanski, A Shon, Y H Ehrlich, E Kornecki, M O Salifu
Peptides with enhanced resistance to proteolysis, based on the amino acid sequence of the F11 receptor molecule (F11R, aka JAM-A/Junctional adhesion molecule-A), were designed, prepared, and examined as potential candidates for the development of anti-atherosclerotic and anti-thrombotic therapeutic drugs. A sequence at the N-terminal of F11R together with another sequence located in the first Ig-loop of this protein, were identified to form a steric active-site operating in the F11R-dependent adhesion between cells that express F11R molecules on their external surface...
July 2014: Biopolymers
Jun-Gyu Moon, Hyuk-Nam Kwon, Sandeep Biraris, Won-Yong Shon
Minimally invasive plate osteosynthesis (MIPO) has been used for humeral shaft fractures, but concerns exist about soft tissue injuries. The purpose of this study was to report the surgical technique and clinical outcomes of MIPO using a helical plate for metadiaphyseal complex humeral shaft fractures. Twelve patients with acute displacement involving proximal and middle third humeral shaft fractures (AO type C) were treated using the MIPO technique with a helical plate. Fracture union, complications, and functional outcomes were evaluated using the Constant-Murley score and Mayo Elbow Performance Score (MEPS) at final follow-up...
March 2014: Orthopedics
Myung-Kul Yum, Jin-Hwa Moon, Joong Koo Kang, Oh-Young Kwon, Ki-Jong Park, Young-Min Shon, Il Keun Lee, Ki-Young Jung
OBJECTIVE: To investigate the characteristics of event-related synchronization (ERS) fading and phase de-locking of alpha waves during passive auditory stimulation (PAS) in the migraine patients. METHODS: The subjects were 16 adult women with migraine and 16 normal controls. Electroencephalographic (EEG) data obtained during PAS with standard (SS) and deviant stimuli (DS) were used. Alpha ERS fading, the phase locking index (PLI) and de-locking index (DLI) were evaluated from the 10 Hz complex Morlet wavelet components at 100 ms (t100) and 300 ms (t300) after PAS...
July 2014: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Seoung-Ae Lee, Bo-Ram Kim, Bu-Kyung Kim, Dong-Won Kim, Won-Jun Shon, Na-Rae Lee, Kyung-Soo Inn, Bum-Joon Kim
A reverse-transcriptase-subunit of telomerase (hTERT) derived peptide, GV1001, has been developed as a vaccine against various cancers. Here, we report an unexpected function of GV1001 as a cell-penetrating peptide (CPP). GV1001 was delivered into a variety of cells including various cancer cell lines and primary blood cells. Moreover, the delivered GV1001 was predominantly located in the cytoplasm of the cells, while a significantly higher proportion of TAT peptide was localized in the nucleus. Macromolecules such as proteins, DNA and siRNA, which were linked to GV1001 by direct covalent conjugation or non-covalent complexation through poly-lysine, were successfully delivered into cells, indicating that GV1001 can be used as a carrier for macromolecules...
October 2013: Biomaterials
Seung-Pyo Lee, Tae-Il Kim, Hong-Kyun Kim, Won-Jun Shon, Young-Seok Park
BACKGROUND: There have been no objective criteria for classifying the periodontal biotype. The purpose of this study is to suggest clinical guidelines for discriminating the thin biotype, which might be susceptible to gingival recession, using statistical analyses based on the measurement of the dento-gingival complex on three-dimensional virtual models. METHODS: From canine to canine, the area of the facial papilla, the facial surface area of the anterior tooth, the proportion of the dento-papillary complex, clinical papillary length, and the clinical papillary angle were measured on a three-dimensional virtual model of 133 young participants...
November 2013: Journal of Periodontology
Cristina Aurrecoechea, Ana Barreto, John Brestelli, Brian P Brunk, Shon Cade, Ryan Doherty, Steve Fischer, Bindu Gajria, Xin Gao, Alan Gingle, Greg Grant, Omar S Harb, Mark Heiges, Sufen Hu, John Iodice, Jessica C Kissinger, Eileen T Kraemer, Wei Li, Deborah F Pinney, Brian Pitts, David S Roos, Ganesh Srinivasamoorthy, Christian J Stoeckert, Haiming Wang, Susanne Warrenfeltz
EuPathDB ( resources include 11 databases supporting eukaryotic pathogen genomic and functional genomic data, isolate data and phylogenomics. EuPathDB resources are built using the same infrastructure and provide a sophisticated search strategy system enabling complex interrogations of underlying data. Recent advances in EuPathDB resources include the design and implementation of a new data loading workflow, a new database supporting Piroplasmida (i.e. Babesia and Theileria), the addition of large amounts of new data and data types and the incorporation of new analysis tools...
January 2013: Nucleic Acids Research
Shon S Schooler, Buck Salau, Mic H Julien, Anthony R Ives
Suppression of the invasive plant Salvinia molesta by the salvinia weevil is an iconic example of successful biological control. However, in the billabongs (oxbow lakes) of Kakadu National Park, Australia, control is fitful and incomplete. By fitting a process-based nonlinear model to thirteen-year data sets from four billabongs, here we show that incomplete control can be explained by alternative stable states--one state in which salvinia is suppressed and the other in which salvinia escapes weevil control...
February 3, 2011: Nature
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