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Shon's complex

Ji Wan Kim, Yongkoo Lee, Joonho Seo, Jai Hyung Park, Yong Min Seo, Sung Soo Kim, Hyun Chul Shon
BACKGROUND: To report our experiences with the use of three-dimensional (3D) printing in the field of orthopedic trauma. METHODS: This retrospective study enrolled 24 patients from three university teaching hospitals in whom 3D printing technique was applied: 14 patients with acetabular fractures and 10 patients with clavicular shaft fractures. We summarized our experiences with 3D printed bone models. RESULTS: Three-dimensional printed acetabular models improved understanding of complex acetabular anatomy and fracture pattern to plan the optimal positioning of a reduction clamp and the trajectory of screws...
March 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Jong-Hwa Shon, Thomas S Teets
In this work, we outline a strategy to prepare a class of improved visible-light photosensitizers. Bis-cyclometalated iridium complexes with electron-rich β-diketiminate (NacNac) ancillary ligands are demonstrated to be potent excited-state electron donors. Evaluation of the photophysical and electrochemical properties establishes the excited-state redox potentials of the complexes, and Stern-Volmer quenching experiments inform on the kinetics of photoinduced electron transfer to the model substrates methyl viologen (MV2+ ) and benzophenone (BP)...
December 18, 2017: Inorganic Chemistry
Jihyun Lee, Myung-Baek Shon, Hyung-Gon Cha, Keun-Hyung Choi
In the G8 and G9 approval tests for ballast water management systems, organic carbon additives are frequently supplemented into test water to satisfy the water quality requirements. Because organic additives can affect the approval test, the additive selected, and its use and validation should be included in the test report. This study assessed the effects of organic carbon additives on the concentration of total residual oxidants (TROs) and the formation of disinfection by-products (DBPs). The concentration of dissolved organic carbon (DOC) in test water containing additives varied depending on the type of additive, but all additives, except for methylcellulose, had concentrations similar to or higher than the theoretical values...
December 15, 2017: Science of the Total Environment
Yanxia Zhao, Sherub Phuntsho, Baoyu Gao, Hokyong Shon
Interest in the development of inorganic polymerized coagulants is growing; however, there are only limited studies on the synthesis of polytitanium coagulants, which are expected to exhibit improved coagulation efficiency with better floc properties. This study presents the synthesis of polytitanium sulfate (PTS) for potential application in water purification, followed by characterization of PTS flocs and titanium species detection. Stable PTS solutions were successfully synthesized and standard jar tests were conducted to evaluate their coagulation efficiency...
February 2017: Journal of Environmental Sciences (China)
Khin Aye San, Vivian Chen, Young-Seok Shon
Stable and isolable alkanethiolate-stabilized Pt nanoparticles (PtNP) were synthesized using the two-phase thiosulfate method with sodium S-alkylthiosulfate as ligand precursor. The mechanistic formation of octanethiolate-capped PtNP (Pt-SC8) from both sodium S-octylthiosulfate and 1-octanethiol ligands was investigated by using (1)H NMR and UV-vis spectroscopies, which revealed the formation of different Pt complexes as the reaction intermediates. The synthesis using S-octylthiosulfate ligand precursor produced Pt-SC8 in higher yields than that using 1-octanethiol ligand...
March 22, 2017: ACS Applied Materials & Interfaces
Keri J Fogle, J Ian Hertzler, Joy H Shon, Michael J Palladino
Effective therapies are lacking for mitochondrial encephalomyopathies (MEs). MEs are devastating diseases that predominantly affect the energy-demanding tissues of the nervous system and muscle, causing symptoms such as seizures, cardiomyopathy, and neuro- and muscular degeneration. Even common anti-epileptic drugs which are frequently successful in ameliorating seizures in other diseases tend to have a lower success rate in ME, highlighting the need for novel drug targets, especially those that may couple metabolic sensitivity to neuronal excitability...
September 2016: Journal of Neurogenetics
Amutha Boominathan, Shon Vanhoozer, Nathan Basisty, Kathleen Powers, Alexandra L Crampton, Xiaobin Wang, Natalie Friedricks, Birgit Schilling, Martin D Brand, Matthew S O'Connor
We explore the possibility of re-engineering mitochondrial genes and expressing them from the nucleus as an approach to rescue defects arising from mitochondrial DNA mutations. We have used a patient cybrid cell line with a single point mutation in the overlap region of the ATP8 and ATP6 genes of the human mitochondrial genome. These cells are null for the ATP8 protein, have significantly lowered ATP6 protein levels and no Complex V function. Nuclear expression of only the ATP8 gene with the ATP5G1 mitochondrial targeting sequence appended restored viability on Krebs cycle substrates and ATP synthesis capabilities but, failed to restore ATP hydrolysis and was insensitive to various inhibitors of oxidative phosphorylation...
November 2, 2016: Nucleic Acids Research
Kristen E Elstner, John W Read, Omar Rodriguez-Acevedo, Kevin Ho-Shon, John Magnussen, Nabeel Ibrahim
BACKGROUND: A rarely used technique for enabling closure of large ventral hernias with loss of domain is preoperative progressive pneumoperitoneum (PPP), which uses intermittent insufflation to gradually stretch the contracted abdominal wall muscles, increasing the capacity of the abdominal cavity. This allows the re-introduction of herniated viscera into the abdominal cavity and assists in closure of giant hernias which may otherwise be considered inoperable. METHODS: This was a prospective study assessing 16 patients between 2013 and 2015 with multi-recurrent ventral hernia...
April 2017: Surgical Endoscopy
Hong Liu, Yiyang Xu, Jingyi Xiang, Li Long, Shon Green, Zhiyuan Yang, Bryan Zimdahl, Jingwei Lu, Neal Cheng, Lucas H Horan, Bin Liu, Su Yan, Pei Wang, Juan Diaz, Lu Jin, Yoko Nakano, Javier F Morales, Pengbo Zhang, Lian-Xing Liu, Binnaz K Staley, Saul J Priceman, Christine E Brown, Stephen J Forman, Vivien W Chan, Cheng Liu
PURPOSE: The majority of tumor-specific antigens are intracellular and/or secreted and therefore inaccessible by conventional chimeric antigen receptor (CAR) T-cell therapy. Given that all intracellular/secreted proteins are processed into peptides and presented by class I MHC on the surface of tumor cells, we used alpha-fetoprotein (AFP), a specific liver cancer marker, as an example to determine whether peptide-MHC complexes can be targets for CAR T-cell therapy against solid tumors...
January 15, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Jai Hyung Park, Yongkoo Lee, Oog-Jin Shon, Hyun Chul Shon, Ji Wan Kim
INTRODUCTION: The surgical management of atypical femoral fractures (AFFs) is complex in cases with severe bowing of the femur, being associated with a high rate of failure. Our first aim was to use preoperative templating and 3D printed model characterise the technical difficulties associated with use of current commercially available intramedullary nail (IMN) systems for the management of AFFs with severe bowing. Our second aim was to use outcomes of our 3D printing analysis to define technical criteria to overcome these problems...
June 2016: Injury
Hyeon Ah Park, Taewook Kim, Meijing Li, Ho Sun Shon, Jeong Seok Park, Keun Ho Ryu
OBJECTIVES: Predicting protein function from the protein-protein interaction network is challenging due to its complexity and huge scale of protein interaction process along with inconsistent pattern. Previously proposed methods such as neighbor counting, network analysis, and graph pattern mining has predicted functions by calculating the rules and probability of patterns inside network. Although these methods have shown good prediction, difficulty still exists in searching several functions that are exceptional from simple rules and patterns as a result of not considering the inconsistent aspect of the interaction network...
April 2015: Osong Public Health and Research Perspectives
L Chekli, S Phuntsho, L D Tijing, J L Zhou, J-H Kim, H K Shon
Manufactured nanoparticles (MNPs) are increasingly released into the environment and thus research on their fate and behaviour in complex environmental samples is urgently needed. The fate of MNPs in the aquatic environment will mainly depend on the physico-chemical characteristics of the medium. The presence and concentration of natural organic matter (NOM) will play a significant role on the stability of MNPs by either decreasing or exacerbating the aggregation phenomenon. In this study, we firstly investigated the effect of NOM concentration on the aggregation behaviour of manufactured Fe-oxide nanoparticles...
2014: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Behzad Rad, Thomas K Haxton, Albert Shon, Seong-Ho Shin, Stephen Whitelam, Caroline M Ajo-Franklin
Self-assembling proteins offer a potential means of creating nanostructures with complex structure and function. However, using self-assembly to create nanostructures with long-range order whose size is tunable is challenging, because the kinetics and thermodynamics of protein interactions depend sensitively on solution conditions. Here we systematically investigate the impact of varying solution conditions on the self-assembly of SbpA, a surface-layer protein from Lysinibacillus sphaericus that forms two-dimensional nanosheets...
January 27, 2015: ACS Nano
Maria F Ramirez, Di Ai, Maria Bauer, Jean-Nicolas Vauthey, Vijaya Gottumukkala, Spencer Kee, Daliah Shon, Mark Truty, Henry M Kuerer, Anrea Kurz, Mike Hernandez, Juan P Cata
BACKGROUND: The cytotoxic activity and count of natural killer (NK) cells appear to be reduced after surgery; however, it is unknown whether the magnitude of this immune suppression is similar among different types of oncological surgery. In this study, we compared the innate immune function of patients undergoing three different oncological surgeries. METHODS: We compared the number and function of NK cells obtained from patients who had undergone mastectomies (n = 17), thoracotomies (n = 21), or liver resections for cancer (n = 22)...
March 2015: Journal of Surgical Research
Chunrong Qu, Erqing Tang, Richard Loeppky, Zixin Deng, Shon R Pulley, Xuechuan Hong
The C-arylglycosides are available in enantiomerically pure form via the Dötz benzannulation reaction between Fischer alkenyl chromium carbene complexes and alkynes; it also could be converted to a precursor of medermycin by O-carbamate directed ipso bromination and nitrile substitution in good overall yields.
January 2015: Chirality
Seok-Bong Kang, Ho-Sang Shon, Soo-Jin Park, Chang-Hyun Song, Sae-Kwang Ku
For sufficient antihypertension with less adverse effects, numerous clinical trials have recommended combination therapy using two or more hypertensive drugs. Chungsinoryungsan (CSORS) is a polyherbal complex based on oriental medicine, which has shown therapeutic potentials for antihypertension and additional renal improvement. Therefore, the affect of CSORS on the pharmacokinetic profiles of perindopril, an antihypertensive drug, was analyzed as a novel combination of hypertensive drugs. Rats received perindopril with CSORS as the combination or distilled water as the control...
November 2014: Biomedical Reports
Seok Woo Chang, Young-Kyu Lee, Qiang Zhu, Won Jun Shon, Woo Cheol Lee, Kee Yeon Kum, Seung Ho Baek, In Bog Lee, Bum-Soon Lim, Kwang Shik Bae
The flowability of a root canal sealer is clinically important because it improves the penetration of the sealer into the complex root canal system. The purpose of this study was to compare the flowabilities of four root canal sealers, measured using the simple press method (ISO 6876), and their viscosities, measured using a strain-controlled rheometer. A newly developed, calcium phosphate-based root canal sealer (Capseal) and three commercial root canal sealers (AH Plus, Sealapex and Pulp Canal Sealer EWT) were used in this study...
March 2015: International Journal of Oral Science
Young-Pil Kim, Hyun Kyong Shon, Seung Koo Shin, Tae Geol Lee
Bio-conjugated nanoparticles have emerged as novel molecular probes in nano-biotechnology and nanomedicine and chemical analyses of their surfaces have become challenges. The time-of-flight (TOF) secondary ion mass spectrometry (SIMS) has been one of the most powerful surface characterization techniques for both nanoparticles and biomolecules. When combined with various nanoparticle-based signal enhancing strategies, TOF-SIMS can probe the functionalization of nanoparticles as well as their locations and interactions in biological systems...
March 2015: Mass Spectrometry Reviews
A Babinska, C C Clement, M Swiatkowska, J Szymanski, A Shon, Y H Ehrlich, E Kornecki, M O Salifu
Peptides with enhanced resistance to proteolysis, based on the amino acid sequence of the F11 receptor molecule (F11R, aka JAM-A/Junctional adhesion molecule-A), were designed, prepared, and examined as potential candidates for the development of anti-atherosclerotic and anti-thrombotic therapeutic drugs. A sequence at the N-terminal of F11R together with another sequence located in the first Ig-loop of this protein, were identified to form a steric active-site operating in the F11R-dependent adhesion between cells that express F11R molecules on their external surface...
July 2014: Biopolymers
Jun-Gyu Moon, Hyuk-Nam Kwon, Sandeep Biraris, Won-Yong Shon
Minimally invasive plate osteosynthesis (MIPO) has been used for humeral shaft fractures, but concerns exist about soft tissue injuries. The purpose of this study was to report the surgical technique and clinical outcomes of MIPO using a helical plate for metadiaphyseal complex humeral shaft fractures. Twelve patients with acute displacement involving proximal and middle third humeral shaft fractures (AO type C) were treated using the MIPO technique with a helical plate. Fracture union, complications, and functional outcomes were evaluated using the Constant-Murley score and Mayo Elbow Performance Score (MEPS) at final follow-up...
March 2014: Orthopedics
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