keyword
https://read.qxmd.com/read/38371024/clinically-actionable-topical-strategies-for-addressing-the-hallmarks-of-skin-aging-a-primer-for-aesthetic-medicine-practitioners
#21
REVIEW
Piercarlo Minoretti, Enzo Emanuele
In this narrative review, we sought to provide a comprehensive overview of the mechanisms underlying cutaneous senescence, framed by the twelve traditional hallmarks of aging. These include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, impaired macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. We also examined how topical interventions targeting these hallmarks can be integrated with conventional aesthetic medicine techniques to enhance skin rejuvenation...
January 2024: Curēus
https://read.qxmd.com/read/38349785/mass-spectrometry-based-profiling-of-histone-post-translational-modifications-in-uveal-melanoma-tissues-human-melanocytes-and-uveal-melanoma-cell-lines-a-pilot-study
#22
JOURNAL ARTICLE
Martina C Herwig-Carl, Amit Sharma, Verena Tischler, Natalie Pelusi, Karin U Loeffler, Frank G Holz, Michael Zeschnigk, Solange Landreville, Claudia Auw-Haedrich, Roberta Noberini, Tiziana Bonaldi
PURPOSE: Epigenetic alterations in uveal melanoma (UM) are still neither well characterized, nor understood. In this pilot study, we sought to provide a deeper insight into the possible role of epigenetic alterations in the pathogenesis of UM and their potential prognostic relevance. To this aim, we comprehensively profiled histone post-translational modifications (PTMs), which represent epigenetic features regulating chromatin accessibility and gene transcription, in UM formalin-fixed paraffin-embedded (FFPE) tissues, control tissues, UM cell lines, and healthy melanocytes...
February 1, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38345302/cumulative-stress-across-the-lifecourse-and-biological-aging-in-adulthood
#23
JOURNAL ARTICLE
Shakira F Suglia Ms, Elizabeth S Clausing, Rachel C Shelton, Karen Conneely, Diddier Prada-Ortega, Immaculata DeVivo, Pam Factor-Litvak, Piera Cirillo, Andrea A Baccarelli, Barbara Cohn, Bruce G Link
OBJECTIVES: Psychosocial stressors have been linked with accelerated biological aging in adults; however, few studies have examined stressors across the lifecourse in relation to biological aging. METHODS: In 359 individuals (57% White; 34% Black) from the Child Health and Development Studies (CHDS) Disparities (DISPAR) Study, economic (income, education, financial strain), social (parent-child relations, caretaker responsibilities) and traumatic (death of a sibling or child, violence exposure) stressors were assessed at multiple timepoints (birth, age 9, 15 and 50)...
January 11, 2024: Psychosomatic Medicine
https://read.qxmd.com/read/38344970/untargeted-metabolomic-profiling-in-children-identifies-novel-pathways-in-asthma-and-atopy
#24
JOURNAL ARTICLE
Stéphanie Lejeune, Abhinav Kaushik, Ella S Parsons, Sharon Chinthrajah, Michael Snyder, Manisha Desai, Monali Manohar, Mary Prunicki, Kévin Contrepois, Philippe Gosset, Antoine Deschildre, Kari Nadeau
BACKGROUND: Asthma and other atopic disorders can present with varying clinical phenotypes marked by differential metabolomic manifestations and enriched biological pathways. OBJECTIVE: We sought to identify these unique metabolomic profiles in atopy and asthma. METHODS: We analyzed baseline nonfasted plasma samples from a large multisite pediatric population of 470 children aged <13 years from 3 different sites in the United States and France...
February 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38339142/human-induced-pluripotent-stem-cells-in-plastic-and-reconstructive-surgery
#25
REVIEW
Nina Hadzimustafic, Andrew D'Elia, Valentina Shamoun, Siba Haykal
A hallmark of plastic and reconstructive surgery is restoring form and function. Historically, tissue procured from healthy portions of a patient's body has been used to fill defects, but this is limited by tissue availability. Human-induced pluripotent stem cells (hiPSCs) are stem cells derived from the de-differentiation of mature somatic cells. hiPSCs are of particular interest in plastic surgery as they have the capacity to be re-differentiated into more mature cells, and cultured to grow tissues. This review aims to evaluate the applications of hiPSCs in the plastic surgery context, with a focus on recent advances and limitations...
February 3, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38338858/epigenetic-methylation-changes-in-pregnant-women-bisphenol-exposure-and-atopic-dermatitis
#26
JOURNAL ARTICLE
Seung Hwan Kim, So Yeon Yu, Jeong Hyeop Choo, Jihyun Kim, Kangmo Ahn, Seung Yong Hwang
Bisphenol is a chemical substance widely used in plastic products and food containers. In this study, we observed a relationship between DNA methylation and atopic dermatitis (AD) in the peripheral blood mononuclear cells (PBMCs) of pregnant women exposed to bisphenol A (BPA) and its alternatives, bisphenol S (BPS) and bisphenol F (BPF). DNA methylation is an epigenetic mechanism that regulates gene expression, which can be altered by environmental factors, and affects the onset and progression of diseases...
January 27, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38331641/decreased-tet2-5-hmc-reduces-the-integrity-of-the-epidermal-barrier-via-epigenetic-dysregulation-of-filaggrin-in-psoriatic-lesions
#27
JOURNAL ARTICLE
Huan Zhang, Tao Jia, Delu Che, Bin Peng, Zhaowei Chu, Xiangjin Song, Weihui Zeng, Songmei Geng
BACKGROUND: TET2 participates in tumor progression and intrinsic immune homeostasis via epigenetic regulation. TET2 has been reported to be involved in maintaining epithelial barrier homeostasis and inflammation. Abnormal epidermal barrier function and TET2 expression have been detected in psoriatic lesions. However, the mechanisms underlying the role of TET2 in psoriasis have not yet been elucidated. OBJECTIVE: To define the role of TET2 in maintaining epithelial barrier homeostasis and the exact epigenetic mechanism in the dysfunction of the epidermal barrier in psoriasis...
January 20, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38322551/unlocking-the-diagnostic-prognostic-roles-and-immune-implications-of-bax-gene-expression-in-pan-cancer-analysis
#28
JOURNAL ARTICLE
Mostafa A Abdel-Maksoud, Sajid Ullah, Amun Nadeem, Aisha Shaikh, Muhammad Khurram Zia, Adel M Zakri, Taghreed N Almanaa, Akram A Alfuraydi, Ayman Mubarak, Yasir Hameed
OBJECTIVES: Cancer, a formidable disease, continues to challenge our understanding and therapeutic approaches. This study delves into the pan-cancer analysis of BCL2 Associated X (BAX) gene expression, seeking to unravel its significance in cancer development, prognosis, and potential therapeutic strategies. METHODS: A combination of bioinformatics and molecular experiments. RESULTS: Our pan-cancer investigation into BAX expression encompassed 33 distinct cancer types, revealing a remarkable and uniform increase in BAX expression...
2024: American Journal of Translational Research
https://read.qxmd.com/read/38294557/sirt3-6-an-amazing-challenge-and-opportunity-in-the-fight-against-fibrosis-and-aging
#29
REVIEW
Wenxin Wei, Tian Li, Jinlong Chen, Zhen Fan, Feng Gao, Zhibiao Yu, Yihao Jiang
Fibrosis is a typical aging-related pathological process involving almost all organs, including the heart, kidney, liver, lung, and skin. Fibrogenesis is a highly orchestrated process defined by sequences of cellular response and molecular signals mechanisms underlying the disease. In pathophysiologic conditions associated with organ fibrosis, a variety of injurious stimuli such as metabolic disorders, epigenetic changes, and aging may induce the progression of fibrosis. Sirtuins protein is a kind of deacetylase which can regulate cell metabolism and participate in a variety of cell physiological functions...
January 31, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38284199/the-rhythms-of-histones-in-regeneration-the-epigenetic-modifications-determined-by-clock-genes
#30
JOURNAL ARTICLE
Ericka J D da Silveira, Caio C D S Barros, Marco C Bottino, Rogerio M Castilho, Cristiane Squarize
The evolutionary establishment of an internal biological clock is a primordial event tightly associated with a 24-h period. Changes in the circadian rhythm can affect cellular functions, including proliferation, DNA repair and redox state. Even isolated organs, tissues and cells can maintain an autonomous circadian rhythm. These cell-autonomous molecular mechanisms are driven by intracellular clock genes, such as BMAL1. Little is known about the role of core clock genes and epigenetic modifications in the skin...
January 2024: Experimental Dermatology
https://read.qxmd.com/read/38255677/genetic-association-and-differential-rna-expression-of-histone-de-acetylation-related-genes-in-pemphigus-foliaceus-a-possible-epigenetic-effect-in-the-autoimmune-response
#31
JOURNAL ARTICLE
Maiara Sulzbach Denardin, Valéria Bumiller-Bini Hoch, Amanda Salviano-Silva, Sara Cristina Lobo-Alves, Gabriel Adelman Cipolla, Danielle Malheiros, Danillo G Augusto, Michael Wittig, Andre Franke, Claudia Pföhler, Margitta Worm, Nina van Beek, Matthias Goebeler, Miklós Sárdy, Saleh Ibrahim, Hauke Busch, Enno Schmidt, Jennifer Elisabeth Hundt, Maria Luiza Petzl-Erler, Angelica Beate Winter Boldt
Pemphigus foliaceus (PF) is an autoimmune skin blistering disease characterized by antidesmoglein-1 IgG production, with an endemic form (EPF) in Brazil. Genetic and epigenetic factors have been associated with EPF, but its etiology is still not fully understood. To evaluate the genetic association of histone (de)acetylation-related genes with EPF susceptibility, we evaluated 785 polymorphisms from 144 genes, for 227 EPF patients and 194 controls. Carriers of HDAC4_rs4852054*A were more susceptible (OR = 1...
December 29, 2023: Life
https://read.qxmd.com/read/38255297/role-of-a-polyphenol-enriched-blueberry-preparation-on-inhibition-of-melanoma-cancer-stem-cells-and-modulation-of-micrornas
#32
JOURNAL ARTICLE
Nawal Alsadi, Nour Yahfoufi, Carolyn Nessim, Chantal Matar
Melanoma is a type of skin cancer known for its high mortality rate. Cancer stem cells (CSCs) are a subpopulation of cancer cells that significantly contribute to tumour recurrence and differentiation. Epigenetic-specific changes involving miRNAs maintain CSCs. Plant polyphenols have been reported to be involved in cancer chemoprevention and chemotherapy, with miRNAs being the novel effectors in their biological activities. A polyphenol-enriched blueberry preparation (PEBP) derived from fermented blueberries has demonstrated promising chemopreventative properties on breast cancer stem cells by influencing inflammatory pathways and miRNAs...
January 16, 2024: Biomedicines
https://read.qxmd.com/read/38254928/unraveling-the-epigenetic-tapestry-decoding-the-impact-of-epigenetic-modifications-in-hidradenitis-suppurativa-pathogenesis
#33
REVIEW
Elena Maria Nardacchione, Paola Maura Tricarico, Ronald Moura, Adamo Pio d'Adamo, Ayshath Thasneem, Muhammad Suleman, Angelo Valerio Marzano, Sergio Crovella, Chiara Moltrasio
Hidradenitis suppurativa (HS) is a chronic autoinflammatory skin disorder, which typically occurs during puberty or early adulthood. The pathogenesis of HS is complex and multifactorial; a close interaction between hormonal, genetic, epigenetics factors, host-specific aspects, and environmental influences contributes to the susceptibility, onset, severity, and clinical course of this disease, although the exact molecular mechanisms are still being explored. Epigenetics is currently emerging as an interesting field of investigation that could potentially shed light on the molecular intricacies underlying HS, but there is much still to uncover on the subject...
December 26, 2023: Genes
https://read.qxmd.com/read/38250727/gsdmd-suppresses-keratinocyte-differentiation-by-inhibiting-flg-expression-and-attenuating-kctd6-mediated-hdac1-degradation-in-atopic-dermatitis
#34
JOURNAL ARTICLE
Yi Zhong, Taoyuan Huang, Xiaoli Li, Peiyi Luo, Bingjun Zhang
BACKGROUND: Recent studies have shown that activated pyroptosis in atopic dermatitis (AD) switches inflammatory processes and causes abnormal cornification and epidermal barrier dysfunction. Little research has focused on the interaction mechanism between pyroptosis-related genes and human keratinocyte differentiation. METHODS: The AD dataset from the Gene Expression Omnibus (GEO) was used to identify differently expressed pyroptosis-related genes (DEPRGs). Hub genes were identified and an enrichment analysis was performed to select epithelial development-related genes...
2024: PeerJ
https://read.qxmd.com/read/38248064/evaluation-of-the-microbiome-identification-of-forensically-relevant-biological-fluids-a-pilot-study
#35
JOURNAL ARTICLE
Audrey Gouello, Laura Henry, Djamel Chadli-Benhemani, Florian Salipante, Joséphine Gibert, Adeline Boutet-Dubois, Jean-Philippe Lavigne
In forensic sciences, body fluids, or biological traces, are a major source of information, and their identification can play a decisive role in criminal investigations. Currently, the nature of biological fluids is assessed using immunological, physico-chemical, mRNA and epigenetic methods, but these have limits in terms of sensitivity and specificity. The emergence of next-generation sequencing technologies offers new opportunities to identify the nature of body fluids by determining bacterial communities...
January 15, 2024: Diagnostics
https://read.qxmd.com/read/38239496/update-of-the-risk-assessment-of-inorganic-arsenic-in-food
#36
JOURNAL ARTICLE
Dieter Schrenk, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Jesús Del Mazo, Bettina Grasl-Kraupp, Christer Hogstrand, Laurentius Ron Hoogenboom, Jean-Charles Leblanc, Carlo Stefano Nebbia, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Christiane Vleminckx, Heather Wallace, Lars Barregård, Diane Benford, Karin Broberg, Eugenia Dogliotti, Tony Fletcher, Lars Rylander, José Cortiñas Abrahantes, Jose Ángel Gómez Ruiz, Hans Steinkellner, Tuuli Tauriainen, Tanja Schwerdtle
The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard assessment of inorganic arsenic (iAs) and using the revised exposure assessment issued by EFSA in 2021. Epidemiological studies show that the chronic intake of iAs via diet and/or drinking water is associated with increased risk of several adverse outcomes including cancers of the skin, bladder and lung. The CONTAM Panel used the benchmark dose lower confidence limit based on a benchmark response (BMR) of 5% (relative increase of the background incidence after adjustment for confounders, BMDL05 ) of 0...
January 2024: EFSA journal
https://read.qxmd.com/read/38190040/direct-reprogramming-of-somatic-skin-cells-from-a-patient-with-huntington-s-disease-into-striatal-neurons-to-create-models-of-pathology
#37
JOURNAL ARTICLE
N A Kraskovskaya, M G Khotin, A N Tomilin, N A Mikhailova
A new in vitro model of Huntington's disease (HD) was developed via a direct reprogramming of dermal fibroblasts from HD patients into striatal neurons. A reprogramming into induced pluripotent stem (iPS) cells is obviated in the case of direct reprogramming, which thus yields neurons that preserve the epigenetic information inherent in cells of a particular donor and, consequently, the age-associated disease phenotype. A main histopathological feature of HD was reproduced in the new model; i.e., aggregates of mutant huntingtin accumulated in striatal neurons derived from a patient's fibroblasts...
January 8, 2024: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://read.qxmd.com/read/38183626/chemotherapy-mediated-complications-of-wound-healing-an-understudied-side-effect
#38
JOURNAL ARTICLE
Paulina Słonimska, Paweł Sachadyn, Jacek Zieliński, Marcin Skrzypski, Michał Pikuła
SIGNIFICANCE: Chemotherapy is a primary method to treat cancer. While chemotherapeutic drugs are designed to target rapidly dividing cancer cells, they can also affect other cell types. In the case of dermal cells and macrophages involved in wound healing, cytotoxicity often leads to the development of chronic wounds. The situation becomes even more severe when chemotherapy is combined with surgical tumor excision. RECENT ADVANCES: Despite its significant impact on patients' recovery from surgery, the issue of delayed wound healing in individuals undergoing chemotherapy remains inadequately explored...
January 6, 2024: Advances in Wound Care
https://read.qxmd.com/read/38183207/systematic-analysis-of-the-transcriptional-landscape-of-melanoma-reveals-drug-target-expression-plasticity
#39
JOURNAL ARTICLE
Brad Balderson, Mitchell Fane, Tracey J Harvey, Michael Piper, Aaron Smith, Mikael Bodén
Metastatic melanoma originates from melanocytes of the skin. Melanoma metastasis results in poor treatment prognosis for patients and is associated with epigenetic and transcriptional changes that reflect the developmental program of melanocyte differentiation from neural crest stem cells. Several studies have explored melanoma transcriptional heterogeneity using microarray, bulk and single-cell RNA-sequencing technologies to derive data-driven models of the transcriptional-state change which occurs during melanoma progression...
January 5, 2024: Briefings in Functional Genomics
https://read.qxmd.com/read/38182954/smart-carbon-based-sensors-for-the-detection-of-non-coding-rnas-associated-with-exposure-to-micro-nano-plastics-an-artificial-intelligence-perspective
#40
REVIEW
Pooja Ratre, Nazim Nazeer, Nikita Soni, Prasan Kaur, Rajnarayan Tiwari, Pradyumna Kumar Mishra
Micro(nano)plastics (MNPs) are pervasive environmental pollutants that individuals eventually consume. Despite this, little is known about MNP's impact on public health. In this article, we assess the evidence for potentially harmful consequences of MNPs in the human body, concentrating on molecular toxicity and exposure routes. Since MNPs are present in various consumer products, foodstuffs, and the air we breathe, exposure can occur through ingestion, inhalation, and skin contact. MNPs exposure can cause mitochondrial oxidative stress, inflammatory lesions, and epigenetic modifications, releasing specific non-coding RNAs in circulation, which can be detected to diagnose non-communicable diseases...
January 5, 2024: Environmental Science and Pollution Research International
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