keyword
https://read.qxmd.com/read/38522019/dna-hypomethylation-of-syk-induces-oxidative-stress-and-apoptosis-via-the-pkc%C3%AE-p66shc-signaling-pathway-in-diabetic-kidney-disease
#21
JOURNAL ARTICLE
Rui Zhang, Chunmei Qin, Junlin Zhang, HonghongRen, Yiting Wang, Yucheng Wu, Lijun Zhao, Jiali Wang, Jie Zhang, Fang Liu
Epigenetic alterations, especially DNA methylation, have been shown to play a role in the pathogenesis of diabetes mellitus (DM) and its complications, including diabetic kidney disease (DKD). Spleen tyrosine kinase (Syk) is known to be involved in immune and inflammatory disorders. We, therefore, investigated the possible involvement of Syk promoter methylation in DKD, and the mechanisms underlying this process. Kidney tissues were obtained from renal biopsies of patients with early and advanced DKD. A diabetic mouse model (ApoE-/- DM) was generated from ApoE knockout (ApoE-/- ) mice using a high-fat and high-glucose diet combined with low-dose streptozocin intraperitoneal injection...
March 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38520871/controllers-of-histone-methylation-modifying-enzymes-in-gastrointestinal-cancers
#22
REVIEW
Ling Li, Qing Song, Jing Zhou, Qing Ji
Gastrointestinal (GI) cancers have been considered primarily genetic malignancies, caused by a series of progressive genetic alterations. Accumulating evidence shows that histone methylation, an epigenetic modification program, plays an essential role in the different pathological stages of GI cancer progression, such as precancerous lesions, tumorigenesis, and tumor metastasis. Histone methylation-modifying enzymes, including histone methyltransferases (HMTs) and demethylases (HDMs), are the main executor of post-transcriptional modification...
March 22, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38520591/predominance-of-mgmt-promoter-methylation-among-pakistani-glioblastoma-patients
#23
JOURNAL ARTICLE
Noor Muhammad, Samir Fasih, Bilal Malik, Shahid Hameed, Asif Loya, Muhammad Usman Rashid
BACKGROUND: Glioblastoma multiforme (GBM), the most prevalent subgroup of neuroepithelial tumors, is characterized by dismal overall survival (OS). Several studies have linked O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation to OS in GBM patients. However, MGMT methylation frequencies vary geographically and across ethnicities, with limited data for South Asian populations, including Pakistan. This study aimed to analyze MGMT promoter methylation in Pakistani GBM patients...
March 23, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38519010/early-developmental-changes-in-a-rat-model-of-malformations-of-cortical-development-abnormal-neuronal-migration-and-altered-response-to-nmda-induced-excitotoxic-injury
#24
JOURNAL ARTICLE
Minyoung Lee, Eun-Jin Kim, Mi-Sun Yum
Malformations of cortical development (MCDs) are caused by abnormal neuronal migration processes during the fetal period and are a major cause of intractable epilepsy in infancy. However, the timing of hyperexcitability or epileptogenesis in MCDs remains unclear. To identify the early developmental changes in the brain of the MCD rat model, which exhibits increased seizure susceptibility during infancy (P12-15), we analyzed the pathological changes in the brains of MCD model rats during the neonatal period and tested NMDA-induced seizure susceptibility...
March 20, 2024: Experimental Neurology
https://read.qxmd.com/read/38517565/wtap-mediated-n6-methyladenosine-modification-promotes-the-inflammation-mitochondrial-damage-and-ferroptosis-of-kidney-tubular-epithelial-cells-in-acute-kidney-injury-by-regulating-lmnb1-expression-and-activating-nf-%C3%AE%C2%BAb-and-jak2-stat3-pathways
#25
JOURNAL ARTICLE
Fan Huang, Yuchen Wang, XiaoLi Lv, Chenda Huang
Acute kidney injury (AKI) is a serious complication of sepsis patients, but the pathogenic mechanisms underlying AKI are still largely unclear. In this view, the roles of the key component of N6-methyladenosine (m6A)-wilms tumor 1 associated protein (WTAP) in AKI progression were investigated. AKI mice model was established by using cecal ligation and puncture (CLP). AKI cell model was established by treating HK-2 cells with LPS. Cell apoptosis was analyzed by TdT-mediated dUTP Nick-End Labeling (TUNEL) staining and flow cytometry analysis...
March 22, 2024: Journal of Bioenergetics and Biomembranes
https://read.qxmd.com/read/38516266/methylome-wide-and-meqtl-analysis-helps-to-distinguish-treatment-response-from-non-response-and-pathogenesis-markers-in-schizophrenia
#26
JOURNAL ARTICLE
Binithamol K Polakkattil, Neetha N Vellichirammal, Indu V Nair, Chandrasekharan M Nair, Moinak Banerjee
Schizophrenia is a complex condition with entwined genetic and epigenetic risk factors, posing a challenge to disentangle the intermixed pathological and therapeutic epigenetic signatures. To resolve this, we performed 850K methylome-wide and 700K genome-wide studies on the same set of schizophrenia patients by stratifying them into responders, non-responders, and drug-naïve patients. The key genes that signified the response were followed up using real-time gene expression studies to understand the effect of antipsychotics at the gene transcription level...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38512034/-3-deazaadenosine-3-daa-accelerates-japanese-encephalitis-virus-replication-and-down-regulates-levels-of-inflammatory-factors-in-mouse-and-hamster-cells
#27
JOURNAL ARTICLE
Xueyun Li, Min Yao, Yuexiang Li, Zhirong Cheng, Shizhe Zhang, Fanglin Zhang, Xin Lyu
Objective To investigate the effect of 3-deazaadenosine (3-DAA), an N6 -methyladenosine (m6 A) methylation modification inhibitor, on the replication of the Japanese encephalitis virus (JEV). Methods Neuro2a mouse neuroblastoma cells, N9 mouse microglial cells, and BHK baby hamster kidney cells were exposed to JEV and then treated with 3-DAA. JEV was also injected into the footpad of adult C57BL/6 mice, which were then administered 3-DAA intraperitoneally. Real-time quantitative PCR was utilized to measure mRNA expression levels of JEV, interleukin 1β (IL-1β), IL-6, tumor necrosis factor α (TNF-α), monocyte chemoattractant protein 1 (MCP-1), inducible nitric oxide synthase (iNOS), arginase 1 (Arg1), interferon (IFN)-α, IFN-β, IFN-γ, and C-X-C motif chemokine ligand 10 (CXCL10) in the cells and mouse brain tissues...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38510528/diabetes-and-diabetic-associative-diseases-an-overview-of-epigenetic-regulations-of-tug1
#28
REVIEW
Mohammed Ageeli Hakami
The epigenetic regulation of lncRNA TUG1 has garnered significant attention in the context of diabetes and its associated disorders. TUG1's multifaceted roles in gene expression modulation, and cellular differentiation, and it plays a major role in the growth of diabetes and the issues that are related to it due to pathological processes. In diabetes, aberrant epigenetic modifications can lead to dysregulation of TUG1 expression, contributing to disrupted insulin signaling, impaired glucose metabolism, and beta-cell dysfunction...
May 2024: Saudi Journal of Biological Sciences
https://read.qxmd.com/read/38508349/mzb1-regulates-cellular-proliferation-mitochondrial-dysfunction-and-inflammation-and-targets-the-pi3k-akt-signaling-pathway-in-acute-pancreatitis
#29
JOURNAL ARTICLE
Mengtao Xu, Yong Feng, Xuelian Xiang, Li Liu, Guodu Tang
BACKGROUND: Acute pancreatitis (AP) is a pathological condition characterized by the premature release and activation of trypsinogens and other enzyme precursors. In severe cases, the mortality rates are in the range of 20-30% and may even be as high as 50%. Though various prophylaxes are available for AP, the mechanism of its progression is unclear. Marginal zone B and B-1 cell-specific protein 1 (MZB1) is found in the endoplasmic reticulum (ER) where it is expressed exclusively in the B cells there...
March 18, 2024: Cellular Signalling
https://read.qxmd.com/read/38507551/micrornas-oxidative-stress-and-genotoxicity-as-the-main-inducers-in-the-pathobiology-of-cancer-development
#30
REVIEW
Sogand Vahidi, Shahram Agah, Ebrahim Mirzajani, Elahe Asghari Gharakhyli, Seyedeh Elham Norollahi, Morteza Rahbar Taramsari, Kosar Babaei, Ali Akbar Samadani
Cancer is one of the most serious leading causes of death in the world. Many eclectic factors are involved in cancer progression including genetic and epigenetic alongside environmental ones. In this account, the performance and fluctuations of microRNAs are significant in cancer diagnosis and treatment, particularly as diagnostic biomarkers in oncology. So, microRNAs manage and control the gene expression after transcription by mRNA degradation, or also they can inhibit their translation. Conspicuously, these molecular structures take part in controlling the cellular, physiological and pathological functions, which many of them can accomplish as tumor inhibitors or oncogenes...
March 21, 2024: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/38507065/dna-methylation-profiling-identifies-epigenetic-signatures-of-early-gastric-cancer
#31
JOURNAL ARTICLE
Zhongyue Shi, Xinmeng Guo, Xiumei Hu, Ruiqi Li, Xue Li, Jun Lu, Mulan Jin, Xingran Jiang
Research on the DNA methylation status of gastric cancer (GC) has primarily focused on identifying invasive GC to develop biomarkers for diagnostic. However, DNA methylation in noninvasive GC remains unclear. We conducted a comprehensive DNA methylation profiling study of differentiated-type intramucosal GCs (IMCs). Illumina 850K microarrays were utilized to assess the DNA methylation profiles of formalin-fixed paraffin-embedded tissues from eight patients who were Epstein-Barr virus-negative and DNA mismatch repair proficient, including IMCs and paired adjacent nontumor mucosa...
March 20, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38505602/fsh-induces-emt-in-ovarian-cancer-via-alkbh5-regulated-snail-m6a-demethylation
#32
JOURNAL ARTICLE
Xingyan Xu, Xuefen Zhuang, Haowei Yu, Ping Li, Xiaosa Li, Huiping Lin, Jian-Peng Teoh, Yiwen Chen, Yuanlan Yang, Yang Cheng, Weiyu Chen, Xiaodong Fu
Background: The therapeutic benefits of targeting follicle-stimulating hormone (FSH) receptor in treatment of ovarian cancer are significant, whereas the role of FSH in ovarian cancer progresses and the underlying mechanism remains to be developed. Methods: Tissue microarray of human ovarian cancer, tumor xenograft mouse model, and in vitro cell culture were used to investigate the role of FSH in ovarian carcinogenesis. siRNA, lentivirus and inhibitors were used to trigger the inactivation of genes, and plasmids were used to increase transcription of genes...
2024: Theranostics
https://read.qxmd.com/read/38504541/moxibustion-of-zusanli-st36-and-shenshu-bl23-alleviates-the-inflammation-of-rheumatoid-arthritis-in-rats-through-regulating-macrophage-migration-inhibitory-factor-glucocorticoids-signaling
#33
JOURNAL ARTICLE
Zhang Linlin, Zhong Yumei, L U Wenting, Shang Yanan, Guo Yanding, Luo Xiaochao, Chen Yang, Luo Kun, H U Danhui, Y U Huiling, Zhou Haiyan
OBJECTIVE: To test the hypothesis that moxibustion may inhibit rheumatoid arthritis (RA) synovial inflammation by regulating the expression of macrophage migration inhibitory factor (MIF)/glucocorticoids (GCs). METHODS: Fifty male Sprague-Dawley rats were randomly divided into five groups ( n = 10 each): blank Control (CON) group, RA Model (RA) group, Moxibustion (MOX) group, MIF inhibitor (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester (ISO-1) group, and Moxibustion + MIF inhibitor ISO-1 (MOX + ISO-1) group...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504345/epigenetic-mlh1-silencing-concurs-with-mismatch-repair-deficiency-in-sporadic-naturally-occurring-colorectal-cancer-in-rhesus-macaques
#34
JOURNAL ARTICLE
Simon Deycmar, Brendan J Johnson, Karina Ray, George W Schaaf, Declan Patrick Ryan, Cassandra Cullin, Brandy L Dozier, Betsy Ferguson, Benjamin N Bimber, John D Olson, David L Caudell, Christopher T Whitlow, Kiran Kumar Solingapuram Sai, Emily C Romero, Francois J Villinger, Armando G Burgos, Hannah C Ainsworth, Lance D Miller, Gregory A Hawkins, Jeff W Chou, Bruno Gomes, Michael Hettich, Maurizio Ceppi, Jehad Charo, J Mark Cline
BACKGROUND: Naturally occurring colorectal cancers (CRC) in rhesus macaques share many features with their human counterparts and are useful models for cancer immunotherapy; but mechanistic data are lacking regarding the comparative molecular pathogenesis of these cancers. METHODS: We conducted state-of-the-art imaging including CT and PET, clinical assessments, and pathological review of 24 rhesus macaques with naturally occurring CRC. Additionally, we molecularly characterized these tumors utilizing immunohistochemistry (IHC), microsatellite instability assays, DNAseq, transcriptomics, and developed a DNA methylation-specific qPCR assay for MLH1, CACNA1G, CDKN2A, CRABP1, and NEUROG1, human markers for CpG island methylator phenotype (CIMP)...
March 19, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38504158/pan-cancer-analysis-of-nup155-and-validation-of-its-role-in-breast-cancer-cell-proliferation-migration-and-apoptosis
#35
JOURNAL ARTICLE
Zi-Qiong Wang, Zhi-Xuan Wu, Zong-Pan Wang, Jing-Xia Bao, Hao-Dong Wu, Di-Yan Xu, Hong-Feng Li, Yi-Yin Xu, Rong-Xing Wu, Xuan-Xuan Dai
NUP155 is reported to be correlated with tumor development. However, the role of NUP155 in tumor physiology and the tumor immune microenvironment (TIME) has not been previously examined. This study comprehensively investigated the expression, immunological function, and prognostic significance of NUP155 in different cancer types. Bioinformatics analysis revealed that NUP155 was upregulated in 26 types of cancer. Additionally, NUP155 upregulation was strongly correlated with advanced pathological or clinical stages and poor prognosis in several cancers...
March 19, 2024: BMC Cancer
https://read.qxmd.com/read/38503722/cholesterol-depletion-induces-mesenchymal-properties-in-oral-squamous-cell-carcinoma-cell-line
#36
JOURNAL ARTICLE
Rebeca Barros do Nascimento, Paloma Souza Gonçalves Cerqueira, Jamerson Carvalho Silva, Elisa Kauark Fontes, Elias Almeida Dos Santos, Jean Nunes Dos Santos, Fábio Daumas Nunes, Maria Fernanda Setubal Destro Rodrigues, Katiúcia Batista Silva Paiva, Flávia Caló de Aquino Xavier
BACKGROUND: Cholesterol in cell membranes is crucial for cell signaling, adhesion, and migration. Membranes feature cholesterol-rich caveolae with caveolin proteins, playing roles in epithelial-mesenchymal transition and cancer progression. Despite elevated cholesterol levels in tumors, its precise function and the effects of its depletion in oral squamous cell carcinoma remain unclear. The aim of this study was to evaluate the influence of cholesterol depletion in oral squamous cell carcinoma cell line and epithelial-mesenchymal transition process...
March 19, 2024: Journal of Oral Pathology & Medicine
https://read.qxmd.com/read/38500181/molecular-and-clinicopathologic-characteristics-of-cns-embryonal-tumors-with-brd4-leutx-fusion
#37
JOURNAL ARTICLE
Felipe Andreiuolo, Christina K Ferrone, Sharika Rajan, Arie Perry, Ekin Guney, Elaine Cham, Caterina Giannini, Angus Toland, Nicholas Willard, Andrea Silveira de Souza, Karen Dazelle, Hye-Jung Chung, Omkar Singh, Kyle Conway, Nicholas Coley, Christopher Dampier, Zied Abdullaev, Drew Pratt, Patrick J Cimino, Martha Quezado, Kenneth Aldape
Central nervous system (CNS) embryonal tumors are a heterogeneous group of high-grade malignancies, and the increasing clinical use of methylation profiling and next-generation sequencing has led to the identification of molecularly distinct subtypes. One proposed tumor type, CNS tumor with BRD4::LEUTX fusion, has been described. As only a few CNS tumors with BRD4::LEUTX fusions have been described, we herein characterize a cohort of 9 such cases (4 new, 5 previously published) to further describe their clinicopathologic and molecular features...
March 18, 2024: Acta Neuropathologica Communications
https://read.qxmd.com/read/38499830/the-impact-of-dna-methylation-on-ctcf-mediated-3d-genome-organization
#38
REVIEW
Ana Monteagudo-Sánchez, Daan Noordermeer, Maxim V C Greenberg
Cytosine DNA methylation is a highly conserved epigenetic mark in eukaryotes. Although the role of DNA methylation at gene promoters and repetitive elements has been extensively studied, the function of DNA methylation in other genomic contexts remains less clear. In the nucleus of mammalian cells, the genome is spatially organized at different levels, and strongly influences myriad genomic processes. There are a number of factors that regulate the three-dimensional (3D) organization of the genome, with the CTCF insulator protein being among the most well-characterized...
March 2024: Nature Structural & Molecular Biology
https://read.qxmd.com/read/38496171/clinical-characteristics-and-neuroimaging-correlations-in-autoimmune-encephalitis-a-report-of-two-cases
#39
Carla B Graos, Victor M Montalvan, Percy Torres, Camila Coboj, Fernando S Geldres
Autoimmune encephalitis is an infrequent pathological occurrence documented within our local context. When clinical suspicion arises, employing electroencephalogram and brain magnetic resonance imaging (MRI) proves valuable. However, for conclusive diagnosis confirmation, lumbar puncture for cerebrospinal fluid (CSF) analysis is indispensable. Managing this condition involves a combination of immunosuppression and, when necessary, tumor resection. We document the initial cases reported in our city, featuring two young patients without significant pre-existing conditions...
February 2024: Curēus
https://read.qxmd.com/read/38495012/intratumoral-histological-and-molecular-heterogeneity-in-an-adult-diffuse-glioma
#40
JOURNAL ARTICLE
Trishhani Yogaretnam, Josephine Heffernan, Rosa Leung, Ciara Heeney, Andrea Walsh, Seamus Looby, John Caird, Francesca M Brett
Adult-type diffuse gliomas are the most prevalent type of malignant adult brain tumors. Intratumoral heterogeneity can hinder accurate diagnosis and subsequent treatment. This case report documents a tumor with intratumoral heterogeneity, both histologically and by methylation analysis, located within the left cerebral hemisphere of a 29-year-old female. She presented after a witnessed generalized tonic clonic seizure at home. Two years prior she had a witnessed seizure; however, no brain imaging was done at the time...
March 15, 2024: Clinical Neuropathology
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