Jeong Hyun Lee, Vishal M Gohil, Pedram Heidari, Jessica L Seidel, Mohammad Zulkifli, Ying Wei, Yuhua Ji, Ali Daneshmand, Umar Mahmood, Clary B Clish, Vamsi K Mootha, Cenk Ayata
BACKGROUND: Mild chemical inhibition of mitochondrial respiration can confer resilience against a subsequent stroke or myocardial infarction, also known as preconditioning. However, the lack of chemicals that can safely inhibit mitochondrial respiration has impeded the clinical translation of the preconditioning concept. We previously showed that meclizine, an over-the-counter antivertigo drug, can toggle metabolism from mitochondrial respiration toward glycolysis and protect against ischemia-reperfusion injury in the brain, heart, and kidney...
April 4, 2024: Stroke; a Journal of Cerebral Circulation