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Epigenetic trauma

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https://www.readbyqxmd.com/read/29748862/association-of-dna-methylation-in-bdnf-with-escitalopram-treatment-response-in-depressed-chinese-han-patients
#1
Peipei Wang, Cuizhen Zhang, Qinyu Lv, Chenxi Bao, Hong Sun, Guo Ma, Yiru Fang, Zhenghui Yi, Weimin Cai
PURPOSE: The neurotrophin brain-derived neurotrophic factor (BDNF) has been found to be associated with both the pathophysiology of depression and antidepressants response. Gene expression differences were partly mediated by SNP, which might be identified as a predictor of antidepressant response. In the present study, we attempt to identify whether DNA methylation, another factor known to affect gene transcription, might also predict antidepressant response. METHODS: A total of 85 depressed Chinese Han patients were followed-up 8 weeks after initiating escitalopram treatment...
May 10, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29739062/new-molecular-and-epigenetic-expressions-as-novel-biomarkers-in-critically-ill-polytrauma-patients-with-acute-kidney-injury-aki
#2
REVIEW
Mihaela V Ivan, Alexandru F Rogobete, Ovidiu H Bedreag, Marius Papurica, Sonia E Popovici, Anca Dinu, Mihai Sandesc, Andrei Beceanu, Lavinia M Bratu, Calin M Popoiu, Dorel Sandesc, Ovidiu Boruga, Lazar Fulger
BACKGROUND: A high percentage of the critically ill polytrauma patients develop acute kidney injury (AKI) secondary to trauma and are therefore prone to high morbidity and mortality rates. One of the main objectives in these cases is the fast detection of the condition and continuous rigorous monitoring of the patients. Currently the panel of biomarkers available for monitoring and for the prognosis of AKI is limited. Numerous studies have proven the importance of microRNAs in this field...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29738444/the-effects-of-trauma-with-or-without-ptsd-on-the-transgenerational-dna-methylation-alterations-in-human-offsprings
#3
REVIEW
Nagy A Youssef, Laura Lockwood, Shaoyong Su, Guang Hao, Bart P F Rutten
Exposure to psychological trauma is a strong risk factor for several debilitating disorders including post-traumatic stress disorder (PTSD) and depression. Besides the impact on mental well-being and behavior in the exposed individuals, it has been suggested that psychological trauma can affect the biology of the individuals, and even have biological and behavioral consequences on the offspring of exposed individuals. While knowledge of possible epigenetic underpinnings of the association between exposure to trauma and risk of PTSD has been discussed in several reviews, it remains to be established whether trauma-induced epigenetic modifications can be passed from traumatized individuals to subsequent generations of offspring...
May 8, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29707086/epigenetics-of-metabolic-syndrome-as-a-mood-disorder
#4
REVIEW
Sermin Kesebir
Mood disorders comprise major depressive disorder (MDD), bipolar disorder (BD) and the milder forms of these two disorders. Reccurring MDD is also known as unipolar disorder. The distinction between unipolar and bipolar disorders was first suggested in 1957 by Leonard and was made official after support by several studies in 1980. Indeed, in 150 AD, Aretaeus of Cappadocia wrote "It seems to me that melancholia is the beginning and a part of mania". Additionally, Kraepelin, who proposed the first medical disease model in psychiatry a century ago, considered recurrent unipolar depression cases under the category of bipolar disorder and conceptualized spectrum disorders...
June 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29674970/hypothesis-the-psychedelic-ayahuasca-heals-traumatic-memories-via-a-sigma-1-receptor-mediated-epigenetic-mnemonic-process
#5
Antonio Inserra
Ayahuasca ingestion modulates brain activity, neurotransmission, gene expression and epigenetic regulation. N,N -Dimethyltryptamine (DMT, one of the alkaloids in Ayahuasca) activates sigma 1 receptor (SIGMAR1) and others. SIGMAR1 is a multi-faceted stress-responsive receptor which promotes cell survival, neuroprotection, neuroplasticity, and neuroimmunomodulation. Simultaneously, monoamine oxidase inhibitors (MAOIs) also present in Ayahuasca prevent the degradation of DMT. One peculiarity of SIGMAR1 activation and MAOI activity is the reversal of mnemonic deficits in pre-clinical models...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29656664/epigenetic-aging-in-major-depressive-disorder
#6
Laura K M Han, Moji Aghajani, Shaunna L Clark, Robin F Chan, Mohammad W Hattab, Andrey A Shabalin, Min Zhao, Gaurav Kumar, Lin Ying Xie, Rick Jansen, Yuri Milaneschi, Brian Dean, Karolina A Aberg, Edwin J C G van den Oord, Brenda W J H Penninx
OBJECTIVE: Major depressive disorder is associated with an increased risk of mortality and aging-related diseases. The authors examined whether major depression is associated with higher epigenetic aging in blood as measured by DNA methylation (DNAm) patterns, whether clinical characteristics of major depression have a further impact on these patterns, and whether the findings replicate in brain tissue. METHOD: DNAm age was estimated using all methylation sites in blood of 811 depressed patients and 319 control subjects with no lifetime psychiatric disorders and low depressive symptoms from the Netherlands Study of Depression and Anxiety...
April 16, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29623448/recent-genetics-and-epigenetics-approaches-to-ptsd
#7
REVIEW
Nikolaos P Daskalakis, Chuda M Rijal, Christopher King, Laura M Huckins, Kerry J Ressler
PURPOSE OF REVIEW: Following a life-threatening traumatic exposure, about 10% of those exposed are at considerable risk for developing posttraumatic stress disorder (PTSD), a severe and disabling syndrome characterized by uncontrollable intrusive memories, nightmares, avoidance behaviors, and hyperarousal in addition to impaired cognition and negative emotion symptoms. This review will explore recent genetic and epigenetic approaches to PTSD that explain some of the differential risk following trauma exposure...
April 5, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29555185/genomic-approaches-to-posttraumatic-stress-disorder-the-psychiatric-genomic-consortium-initiative
#8
REVIEW
Caroline M Nievergelt, Allison E Ashley-Koch, Shareefa Dalvie, Michael A Hauser, Rajendra A Morey, Alicia K Smith, Monica Uddin
Posttraumatic stress disorder (PTSD) after exposure to a traumatic event is a highly prevalent psychiatric disorder. Heritability estimates from twin studies as well as from recent molecular data (single nucleotide polymorphism-based heritability) indicate moderate to high heritability, yet robust genetic variants for PTSD have not yet been identified and the genetic architecture of this polygenic disorder remains largely unknown. To date, fewer than 10 large-scale genome-wide association studies of PTSD have been published, with findings that highlight the unique challenges for PTSD genomics, including a complex diagnostic entity with contingency of PTSD diagnosis on trauma exposure and the large genetic diversity of the study populations...
February 2, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29513367/the-familial-aggregation-of-atopic-diseases-and-depression-or-anxiety-in-children
#9
B K Brew, C Lundholm, T Gong, H Larsson, C Almqvist
BACKGROUND: Children with asthma and atopic diseases have an increased risk of depression or anxiety. Each of these diseases has strong genetic and environmental components; therefore, it seems likely that there is a shared liability rather than causative risk. OBJECTIVE: To investigate the existence and nature of familial aggregation for the comorbidity of atopic diseases and depression or anxiety. METHODS: Participants came from the Childhood and Adolescent Twin Study in Sweden (CATSS), n = 14 197...
March 7, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29478287/altered-epigenetic-pathways-and-cell-cycle-dysregulation-in-healthy-appearing-skin-of-patients-with-koebnerized-squamous-cell-carcinomas-following-skin-surgery
#10
T Gambichler, I Rüddel, S Hessam, F G Bechara, E Stockfleth, L Schmitz
BACKGROUND: Koebnerized non-melanoma skin cancer following skin trauma represents a rare and obscure event. OBJECTIVES: To study molecular pathological parameters in koebnerized squamous cell carcinomas (K-SCCs) occurring after complete tumour removal. METHODS: We assessed two patients with multiple sclerosis who were on treatment with dimethylfumarate (DMF) preceded by long-term azathioprine therapy. Both patients rapidly developed several K-SCCs following histopathologically proven complete excision of cutaneous SCCs...
February 25, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29475430/systematic-review-of-pediatric-health-outcomes-associated-with-childhood-adversity
#11
Debora Lee Oh, Petra Jerman, Sara Silvério Marques, Kadiatou Koita, Sukhdip Kaur Purewal Boparai, Nadine Burke Harris, Monica Bucci
BACKGROUND: Early detection of and intervention in childhood adversity has powerful potential to improve the health and well-being of children. A systematic review was conducted to better understand the pediatric health outcomes associated with childhood adversity. METHODS: PubMed, PsycArticles, and CINAHL were searched for relevant articles. Longitudinal studies examining various adverse childhood experiences and biological health outcomes occurring prior to age 20 were selected...
February 23, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29452766/traumatic-stress-and-accelerated-dna-methylation-age-a-meta-analysis
#12
Erika J Wolf, Hannah Maniates, Nicole Nugent, Adam X Maihofer, Don Armstrong, Andrew Ratanatharathorn, Allison E Ashley-Koch, Melanie Garrett, Nathan A Kimbrel, Adriana Lori, Va Mid-Atlantic Mirecc Workgroup, Allison E Aiello, Dewleen G Baker, Jean C Beckham, Marco P Boks, Sandro Galea, Elbert Geuze, Michael A Hauser, Ronald C Kessler, Karestan C Koenen, Mark W Miller, Kerry J Ressler, Victoria Risbrough, Bart P F Rutten, Murray B Stein, Robert J Ursano, Eric Vermetten, Christiaan H Vinkers, Monica Uddin, Alicia K Smith, Caroline M Nievergelt, Mark W Logue
BACKGROUND: Recent studies examining the association between posttraumatic stress disorder (PTSD) and accelerated aging, as defined by DNA methylation-based estimates of cellular age that exceed chronological age, have yielded mixed results. METHODS: We conducted a meta-analysis of trauma exposure and PTSD diagnosis and symptom severity in association with accelerated DNA methylation age using data from 9 cohorts contributing to the Psychiatric Genomics Consortium PTSD Epigenetics Workgroup (combined N = 2186)...
June 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29448178/modification-of-the-association-between-antipsychotic-treatment-response-and-childhood-adversity-by-mmp9-gene-variants-in-a-first-episode-schizophrenia-cohort
#13
Nathaniel McGregor, Nicole Thompson, Kevin Sean O'Connell, Robin Emsley, Lize van der Merwe, Louise Warnich
Antipsychotics remain the most effective, and wide used option for ameliorating the symptoms of schizophrenia. However, inter-individual differences in treatment outcome are vast and suggest a role for genetic and environmental factors in affording favourable outcomes. A notable epigenetic relationship which has gained considerable traction in recent literature is the way in which the severity of childhood trauma can modify associations seen between genetic variation and antipsychotic treatment response. A potential mechanism of action which may facilitate this relationship is synaptic plasticity...
April 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29433843/biological-alterations-affecting-risk-of-adult-psychopathology-following-childhood-trauma-a-review-of-sex-differences
#14
REVIEW
Ashwini Tiwari, Andrea Gonzalez
Childhood trauma exposure is a significant public health problem. While adult mental health consequences of such experiences are well documented, sex differences in both prevalence and severity are less understood. Sex-based differences in biological circuitry and physiological trauma responses are proposed to potentiate the differential risk for pathogenesis of mental health disorders among adults. This paper will provide a contextualized summary of neuroendocrine, neuroimaging, and behavioral epigenetic studies on biological sex differences contributing to internalizing psychopathology, specifically posttraumatic stress disorder and depression, among adults with a history of childhood abuse...
February 2, 2018: Clinical Psychology Review
https://www.readbyqxmd.com/read/29433075/glucocorticoid-receptor-gene-methylation-moderates-the-association-of-childhood-trauma-and-cortisol-stress-reactivity
#15
Nina Alexander, Clemens Kirschbaum, Matthis Wankerl, Benjamin J Stauch, Tobias Stalder, Susann Steudte-Schmiedgen, Markus Muehlhan, Robert Miller
Exposure to childhood trauma (CT) has been linked to sustained dysregulations of major stress response systems, including findings of both exaggerated and attenuated hypothalamus-pituitary-adrenal (HPA) axis activity. Likewise, CT constitutes a common risk factor for a broad range of psychiatric conditions that involve distinct neuroendocrine profiles. In this study, we investigated the role of epigenetic variability in a stress-related gene as a potential mediator or moderator of such differential trajectories in CT survivors...
April 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29415058/integration-of-neural-and-epigenetic-contributions-to-posttraumatic-stress-symptoms-the-role-of-hippocampal-volume-and-glucocorticoid-receptor-gene-methylation
#16
M Windy McNerney, Tong Sheng, Jordan M Nechvatal, Alex G Lee, David M Lyons, Salil Soman, Chun-Ping Liao, Ruth O'Hara, Joachim Hallmayer, Joy Taylor, J Wesson Ashford, Jerome Yesavage, Maheen M Adamson
Many Veterans exposed to physical and psychological trauma experience symptoms of posttraumatic stress disorder (PTSD). As the etiology of PTSD symptoms is complex, a better understanding of the underlying biological mechanisms may improve preventative care and treatment for PTSD. Recent findings from the fields of neuroimaging and epigenetics offer important insights into the potential brain structures and biochemical pathways of modified gene expression associated with PTSD. We combined neuroimaging and epigenetic measures to assess current PTSD symptoms by measuring overall hippocampal volume and methylation of the glucocorticoid receptor (GR) gene (promoter region)...
2018: PloS One
https://www.readbyqxmd.com/read/29408885/ezh2-does-not-mediate-retinal-ganglion-cell-homeostasis-or-their-susceptibility-to-injury
#17
Lin Cheng, Lucy J Wong, Naihong Yan, Richard C Han, Honghua Yu, Chenying Guo, Khulan Batsuuri, Aniket Zinzuwadia, Ryan Guan, Kin-Sang Cho, Dong Feng Chen
Epigenetic predisposition is thought to critically contribute to adult-onset disorders, such as retinal neurodegeneration. The histone methyltransferase, enhancer of zeste homolog 2 (Ezh2), is transiently expressed in the perinatal retina, particularly enriched in retinal ganglion cells (RGCs). We previously showed that embryonic deletion of Ezh2 from retinal progenitors led to progressive photoreceptor degeneration throughout life, demonstrating a role for embryonic predisposition of Ezh2-mediated repressive mark in maintaining the survival and function of photoreceptors in the adult...
2018: PloS One
https://www.readbyqxmd.com/read/29362489/genetic-variant-in-cacna1c-is-associated-with-ptsd-in-traumatized-police-officers
#18
Izabela M Krzyzewska, Judith B M Ensink, Laura Nawijn, Adri N Mul, Saskia B Koch, Andrea Venema, Vinod Shankar, Jessie L Frijling, Dirk J Veltman, Ramon J L Lindauer, Miranda Olff, Marcel M A M Mannens, Mirjam van Zuiden, Peter Henneman
Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder that may develop after a traumatic event. Here we aimed to identify epigenetic and genetic loci associated with PTSD. We included 73 traumatized police officers with extreme phenotypes regarding symptom severity despite similar trauma history: n = 34 had PTSD and n = 39 had minimal PTSD symptoms. Epigenetic and genetic profiles were based on the Illumina HumanMethylation450 BeadChip. We searched for differentially methylated probes (DMPs) and differentially methylated regions (DMRs)...
February 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29285792/kernel-machine-methods-for-integrative-analysis-of-genome-wide-methylation-and-genotyping-studies
#19
Ni Zhao, Xiang Zhan, Yen-Tsung Huang, Lynn M Almli, Alicia Smith, Michael P Epstein, Karen Conneely, Michael C Wu
Many large GWAS consortia are expanding to simultaneously examine the joint role of DNA methylation in addition to genotype in the same subjects. However, integrating information from both data types is challenging. In this paper, we propose a composite kernel machine regression model to test the joint epigenetic and genetic effect. Our approach works at the gene level, which allows for a common unit of analysis across different data types. The model compares the pairwise similarities in the phenotype to the pairwise similarities in the genotype and methylation values; and high correspondence is suggestive of association...
March 2018: Genetic Epidemiology
https://www.readbyqxmd.com/read/29279330/microrna-146-and-cell-trauma-down-regulate-expression-of-the-psoriasis-associated-atypical-chemokine-receptor-ackr2
#20
Kave Shams, Mariola Kurowska-Stolarska, Fabian Schütte, A David Burden, Clive S McKimmie, Gerard J Graham
Chemokines are the principal regulators of leukocyte migration and are essential for initiation and maintenance of inflammation. Atypical chemokine receptor 2 (ACKR2) binds and scavenges proinflammatory CC-chemokines, regulates cutaneous T-cell positioning, and limits the spread of inflammation in vivo Altered ACKR2 function has been implicated in several inflammatory disorders, including psoriasis, a common and debilitating T-cell-driven disorder characterized by thick erythematous skin plaques. ACKR2 expression is abnormal in psoriatic skin, with decreased expression correlating with recruitment of T-cells into the epidermis and increased inflammation...
February 23, 2018: Journal of Biological Chemistry
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