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https://www.readbyqxmd.com/read/29161590/skin-and-its-regenerative-powers-an-alliance-between-stem-cells-and-their-niche
#1
REVIEW
Kevin Andrew Uy Gonzales, Elaine Fuchs
Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A high demand is placed on renewal and regeneration of the skin's barrier in order to protect the body from infection and dehydration and to heal wounds. This review focuses on the epithelial stem cells of skin, where they come from, where they reside, and how they function in normal homeostasis and wound repair...
November 20, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29161332/osteoglycin-inhibition-by-microrna-mir-155-impairs-myogenesis
#2
Paula Paccielli Freire, Sarah Santiloni Cury, Grasieli de Oliveira, Geysson Javier Fernandez, Leonardo Nazario Moraes, Bruno Oliveira da Silva Duran, Juarez Henrique Ferreira, César Seigi Fuziwara, Edna Teruko Kimura, Maeli Dal-Pai-Silva, Robson Francisco Carvalho
Skeletal myogenesis is a regulated process in which mononucleated cells, the myoblasts, undergo proliferation and differentiation. Upon differentiation, the cells align with each other, and subsequently fuse to form terminally differentiated multinucleated myotubes. Previous reports have identified the protein osteoglycin (Ogn) as an important component of the skeletal muscle secretome, which is expressed differentially during muscle development. However, the posttranscriptional regulation of Ogn by microRNAs during myogenesis is unknown...
2017: PloS One
https://www.readbyqxmd.com/read/29161095/resection-induced-leveling-of-elevated-plug-cartilage-in-osteochondral-autologous-transplantation-of-the-knee-achieves-acceptable-clinical-results
#3
Kohei Nishitani, Yasuaki Nakagawa, Shinichiro Nakamura, Shogo Mukai, Shinichi Kuriyama, Shuichi Matsuda
BACKGROUND: Plug protuberance occasionally occurs in osteochondral autologous transplantation (OAT). The incongruity of plugs results in poor clinical outcomes, especially in cases of protuberance. However, a surgical procedure to deal with this problem has not been reported. Purpose/Hypothesis: The purpose was to evaluate the efficacy and safety of cartilage resection of elevated plugs, with the hypothesis that patients whose elevated plugs were resected and leveled would achieve clinical outcomes equivalent to those of patients with flush plugs...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29161065/from-nuremberg-to-guantanamo-bay-uses-of-physicians-in-the-war-on-terror
#4
Sondra S Crosby, Gilbert Benavidez
Seventy years after the Nuremberg Doctors' Trial, health professionals and lawyers working together after 9/11 played a critical role in designing, justifying, and carrying out the US state-sponsored torture program in the CIA "Black Sites" and US military detention centers, including Abu Ghraib, Bagram, and Guantanamo Bay, Cuba. We analyze the similarities between the Nazi doctors and health professionals in the War on Terror and address the question of how it happened that health professionals, including doctors, psychologists, physician assistants, and nurses, acted as agents of the state to utilize their medical and healing skills to cause harm and sanitize barbarous acts, similar to (though not on the scale of) how Nazi doctors were used by the Third Reich...
November 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29160975/peritoneal-dialysis-access-management-more-than-skin-deep
#5
Susan Bridger
Providing care and education for a patient on peritoneal dialysis (PD) requires that the nephrology nurse have knowledge and expertise in the PD access. This article provides information on types and placement of PD catheters, pre-placement and post-placement education and care, how to assess PD catheter exit site healing, and initial use of the PD catheter for access.
September 2017: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29160857/synergistic-effects-of-danshen-salvia-miltiorrhizae-radix-et-rhizoma-and-sanqi-notoginseng-radix-et-rhizoma-combination-in-angiogenesis-behavior-in-eahy-926-cells
#6
Xian Zhou, Valentina Razmovski-Naumovski, Antony Kam, Dennis Chang, Chunguang Li, Alan Bensoussan, Kelvin Chan
Background: This study investigated the combination effects of the Danshen and Sanqi herb pair on angiogenesis in vitro. Methods: Nine combination ratios of Danshen-Sanqi extracts (DS-SQ) were screened for their angiogenic effects in the human vascular endothelial EAhy 926 cell line via cell proliferation, cell migration and tube formation activities against the damage to the cells exerted by DL-homocysteine (Hcy) and adenosine (Ado). The type of interaction (synergistic, antagonistic, additive) between Danshen and Sanqi was analyzed using combination index (CI) and isobologram models...
November 21, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29160629/chitosan-and-its-composites-properties-for-use-in-bone-substitution
#7
REVIEW
Marek Stępniewski, Jacek Martynkiewicz, Jerzy Gosk
For many years, research has been carried out on finding an ideal bone substitute. Chitosan (CTS) is a naturally occurring polysaccharide, obtained mainly from, inter alia, the shells of crustaceans. It is characterized by its high level of biocompatibility, biodegradability and antimicrobial properties as well as its support in the healing of wounds. Chitosan, due to its ability to form porous structures, can be used in the production of scaffolds used in the treatment of bone defects. There are numerous studies on the use of CTS in combination with other substances which aim to improve its biological and mechanical properties...
January 2017: Polimery W Medycynie
https://www.readbyqxmd.com/read/29160619/tendinopathy-diagnosis-and-treatment-monitoring-using-attenuated-total-reflectance-fourier-transform-infrared-spectroscopy
#8
Tanmoy T Bhattacharjee, Mariana C Nicodemo, Luciana B Sant'Anna, Emilia A Lo Schiavo Arisawa, Leandro Raniero
Tendinopathy, an important sports injury afflicting athletes and general public, is associated with huge economic losses. The currently used diagnostic tests are subjective, show moderate sensitivity and specificity; while treatment failures persist despite advances in therapy. This highlights the need for tendinopathy diagnostic and treatment monitoring tools. The current study investigates tendon injury, natural healing and effect of treatment using ATR-FTIR complemented with histopathology. Control (C), injured (I) and treated (T) rat tendons were extracted 3, 7, 14 and 28 days post injury/treatment, representing phases of healing; and subjected to H&E staining as well as spectroscopy...
November 21, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29160425/local-and-systemic-effects-of-fibrin-and-cyanoacrylate-adhesives-on-lung-lesions-in-rabbits
#9
Marcus V H Carvalho, Evaldo Marchi, Andre J Fruchi, Bruno V B Dias, Clovis L Pinto, Geovane R Dos Santos, Milena M P Acencio
OBJECTIVES: Tissue adhesives can be used to prevent pulmonary air leaks, which frequently occur after lung interventions. The objective of this study is to evaluate local and systemic effects of fibrin and cyanoacrylate tissue adhesives on lung lesions in rabbits. METHODS: Eighteen rabbits were submitted to videothoracoscopy + lung incision alone (control) or videothoracoscopy + lung incision + local application of fibrin or cyanoacrylate adhesive. Blood samples were collected and assessed for leukocyte, neutrophil and lymphocyte counts and interleukin-8 levels preoperatively and at 48 hours and 28 days post-operatively...
October 2017: Clinics
https://www.readbyqxmd.com/read/29160369/biomechanical-study-of-the-effect-of-platelet-rich-plasma-on-the-treatment-of-medial-collateral-ligament-lesion-in-rabbits
#10
Eduardo Louzada da Costa, Luiz Eduardo Moreira Teixeira, Bruno Jannotti Pádua, Ivana Duval de Araújo, Leonardo de Souza Vasconcellos, Luide Scalioni Borges Dias
PURPOSE: To evaluate the use of platelet-rich plasma in the early stages of healing of traumatic injury of the medial collateral ligament in the knee of rabbits. METHODS: Thirty rabbits were subjected to surgical lesion of the medial collateral ligament. Of these, 16 were treated with platelet-rich plasma and 14 with saline (control). After 3 and 6 weeks of treatment, 50% of the animals from each group were sacrificed, and biomechanical tests were performed on the injured ligament to compare the tensile strength between the two groups...
October 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29160182/enhanced-bone-regeneration-via-diabetic-cell-based-adenoviral-bmp2-gene-therapy-in-diabetic-animals
#11
Shin-Young Park, Kyoung-Hwa Kim, Chan Ho Park, Seung-Yun Shin, In-Chul Rhuy, Yong-Moo Lee, Yang Jo Seol
The application of bone morphogenetic protein 2 (BMP-2) has been extensively investigated to improve diabetes-impaired bone healing; however, the delivery of BMP-2 via gene therapy for bone regeneration has rarely been investigated in diabetic animals. In this study, we aimed to evaluate which cells induce more new bone formation in diabetic animals when cell-based BMP2 gene therapy is applied. For this purpose, we harvested bone marrow stromal cells (BMSCs) twice in the same animal before (non-diabetic BMSCs; nBMSCs) and after diabetes induction (diabetic BMSCs; dBMSCs) using modified bone marrow ablation methods...
November 21, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29160147/impact-of-complete-spinal-cord-injury-on-healing-of-skin-ulcers-in-mouse-models
#12
Suneel Kumar, Martin L Yarmush, Biraja C Dash, Henry C Hsia, Francois Berthiaume
Pressure ulcers (PUs) are common debilitating complications of traumatic spinal cord injury (SCI) and tend to occur in soft tissues around bony prominences. There is, however, little known about the impact of SCI on skin wound healing due to the lack of suitable animal models for studies in controlled experimental settings. Herein we describe a reproducible and clinically relevant mouse model of PUs in the context of complete SCI. Adult male mice (BALB/c) were subjected to thoracic (T9-T10) complete SCI. Immediately after, a skin fold on the back of the mice was lifted and sandwiched between two magnetic discs held in place for 12 hours, thus creating an ischemic area that developed into a PU over the following days...
November 21, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29160090/two-consecutive-cases-of-persistent-stapedial-artery-managed-with-a-carbon-dioxide-laser
#13
Shawn M Stevens, Zoe A Walters, Kareem Tawfik, Ravi N Samy
OBJECTIVE: (1) Discuss the presentation and management of persistent stapedial artery (PSA) discovered incidentally during cholesteatoma surgery. (2) Review use of carbon dioxide (CO2) laser for treatment of PSA in the setting of chronic ear disease. PATIENTS: Two consecutive patients with PSA and primary acquired cholesteatoma. INTERVENTION(S): Tympanomastoidectomy using a canal wall reconstruction technique. MAIN OUTCOME MEASURE(S): Surgical healing, collateral damage to surrounding anatomy, and postoperative hearing...
November 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29160038/endoplasmic-reticulum-in-health-and-disease-the-12th-international-calreticulin-workshop-delphi-greece
#14
REVIEW
Aristidis S Charonis, Marek Michalak, Jody Groenendyk, Luis B Agellon
Starting from 1994, every 2 years, an international workshop is organized focused on calreticulin and other endoplasmic reticulum chaperones. In 2017, the workshop took place at Delphi Greece. Participants from North and South America, Europe, Asia and Australia presented their recent data and discussed them extensively with their colleagues. Presentations dealt with structural aspects of calreticulin and calnexin, the role of Ca(2+) in cellular signalling and in autophagy, the endoplasmic reticulum stress and the unfolded protein response, the role of calreticulin in immune responses...
November 21, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29159911/early-mechanical-stimulation-only-permits-timely-bone-healing-in-sheep
#15
Tufekci Pelin, Tavakoli Aramesh, Dlaska Constantin, Neumann Mirjam, Shanker Mihir, Saifzadeh Siamak, Steck Roland, Schuetz Michael, Epari Devakar
Bone fracture healing is sensitive to the fixation stability. However, it is unclear which phases of healing are mechano-sensitive and if mechanical stimulation is required throughout repair. In this study, a novel bone defect model, which isolates an experimental fracture from functional loading, was applied in sheep to investigate if stimulation limited to the early proliferative phase is sufficient for bone healing. An active fixator controlled motion in the fracture. Animals of the control group were unstimulated...
November 21, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29159900/p100-functions-as-a-metastasis-activator-and-is-targeted-by-tumor-suppressing-microrna-320a-in-lung-cancer
#16
Aimin Xing, Li Pan, Jingzhen Gao
BACKGROUND: Lung cancer is among the most frequently diagnosed types of cancer worldwide, with high morbidity and mortality. Metastasis accounts for the deadliest and most poorly understood feature of lung cancer. Herein, we demonstrate that SND1 (also known as p100) acts as a candidate metastasis activator and is targeted by microRNA-320a (miR-320a) in lung cancer cells. METHODS: p100 expression in lung cancer cell lines and tissues was determined by quantitative real time-PCR and Western blot...
November 21, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/29159695/a-novel-lignin-based-nanofibrous-dressing-containing-arginine-for-wound-healing-applications
#17
Fatemeh Reesi, Mohsen Minaiyan, Azade Taheri
Nanofiber-based wound dressings have attracted much attention in wound care owing to their unique properties such as high aspect ratio and three-dimensional structure. Arginine is a precursor of nitric oxide that plays an important role in the wound-healing process. Therefore, in this study, we have developed a gel which contains lignin nanofibers (Lig-NFs) that were surface modified by arginine molecules via electrostatic interaction (Arg-Lig-NF gel). The effect of pH on the amount of arginine attached on Lig-NF surface was evaluated at three different pH values-5, 6, and 7...
November 20, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29159589/the-effect-of-mindfulness-based-stress-reduction-on-wound-healing-a-preliminary-study
#18
Astrid Meesters, Yvo M C In den Bosch-Meevissen, Chantal A H Weijzen, Wim A Buurman, Mario Losen, Jan Schepers, Monique R T M Thissen, Hugo J E M Alberts, Casper G Schalkwijk, Madelon L Peters
Psychological factors have been shown to influence the process of wound healing. This study examined the effect of Mindfulness-Based Stress Reduction (MBSR) on the speed of wound healing. The local production of pro-inflammatory cytokines and growth factors was studied as potential underlying mechanism. Forty-nine adults were randomly allocated to a waiting-list control group (n = 26) or an 8-week MBSR group (n = 23). Pre- and post-intervention/waiting period assessment for both groups consisted of questionnaires...
November 20, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29159531/very-early-neointimal-coverage-of-new-biodegradable-polymer-drug-eluting-stent-compared-with-durable-polymer-everolimus-eluting-stent-evaluated-by-optical-frequency-domain-imaging
#19
Norihiro Kobayashi, Yoshiaki Ito, Masahiro Yamawaki, Motoharu Araki, Tsuyoshi Sakai, Yasunari Sakamoto, Shinsuke Mori, Masakazu Tsutsumi, Masahiro Nauchi, Yohsuke Honda, Takahiro Tokuda, Kenji Makino, Shigemitsu Shirai, Keisuke Hirano
Polymeric component is associated with the increased risk of delayed vessel healing and stent endothelialization. We aimed to clarify neointimal coverage within 1 month after implantation of the new-generation abluminal biodegradable polymer (BP) drug-eluting stent (DES) compared with the second-generation durable polymer (DP) everolimus-eluting stent (EES). Between November 2015 and October 2016, 32 BP-DES and 25 DP-EES were evaluated by optical frequency domain imaging (OFDI) within 1 month after the procedure...
November 20, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29159515/the-effect-of-low-level-laser-therapy-660%C3%A2-nm-on-the-gene-expression-involved-in-tissue-repair
#20
Stheace Kelly Fernandes Szezerbaty, Rodrigo Franco de Oliveira, Deise A A Pires-Oliveira, Cristina Pacheco Soares, Daniele Sartori, Regina Célia Poli-Frederico
The effect of low-level laser therapy (LLLT) on the healing of skin lesions has been evaluated in many studies; however, the molecular mechanisms involved in the biostimulatory effects resulting from this treatment need to be better understood. The paper aims to analyze the effects of LLLT (660 nm) at doses of 1 and 5 J/cm(2) on cell viability and expression of vascular endothelial growth factor (VEGF) and interleukin (IL6) genes in L929 fibroblast cells. The dose-response curve was performed with the GaInAlAs (660 nm) laser-treated cells at energy rates of 1 and 5 J/cm(2)...
November 20, 2017: Lasers in Medical Science
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