Strok

OBJECTIVE: This study aims to comprehensively assess the characteristics of patent foramen ovale (PFO) in relation to Cryptogenic Strok (CS) by utilizing transesophageal echocardiography (TEE) and contrast transthoracic echocardiography (c-TTE) and to identify high-risk factors associated with PFO-related CS. BACKGROUND: Transcatheter PFO closure has demonstrated its effectiveness in preventing PFO-related CS. Therefore, understanding the specific structural attributes of PFO associated with CS is imperative...

INTRODUCTION: Carotid Artery Stenosis (CAS) is common in elderly patients undergoing Transcatheter Aortic Valve Replacement (TAVR). However, the impact of CAS on the outcomes of TAVR is unclear. PURPOSE: This systematic review and meta-analysis aimed to compare the clinical and periprocedural outcomes in patients with and without CAS undergoing TAVR. METHODS: PubMed, Embase, and Cochrane databases were searched until February 2023. We included studies that performed a direct comparison of outcomes of TAVR in CAS versus non-CAS patients...

BACKGROUND: Pueraria lobata is an important herbal medicine of Fabaceae family that has been clinically used in Traditional Chinese Medicine to counteract human disorders and associated secondary complications. Kakkalide also called irisolidone 7-xylosylglucoside is an isoflavonoid of Puerariae flos, Pueraria lobata and Flos Puerariae. Moreover, Kakkalide has a wide range of bioactivities in medicine. METHODS: Biological potential of kakkalide was investigated in the present work through scientific data analysis of different scientific research work on kakkalide in order to know its therapeutic potential in medicine...

BACKGROUND: Initial D-dimer level is a well-known prognostic parameter in patients with acute ischemic stroke (AIS). However, there have been no studies on the clinical significance of follow-up D-dimer levels. In this study, we evaluated the association between initial and follow-up D-dimer levels and early neurological deterioration (END) in patients with AIS. METHODS: We included consecutive patients with AIS who had a positive initial D-dimer test (> 0...

Focal ischemia occurs when an embolus or thrombus occludes an artery, causing the rapid obstruction of cerebral blood flow. Although stroke represents a main cause of disability and mortality in developing countries, therapeutic approaches available for this condition remain very limited. The aim of the present study was to examine the effects of the phytochemical, 6-gingerol, on the brain infarct volume, neuronal loss and on the oxidative stress parameters, cyclooxygenase-2 (COX-2) and interleukin (IL)-6, in an animal model of focal ischemic stroke...

Obesity is a major risk factor for type 2 diabetes, coronary heart disease, and strok. These diseases are associated with profound alterations in gene expression in metabolic tissues. Epigenetic-mediated regulation of gene expression is one mechanism through which environmental factors, such as diet, modify gene expression and disease predisposition. However, epigenetic control of gene expression in obesity and insulin resistance is not fully characterized. We discovered that liver-specific stearoyl-CoA desaturase-1 (Scd1) knockout mice (LKO) fed a high-carbohydrate low-fat diet exhibit dramatic changes in hepatic gene expression and metabolites of the folate cycle and one-carbon metabolism respectively for the synthesis of S-adenosylmethionine (SAM)...

Bio-monitoring of mercury (Hg) in air using transplanted and in-situ lichens was conducted at three locations in Slovenia: (I) the town of Idrija in the area of the former Hg mine, where Hg contamination is well known; (II) Anhovo, a settlement with a cement production plant, which is a source of Hg pollution, and (III) Pokljuka, a part of a national park. Lichens from Pokljuka were transplanted to different sites and sampled four times-once per season, from January 2020 to February 2021. Lichens were set on tree branches, fences, and under cover, allowing them to be exposed to different environmental conditions (e...

Coal ash deposited in open landfills is a potential source of environmental pollutants due to the contained toxic element content. The weathered coal ash used in this study additionally contains enhanced activity concentrations of 238 U series radionuclides. This study aimed to determine the physiological effects of enhanced ionizing radiation and toxic elements on five plant species (smilo grass, sticky fleabane, blackberry, mastic and pine tree) inhabiting the coal ash disposal site. Among the potentially toxic measured elements, contents of Sb, As and especially V significantly exceeded their respective levels at the control site, as well as the content of 238 U and its progenies...

Non-controlled usage of mineral fertilisers in agriculture land of Kazakhstan is a concerning issue, due to possible contamination of the soil by radionuclides. Pot experiment of growing of R. sativus with application of mineral fertilisers was carried out under natural conditions. Two commonly used mineral fertilisers, mono-potassium phosphate and ammonium nitrate, were chosen in the frame of current research to determine the impact of mineral fertiliser on transfer of natural radionuclides from soil to R...

BACKGROUND: Symptomatic intracranial hemorrhage (sICH) is a serious hemorrhagic complication after intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) patients. Most existing predictive scoring systems were derived from Western countries. OBJECTIVE: To develop a nomogram to predict the possibility of sICH after IVT in an Asian population. METHODS: This retrospective cohort study included AIS patients treated with recombinant tissue plasminogen activator (rt-PA) in a tertiary hospital in Shenzhen, China, from January 2014 to December 2020...

The concentration and isotopic composition of uranium (δ238 U, 234 U/238 U activity ratio) in combination with traditional isotopes (δ18 O, δ13 C) were examined as potential tracers of authigenic carbonate formation in a karst aquifer. The U concentration and 234 U/238 U activity ratios in the tufa-precipitating sections of two connected karst rivers (Krka and Zrmanja, Croatia) decreased downstream in water and in precipitated carbonate due to active self-purification processes, i.e. adsorption of isotopically lighter U(VI) on mineral particles, sedimentation and co-precipitation with carbonate...

OBJECTIVE: The objective is to compare the effect of general anesthesia (GA) and monitored anesthesia care (MAC) on clinical outcomes in patients with endovascular therapy for vertebrobasilar occlusion stroke. METHODS: 139 patients undergoing endovascular therapy for vertebrobasilar stroke, were recruited. The patients were randomized into GA group and MAC group (about 1:1 ratio). GA group received general anesthesia and MAC group received monitored anesthesia care during endovascular therapy...

Introduction: In the current days, stroke has become one of the common reasons for admission in many health care setups and becoming an alarming public health problem in Ethiopia. Hence, this study aimed to assess the incidence and associated factors of stroke among patients admitted to the medical wards in Yirgalem hospital. Methods: An institution-based retrospective cross-sectional study design was carried out from 01 January 2017, to 30 December 2019. Admitted adult patients' medical charts were used to collect all required information using structured checklists...

OBJECTIVES: Saffron ( Crocus sativus L. ) has been widely used in traditional medicine as a treatment of nervous disorders. Saffron as an antioxidant can be considered effective for treatment of oxidative stress in ischemia stroke. Therefore, the aim of the present study was to investigate the role of aqueous extract of saffron in reducing oxidative stress in ischemic strokes patients. METHODS: Forty patients with acute ischemic stroke were randomly divided into two groups including control group and saffron group...

Mobility is a fundamental characteristic of mammalian teeth, and has been widely used to determine individual tooth prognosis. However, the direction and extent of tooth movement under functional loads are unknown. This study investigated maxillary molar mobility, alveolar bending, and periodontal space (PDL) fluid pressure during mastication and masseter muscle contraction in young pigs, along with PDL space measurements. Twelve three-month-old farm pigs were instrumented with some or all of the following: (1) ultrasonic crystals, one implanted into the pulp chamber of a deciduous maxillary molar and additional crystals glued onto its buccal and palatal alveolar plates; (2) rosette strain gauges affixed to the buccal and palatal of alveolar ridges; (3) a pressure transducer inserted into palatal alveolar bone facing the PDL...

90 Sr detection efficiency determination was applied for liquid scintillation counting (LSC) by computing a model for the relation between detection efficiency and the time passed since radiochemical separation. This allowed more flexibility in analysis times after separation as the model accounts for 90 Y in-growth. Establishment of secular equilibrium was therefore not required for LSC measurements. In addition, this approach increases counting efficiency compared to classical ones as both 90 Sr and 90 Y spectrums are used...

Cyclophosphamide (CPA) is a most widely prescribed cancer chemotherapeutic agent which shows serious neurotoxic side effect. Generation of reactive oxygen species at cellular level is basic mechanism of cyclophosphamide induced neurotoxicity. Edaravone is the synthetic drug used it brain strok havening potent antioxidant property. This study aimed to investigate the effect of edaravone on neurobehavioral and neuropathological alteration induced by cyclophosphamide in male rats. Twenty eight Sprague-Dawley rats were equally divided into four groups of seven rats in each...

Tobacco and tobacco smoke are very complex mixtures. In addition to various chemical and organic compounds they also contain natural radioactive elements (radionuclides). In this work, the natural radionuclide activity concentrations ((234)U, (238)U, (228)Th, (230)Th, (232)Th, (226)Ra, (210)Pb and (210)Po) of nine different cigarette samples available on the Slovenian market are reported. In addition to (210)Po, the transfer of thorium isotopes from a cigarette to a smoker's body and lungs have been determined for the first time...

A novel method for determination of (210)Pb activity concentration using a liquid scintillation counter (LSC) in environmental samples is presented. After radiochemical separation of (210)Pb on Eichrom Sr Resin column, the decay product (210)Bi starts to in-grow and interfere with the (210)Pb during measurement with LSC. Instead of eliminating this interference, a novel method utilises (210)Bi in-growth to improve the detection efficiency and subsequently to lower the minimum detectable activity (MDA). This allows for substantial reduction of the MDA compared to conventional methods...

OBJECTIVE: To evaluate the relationship between structural integrity of descending motor tracts and motor status in patients with chronic ischemic stroke using diffusion tensor imaging (DTI). METHODS: From April 2012 to December 2013, 47 patients with chronic ischemic strok were recruited along with 20 matched normal controls. The DTI data was acquired and preprocessed. Bilateral descending motor tracts includingcorticospinal tract (CST) and alternate motor fibers (aMF) were constructed...