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Taylor C Wallace
In 2030, one in five Americans will be older than 65 years, and with that an increase in the number of individuals who experience loss in cognitive capacity is to be expected. At the same time, nutrition within the first 1000 days postconception has been suggested to strongly influence cognitive outcomes across the life-span in humans. Eggs are a primary source of both choline and the xanthophyll carotenoid lutein in the western diet, and both have been suggested to influence cognitive function in humans. This comprehensive review critically examines the effects of eggs, choline, and lutein on cognition across the life-span...
February 16, 2018: Journal of the American College of Nutrition
Letícia Pinto Coelho Jorge, Carlos Eduardo Gonçalves Pereira, Eduardo Jorge, Marcos Pereira de Ávila
Background: To evaluate macular pigment optical density (MPOD) and to identify its determinants in a sample of Brazilian individuals. Methods: This was a cross-sectional study. One hundred three healthy individuals had both eyes photographed using a Visucam 500 digital fundus camera (Carl Zeiss Meditec, Jena, Germany) in combination with the MPOD module. Four variables were obtained: maximum MPOD, mean MPOD, MPOD volume, and MPOD area. Demographic data and information on lifestyle habits were also collected...
2018: International Journal of Retina and Vitreous
Akira Obana, Werner Gellermann, Yuko Gohto, Takahiko Seto, Hiroyuki Sasano, Masaki Tanito, Shigetoshi Okazaki
This study evaluates the accuracy of an objective two-wavelength fundus autofluorescence technique for the purpose of measuring the macular pigment optical density (MPOD) in Asian pigmented eyes. Potential differences between MPOD values obtained via autofluorescence technique and subjective heterochromatic photometry (HFP) were examined. Inter-examiner reproducibility between three examiners and test-retest reliability over five time points were also explored. Subjects were 27 healthy Japanese volunteers aged 24 to 58 (mean ± standard deviation, 40...
January 19, 2018: Experimental Eye Research
Catherine M Mewborn, Douglas P Terry, Lisa M Renzi-Hammond, Billy R Hammond, L Stephen Miller
Objective: Lutein (L) and zeaxanthin (Z) are phytonutrients that accumulate in human brain tissue and positively impact cognition. Given their antioxidant and anti-inflammatory properties and their role in stabilizing cell membranes, L&Z may relate to measures of white matter integrity (WMI). Method: The current study tested the relation of retinal (macular pigment optical density/MPOD) and blood serum concentrations of L&Z to WMI in community-dwelling older adults (n = 54) using diffusion tensor imaging (DTI)...
November 17, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
Lisa M Renzi-Hammond, Emily R Bovier, Laura M Fletcher, L Stephen Miller, Catherine M Mewborn, Cutter A Lindbergh, Jeffrey H Baxter, Billy R Hammond
Background: Past studies have suggested that higher lutein (L) and zeaxanthin (Z) levels in serum and in the central nervous system (as quantified by measuring macular pigment optical density, MPOD) are related to improved cognitive function in older adults. Very few studies have addressed the issue of xanthophylls and cognitive function in younger adults, and no controlled trials have been conducted to date to determine whether or not supplementation with L + Z can change cognitive function in this population...
November 14, 2017: Nutrients
We Fong Siah, Colm O'Brien, James J Loughman
AIM: To evaluate the relationship between macular pigment optical density (MPOD) and glare disability in open-angle glaucoma. METHODS: A cross-sectional analysis of baseline data (88 subjects; median age, 67 (range 36-84) years) collected during the Macular Pigment and Glaucoma Trial (ISRCTN registry number: 56985060). MPOD at 0.25°, 0.5° and 1° of retinal eccentricity was measured using customised heterochromatic flicker photometry. Mesopic contrast sensitivity with glare (mCSg), photostress recovery time (PRT) and self-reported glare symptoms were evaluated...
October 5, 2017: British Journal of Ophthalmology
Jean-François Korobelnik, Marie-Bénédicte Rougier, Marie-Noëlle Delyfer, Alain Bron, Bénédicte M J Merle, Hélène Savel, Geneviève Chêne, Cécile Delcourt, Catherine Creuzot-Garcher
Importance: Nutritional uptake of lutein, zeaxanthin, and ω-3 polyunsaturated fatty acids may increase macular pigment optical density (MPOD) and thereby protect against the development of age-related macular degeneration (AMD). Objectives: To estimate the efficiency of dietary supplementation containing lutein, zeaxanthin, ω-3 polyunsaturated fatty acids, and vitamins to increase the density of macular pigment in first-generation offspring of parents with neovascular AMD...
November 1, 2017: JAMA Ophthalmology
Raimondo Forte, Lucia Panzella, Ida Cesarano, Gilda Cennamo, Thomas Eidenberger, Alessandra Napolitano
PURPOSE: The hypothesis that oral supplementation of the epilutein/lutein combination could augment the macular pigment optical density (MPOD) in patients with age-related macular degeneration (AMD) was tested. METHODS: In a prospective randomized interventional study, 40 consecutive patients with early-stage AMD were recruited. After a 2-week run-in period, patients were randomly treated with a daily oral administration of 8 mg epilutein and 2 mg lutein (group 1) or 10 mg lutein (group 2) for 2 months...
2017: Ophthalmic Research
Emily R Bovier, Billy R Hammond
Lutein (L) and zeaxanthin (Z) status can be quantified by measuring their concentrations both in serum and, non-invasively, in retinal tissue. This has resulted in a unique ability to assess their role in a number of tissues ranging from cardiovascular to central nervous system tissue. Recent reports using animal models have suggested yet another role, a developmental increase in bone mass. To test this, we assessed L and Z status in 63 young healthy adults. LZ status was determined by measuring LZ in serum (using HPLC) and retina tissue (measuring macular pigment optical density, MPOD, using customized heterochromatic flicker photometry)...
September 7, 2017: Foods (Basel, Switzerland)
Yoko Ozawa, Yuta Shigeno, Norihiro Nagai, Misa Suzuki, Toshihide Kurihara, Sakiko Minami, Eri Hirano, Hajime Shinoda, Saori Kobayashi, Kazuo Tsubota
BACKGROUND: Lutein and zeaxanthin are suggested micronutrient supplements to prevent the progression of age-related macular degeneration (AMD), a leading cause of blindness worldwide. To monitor the levels of lutein/zeaxanthin in the macula, macular pigment optical density (MPOD) is measured. A commercially available device (MPSII®, Elektron Technology, Switzerland), using technology based on heterochromatic flicker photometry, can measure both absolute and estimated values of MPOD. However, whether the estimated value is applicable to Asian individuals and/or AMD patients remains to be determined...
August 29, 2017: BMC Ophthalmology
Christopher D Conrady, James P Bell, Brian M Besch, Aruna Gorusupudi, Kelliann Farnsworth, Igor Ermakov, Mohsen Sharifzadeh, Maia Ermakova, Werner Gellermann, Paul S Bernstein
Purpose: Ocular and systemic measurement and imaging of the macular carotenoids lutein and zeaxanthin have been employed extensively as potential biomarkers of AMD risk. In this study, we systematically compare dual wavelength retinal autofluorescence imaging (AFI) of macular pigment with skin resonance Raman spectroscopy (RRS) and serum carotenoid levels in a clinic-based population. Methods: Eighty-eight patients were recruited from retina and general ophthalmology practices from a tertiary referral center and excluded only if they did not have all three modalities tested, had a diagnosis of macular telangiectasia (MacTel) or Stargardt disease, or had poor AFI image quality...
July 1, 2017: Investigative Ophthalmology & Visual Science
Min-Chun Liao, Xin-Ping Zhao, Shiao-Ying Chang, Chao-Sheng Lo, Isabelle Chenier, Tomoko Takano, Julie R Ingelfinger, Shao-Ling Zhang
Angiotensin II type 2 receptor (AT2 R) deficiency in AT2 R knockout (KO) mice has been linked to congenital abnormalities of the kidney and urinary tract; however, the mechanisms by which this occurs are poorly understood. In this study, we examined whether AT2 R deficiency impaired glomerulogenesis and mediated podocyte loss/dysfunction in vivo and in vitro. Nephrin-cyan fluorescent protein (CFP)-transgenic (Tg) and Nephrin/AT2 RKO mice were used to assess glomerulogenesis, while wild-type and AT2 RKO mice were used to evaluate maturation of podocyte morphology/function...
November 2017: Journal of Pathology
James M Stringham, Nicole T Stringham, Kevin J O'Brien
The dramatic rise in the use of smartphones, tablets, and laptop computers over the past decade has raised concerns about potentially deleterious health effects of increased "screen time" (ST) and associated short-wavelength (blue) light exposure. We determined baseline associations and effects of 6 months' supplementation with the macular carotenoids (MC) lutein, zeaxanthin, and mesozeaxanthin on the blue-absorbing macular pigment (MP) and measures of sleep quality, visual performance, and physical indicators of excessive ST...
June 29, 2017: Foods (Basel, Switzerland)
Anne M Walk, Caitlyn G Edwards, Nicholas W Baumgartner, Morgan R Chojnacki, Alicia R Covello, Ginger E Reeser, Billy R Hammond, Lisa M Renzi-Hammond, Naiman A Khan
One apparent consequence of aging appears to be loss of some aspects of cognitive control. This loss is measurable as early as mid-adulthood. Since, like many aspects of cognition, there is wide variance among individuals, it is possible that behavior, such as one's diet, could drive some of these differences. For instance, past data on older humans and non-human primates have suggested that dietary carotenoids could slow cognitive decline. In this study, we tested how early such protection might manifest by examining a sample (n = 60) of 25-45 year olds...
2017: Frontiers in Aging Neuroscience
Ayhan Ozyurt, Nilufer Kocak, Pınar Akan, Ozlem Gursoy Calan, Taylan Ozturk, Mahmut Kaya, Eyup Karahan, Suleyman Kaynak
AIM: The aim of the study was to evaluate the macular pigment optical density (MPOD) levels in patients with wet age-related macular degeneration (AMD), dry AMD, and also in healthy controls. SETTINGS AND DESIGN: This study was conducted at Department of Ophthalmology, and the study design was a prospective study. PATIENTS AND METHODS: Forty-eight patients with wet AMD, 51 patients with dry AMD, and 50 controls were included in the study. All patients were naive to both previous lutein or zeaxanthin administration and any previous intravitreal injections...
June 2017: Indian Journal of Ophthalmology
Sasha M Barnett, Naiman A Khan, Anne M Walk, Lauren B Raine, Christopher Moulton, Neal J Cohen, Arthur F Kramer, Billy R Hammond, Lisa Renzi-Hammond, Charles H Hillman
OBJECTIVE: Macular pigment optical density (MPOD) - a non-invasive indicator of retinal xanthophylls and correlate of brain lutein - has been associated with superior cognitive function among adult populations. Given that lutein accumulation in the brain occurs in early life, it is possible that the cognitive implications of greater MPOD may be evident in childhood. METHODS: Participants aged 8-9 years (n = 56) completed MPOD measurements via heterochromatic flicker photometry...
May 23, 2017: Nutritional Neuroscience
Anne M Walk, Naiman A Khan, Sasha M Barnett, Lauren B Raine, Arthur F Kramer, Neal J Cohen, Christopher J Moulton, Lisa M Renzi-Hammond, Billy R Hammond, Charles H Hillman
Lutein and zeaxanthin are plant pigments known to preferentially accumulate in neural tissue. Macular Pigment Optical Density (MPOD), a non-invasive measure of retinal carotenoids and surrogate measure of brain carotenoid concentration, has been associated with disease prevention and cognitive health. Superior MPOD status in later adulthood has been shown to provide neuroprotective effects on cognition. Given that childhood signifies a critical period for carotenoid accumulation in brain, it is likely that the beneficial impact would be evident during development, though this relationship has not been directly investigated...
August 2017: International Journal of Psychophysiology
James M Stringham, Kevin J O'Brien, Nicole T Stringham
Purpose: Once deposited in the retina, the so-called macular carotenoids lutein (L), zeaxanthin (Z), and mesozeaxanthin (MZ) have been shown to enhance visual performance. The purpose of our study was to investigate whether increasing macular pigment optical density (MPOD) could enhance lateral inhibitory processes, and thereby improve contrast sensitivity (CS). Methods: A total of 59 young (18-25 years), healthy individuals participated in this 1-year, double-masked, placebo-controlled study...
April 1, 2017: Investigative Ophthalmology & Visual Science
Chiara M Eandi, Marco Nassisi, Carlo Lavia, Camilla Alovisi, Ugo de Sanctis
Purpose: To measure macular pigment (MP) and find possible correlation between heterochromatic flicker photometry (HFP) and quantitative autofluorescence (qAF) in young healthy subjects. Methods: We enrolled 80 eyes of 40 young healthy subjects. Macular pigment optical density (MPOD) was automatically calculated with a macular pigment screener (MPS; MPODHFP). We calculated qAF comparing gray levels (GL) of qAF images with GL of internal reference of a confocal scanning laser ophthalmoscopy...
April 1, 2017: Investigative Ophthalmology & Visual Science
G Azar, M Quaranta-El Maftouhi, J-J Masella, M Mauget-Faÿsse
PURPOSE: To assess the evolution of macular pigment optical density (MPOD) following supplementation with various macular formulations obtained with the Visucam(®) 200, and to study the factors affecting MPOD measurements. MATERIALS AND METHODS: In this prospective, randomized, double-masked multicenter study, patients were divided into 2 groups: group A (patients without retinal pathology who underwent cataract surgery 1 month previously) and group B (patients with neovascular age-related macular degeneration [AMD] in one eye)...
April 2017: Journal Français D'ophtalmologie
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