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https://www.readbyqxmd.com/read/27885710/clinical-imaging-of-macular-pigment-optical-density-and-spatial-distribution
#1
REVIEW
Christopher M Putnam
Clinical research continues to provide an increasing number of studies that reveal an association between macular pigment optical density (MPOD) and both visual function and ocular health. As a result, there is a growing need for repeatable, accurate measures of MPOD that can describe peak optical density as well as spatial distribution. Measurement of MPOD in a research setting has an established history encompassing a number of both objective and subjective techniques. Transition of these techniques to a clinical setting has produced an array of commercial devices using three primary methods: heterochromatic flicker photometry, fundus autofluorescence and fundus reflectometry...
November 24, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/27866829/lutein-and-zeaxanthin-supplied-by-red-orange-foods-and-fruits-are-more-closely-associated-with-macular-pigment-optical-density-than-those-from-green-vegetables-in-spanish-subjects
#2
Rocío Estévez-Santiago, Begoña Olmedilla-Alonso, Beatriz Beltrán-de-Miguel, Carmen Cuadrado-Vives
Lutein and zeaxanthin (L+Z) accumulate in the retina. Although vegetables are major contributors to their intake, a stronger association between fruits and macular pigment optical density (MPOD) has been reported. We hypothesized that L+Z intake from fruits would have a stronger association with L+Z status markers (MPOD, serum concentrations) than intake from vegetables or eggs, and that those associations would also differ according to plant foods color. One hundred eight subjects (57 men; age groups, 20-35 and 45-65 years) were enrolled in a cross-sectional study...
September 14, 2016: Nutrition Research
https://www.readbyqxmd.com/read/27857944/macular-carotenoid-supplementation-improves-disability-glare-performance-and-dynamics-of-photostress-recovery
#3
James M Stringham, Kevin J O'Brien, Nicole T Stringham
BACKGROUND: The so-called macular carotenoids (MC) lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) comprise the diet-derived macular pigment (MP). The purpose of this study was to determine effects of MC supplementation on the optical density of MP (MPOD), repeated-exposure photostress recovery (PSR), and disability glare (DG) thresholds. METHODS: This was a double-blind, placebo-controlled trial. Fifty-nine young (mean age = 21.7), healthy volunteers participated in this study...
2016: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/27847632/changes-of-macular-pigment-optical-density-in-elderly-eyes-a-longitudinal-analysis-from-the-mars-study
#4
Verena Meyer Zu Westrup, Martha Dietzel, Meike Zeimer, Daniel Pauleikhoff, Hans-Werner Hense
BACKGROUND: Macular pigment (MP) has been related to the occurrence of age related macular degeneration (AMD). We investigated prospectively in eyes of elderly individuals how magnitude and spatial distribution of MP had changed after 4 years. METHODS: The study included 380 eyes from 237 participants of the Münster Ageing and Retina Study cohort which were free of advanced stages of AMD. MP optical density (MPOD) was measured in density units (D.U.) at eccentricities of 0...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27826180/preliminary-analysis-of-the-relationship-between-serum-lutein-and-zeaxanthin-levels-and-macular-pigment-optical-density
#5
Shigeto Fujimura, Kohei Ueda, Yoko Nomura, Yasuo Yanagi
PURPOSE: To assess the relationship between combined serum lutein and zeaxanthin (L+Z) concentration and macular pigment optical density (MPOD), and to investigate the effect of L+Z+docosahexaenoic acid (DHA) dietary supplementation on the spatial distribution of MPOD. METHODS: Twenty healthy fellow eyes with unilateral wet age-related macular degeneration or chronic central serous chorioretinopathy were included. All participants received a dietary supplement for 6 months that contained 20 mg L, 1 mg Z, and 200 mg DHA...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27803860/association-of-macular-pigment-optical-density-with-early-stage-of-non-proliferative-diabetic-retinopathy-in-chinese-patients-with-type-2-diabetes-mellitus
#6
Chong-Yang She, Hong Gu, Jun Xu, Xiu-Fen Yang, Xue-Tao Ren, Ning-Pu Liu
AIM: To detect the association between macular pigment optical density (MPOD), which reflects the antioxidant ability of retina, and diabetic retinopathy (DR) and to investigate the correlated factors of MPOD. METHODS: Totally 435 subjects of urban Chinese were recruited to the study and divided into 3 groups: non-diabetes mellitus controls (NDM), diabetic patients without retinopathy (DWR), and patients with early stage of non-proliferative diabetic retinopathy (DR)...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27775222/monitoring-macular-pigment-changes-in-macular-holes-using-fluorescence-lifetime-imaging-ophthalmoscopy
#7
Lydia Sauer, Sven Peters, Johanna Schmidt, Dietrich Schweitzer, Matthias Klemm, Lisa Ramm, Regine Augsten, Martin Hammer
PURPOSE: To investigate the impact of macular pigment (MP) on fundus autofluorescence (FAF) lifetimes in vivo by characterizing full-thickness idiopathic macular holes (MH) and macular pseudo-holes (MPH). METHODS: A total of 37 patients with MH and 52 with MPH were included. Using the fluorescence lifetime imaging ophthalmoscope (FLIO), based on a Heidelberg Engineering Spectralis system, a 30° retinal field was investigated. FAF decays were detected in a short (498-560 nm; ch1) and long (560-720 nm; ch2) wavelength channel...
October 24, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27750290/spatial-distribution-of-macular-pigment-in-an-elderly-french-population-the-montrachet-study
#8
Seydou Alassane, Christine Binquet, Louis Arnould, Olivier Fleck, Niyazi Acar, Cécile Delcourt, Lionel Bretillon, Alain M Bron, Catherine Creuzot-Garcher
Purpose: We describe the spatial distribution and cross-sectional associations with physical and lifestyle attributes. Methods: The participants of the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular and HEarT) study underwent an exhaustive ophthalmologic examination, including optical coherence tomography, to measure retinal thickness. The spatial distribution of macular pigment optical density (MPOD) defined as a ring-like, intermediate or no-ring pattern, was assessed by means of the two-wavelength autofluorescence technique...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27622189/lens-density-measurements-by-two-independent-psychophysical-techniques
#9
Anirbaan Mukherjee, Richard A Bone
BACKGROUND: Cataract, a leading cause of vision impairment, is due to the lens becoming excessively optically dense. Change in the lens optical density (LOD) could be a useful indicator of incipient nuclear cataract and would necessitate the development of accurate measurement techniques. Mapcat sf™ is a heterochromatic flicker photometer for measuring macular pigment optical density (MPOD) under photopic conditions. In the process, it also measures LOD that is needed in the calculation of MPOD...
2016: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/27621586/macular-pigment-optical-density-repeatability-intereye-correlation-and-effect-of-ocular-dominance
#10
Pinakin Gunvant Davey, Silverio D Alvarez, Jessica Y Lee
PURPOSE: To evaluate short-term repeatability, intereye correlation, and effect of ocular dominance on macular pigment optical density (MPOD) measurements obtained using the QuantifEye Heterochromatic Flicker Photometer. PATIENTS AND METHODS: A total of 72 study participants were enrolled in this prospective, cross-sectional study. Participants underwent a comprehensive ocular evaluation, including visual acuity, evaluation of ocular dominance, slit lamp examination, intraocular pressure measurement, and optic nerve head and macula analysis using optical coherence tomography and fundus photography...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27587715/pilot-evaluation-of-short-term-changes-in-macular-pigment-and-retinal-sensitivity-in-different-phenotypes-of-early-age-related-macular-degeneration-after-carotenoid-supplementation
#11
Federico Corvi, Eric H Souied, Yousra Falfoul, Anouk Georges, Camille Jung, Lea Querques, Giuseppe Querques
PURPOSE: To investigate the response of carotenoid supplementation in different phenotypes of early age-related macular degeneration (AMD) by measuring macular pigment optical density (MPOD) and retinal sensitivity. METHODS: Consecutive patients with only medium/large drusen and only reticular pseudodrusen (RPD) and age-matched and sex-matched controls were enrolled. At baseline, participants underwent a complete ophthalmological examination including measurement of best-corrected visual acuity (BCVA), MPOD and retinal sensitivity...
September 1, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27580077/blue-black-or-white-gold-early-stage-processing-and-the-color-of-the-dress
#12
Jeff Rabin, Brook Houser, Carolyn Talbert, Ruh Patel
PURPOSE: In Feb 2015 an image of a dress posted on Tumblr triggered an internet phenomenon: Is the Dress blue and black (BB) or white and gold (WG)? Many claim BB and others insist WG while the true colors are BB. The prevailing theory is that assumptions about the illuminant govern perception of the Dress with WG due to bluish lighting and BB due to yellowish. Our purpose was to determine if early stage optical, retinal and/or neural factors also impact perception of the Dress. METHODS: Thirty-nine subjects were categorized as BB or WG based on their initial perception of the Dress and their perception reported when viewing the Dress on iPhone 5, iPad, and 22" LCD displays...
2016: PloS One
https://www.readbyqxmd.com/read/27544327/relationships-between-macular-pigment-optical-density-and-lacquer-cracks-in-high-myopia
#13
L Benoudis, P Ingrand, J Jeau, O Lichtwitz, M Boissonnot, N Leveziel
PURPOSE: A low concentration of macular carotenoid pigment (lutein and zeaxanthin) is a significant risk factor for macular degeneration. The goal of this paper is to investigate the relationship between macular pigment optical density (MPOD) and lacquer cracks (LC) in high myopia. METHODS: This is a prospective comparative observational study (NCT02205632) including high myopic patients with or without LC. High myopia was defined as a refractive error greater than 6 diopters of myopia or axial length greater than 26mm...
September 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27426932/serum-and-retinal-responses-to-three-different-doses-of-macular-carotenoids-over-12-weeks-of-supplementation
#14
James M Stringham, Nicole T Stringham
The macular carotenoids lutein (L), zeaxanthin (Z), and mesozeaxanthin (MZ) have been shown to have neuroprotective and visual performance benefits once deposited in retinal tissues. The purpose of this 12-week trial was to determine biweekly the absorption kinetics, efficiency of retinal deposition, and effects on the spatial profile of macular pigment for three levels of L + Z + MZ supplement. This study was a double-blind, placebo-controlled 12-week trial. Twenty-eight healthy subjects, aged 18-25 yrs participated...
October 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27420092/lutein-zeaxanthin-and-meso-zeaxanthin-supplementation-associated-with-macular-pigment-optical-density
#15
Le Ma, Rong Liu, Jun Hui Du, Tao Liu, Shan Shan Wu, Xiao Hong Liu
The purpose of this study was to evaluate the effects of lutein, zeaxanthin and meso-zeaxanthin on macular pigment optical density (MPOD) in randomized controlled trials (RCTs) among patients with age-related macular degeneration (AMD) and healthy subjects. Medline, Embase, Web of Science and Cochrane Library databases was searched through May 2016. Meta-analysis was conducted to obtain adjusted weighted mean differences (WMD) for intervention-versus-placebo group about the change of MPOD between baseline and terminal point...
2016: Nutrients
https://www.readbyqxmd.com/read/27367585/enrichment-of-macular-pigment-enhances-contrast-sensitivity-in-subjects-free-of-retinal-disease-central-retinal-enrichment-supplementation-trials-report-1
#16
John M Nolan, Rebecca Power, Jim Stringham, Jessica Dennison, Jim Stack, David Kelly, Rachel Moran, Kwadwo O Akuffo, Laura Corcoran, Stephen Beatty
PURPOSE: The high-performance visual function associated with central vision is mediated by the macula (the central retina), which accumulates three diet-derived pigments (the carotenoids lutein [L], zeaxanthin [Z], and meso-zeaxanthin [MZ]). Our study sought to investigate the impact on visual function, including contrast sensitivity (CS), of supplementation with these naturally occurring carotenoids, in individuals with low retinal concentrations. METHODS: Subjects consumed daily a formulation containing 10 mg L, 2 mg Z, and 10 mg MZ (active group; n = 53) or placebo (n = 52) for a period of 12 months...
June 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27273910/comparison-of-macular-pigment-and-serum-lutein-concentration-changes-between-free-lutein-and-lutein-esters-supplements-in-japanese-subjects
#17
Hiroko Yoshizako, Katunori Hara, Yasuyuki Takai, Sachiko Kaidzu, Akira Obana, Akihiro Ohira
PURPOSE: To compare changes in macular pigment optical density (MPOD) and serum lutein concentration between free lutein and lutein esters supplements in healthy Japanese individuals. METHODS: Twenty healthy subjects (age range, 22-47 years) were recruited into this prospective, randomized, doubled-blind comparative study. Individuals were evenly divided into two groups: free lutein group, supplementation with 10 mg of free lutein; or lutein esters group, supplementation with 20 mg of lutein esters equivalent to 10 mg of free lutein...
September 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27262538/assessment-of-lutein-and-zeaxanthin-status-and-dietary-markers-as-predictors-of-the-contrast-threshold-in-2-age-groups-of-men-and-women
#18
Rocío Estévez-Santiago, Begoña Olmedilla-Alonso, Beatriz Beltrán-de-Miguel
Lutein and zeaxanthin (L + Z) status is associated with the macular pigment (MP). The relationship between MP and visual function is controversial. We hypothesized that, within the framework of nutrition, visual function was related to MP and nutritional and/or/dietary factors influencing it. A cross-sectional study was performed in 108 volunteers divided into 2 age groups (20-35 years; 45-65 years), each 27 women and 27 men, to assess the relationship between MP optical density (MPOD) and contrast threshold (CT), considering the influence of L + Z and, fruit and vegetable (F + V) intake...
July 2016: Nutrition Research
https://www.readbyqxmd.com/read/27144013/macular-pigment-optical-density-in-chinese-primary-open-angle-glaucoma-using-the-one-wavelength-reflectometry-method
#19
Yuying Ji, Chengguo Zuo, Mingkai Lin, Xiongze Zhang, Miaoling Li, Lan Mi, Bing Liu, Feng Wen
Purpose. To investigate macular pigment optical density (MPOD) and its relationship with retinal thickness in primary open angle glaucoma (POAG) patients using the one-wavelength reflectometry method. Methods. A total of 30 eyes from 30 POAG patients (18 males and 12 females, mean age 47.27 ± 16.93) and 52 eyes from 52 controls (27 males and 25 females, mean age 49.54 ± 19.15) were included in this prospective, observational, case-control study. MPOD was measured in a 7-degree area using one-wavelength reflectometry method...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27064326/increased-macular-pigment-optical-density-and-visual-acuity-following-consumption-of-a-buttermilk-drink-containing-lutein-enriched-egg-yolks-a-randomized-double-blind-placebo-controlled-trial
#20
Sanne M van der Made, Elton R Kelly, Aize Kijlstra, Jogchum Plat, Tos T J M Berendschot
Purpose. To study the effect of 1-year daily consumption of a dairy drink containing lutein-enriched egg yolks on macular pigment optical density (MPOD) and visual function parameters in elderly subjects with ocular drusen and/or retinal pigment abnormalities. Methods. One hundred and one subjects were recruited to participate in this randomized, double-blind, placebo-controlled parallel intervention trial. Statistical analyses were performed with 46 subjects in the lutein group and 43 in the control group...
2016: Journal of Ophthalmology
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