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Seydou Alassane, Christine Binquet, Louis Arnould, Olivier Fleck, Niyazi Acar, Cécile Delcourt, Lionel Bretillon, Alain M Bron, Catherine Creuzot-Garcher
Purpose: We describe the spatial distribution and cross-sectional associations with physical and lifestyle attributes. Methods: The participants of the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular and HEarT) study underwent an exhaustive ophthalmologic examination, including optical coherence tomography, to measure retinal thickness. The spatial distribution of macular pigment optical density (MPOD) defined as a ring-like, intermediate or no-ring pattern, was assessed by means of the two-wavelength autofluorescence technique...
August 1, 2016: Investigative Ophthalmology & Visual Science
Anirbaan Mukherjee, Richard A Bone
BACKGROUND: Cataract, a leading cause of vision impairment, is due to the lens becoming excessively optically dense. Change in the lens optical density (LOD) could be a useful indicator of incipient nuclear cataract and would necessitate the development of accurate measurement techniques. Mapcat sf™ is a heterochromatic flicker photometer for measuring macular pigment optical density (MPOD) under photopic conditions. In the process, it also measures LOD that is needed in the calculation of MPOD...
2016: Eye and Vision (London, England)
Pinakin Gunvant Davey, Silverio D Alvarez, Jessica Y Lee
PURPOSE: To evaluate short-term repeatability, intereye correlation, and effect of ocular dominance on macular pigment optical density (MPOD) measurements obtained using the QuantifEye Heterochromatic Flicker Photometer. PATIENTS AND METHODS: A total of 72 study participants were enrolled in this prospective, cross-sectional study. Participants underwent a comprehensive ocular evaluation, including visual acuity, evaluation of ocular dominance, slit lamp examination, intraocular pressure measurement, and optic nerve head and macula analysis using optical coherence tomography and fundus photography...
2016: Clinical Ophthalmology
Federico Corvi, Eric H Souied, Yousra Falfoul, Anouk Georges, Camille Jung, Lea Querques, Giuseppe Querques
PURPOSE: To investigate the response of carotenoid supplementation in different phenotypes of early age-related macular degeneration (AMD) by measuring macular pigment optical density (MPOD) and retinal sensitivity. METHODS: Consecutive patients with only medium/large drusen and only reticular pseudodrusen (RPD) and age-matched and sex-matched controls were enrolled. At baseline, participants underwent a complete ophthalmological examination including measurement of best-corrected visual acuity (BCVA), MPOD and retinal sensitivity...
September 1, 2016: British Journal of Ophthalmology
Jeff Rabin, Brook Houser, Carolyn Talbert, Ruh Patel
PURPOSE: In Feb 2015 an image of a dress posted on Tumblr triggered an internet phenomenon: Is the Dress blue and black (BB) or white and gold (WG)? Many claim BB and others insist WG while the true colors are BB. The prevailing theory is that assumptions about the illuminant govern perception of the Dress with WG due to bluish lighting and BB due to yellowish. Our purpose was to determine if early stage optical, retinal and/or neural factors also impact perception of the Dress. METHODS: Thirty-nine subjects were categorized as BB or WG based on their initial perception of the Dress and their perception reported when viewing the Dress on iPhone 5, iPad, and 22" LCD displays...
2016: PloS One
L Benoudis, P Ingrand, J Jeau, O Lichtwitz, M Boissonnot, N Leveziel
PURPOSE: A low concentration of macular carotenoid pigment (lutein and zeaxanthin) is a significant risk factor for macular degeneration. The goal of this paper is to investigate the relationship between macular pigment optical density (MPOD) and lacquer cracks (LC) in high myopia. METHODS: This is a prospective comparative observational study (NCT02205632) including high myopic patients with or without LC. High myopia was defined as a refractive error greater than 6 diopters of myopia or axial length greater than 26mm...
September 2016: Journal Français D'ophtalmologie
James M Stringham, Nicole T Stringham
The macular carotenoids lutein (L), zeaxanthin (Z), and mesozeaxanthin (MZ) have been shown to have neuroprotective and visual performance benefits once deposited in retinal tissues. The purpose of this 12-week trial was to determine biweekly the absorption kinetics, efficiency of retinal deposition, and effects on the spatial profile of macular pigment for three levels of L + Z + MZ supplement. This study was a double-blind, placebo-controlled 12-week trial. Twenty-eight healthy subjects, aged 18-25 yrs participated...
October 2016: Experimental Eye Research
Le Ma, Rong Liu, Jun Hui Du, Tao Liu, Shan Shan Wu, Xiao Hong Liu
The purpose of this study was to evaluate the effects of lutein, zeaxanthin and meso-zeaxanthin on macular pigment optical density (MPOD) in randomized controlled trials (RCTs) among patients with age-related macular degeneration (AMD) and healthy subjects. Medline, Embase, Web of Science and Cochrane Library databases was searched through May 2016. Meta-analysis was conducted to obtain adjusted weighted mean differences (WMD) for intervention-versus-placebo group about the change of MPOD between baseline and terminal point...
2016: Nutrients
John M Nolan, Rebecca Power, Jim Stringham, Jessica Dennison, Jim Stack, David Kelly, Rachel Moran, Kwadwo O Akuffo, Laura Corcoran, Stephen Beatty
PURPOSE: The high-performance visual function associated with central vision is mediated by the macula (the central retina), which accumulates three diet-derived pigments (the carotenoids lutein [L], zeaxanthin [Z], and meso-zeaxanthin [MZ]). Our study sought to investigate the impact on visual function, including contrast sensitivity (CS), of supplementation with these naturally occurring carotenoids, in individuals with low retinal concentrations. METHODS: Subjects consumed daily a formulation containing 10 mg L, 2 mg Z, and 10 mg MZ (active group; n = 53) or placebo (n = 52) for a period of 12 months...
June 1, 2016: Investigative Ophthalmology & Visual Science
Hiroko Yoshizako, Katunori Hara, Yasuyuki Takai, Sachiko Kaidzu, Akira Obana, Akihiro Ohira
PURPOSE: To compare changes in macular pigment optical density (MPOD) and serum lutein concentration between free lutein and lutein esters supplements in healthy Japanese individuals. METHODS: Twenty healthy subjects (age range, 22-47 years) were recruited into this prospective, randomized, doubled-blind comparative study. Individuals were evenly divided into two groups: free lutein group, supplementation with 10 mg of free lutein; or lutein esters group, supplementation with 20 mg of lutein esters equivalent to 10 mg of free lutein...
September 2016: Acta Ophthalmologica
Rocío Estévez-Santiago, Begoña Olmedilla-Alonso, Beatriz Beltrán-de-Miguel
Lutein and zeaxanthin (L + Z) status is associated with the macular pigment (MP). The relationship between MP and visual function is controversial. We hypothesized that, within the framework of nutrition, visual function was related to MP and nutritional and/or/dietary factors influencing it. A cross-sectional study was performed in 108 volunteers divided into 2 age groups (20-35 years; 45-65 years), each 27 women and 27 men, to assess the relationship between MP optical density (MPOD) and contrast threshold (CT), considering the influence of L + Z and, fruit and vegetable (F + V) intake...
July 2016: Nutrition Research
Yuying Ji, Chengguo Zuo, Mingkai Lin, Xiongze Zhang, Miaoling Li, Lan Mi, Bing Liu, Feng Wen
Purpose. To investigate macular pigment optical density (MPOD) and its relationship with retinal thickness in primary open angle glaucoma (POAG) patients using the one-wavelength reflectometry method. Methods. A total of 30 eyes from 30 POAG patients (18 males and 12 females, mean age 47.27 ± 16.93) and 52 eyes from 52 controls (27 males and 25 females, mean age 49.54 ± 19.15) were included in this prospective, observational, case-control study. MPOD was measured in a 7-degree area using one-wavelength reflectometry method...
2016: Journal of Ophthalmology
Sanne M van der Made, Elton R Kelly, Aize Kijlstra, Jogchum Plat, Tos T J M Berendschot
Purpose. To study the effect of 1-year daily consumption of a dairy drink containing lutein-enriched egg yolks on macular pigment optical density (MPOD) and visual function parameters in elderly subjects with ocular drusen and/or retinal pigment abnormalities. Methods. One hundred and one subjects were recruited to participate in this randomized, double-blind, placebo-controlled parallel intervention trial. Statistical analyses were performed with 46 subjects in the lutein group and 43 in the control group...
2016: Journal of Ophthalmology
Philipp L Müller, Simone Müller, Martin Gliem, Kristina Küpper, Frank G Holz, Wolf M Harmening, Peter Charbel Issa
PURPOSE: To optimize the perceptibility of Haidinger brushes (HB) and to investigate its association with visual acuity and macular pigment density. METHODS: In this prospective cross-sectional study, each subject underwent best-corrected visual acuity (BCVA) testing, funduscopy, and assessment of macular pigment optical density (MPOD) using the two-wavelength fundus autofluorescence method. Haidinger brush visibility was tested with a rotating linear polarizer and a controllable three-color light-emitting diode (LED) panel as light source...
March 2016: Investigative Ophthalmology & Visual Science
Emma J Berrow, Hannah E Bartlett, Frank Eperjesi
BACKGROUND: Previous studies have demonstrated an increase in macular pigment optical density (MPOD) with lutein (L)-based supplementation in healthy eyes. However, not all studies have assessed whether this increase in MPOD is associated with changes to other measures of retinal function such as the multifocal ERG (mfERG). Some studies also fail to report dietary levels of L and zeaxanthin (Z). Because of the associations between increased levels of L and Z, and reduced risk of AMD, this study was designed to assess the effects of L-based supplementation on mfERG amplitudes and latencies in healthy eyes...
April 2016: Documenta Ophthalmologica. Advances in Ophthalmology
Seydou Alassane, Christine Binquet, Vanessa Cottet, Olivier Fleck, Niyazi Acar, Sandrine Daniel, Cécile Delcourt, Lionel Bretillon, Alain M Bron, Catherine Creuzot-Garcher
PURPOSE: To investigate the association of macular pigment optical density (MPOD) with plasma lutein, zeaxanthin, and diet in an elderly population. METHODS: We conducted a population-based study, the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular, and HEarT disease) study, in subjects older than 75 years. The MPOD was measured by means of the two-wavelength autofluorescence technique. Plasma lutein and zeaxanthin were measured in fasting blood samples using HPLC...
March 2016: Investigative Ophthalmology & Visual Science
Yoko Ozawa, Norihiro Nagai, Misa Suzuki, Toshihide Kurihara, Hajime Shinoda, Mitsuru Watanabe, Kazuo Tsubota
PURPOSE: Anti-oxidative nutrient supplements, including lutein, are an important preventive approach for age-related macular degeneration (AMD). In this pilot study, we obtained data required for planning a future dietary intervention study investigating the prevention of AMD progression with lutein-rich spinach. METHODS: We examined 22 eyes from 11 healthy nonsmokers (ages 21-45 years) who ingested 75 g of frozen spinach containing 10 mg lutein every day for 2 months...
January 2016: Nippon Ganka Gakkai Zasshi
Sibel Demirel, Emin Ozmert, Figen Batioglu, Yesim Gedik-Oguz
PURPOSE: To evaluate differences in measurements of macular pigment optical density (MPOD) in patients with dry age-related macular degeneration (AMD) and a group of healthy patients (control group). Short-term repeatability of MPOD measures was also assessed in the control group. METHODS: This cross-sectional study included 31 eyes from 31 patients with bilateral dry AMD, 21 eyes from 21 cases with dry AMD in the study eye and exudative AMD in the fellow eye. The control group included 17 eyes from 17 healthy patients of similar age and sex...
June 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Xu Han, Xuetao Ren, Xue Li, Junyan Zhang, Jie Yu, Ningpu Liu
OBJECTIVE: To evaluate the measurement of macular pigment optical density (MPOD) by a novel instrument MPS1000 as compared to that measured by the traditional heterochromatic flicker photometer (HFP). METHODS: Method-comparative study. MPOD at 0.5° eccentricity was measured simultaneously by the two different instruments in 111 eyes of the 59 healthy subjects. Test-retest variability was evaluated for each instrument over a 1-week period in 8 subjects. RESULT: The mean MPOD levels measured by the MPS1000 and HFP were 0...
November 2015: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Ute E K Wolf-Schnurrbusch, Martin S Zinkernagel, Marion R Munk, Andreas Ebneter, Sebastian Wolf
PURPOSE: It has been shown that lutein and zeaxanthin accumulate in the macula where they enhance contrast sensitivity and may reduce the risk of progression to advanced age-related macular degeneration (AMD). Furthermore, omega-3 long-chain polyunsaturated fatty acids (PUFA) might further reduce this risk. However, controversy exists regarding whether PUFA may reduce the bioavailability of lutein. METHODS: This was a prospective 12-month, randomized, open label study evaluating the effect of supplementation with lutein, other antioxidants, and minerals on contrast sensitivity (CS) and macular pigment optical density (MPOD) in patients with age-related maculopathy...
December 2015: Investigative Ophthalmology & Visual Science
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