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https://www.readbyqxmd.com/read/28431432/contrast-sensitivity-and-lateral-inhibition-are-enhanced-with-macular-carotenoid-supplementation
#1
James M Stringham, Kevin J O'Brien, Nicole T Stringham
Purpose: Once deposited in the retina, the so-called macular carotenoids lutein (L), zeaxanthin (Z), and mesozeaxanthin (MZ) have been shown to enhance visual performance. The purpose of our study was to investigate whether increasing macular pigment optical density (MPOD) could enhance lateral inhibitory processes, and thereby improve contrast sensitivity (CS). Methods: A total of 59 young (18-25 years), healthy individuals participated in this 1-year, double-masked, placebo-controlled study...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28426871/macular-pigment-density-and-quantitative-fundus-autofluorescence-in-young-healthy-subjects
#2
Chiara M Eandi, Marco Nassisi, Carlo Lavia, Camilla Alovisi, Ugo de Sanctis
Purpose: To measure macular pigment (MP) and find possible correlation between heterochromatic flicker photometry (HFP) and quantitative autofluorescence (qAF) in young healthy subjects. Methods: We enrolled 80 eyes of 40 young healthy subjects. Macular pigment optical density (MPOD) was automatically calculated with a macular pigment screener (MPS; MPODHFP). We calculated qAF comparing gray levels (GL) of qAF images with GL of internal reference of a confocal scanning laser ophthalmoscopy...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28336284/macular-pigment-density-variation-after-supplementation-of-lutein-and-zeaxanthin-using-the-visucam-%C3%A2-200-pigment-module-impact-of-age-related-macular-degeneration-and-lens-status
#3
G Azar, M Quaranta-El Maftouhi, J-J Masella, M Mauget-Faÿsse
PURPOSE: To assess the evolution of macular pigment optical density (MPOD) following supplementation with various macular formulations obtained with the Visucam(®) 200, and to study the factors affecting MPOD measurements. MATERIALS AND METHODS: In this prospective, randomized, double-masked multicenter study, patients were divided into 2 groups: group A (patients without retinal pathology who underwent cataract surgery 1 month previously) and group B (patients with neovascular age-related macular degeneration [AMD] in one eye)...
April 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28271618/plasma-long-chain-omega-3-polyunsaturated-fatty-acids-and-macular-pigment-in-subjects-with-family-history-of-age-related-macular-degeneration-the-limpia-study
#4
Bénédicte M J Merle, Benjamin Buaud, Jean-François Korobelnik, Alain Bron, Marie-Noëlle Delyfer, Marie-Bénédicte Rougier, Hélène Savel, Carole Vaysse, Catherine Creuzot-Garcher, Cécile Delcourt
PURPOSE: In numerous epidemiological studies, omega-3 polyunsaturated fatty acids (PUFAs) have been associated with a decreased risk of age-related macular degeneration (AMD). Beyond their structural, functional and neuroprotective roles, omega-3 PUFAs may favour the retinal accumulation of lutein and zeaxanthin and thus increase macular pigment optical density (MPOD). We examined the associations of MPOD with plasma omega-3 PUFAs in subjects with family history of AMD. METHODS: The Limpia study is a double-blind, placebo-controlled, prospective randomized clinical trial performed in 120 subjects...
March 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28231126/macular-pigment-optical-density-and-measures-of-macular-function-test-retest-variability-cross-sectional-correlations-and-findings-from-the-zeaxanthin-pilot-study-of-response-to-supplementation-zeastress-pilot
#5
Alessandro Iannaccone, Giovannella Carboni, Gina Forma, Maria Giulia Mutolo, Barbara J Jennings
We report on the short-term test-retest baseline variability in macular function tests in ZEASTRESS-Pilot participants (n = 18), on their cross-sectional correlation with macular pigment optical density (MPOD), and on the effects of four months (FUV4) of 20 mg/day zeaxanthin (ZX), followed by a four-month washout (FUV8; n = 24, age 50-81 years old). Outcomes included: MPOD at 0.5 and 2.0 deg eccentricity (MPOD-0.5 and -2.0); contrast sensitivity (CS); pattern-reversal electroretinogram (PERG) amplitude; dark-adapted 650 nm foveal cone sensitivity (DA650-FCS); and 500 mn parafoveal rod sensitivity (DA500-PFRS)...
April 29, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28198205/supplementation-with-macular-carotenoids-reduces-psychological-stress-serum-cortisol-and-sub-optimal-symptoms-of-physical-and-emotional-health-in-young-adults
#6
Nicole Tressa Stringham, Philip V Holmes, James M Stringham
PURPOSE: Oxidative stress and systemic inflammation are the root cause of several deleterious effects of chronic psychological stress. We hypothesize that the antioxidant and anti-inflammatory capabilities of the macular carotenoids (MCs) lutein, zeaxanthin, and meso-zeaxanthin could, via daily supplementation, provide a dietary means of benefit. METHODS: A total of 59 young healthy subjects participated in a 12-month, double-blind, placebo-controlled trial to evaluate the effects of MC supplementation on blood cortisol, psychological stress ratings, behavioural measures of mood, and symptoms of sub-optimal health...
February 15, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28068388/the-association-between-foveal-morphology-and-macular-pigment-spatial-distribution-an-ethnicity-study
#7
Irene Ctori, Byki Huntjens
PURPOSE: Macular pigment (MP) spatial distribution varies considerably among individuals. We investigated ethnic variations in MP spatial distribution in relation to foveal architecture. METHODS: We measured MP optical density (MPOD) using heterochromatic flicker photometry (MAP test, City, University of London) in 76 white, 80 South Asian and 70 black volunteers (18 to 39 years). MPOD spatial profiles were classified objectively as exponential, ring-like or central dip, based on deviations away from an exponential fit...
2017: PloS One
https://www.readbyqxmd.com/read/27885710/clinical-imaging-of-macular-pigment-optical-density-and-spatial-distribution
#8
REVIEW
Christopher M Putnam
Clinical research continues to provide an increasing number of studies that reveal an association between macular pigment optical density (MPOD) and both visual function and ocular health. As a result, there is a growing need for repeatable, accurate measures of MPOD that can describe peak optical density as well as spatial distribution. Measurement of MPOD in a research setting has an established history encompassing a number of both objective and subjective techniques. Transition of these techniques to a clinical setting has produced an array of commercial devices using three primary methods: heterochromatic flicker photometry, fundus autofluorescence and fundus reflectometry...
November 24, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/27866829/lutein-and-zeaxanthin-supplied-by-red-orange-foods-and-fruits-are-more-closely-associated-with-macular-pigment-optical-density-than-those-from-green-vegetables-in-spanish-subjects
#9
Rocío Estévez-Santiago, Begoña Olmedilla-Alonso, Beatriz Beltrán-de-Miguel, Carmen Cuadrado-Vives
Lutein and zeaxanthin (L+Z) accumulate in the retina. Although vegetables are major contributors to their intake, a stronger association between fruits and macular pigment optical density (MPOD) has been reported. We hypothesized that L+Z intake from fruits would have a stronger association with L+Z status markers (MPOD, serum concentrations) than intake from vegetables or eggs, and that those associations would also differ according to plant foods color. One hundred eight subjects (57 men; age groups, 20-35 and 45-65 years) were enrolled in a cross-sectional study...
November 2016: Nutrition Research
https://www.readbyqxmd.com/read/27857944/macular-carotenoid-supplementation-improves-disability-glare-performance-and-dynamics-of-photostress-recovery
#10
James M Stringham, Kevin J O'Brien, Nicole T Stringham
BACKGROUND: The so-called macular carotenoids (MC) lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) comprise the diet-derived macular pigment (MP). The purpose of this study was to determine effects of MC supplementation on the optical density of MP (MPOD), repeated-exposure photostress recovery (PSR), and disability glare (DG) thresholds. METHODS: This was a double-blind, placebo-controlled trial. Fifty-nine young (mean age = 21.7), healthy volunteers participated in this study...
2016: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/27847632/changes-of-macular-pigment-optical-density-in-elderly-eyes-a-longitudinal-analysis-from-the-mars-study
#11
Verena Meyer Zu Westrup, Martha Dietzel, Meike Zeimer, Daniel Pauleikhoff, Hans-Werner Hense
BACKGROUND: Macular pigment (MP) has been related to the occurrence of age related macular degeneration (AMD). We investigated prospectively in eyes of elderly individuals how magnitude and spatial distribution of MP had changed after 4 years. METHODS: The study included 380 eyes from 237 participants of the Münster Ageing and Retina Study cohort which were free of advanced stages of AMD. MP optical density (MPOD) was measured in density units (D.U.) at eccentricities of 0...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27826180/preliminary-analysis-of-the-relationship-between-serum-lutein-and-zeaxanthin-levels-and-macular-pigment-optical-density
#12
Shigeto Fujimura, Kohei Ueda, Yoko Nomura, Yasuo Yanagi
PURPOSE: To assess the relationship between combined serum lutein and zeaxanthin (L+Z) concentration and macular pigment optical density (MPOD), and to investigate the effect of L+Z+docosahexaenoic acid (DHA) dietary supplementation on the spatial distribution of MPOD. METHODS: Twenty healthy fellow eyes with unilateral wet age-related macular degeneration or chronic central serous chorioretinopathy were included. All participants received a dietary supplement for 6 months that contained 20 mg L, 1 mg Z, and 200 mg DHA...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27803860/association-of-macular-pigment-optical-density-with-early-stage-of-non-proliferative-diabetic-retinopathy-in-chinese-patients-with-type-2-diabetes-mellitus
#13
Chong-Yang She, Hong Gu, Jun Xu, Xiu-Fen Yang, Xue-Tao Ren, Ning-Pu Liu
AIM: To detect the association between macular pigment optical density (MPOD), which reflects the antioxidant ability of retina, and diabetic retinopathy (DR) and to investigate the correlated factors of MPOD. METHODS: Totally 435 subjects of urban Chinese were recruited to the study and divided into 3 groups: non-diabetes mellitus controls (NDM), diabetic patients without retinopathy (DWR), and patients with early stage of non-proliferative diabetic retinopathy (DR)...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27775222/monitoring-macular-pigment-changes-in-macular-holes-using-fluorescence-lifetime-imaging-ophthalmoscopy
#14
Lydia Sauer, Sven Peters, Johanna Schmidt, Dietrich Schweitzer, Matthias Klemm, Lisa Ramm, Regine Augsten, Martin Hammer
PURPOSE: To investigate the impact of macular pigment (MP) on fundus autofluorescence (FAF) lifetimes in vivo by characterizing full-thickness idiopathic macular holes (MH) and macular pseudo-holes (MPH). METHODS: A total of 37 patients with MH and 52 with MPH were included. Using the fluorescence lifetime imaging ophthalmoscope (FLIO), based on a Heidelberg Engineering Spectralis system, a 30° retinal field was investigated. FAF decays were detected in a short (498-560 nm; ch1) and long (560-720 nm; ch2) wavelength channel...
October 24, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27750290/spatial-distribution-of-macular-pigment-in-an-elderly-french-population-the-montrachet-study
#15
Seydou Alassane, Christine Binquet, Louis Arnould, Olivier Fleck, Niyazi Acar, Cécile Delcourt, Lionel Bretillon, Alain M Bron, Catherine Creuzot-Garcher
Purpose: We describe the spatial distribution and cross-sectional associations with physical and lifestyle attributes. Methods: The participants of the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular and HEarT) study underwent an exhaustive ophthalmologic examination, including optical coherence tomography, to measure retinal thickness. The spatial distribution of macular pigment optical density (MPOD) defined as a ring-like, intermediate or no-ring pattern, was assessed by means of the two-wavelength autofluorescence technique...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27622189/lens-density-measurements-by-two-independent-psychophysical-techniques
#16
Anirbaan Mukherjee, Richard A Bone
BACKGROUND: Cataract, a leading cause of vision impairment, is due to the lens becoming excessively optically dense. Change in the lens optical density (LOD) could be a useful indicator of incipient nuclear cataract and would necessitate the development of accurate measurement techniques. Mapcat sf™ is a heterochromatic flicker photometer for measuring macular pigment optical density (MPOD) under photopic conditions. In the process, it also measures LOD that is needed in the calculation of MPOD...
2016: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/27621586/macular-pigment-optical-density-repeatability-intereye-correlation-and-effect-of-ocular-dominance
#17
Pinakin Gunvant Davey, Silverio D Alvarez, Jessica Y Lee
PURPOSE: To evaluate short-term repeatability, intereye correlation, and effect of ocular dominance on macular pigment optical density (MPOD) measurements obtained using the QuantifEye Heterochromatic Flicker Photometer. PATIENTS AND METHODS: A total of 72 study participants were enrolled in this prospective, cross-sectional study. Participants underwent a comprehensive ocular evaluation, including visual acuity, evaluation of ocular dominance, slit lamp examination, intraocular pressure measurement, and optic nerve head and macula analysis using optical coherence tomography and fundus photography...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27587715/pilot-evaluation-of-short-term-changes-in-macular-pigment-and-retinal-sensitivity-in-different-phenotypes-of-early-age-related-macular-degeneration-after-carotenoid-supplementation
#18
Federico Corvi, Eric H Souied, Yousra Falfoul, Anouk Georges, Camille Jung, Lea Querques, Giuseppe Querques
PURPOSE: To investigate the response of carotenoid supplementation in different phenotypes of early age-related macular degeneration (AMD) by measuring macular pigment optical density (MPOD) and retinal sensitivity. METHODS: Consecutive patients with only medium/large drusen and only reticular pseudodrusen (RPD) and age-matched and sex-matched controls were enrolled. At baseline, participants underwent a complete ophthalmological examination including measurement of best-corrected visual acuity (BCVA), MPOD and retinal sensitivity...
September 1, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27580077/blue-black-or-white-gold-early-stage-processing-and-the-color-of-the-dress
#19
Jeff Rabin, Brook Houser, Carolyn Talbert, Ruh Patel
PURPOSE: In Feb 2015 an image of a dress posted on Tumblr triggered an internet phenomenon: Is the Dress blue and black (BB) or white and gold (WG)? Many claim BB and others insist WG while the true colors are BB. The prevailing theory is that assumptions about the illuminant govern perception of the Dress with WG due to bluish lighting and BB due to yellowish. Our purpose was to determine if early stage optical, retinal and/or neural factors also impact perception of the Dress. METHODS: Thirty-nine subjects were categorized as BB or WG based on their initial perception of the Dress and their perception reported when viewing the Dress on iPhone 5, iPad, and 22" LCD displays...
2016: PloS One
https://www.readbyqxmd.com/read/27544327/relationships-between-macular-pigment-optical-density-and-lacquer-cracks-in-high-myopia
#20
L Benoudis, P Ingrand, J Jeau, O Lichtwitz, M Boissonnot, N Leveziel
PURPOSE: A low concentration of macular carotenoid pigment (lutein and zeaxanthin) is a significant risk factor for macular degeneration. The goal of this paper is to investigate the relationship between macular pigment optical density (MPOD) and lacquer cracks (LC) in high myopia. METHODS: This is a prospective comparative observational study (NCT02205632) including high myopic patients with or without LC. High myopia was defined as a refractive error greater than 6 diopters of myopia or axial length greater than 26mm...
September 2016: Journal Français D'ophtalmologie
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