keyword
https://read.qxmd.com/read/38483610/comparing-2-dimensional-macular-pigment-optical-density-with-objective-and-subjective-perimetry-and-visual-acuity-in-age-related-macular-degeneration
#1
JOURNAL ARTICLE
Bhim B Rai, Faran Sabeti, Joshua P van Kleef, Corinne F Carle, Emilie M F Rohan, Rohan W Essex, Richard C Barry, Ted Maddess
PURPOSE: To compare diagnostic power for different severities of age-related macular degeneration (AMD) of two-dimensional macular pigment optical densities (2D-MPOD) and spatially matched objective perimetry, with standard perimetry and best-corrected visual acuity (BCVA). METHODS: The ObjectiveField Analyser (OFA) provided objective perimetry, and a Heidelberg Spectralis optical coherence tomography (OCT) measured 2D-MPOD in AMD patients, both completed twice over 0...
March 14, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38472988/analysis-of-oct-scanning-parameters-in-amd-and-rvo
#2
JOURNAL ARTICLE
Claus von der Burchard, Johann Roider, Timo Kepp
Optical coherence tomography (OCT) is an extensively used imaging tool for disease monitoring in both age-related macular degeneration (AMD) and retinal vein occlusion (RVO). However, there is limited literature on minimum requirements of OCT settings for reliable biomarker detection. This study systematically investigates both the influence of scan size and interscan distance (ISD) on disease activity detection. We analyzed 80 OCT volumes of AMD patients and 12 OCT volumes of RVO patients for the presence of subretinal fluid (SRF), intraretinal fluid (IRF), and pigment epithelium detachment (PED)...
February 29, 2024: Diagnostics
https://read.qxmd.com/read/38466282/adaptive-optics-retinal-imaging-in-rdh12-associated-early-onset-severe-retinal-dystrophy
#3
JOURNAL ARTICLE
Malena Daich Varela, Mira Dixit, Angelos Kalitzeos, Michel Michaelides
PURPOSE: RDH12 is among the most common genes found in individuals with early-onset severe retinal (EOSRD). Adaptive optics scanning light ophthalmoscopy (AOSLO) enables resolution of individual rod and cone photoreceptors in the retina. This study presents the first AOSLO imaging of individuals with RDH12-associated EOSRD. METHODS: Case series of patients who attended Moorfields Eye Hospital (London, UK). Spectral-domain optical coherence tomography, near-infrared reflectance (NIR), and blue autofluorescence imaging were analyzed...
March 5, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38404299/measuring-the-visual-angle-of-polarization-related-entoptic-phenomena-using-structured-light
#4
JOURNAL ARTICLE
C Kapahi, A E Silva, D G Cory, M Kulmaganbetov, M A Mungalsingh, D A Pushin, T Singh, B Thompson, D Sarenac
The ability to perceive polarization-related entoptic phenomena arises from the dichroism of macular pigments held in Henle's fiber layer of the retina and can be inhibited by retinal diseases, such as age-related macular degeneration, which alters the structure of the macula. Structured light tools enable the direct probing of macular pigment density and retinal structure through the perception of polarization-dependent entoptic patterns. Here, we directly measure the visual angle of an entoptic pattern created through the illumination of the retina with a structured state of light and a perception task that is insensitive to corneal birefringence...
February 1, 2024: Biomedical Optics Express
https://read.qxmd.com/read/38373901/efficacy-and-safety-of-intravitreal-injections-of-conbercept-for-the-treatment-of-idiopathic-choroidal-neovascularization
#5
JOURNAL ARTICLE
Gaixia Zhai, Yuanzhen Su, Shaopeng Wang, Hui Lu, Na Liu
BACKGROUND: To determine the efficacy and safety of intravitreally injected conbercept, a vascular endothelial growth factor receptor fusion protein, for the treatment of idiopathic choroidal neovascularization (ICNV). METHODS: This retrospective study analyzed outcomes in 40 patients (40 eyes) with ICNV who received intravitreal injections of conbercept 0.5 mg (0.05 ml) and were followed up for at least 12 months. All patients underwent full ophthalmic examinations, including best-corrected vision acuity (BCVA), intraocular pressure (IOP), slit-lamp examination, color fundus photography, optical coherence tomography angiography, multifocal electroretinogram, and fundus fluorescence angiography, if necessary, at baseline and after 1, 3, 6, and 12 months...
February 19, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38363462/lutein-and-zeaxanthin-supplementation-improves-dynamic-visual-and-cognitive-performance-in-children-a-randomized-double-blind-parallel-placebo-controlled-study
#6
JOURNAL ARTICLE
Rajesh Parekh, Billy R Hammond, Divya Chandradhara
INTRODUCTION: Supplementation with dietary neuro-pigments lutein (L) and zeaxanthin (Z) has been shown to improve many aspects of visual and cognitive function in adults. In this study, we tested whether a similar intervention could improve such outcomes in preadolescent children. METHODS: Sixty children (age range 5-12 years) were randomized in a 2:1 ratio in this double-blind, placebo-controlled clinical trial. Subjects were supplemented with gummies containing either a combination of 10 mg lutein and 2 mg zeaxanthin (LZ) or placebo for 180 days...
February 16, 2024: Advances in Therapy
https://read.qxmd.com/read/38358437/in-vivo-cone-photoreceptor-density-comparison-between-eyes-with-subretinal-drusenoid-deposits-and-healthy-eyes-using-high-magnification-imaging
#7
JOURNAL ARTICLE
Djazia El Ghazi, Alexandra Miere, Emanuele Crincoli, Hoang Mai Le, Eric H Souied
PURPOSE: To compare photoreceptor density automated quantification in eyes with subretinal drusenoid deposits (SDD) and healthy controls using Heidelberg Spectralis High Magnification Module (HMM) imaging. METHODS: Twelve eyes of 6 patients with intermediate AMD, presenting with SDD were included, as well as twelve eyes of healthy controls. Individual dot SDD within the central 30° retina were examined with infrared confocal laser ophthalmoscopy, HMM, and spectral-domain optical coherence tomography (SD-OCT)...
February 15, 2024: International Ophthalmology
https://read.qxmd.com/read/38349916/deep-learning-based-correction-of-cataract-induced-influence-on-macular-pigment-optical-density-measurement-by-autofluorescence-spectroscopy
#8
JOURNAL ARTICLE
Akira Obana, Kibo Ote, Yuko Gohto, Hidenao Yamada, Fumio Hashimoto, Shigetoshi Okazaki, Ryo Asaoka
PURPOSE: Measurements of macular pigment optical density (MPOD) using the autofluorescence spectroscopy yield underestimations of actual values in eyes with cataracts. Previously, we proposed a correction method for this error using deep learning (DL); however, the correction performance was validated through internal cross-validation. This cross-sectional study aimed to validate this approach using an external validation dataset. METHODS: MPODs at 0.25°, 0...
2024: PloS One
https://read.qxmd.com/read/38346091/morphological-biomarkers-predicting-exudative-conversion-in-type-1-nonexudative-macular-neovascularization-using-oct-angiography
#9
JOURNAL ARTICLE
Su Ho Bae, Kunho Bae, Chang Ki Yoon, Un Chul Park, Kyu Hyung Park, Eun Kyoung Lee
PURPOSE: To investigate the incidence and morphological biomarkers to predict the exudative conversion in eyes with type 1 nonexudative macular neovascularization (MNV) using swept-source optical coherence tomography angiography (SS-OCTA). METHODS: MNVs were detected using the retinal pigment epithelium (RPE)-to-RPE-fit slab of SS-OCTA scan. Depending on whether exudation developed within a year, the eyes were divided into two groups: active and silent. Qualitative and quantitative OCTA parameters of the two groups were evaluated to discriminate the biomarkers associated with exudative conversion...
February 12, 2024: Retina
https://read.qxmd.com/read/38175467/analysis-of-macular-pigment-optical-density-in-macular-holes-with-different-border-phenotypes
#10
JOURNAL ARTICLE
Alberto Quarta, Matteo Gironi, Maria Ludovica Ruggeri, Annamaria Porreca, Rossella D'Aloisio, Lisa Toto, Marta Di Nicola, Rodolfo Mastropasqua
INTRODUCTION: We conducted a cross-sectional study to compare macular pigment optical density (MPOD) in eyes with idiopathic macular holes with bumpy (bbMH) and smooth borders (sbMH) and to assess the relation between MPOD and optical coherence tomography findings. Thirty eyes from thirty patients affected by idiopathic macular hole were studied. METHODS: All patients underwent SD-OCT and macular pigment optical density (MPOD) analysis. Comparison between the two border phenotypes were estimated at baseline, as well as  the differences in MPOD, minimum and basal hole diameter, tractional hole index (THI), macular hole index (MHI), diameter hole index (DHI), and ELM integrity metrics between the two groups...
January 4, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38163108/effect-of-mediterranean-diet-and-blue-light-exposition-on-macular-pigment-optical-density-values-in-a-spanish-childhood-population
#11
JOURNAL ARTICLE
García-Romera Marta-C, Torres-Parejo Úrsula, Ponce-García Victor
BACKGROUND: Macular pigment in retina is formed by lutein and zeaxanthin. These carotenoids must be ingested. Fruit, vegetables, and eggs are rich in lutein and zeaxanthin. In adults, there are many factors that increase macular pigment values, although not enough studies have been performed in children. OBJECTIVE: The main aim of this study was to analyze macular pigment in children considering healthy habits and exposure to LEDs screens. METHODS: A cross-sectional, observational study was conducted, recruiting 27 children aged 7-13 years...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38145775/changes-in-macular-pigment-optical-density-after-full-thickness-macular-hole-closure-using-inverted-flap-technique
#12
Michele Rinaldi, Gilda Cennamo, Maria Laura Passaro, Ciro Costagliola
Full-thickness macular hole (FTMH) is a debilitating retinal disorder, particularly in its advanced forms, necessitating surgical intervention for vision restoration. This case report details the successful closure of a large FTMH using the inverted flap technique, highlighting the essential role of multimodal imaging, and particularly macular pigment optical density (MPOD) assessment, in preoperative and postoperative evaluation. A 55-year-old patient presented with severe vision loss in one eye due to a large FTMH...
December 23, 2023: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/37966565/measuring-macular-pigment-optical-density-using-reflective-images-of-confocal-scanning-laser-system
#13
JOURNAL ARTICLE
Hirofumi Morita, Itsuka Matsushita, Yoshihisa Fujino, Akira Obana, Hiroyuki Kondo
PURPOSE: To develop a method to measure the macular pigment optical density (MPOD) using scanning laser ophthalmoscopic images in young adults and children. STUDY DESIGN: Cross-sectional study. METHODS: Blue light reflectance fundus images of 32 healthy subjects were used. A profile of the linear reflectance changes across the center of the fovea on a grayscale fundus image was generated. The ratio of the macula-to-periphery reflection was designated as the peak value of the MPOD (MPOD[FR] ) based on established fundamentals...
November 15, 2023: Japanese Journal of Ophthalmology
https://read.qxmd.com/read/37945766/pachychoroid-neovasculopathy-versus-macular-neovascularization-in-age-related-macular-degeneration-with-and-without-shallow-irregular-pigment-epithelial-detachment
#14
JOURNAL ARTICLE
Hamid Riazi-Esfahani, Esmaeil Asadi Khameneh, Fariba Ghassemi, Mohammadreza Mehrabi Bahar, Ali Torkashvand, Alireza Mahmoudi, Ahmed Husein Ahmed, Shahin Faghihi, Masoud Rahimi, Ali Akbarzadeh, Hooshang Faghihi, Elias Khalili Pour
To compare the choroidal neovascular features of individuals with pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) with and without shallow irregular pigment epithelial detachment (SIPED). Using optical coherence tomography angiography, the choroidal neovascular complexes of 27 patients with PNV, 34 patients with nAMD and SIPED, and 15 patients with nAMD without SIPED were analyzed with FIJI and AngioTool software. PNV compared to nAMD with SIPED had a greater vessel percentage area (P = 0...
November 9, 2023: Scientific Reports
https://read.qxmd.com/read/37943552/imaging-histology-correlations-of-intraretinal-fluid-in-neovascular-age-related-macular-degeneration
#15
JOURNAL ARTICLE
Andreas Berlin, Jeffrey D Messinger, Chandrakumar Balaratnasingam, Randev Mendis, Daniela Ferrara, K Bailey Freund, Christine A Curcio
PURPOSE: Fluid presence and dynamism is central to the diagnosis and management of neovascular age-related macular degeneration. On optical coherence tomography (OCT), some hyporeflective spaces arise through vascular permeability (exudation) and others arise through degeneration (transudation). Herein we determined whether the histological appearance of fluid manifested this heterogeneity. METHODS: Two eyes of a White woman in her 90s with anti-vascular endothelial growth factor treated bilateral type 3 neovascularization secondary to age-related macular degeneration were osmicated, prepared for submicrometer epoxy resin sections, and correlated to eye-tracked spectral domain OCT...
November 1, 2023: Translational Vision Science & Technology
https://read.qxmd.com/read/37899478/influence-of-macular-pigment-on-the-sensitivity-to-discomfort-glare-from-daylight
#16
JOURNAL ARTICLE
Sneha Jain, Jan Wienold, Chiara Eandi, Sara Gisselbaek, Aki Kawasaki, Marilyne Andersen
Understanding the factors that influence the human perception of glare is necessary to properly address glare risks in buildings and achieve comfortable visual environments, especially in the workplace. Yet large inter-individual variabilities in glare perception remain unexplained and thus uncovered by the current empirical glare models. We hypothesize that this variability has an origin in the human retina, in particular in the density of macular pigments present in its central area, which varies between individuals...
October 29, 2023: Scientific Reports
https://read.qxmd.com/read/37890895/association-of-macular-pigment-optical-density-with-retinal-layer-thicknesses-in-eyes-with-and-without-manifest-primary-open-angle-glaucoma
#17
JOURNAL ARTICLE
Thomas Lawler, J A Mares, Zhe Liu, Catherine Thuruthumaly, Tyler Etheridge, Thasarat S Vajaranant, Amitha Domalpally, Billy R Hammond, Robert B Wallace, Lesley F Tinker, Marine Nalbandyan, Barbara E K Klein, Yao Liu
OBJECTIVE: To investigate associations between baseline macular pigment optical density (MPOD) and retinal layer thicknesses in eyes with and without manifest primary open-angle glaucoma (POAG) in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2). METHODS AND ANALYSIS: MPOD was measured at CAREDS baseline (2001-2004) via heterochromatic flicker photometry (0.5° from foveal centre). Peripapillary retinal nerve fibre layer (RNFL), macular ganglion cell complex (GCC), ganglion cell layer (GCL), inner plexiform layer (IPL), and RNFL thicknesses were measured at CAREDS2 (2016-2019) via spectral-domain optical coherence tomography...
October 2023: BMJ Open Ophthalmology
https://read.qxmd.com/read/37875097/reply-to-finsterer-et-al
#18
JOURNAL ARTICLE
Weili Hu, Pavitra Shankar, Yuanhang Yao, Xinyi Su, Jung Eun Kim
This letter acknowledges Finsterer and colleagues' insightful comments on pesticide use in fruits and vegetables and impact on eye health. Pesticides can harm eyes through various exposures. Adverse effects occur due to direct entry into ocular tissues, with absorption through eye components. While the potential of organic diets to reduce pesticide exposure is acknowledged, the original paper's cited studies lack clarity on whether organic diet interventions were used. Future systematic reviews comparing organic and nonorganic diets could provide further insights...
October 24, 2023: Nutrition Reviews
https://read.qxmd.com/read/37818160/the-relationship-between-inflammatory-biomarkers-and-macular-pigment-optical-density-in-hypertensive-patients-a-cross-sectional-study
#19
JOURNAL ARTICLE
Chunchuree Kongmeesuk Kaneko, Katsunori Kaneko, Vitoon Jularattanaporn, Thamthiwat Nararatwanchai
BACKGROUND: Inflammation may be associated with macular pigment optical density (MPOD) degradation. OBJECTIVES: The relationship between inflammation and MPOD is evaluated using inflammatory biomarkers, including high sensitivity C-reactive protein (hsCRP), lipid level and ratio, waist circumference (WC), and body mass index (BMI). METHOD: In this cross-sectional design, 62 hypertensive patients were recruited between January 6 and January 8, 2022, at a primary care unit...
June 2023: Asian Biomedicine: Research, Reviews and News
https://read.qxmd.com/read/37766762/evaluation-of-macular-pigment-optical-density-in-eyes-with-hyperopic-anisometropic-amblyopia-using-fundus-reflectometry
#20
JOURNAL ARTICLE
Mahmut Kaya, Taylan Ozturk, Ziya Ayhan, Ferdane Atas, Betul Akbulut Yagci
OBJECTIVES: This study aimed to evaluate the macular pigment optical density (MPOD) scores in eyes with hyperopic anisometropic amblyopia and compare those with their fellow and control eyes using one-wavelength fundus reflectometry. METHODS: This cross-sectional study enrolled 33 patients diagnosed with hyperopic anisometropic amblyopia aged 12-40 years. The control group consisted of 36 hyperopic and 42 emmetropic children, age-matched to the patients. Central macular thickness (CMT), MPOD, axial length (AL), best-corrected visual acuity, and refraction errors were measured between the study group and the control group...
2023: Beyoglu eye journal
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