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Macular pigment optical density

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https://www.readbyqxmd.com/read/28880221/the-macular-carotenoids-lutein-and-zeaxanthin-are-related-to-increased-bone-density-in-young-healthy-adults
#1
Emily R Bovier, Billy R Hammond
Lutein (L) and zeaxanthin (Z) status can be quantified by measuring their concentrations both in serum and, non-invasively, in retinal tissue. This has resulted in a unique ability to assess their role in a number of tissues ranging from cardiovascular to central nervous system tissue. Recent reports using animal models have suggested yet another role, a developmental increase in bone mass. To test this, we assessed L and Z status in 63 young healthy adults. LZ status was determined by measuring LZ in serum (using HPLC) and retina tissue (measuring macular pigment optical density, MPOD, using customized heterochromatic flicker photometry)...
September 7, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28851319/absolute-and-estimated-values-of-macular-pigment-optical-density-in-young-and-aged-asian-participants-with-or-without-age-related-macular-degeneration
#2
Yoko Ozawa, Yuta Shigeno, Norihiro Nagai, Misa Suzuki, Toshihide Kurihara, Sakiko Minami, Eri Hirano, Hajime Shinoda, Saori Kobayashi, Kazuo Tsubota
BACKGROUND: Lutein and zeaxanthin are suggested micronutrient supplements to prevent the progression of age-related macular degeneration (AMD), a leading cause of blindness worldwide. To monitor the levels of lutein/zeaxanthin in the macula, macular pigment optical density (MPOD) is measured. A commercially available device (MPSII®, Elektron Technology, Switzerland), using technology based on heterochromatic flicker photometry, can measure both absolute and estimated values of MPOD. However, whether the estimated value is applicable to Asian individuals and/or AMD patients remains to be determined...
August 29, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28832731/photoreceptor-assessment-using-adaptive-optics-in-resolved-central-serous-chorioretinopathy
#3
André Luiz Braga Meirelles, Murilo Wendeborn Rodrigues, Aline Fernanda Guirado, Rodrigo Jorge
We present a case of a patient with resolved central serous chorioretinopathy (CSC) in the left eye with persistent mild visual alterations 4 years after the resolution of the disease. Left eye exam revealed a best corrected visual acuity of 20/25 and a slight change of macular pigmentation. Optical coherence tomography revealed only minor irregularities in the topography of retinal pigment epithelium and Bruch's membrane. Adaptive optics (AO) optics demonstrated lower density, spacing, and changes in the photoreceptor mosaic pattern in the left eye than in the right eye, suggesting that CSC may cause damage to cones after clinical recovery...
June 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28728169/correlations-between-macular-skin-and-serum-carotenoids
#4
Christopher D Conrady, James P Bell, Brian M Besch, Aruna Gorusupudi, Kelliann Farnsworth, Igor Ermakov, Mohsen Sharifzadeh, Maia Ermakova, Werner Gellermann, Paul S Bernstein
Purpose: Ocular and systemic measurement and imaging of the macular carotenoids lutein and zeaxanthin have been employed extensively as potential biomarkers of AMD risk. In this study, we systematically compare dual wavelength retinal autofluorescence imaging (AFI) of macular pigment with skin resonance Raman spectroscopy (RRS) and serum carotenoid levels in a clinic-based population. Methods: Eighty-eight patients were recruited from retina and general ophthalmology practices from a tertiary referral center and excluded only if they did not have all three modalities tested, had a diagnosis of macular telangiectasia (MacTel) or Stargardt disease, or had poor AFI image quality...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28727884/oct-angiography-and-ellipsoid-zone-mapping-of-macular-telangiectasia-type-2-from-the-avatar-study
#5
Anne P Runkle, Peter K Kaiser, Sunil K Srivastava, Andrew P Schachat, Jamie L Reese, Justis P Ehlers
Purpose: To evaluate alterations on optical coherence tomography angiography (OCT-A) and quantitatively assess alterations in the ellipsoid zone (EZ) in eyes with macular telangiectasia type 2 (MacTel type 2). Methods: The Observational Assessment of Visualizing and Analyzing Vessels With Optical Coherence Tomography Angiography in Retinal Diseases study is an institutional review board-approved prospective, observational study investigating OCT-A in macular disease...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28661438/macular-carotenoid-supplementation-improves-visual-performance-sleep-quality-and-adverse-physical-symptoms-in-those-with-high-screen-time-exposure
#6
James M Stringham, Nicole T Stringham, Kevin J O'Brien
The dramatic rise in the use of smartphones, tablets, and laptop computers over the past decade has raised concerns about potentially deleterious health effects of increased "screen time" (ST) and associated short-wavelength (blue) light exposure. We determined baseline associations and effects of 6 months' supplementation with the macular carotenoids (MC) lutein, zeaxanthin, and mesozeaxanthin on the blue-absorbing macular pigment (MP) and measures of sleep quality, visual performance, and physical indicators of excessive ST...
June 29, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28649198/the-role-of-retinal-carotenoids-and-age-on-neuroelectric-indices-of-attentional-control-among-early-to-middle-aged-adults
#7
Anne M Walk, Caitlyn G Edwards, Nicholas W Baumgartner, Morgan R Chojnacki, Alicia R Covello, Ginger E Reeser, Billy R Hammond, Lisa M Renzi-Hammond, Naiman A Khan
One apparent consequence of aging appears to be loss of some aspects of cognitive control. This loss is measurable as early as mid-adulthood. Since, like many aspects of cognition, there is wide variance among individuals, it is possible that behavior, such as one's diet, could drive some of these differences. For instance, past data on older humans and non-human primates have suggested that dietary carotenoids could slow cognitive decline. In this study, we tested how early such protection might manifest by examining a sample (n = 60) of 25-45 year olds...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28643712/comparison-of-macular-pigment-optical-density-in-patients-with-dry-and-wet-age-related-macular-degeneration
#8
Ayhan Ozyurt, Nilufer Kocak, Pınar Akan, Ozlem Gursoy Calan, Taylan Ozturk, Mahmut Kaya, Eyup Karahan, Suleyman Kaynak
AIM: The aim of the study was to evaluate the macular pigment optical density (MPOD) levels in patients with wet age-related macular degeneration (AMD), dry AMD, and also in healthy controls. SETTINGS AND DESIGN: This study was conducted at Department of Ophthalmology, and the study design was a prospective study. PATIENTS AND METHODS: Forty-eight patients with wet AMD, 51 patients with dry AMD, and 50 controls were included in the study. All patients were naive to both previous lutein or zeaxanthin administration and any previous intravitreal injections...
June 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28535707/macular-pigment-optical-density-is-positively-associated-with-academic-performance-among-preadolescent-children
#9
Sasha M Barnett, Naiman A Khan, Anne M Walk, Lauren B Raine, Christopher Moulton, Neal J Cohen, Arthur F Kramer, Billy R Hammond, Lisa Renzi-Hammond, Charles H Hillman
OBJECTIVE: Macular pigment optical density (MPOD) - a non-invasive indicator of retinal xanthophylls and correlate of brain lutein - has been associated with superior cognitive function among adult populations. Given that lutein accumulation in the brain occurs in early life, it is possible that the cognitive implications of greater MPOD may be evident in childhood. METHODS: Participants aged 8-9 years (n = 56) completed MPOD measurements via heterochromatic flicker photometry...
May 23, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28528704/from-neuro-pigments-to-neural-efficiency-the-relationship-between-retinal-carotenoids-and-behavioral-and-neuroelectric-indices-of-cognitive-control-in-childhood
#10
Anne M Walk, Naiman A Khan, Sasha M Barnett, Lauren B Raine, Arthur F Kramer, Neal J Cohen, Christopher J Moulton, Lisa M Renzi-Hammond, Billy R Hammond, Charles H Hillman
Lutein and zeaxanthin are plant pigments known to preferentially accumulate in neural tissue. Macular Pigment Optical Density (MPOD), a non-invasive measure of retinal carotenoids and surrogate measure of brain carotenoid concentration, has been associated with disease prevention and cognitive health. Superior MPOD status in later adulthood has been shown to provide neuroprotective effects on cognition. Given that childhood signifies a critical period for carotenoid accumulation in brain, it is likely that the beneficial impact would be evident during development, though this relationship has not been directly investigated...
August 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28431432/contrast-sensitivity-and-lateral-inhibition-are-enhanced-with-macular-carotenoid-supplementation
#11
RANDOMIZED CONTROLLED TRIAL
James M Stringham, Kevin J O'Brien, Nicole T Stringham
Purpose: Once deposited in the retina, the so-called macular carotenoids lutein (L), zeaxanthin (Z), and mesozeaxanthin (MZ) have been shown to enhance visual performance. The purpose of our study was to investigate whether increasing macular pigment optical density (MPOD) could enhance lateral inhibitory processes, and thereby improve contrast sensitivity (CS). Methods: A total of 59 young (18-25 years), healthy individuals participated in this 1-year, double-masked, placebo-controlled study...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28426871/macular-pigment-density-and-quantitative-fundus-autofluorescence-in-young-healthy-subjects
#12
Chiara M Eandi, Marco Nassisi, Carlo Lavia, Camilla Alovisi, Ugo de Sanctis
Purpose: To measure macular pigment (MP) and find possible correlation between heterochromatic flicker photometry (HFP) and quantitative autofluorescence (qAF) in young healthy subjects. Methods: We enrolled 80 eyes of 40 young healthy subjects. Macular pigment optical density (MPOD) was automatically calculated with a macular pigment screener (MPS; MPODHFP). We calculated qAF comparing gray levels (GL) of qAF images with GL of internal reference of a confocal scanning laser ophthalmoscopy...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28336284/macular-pigment-density-variation-after-supplementation-of-lutein-and-zeaxanthin-using-the-visucam-%C3%A2-200-pigment-module-impact-of-age-related-macular-degeneration-and-lens-status
#13
G Azar, M Quaranta-El Maftouhi, J-J Masella, M Mauget-Faÿsse
PURPOSE: To assess the evolution of macular pigment optical density (MPOD) following supplementation with various macular formulations obtained with the Visucam(®) 200, and to study the factors affecting MPOD measurements. MATERIALS AND METHODS: In this prospective, randomized, double-masked multicenter study, patients were divided into 2 groups: group A (patients without retinal pathology who underwent cataract surgery 1 month previously) and group B (patients with neovascular age-related macular degeneration [AMD] in one eye)...
April 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28271618/plasma-long-chain-omega-3-polyunsaturated-fatty-acids-and-macular-pigment-in-subjects-with-family-history-of-age-related-macular-degeneration-the-limpia-study
#14
Bénédicte M J Merle, Benjamin Buaud, Jean-François Korobelnik, Alain Bron, Marie-Noëlle Delyfer, Marie-Bénédicte Rougier, Hélène Savel, Carole Vaysse, Catherine Creuzot-Garcher, Cécile Delcourt
PURPOSE: In numerous epidemiological studies, omega-3 polyunsaturated fatty acids (PUFAs) have been associated with a decreased risk of age-related macular degeneration (AMD). Beyond their structural, functional and neuroprotective roles, omega-3 PUFAs may favour the retinal accumulation of lutein and zeaxanthin and thus increase macular pigment optical density (MPOD). We examined the associations of MPOD with plasma omega-3 PUFAs in subjects with family history of AMD. METHODS: The Limpia study is a double-blind, placebo-controlled, prospective randomized clinical trial performed in 120 subjects...
March 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28244563/non-dietary-correlates-and-determinants-of-plasma-lutein-and-zeaxanthin-concentrations-in-the-irish-population
#15
R Moran, J M Nolan, J Stack, A M O'Halloran, J Feeney, K O Akuffo, R A Kenny, S Beatty
OBJECTIVE: To investigate non-dietary correlates and determinants of plasma lutein (L) and zeaxanthin (Z) concentrations in The Irish Longitudinal Study on Ageing (TILDA) sample. DESIGN: Cross-sectional study. SETTING: Community dwelling adults in the Republic of Ireland (ROI). PARTICIPANTS: 3,681 participants aged 50 years and older. MEASUREMENTS: TILDA is a nationally representative prospective cohort study of community dwelling adults aged 50 years and over in the ROI...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28231126/macular-pigment-optical-density-and-measures-of-macular-function-test-retest-variability-cross-sectional-correlations-and-findings-from-the-zeaxanthin-pilot-study-of-response-to-supplementation-zeastress-pilot
#16
Alessandro Iannaccone, Giovannella Carboni, Gina Forma, Maria Giulia Mutolo, Barbara J Jennings
We report on the short-term test-retest baseline variability in macular function tests in ZEASTRESS-Pilot participants (n = 18), on their cross-sectional correlation with macular pigment optical density (MPOD), and on the effects of four months (FUV4) of 20 mg/day zeaxanthin (ZX), followed by a four-month washout (FUV8; n = 24, age 50-81 years old). Outcomes included: MPOD at 0.5 and 2.0 deg eccentricity (MPOD-0.5 and -2.0); contrast sensitivity (CS); pattern-reversal electroretinogram (PERG) amplitude; dark-adapted 650 nm foveal cone sensitivity (DA650-FCS); and 500 mn parafoveal rod sensitivity (DA500-PFRS)...
April 29, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28198205/supplementation-with-macular-carotenoids-reduces-psychological-stress-serum-cortisol-and-sub-optimal-symptoms-of-physical-and-emotional-health-in-young-adults
#17
Nicole Tressa Stringham, Philip V Holmes, James M Stringham
PURPOSE: Oxidative stress and systemic inflammation are the root cause of several deleterious effects of chronic psychological stress. We hypothesize that the antioxidant and anti-inflammatory capabilities of the macular carotenoids (MCs) lutein, zeaxanthin, and meso-zeaxanthin could, via daily supplementation, provide a dietary means of benefit. METHODS: A total of 59 young healthy subjects participated in a 12-month, double-blind, placebo-controlled trial to evaluate the effects of MC supplementation on blood cortisol, psychological stress ratings, behavioural measures of mood, and symptoms of sub-optimal health...
February 15, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28068388/the-association-between-foveal-morphology-and-macular-pigment-spatial-distribution-an-ethnicity-study
#18
Irene Ctori, Byki Huntjens
PURPOSE: Macular pigment (MP) spatial distribution varies considerably among individuals. We investigated ethnic variations in MP spatial distribution in relation to foveal architecture. METHODS: We measured MP optical density (MPOD) using heterochromatic flicker photometry (MAP test, City, University of London) in 76 white, 80 South Asian and 70 black volunteers (18 to 39 years). MPOD spatial profiles were classified objectively as exponential, ring-like or central dip, based on deviations away from an exponential fit...
2017: PloS One
https://www.readbyqxmd.com/read/27959968/enhanced-visualization-of-subtle-outer-retinal-pathology-by-en-face-optical-coherence-tomography-and-correlation-with-multi-modal-imaging
#19
Danuta M Sampson, David Alonso-Caneiro, Avenell L Chew, Tina Lamey, Terri McLaren, John De Roach, Fred K Chen
PURPOSE: To present en face optical coherence tomography (OCT) images generated by graph-search theory algorithm-based custom software and examine correlation with other imaging modalities. METHODS: En face OCT images derived from high density OCT volumetric scans of 3 healthy subjects and 4 patients using a custom algorithm (graph-search theory) and commercial software (Heidelberg Eye Explorer software (Heidelberg Engineering)) were compared and correlated with near infrared reflectance, fundus autofluorescence, adaptive optics flood-illumination ophthalmoscopy (AO-FIO) and microperimetry...
2016: PloS One
https://www.readbyqxmd.com/read/27911444/impact-of-optical-coherence-tomography-scanning-density-on-quantitative-analyses-in-neovascular-age-related-macular-degeneration
#20
S B Velaga, M G Nittala, R K Konduru, F Heussen, P A Keane, S R Sadda
PurposeTo assess the influence of varying B-scan frame-sampling densities on retinal thickness and volume measurements from spectral domain optical coherence tomography (OCT) in eyes with neovascular age-related macular degeneration (AMD).MethodsVolume OCT data (512 × 128 macular cube over 6 × 6 mm) were collected from 39 eyes with neovascular AMD. All 128 B-scans in each image set were manually segmented, allowing quantification of the neurosensory retina, subretinal fluid (SRF), subretinal hyperreflective material (SRHM), and pigment epithelium detachment (PED)...
January 2017: Eye
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