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Pterygia

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https://www.readbyqxmd.com/read/28489720/expression-of-peroxiredoxin-2-and-vascular-endothelial-growth-factor-receptor-2-in-pterygium
#1
Yuchuan Wang, Jinyong Lin, Luxia Chen, Liming Wang, Peng Hao, Ruifang Han, Ming Ying, Xuan Li
PURPOSE: The expression of peroxiredoxin 2 and vascular endothelial growth factor receptor 2 (VEGFR2) was detected in pterygium to investigate whether they are involved in the pathogenesis or recurrence of pterygium and to evaluate the association between peroxiredoxin 2 and VEGFR2 in pterygium. METHODS: Ten normal bulbar conjunctivae, 35 primary pterygia, and 35 recurrent pterygia were obtained. Formalin-fixed, paraffin-wax-embedded tissues were analyzed by immunohistochemistry with peroxiredoxin 2 and VEGFR2 antibodies...
May 9, 2017: Cornea
https://www.readbyqxmd.com/read/28410726/surgical-techniques-and-adjuvants-for-the-management-of-primary-and-recurrent-pterygia
#2
REVIEW
John A Hovanesian, Christopher E Starr, David T Vroman, Francis S Mah, Jose A P Gomes, Marjan Farid, Neda Shamie, Richard S Davidson, Thomas John, Edward J Holland, Terry Kim
The removal and rate of recurrence of pterygium have been discussed for years. The disorder is highly associated with environmental factors, and recurrence rates can be unacceptably high and cannot be successfully predicted. New techniques and graft preparations and postoperative management strategies are helping to reduce the recurrence rates and provide an ocular surface that is near ideal for future cataract or refractive surgery. This review discusses the advantages and disadvantages of various treatment strategies...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28410547/endocan-overexpression-in-pterygium
#3
Raşit Kiliç, Ali Kurt, Murat Tad, Sedat Taşdemir
PURPOSE: The aim of this study was to evaluate the possible role of endocan in the pathogenesis of pterygium. METHODS: The study was conducted on 33 patients with primary pterygium and 20 control subjects with normal bulbar conjunctiva. Patients with pterygium were graded into 3 groups as atrophic, fleshy, and intermediate, according to the Tan classification. Primary nasal pterygia and normal bulbar conjunctivas were surgically removed. Endocan expression was immunohistochemically investigated...
June 2017: Cornea
https://www.readbyqxmd.com/read/28368995/proposal-for-a-novel-severity-grading-system-for-pterygia-based-on-corneal-topographic-data
#4
Kazunori Miyata, Keiichiro Minami, Atsushi Otani, Tadatoshi Tokunaga, Shouta Tokuda, Shiro Amano
PURPOSE: To propose a grading system of pterygium severity based on corneal higher-order irregularity (HOI) and to evaluate postoperative changes in corneal irregularity of the graded pterygia. METHODS: In 268 eyes of 226 patients undergoing excision surgery of primary nasal pterygium, Placido corneal topography images were taken before and until 6 months after surgery. The best-corrected visual acuity (BCVA) and pterygium size with respect to the corneal diameter were also measured...
March 31, 2017: Cornea
https://www.readbyqxmd.com/read/28367523/stromal-cell-derived-factor-1-cxcr4-and-cxcr7-gene-transcripts-in-pterygia
#5
Shahram Bamdad, Behzad Khademi, Nooshin Chenari, Atta Taseh, Mahboobeh Razmkhah
PURPOSE: Pterygium is a pathologic process with angiogenic and tumor cell like characteristics. Chemokine and chemokine receptors may contribute to the formation and growth of pterygia. The aim of this study was to assess the expression of stromal cell derived factor (SDF)-1, as an angiogenic chemokine, and its receptors, CXCR4 and CXCR7, gene transcripts in pterygia. METHODS: RNA was extracted from tissue samples of 33 patients with primary pterygium and 35 volunteers with conjunctiva as the control group...
March 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28347855/role-of-high-resolution-optical-coherence-tomography-in-diagnosing-ocular-surface-squamous-neoplasia-with-coexisting-ocular-surface-diseases
#6
Marwan Atallah, Madhura Joag, Anat Galor, Guillermo Amescua, Afshan Nanji, Jianhua Wang, Victor L Perez, Sander Dubovy, Carol L Karp
PURPOSE: Coexistence of an ocular surface disease can mask the typical features of ocular surface squamous neoplasia (OSSN). The purpose of this study was to evaluate high resolution optical coherence tomography (HR-OCT) as an adjunct in the detection and differentiation of OSSN within coexisting ocular surface pathologies. METHODS: Retrospective study of 16 patients with ocular surface disease and lesions suspicious for OSSN that were evaluated with HR-OCT. HR-OCT images of the lesions were taken to look for evidence of OSSN...
March 24, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28336317/lethal-multiple-pterygium-syndrome-a-severe-phenotype-associated-with-a-novel-mutation-in-the-nebulin-gene
#7
Ebtesam Abdalla, Gianina Ravenscroft, Louay Zayed, Sarah J Beecroft, Nigel G Laing
Fetal akinesia deformation sequence is a clinically and genetically heterogeneous disorder characterized by a variable combination of fetal akinesia, intrauterine growth restriction, developmental abnormalities such as cystic hygroma, hydrops fetalis, pulmonary hypoplasia, occasional arthrogryposis, and pterygia. The pathogenetic mechanisms of fetal akinesia deformation sequence include neuropathy, muscular disorders, neuromuscular junction disorders, maternal myasthenia gravis, restrictive dermopathy and others...
January 18, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28331283/preoperative-subconjunctival-combined-injection-of-bevacizumab-and-mitomycin-c-before-the-surgical-excision-of-primary-pterygium-clinical-and-histological-results
#8
Alahmady Hamad Alsmman, Gamal Radwan, Mortada Ahmed Abozaid, Usama Ali Mohammed, Nesreen Gamal Abd Elhaleim
PURPOSE: The aim of this study was to detect the clinical and histological effects of preoperative subconjunctival injection of both bevacizumab and mitomycin C (MMC) 1 month before the surgical excision of primary pterygium using a bare sclera technique. PATIENTS AND METHODS: A total of 20 patients with primary pterygium underwent subconjunctival combined injection of 0.1 mL of MMC (0.1 mg/mL) and 0.1 mL of bevacizumab (1.25 mg/0.1 mL) 1 month before bare sclera excision of the pterygium...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28292385/effectiveness-of-preoperative-subconjunctival-injection-of-mitomycin-c-in-primary-pterygium-surgery
#9
Faisal Aziz Khan, Mohammed Awais, Shafaq Pervez Khan Niazi, Naveed Akhter, Mazhar Ishaq
OBJECTIVE: To compare the effectiveness of preoperative subconjunctival injection of Mitomycin-C at 24-hour and at one month before primary pterygium excision. STUDY DESIGN: Randomised controlled trial. PLACE AND DURATION OF STUDY: Eye Department, Combined Military Hospital, Sargodha, from January to December 2014. METHODOLOGY: Eyes of 60 patients were randomly allocated into two equal groups (A and B) of 30 each. In group A Mitomycin-C was injected into the pterygium one month before, and in group B Mitomycin-C was injected 24 hours before excision...
February 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28267910/-surgical-management-of-spinal-deformity-in-a-patient-with-escobar-syndrome-review-of-the-literature
#10
M C Hernández-Hernández, J A Canales-Nájera, J S De La Cruz-Álvarez, M E Tena-Zanabria, J Matus-Jiménez
BACKGROUND: The non-lethal variant of the Escobar or multiple pterygium syndrome is an entity of autosomal recessive inheritance linked to the X chromosome; it is characterized by multiple pterygia (hence its name) located mainly in the neck (95%) and armpits (55%), as well as other orthopedic malformations such as a vertical talus, congenital hip dislocation, and congenital scoliosis. OBJECTIVE: To present an optional surgical technique for the management of severe spinal deformities...
July 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28261971/proteomics-a-new-perspective-for-the-understanding-of-pterygia
#11
Yi-Fan Feng, Fei Yuan
Pterygia is a common ocular surface disease bothering both the patient because of its unsightly appearance and the surgeon because of its tendency to recur. The pathogenesis of pterygia is complex and the exact mechanism(s), especially at the molecular level, remains unknown. The use of modern proteomic techniques such as isobaric tags for relative and absolute quantification (iTRAQ) may yield new knowledge on the underlying pathogenesis of pterygia. In this issue of Proteomics Clinical Applications, Linghu et al...
March 6, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28105011/coincidence-of-inflamed-conjunctival-carcinoma-in-situ-and-primary-pterygium
#12
Hiroaki Endo, Satoru Kase, Yasuo Suzuki, Manabu Kase
BACKGROUND: We report a rare case of carcinoma in situ (CIS) in conjunction with a primary pterygium that exhibited characteristic angiographic and histopathological findings. CASE: A 78-year-old man presented with a pterygium and a whitish tumor adjacent to the pterygium in his right eye. Indocyanine green angiography displayed that feeder vessels within the primary pterygium spread to the whitish tumor. The tumor and pterygial tissues were surgically removed. Histologically, the resected tissue contained CIS as well as squamous metaplasia...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28087900/itraq-based-quantitative-proteomic-analysis-and-bioinformatics-study-of-proteins-in-pterygia
#13
Dandan Linghu, Lili Guo, Yinghua Zhao, Zhiming Liu, Mingwei Zhao, Lvzhen Huang, Xiaoxin Li
PURPOSE: To analysis proteins in the tissue of pterygia, and to investigate their potential roles in pterygia, using the comparative proteomic technique of Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) coupled with offline 2DLC-MS/MS, Western-bolt. METHOD: The tissues of pterygia and healthy conjunctiva were collected from 10 pterygia patients (6 females, 4 males; average age was 52 years old; average course of disease was 6 years) in our hospital from September, 2015 to March, 2016...
January 13, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28068383/inhibition-of-pterygium-fibroblast-migration-and-outgrowth-by-bevacizumab-and-cyclosporine-a-involves-down-regulation-of-matrix-metalloproteinases-3-and-13
#14
Yeoun-Hee Kim, Jae-Chang Jung, Sang Il Gum, Su-Bin Park, Jin Yeul Ma, Yong Il Kim, Kyoo Won Lee, Young Jeung Park
We examined the connection between matrix metalloproteinase (MMP) expression/activity and pterygium fibroblast migration, and how these were affected by bevacizumab and/or cyclosporine A (CsA). Fibroblasts were obtained from 20 pterygia and 6 normal conjunctival specimens. Expression levels of MMP-3 and MMP-13 were examined after bevacizumab administration. Immunofluorescence staining was used to examine expression of both MMPs in fibroblasts migrating out from explanted pterygium tissues. Rates of cell migration from explant-cultured pterygia tissues and scratch-wounded confluent pterygium fibroblasts were examined in the presence of MMP-3 or MMP-13 inhibitors, as well as bevacizumab and/or CsA...
2017: PloS One
https://www.readbyqxmd.com/read/28012607/do-demodex-mites-play-a-role-in-pterygium-development
#15
Witold Tarkowski, Joanna Moneta-Wielgoś, Daniel Młocicki
Numerous reports point to Demodex mites as the aetiology of certain eye and skin conditions, hence it is highly probable that infestation with these mites may also play a role in the aetiology and pathogenesis of pterygium. Therefore here we present a hypothesis: whether the presence of Demodex mites in eyelash hair follicles significantly correlates with the presence of pterygia, which could point to a potential role of these mites in the development of such lesions. We present preliminary data for supporting this hypothesis...
January 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/27956289/pterygium-size-and-effect-on-intraocular-lens-power-calculation
#16
Mustafa Koc, Mehmet Murat Uzel, Emre Aydemir, Fuat Yavrum, Pinar Kosekahya, Pelin Yılmazbaş
PURPOSE: To evaluate the effects of pterygium on biometry measurements and the relationship between these effects and pterygium size. SETTING: Ulucanlar Eye Hospital, Ankara, Turkey. DESIGN: Prospective comparative study. METHODS: Patients who had unilateral primary pterygium excision were included in the study group. Anterior segment photographed images were taken of eyes with pterygia to calculate the pterygium length and area using the ImageJ program...
November 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27938950/pterygium-excision-with-conjunctival-autograft-and-subconjunctival-amniotic-membrane-as-antirecurrence-agents
#17
Alexander Shusko, John A Hovanesian
OBJECTIVE: To determine the outcome of pterygium excision with a conjunctival autograft when the adjunctive use of a subconjunctival graft of amniotic membrane is employed to reduce fibrosis and recurrence after surgery. DESIGN: This is a retrospective, noncomparative study of postoperative outcomes. PARTICIPANTS: Eighty-four patients totalling 101 eyes with clinically significant pterygia that warranted surgical excision. METHODS: Surgeries were performed at South Orange County Outpatient Surgery Center (San Clemente, Calif...
December 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27902173/escobar-multiple-pterygium-syndrome-multidisciplinary-approach-to-a-very-rare-syndrome
#18
Murat Celal Sözbilen, Hüseyin Günay, Funda Atamaz Çalış
Escobar (multiple pterygium) syndrome is progressive and a very rare syndrome. It is generally characterized by multiple pterygia that are found in the cervical, antecubital and popliteal regions. In this report, we present the treatment management of a 14-year-old case with late stage Escobar syndrome who was admitted due to multiple pterygia and bilateral knee contractures. The treatment of this case was conducted in collaboration with the department of orthopedics and the department of physical therapy. The treatment of the case was done in three stages: soft tissue procedures, femoral recurvatum osteotomy and triple arthrodesis, respectively...
December 2016: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/27896441/pterygium-surgery-using-the-principle-of-contact-inhibition-results-of-13-years-experience
#19
Tsutomu Hara, Takako Hashimoto, Takeshi Hara
PURPOSE: To report a technique to prevent pterygium recurrence using the principle of contact inhibition. METHODS: Two hundred and fifteen patients (232 eyes; average age, 64.1 years) with primary pterygia who underwent pterygium surgery at the Hara Eye Hospital between 1999 and 2012. We retrospectively evaluated the patients who underwent the following procedure to prevent pterygium recurrence. The surface conjunctiva on the pterygium body was not removed. After removing the pterygium body, by placing a narrow pedicle autoconjunctival flap along the corneal limbus and tying it tightly to the front area of the residual conjunctiva, there is no room for the active residual tissue to proliferate, thus preventing a recurrence by contact inhibition...
March 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27800243/demographics-of-patients-with-double-headed-pterygium-and-surgical-outcomes
#20
Fulya Duman, Mustafa Köşker
OBJECTIVES: To analyze demographic and ophthalmologic characteristics of patients with double-headed pterygium in the Mediterranean region of Turkey and to evaluate their surgical outcomes. MATERIALS AND METHODS: Records of all patients who underwent surgery for pterygium in Antalya Atatürk State Hospital between November 2012 and March 2014 were retrospectively reviewed. Patients with pterygia on both sides of the cornea (nasal and temporal) were included in the study...
December 2015: Turkish Journal of Ophthalmology
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