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https://www.readbyqxmd.com/read/27918948/adult-autism-subthreshold-spectrum-adas-spectrum-validation-of-a-questionnaire-investigating-subthreshold-autism-spectrum
#1
L Dell'Osso, C Gesi, E Massimetti, I M Cremone, M Barbuti, G Maccariello, I Moroni, S Barlati, G Castellini, M Luciano, L Bossini, M Rocchetti, M Signorelli, E Aguglia, A Fagiolini, P Politi, V Ricca, A Vita, C Carmassi, M Maj
AIM: Increasing literature has shown the usefulness of a dimensional approach to autism. The present study aimed to determine the psychometric properties of the Adult Autism Subthreshold Spectrum (AdAS Spectrum), a new questionnaire specifically tailored to assess subthreshold forms of autism spectrum disorder (ASD) in adulthood. METHODS: 102 adults endorsing at least one DSM-5 symptom criterion for ASD (ASDc), 143 adults diagnosed with a feeding and eating disorder (FED), and 160 subjects with no mental disorders (CTL), were recruited from 7 Italian University Departments of Psychiatry and administered the following: SCID-5, Autism-Spectrum Quotient (AQ), Ritvo Autism and Asperger Diagnostic Scale 14-item version (RAADS-14), and AdAS Spectrum...
November 9, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27871641/longitudinal-course-of-bipolar-disorder-in-youth-with-high-functioning-autism-spectrum-disorder
#2
Xenia Borue, Carla Mazefsky, Brian T Rooks, Michael Strober, Martin B Keller, Heather Hower, Shirley Yen, Mary Kay Gill, Rasim S Diler, David A Axelson, Benjamin I Goldstein, Tina R Goldstein, Neal Ryan, Fangzi Liao, Jeffrey I Hunt, Daniel P Dickstein, Boris Birmaher
OBJECTIVE: To provide the first longitudinal characterization of mood and psychosocial functioning in youth with comorbid bipolar (BD) and autism spectrum (ASD) disorders. METHOD: The Course and Outcome of Bipolar Youth study followed 368 youth (aged 7-17 years) with DSM-IV bipolar I (BP-I), BP-II, or Not Otherwise Specified (NOS) for, on average, 9 years using the Longitudinal Interval Follow-up Evaluation. This subgroup analysis compared youth with and without ASD on clinical presentation, percentage of time with mood symptomatology, and psychosocial functioning...
December 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27867417/from-asperger-s-autistischen-psychopathen-to-dsm-5-autism-spectrum-disorder-and-beyond-a-subthreshold-autism-spectrum-model
#3
REVIEW
Liliana Dell'Osso, Riccardo Dalle Luche, Camilla Gesi, Ilenia Moroni, Claudia Carmassi, Mario Maj
Growing interest has recently been devoted to partial forms of autism, lying at the diagnostic boundaries of those conditions previously diagnosed as Asperger's Disorder. This latter includes an important retrieval of the European classical psychopathological concepts of adult autism to which Hans Asperger referred in his work. Based on the review of Asperger's Autistische Psychopathie, from first descriptions through the DSM-IV Asperger's Disorder and up to the recent DSM-5 Autism Spectrum Disorder, the paper aims to propose a Subthreshold Autism Spectrum Model that encompasses not only threshold-level manifestations but also mild/atypical symptoms, gender-specific features, behavioral manifestations and personality traits associated with Autism Spectrum Disorder...
2016: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/27845486/autism-spectrum-disorder-and-intact-executive-functioning
#4
R Ferrara, F Ansermet, F Massoni, L Petrone, E Onofri, P Ricci, T Archer, S Ricci
: Earliest notions concerning autism (Autism Spectrum Disorders, ASD) describe the disturbance in executive functioning. Despite altered definition, executive functioning, expressed as higher cognitive skills required complex behaviors linked to the prefrontal cortex, are defective in autism. Specific difficulties in children presenting autism or verbal disabilities at executive functioning levels have been identified. Nevertheless, the developmental deficit of executive functioning in autism is highly diversified with huge individual variation and may even be absent...
September 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/27822381/clinical-pearls-how-my-patients-taught-me-the-fainting-lark-symptom
#5
A Kuiper, M E van Egmond, M P M Harms, M D Oosterhoff, B van Harten, D A Sival, T J de Koning, M A J Tijssen
BACKGROUND: Compulsive movements, complex tics and stereotypies are frequent, especially among patients with autism or psychomotor retardation. These movements can be difficult to characterize and can mimic other conditions like epileptic seizures or paroxysmal dystonia, particularly when abnormal breathing and cerebral hypoxia are induced. CASE PRESENTATION: We describe an 18-year-old patient with Asperger syndrome who presented with attacks of tonic posturing of the trunk and neck...
2016: Journal of Clinical Movement Disorders
https://www.readbyqxmd.com/read/27812341/from-high-intellectual-potential-to-asperger-syndrome-evidence-for-differences-and-a-fundamental-overlap-a-systematic-review
#6
REVIEW
Aurélie Boschi, Pascale Planche, Cherhazad Hemimou, Caroline Demily, Laurence Vaivre-Douret
Background: An increasing number of clinicians point to similar clinical features between some children with High Intellectual Potential (HIP or "Giftedness" = Total IQ > 2 SD), and children with Autism Spectrum Disorder (ASD) without intellectual or language delay, formerly diagnosed with Asperger Syndrome. Some of these common features are social interaction impairments, special interests, and in some cases high-verbal abilities. The aim of this article is to determine whether these similarities exist at more fundamental levels, other than clinical, and to explore the literature in order to provide empirical support for an overlap between ASD and HIP...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27730473/cytokine-profile-in-autism-spectrum-disorders-in-children
#7
Vesna Bryn, Hans Christian Dalsbotten Aass, Ola H Skjeldal, Jørn Isaksen, Ola Didrik Saugstad, Heidi Ormstad
The pathogenesis of autism spectrum disorders (ASD) is not completely understood, but there is evidence of associations with altered immune responses. The aim of this study was to determine the serum levels of various cytokines in children with ASD and in healthy controls, in order to determine their role in ASD and its diagnostic subgroups. Sixty-five ASD patients were enrolled from an epidemiological survey in Norway, of which 30 were diagnosed with childhood autism, 16 with Asperger syndrome, 12 with atypical autism, 1 with Rett syndrome, and 6 with another ASD diagnosis...
October 12, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27703778/asperger-syndrome-in-childhood-personality-dimensions-in-adult-life-temperament-character-and-outcome-trajectories
#8
Adam Helles, Märta Wallinius, I Carina Gillberg, Christopher Gillberg, Eva Billstedt
BACKGROUND: Temperament and character have been shown to be important factors in understanding psychiatric and neurodevelopmental disorder. Adults with autism spectrum disorder (ASD) have repeatedly been shown to have a distinct temperament and character, but this has not been evaluated in relation to psychiatric comorbidity and ASD diagnostic stability. AIMS: To examine temperament and character in males that were diagnosed with ASD in childhood and followed prospectively over almost two decades...
May 2016: BJPsych Open
https://www.readbyqxmd.com/read/27703772/the-people-with-asperger-syndrome-and-anxiety-disorders-passa-trial-a-pilot-multicentre-single-blind-randomised-trial-of-group-cognitive-behavioural-therapy
#9
Peter E Langdon, Glynis H Murphy, Lee Shepstone, Edward C F Wilson, David Fowler, David Heavens, Aida Malovic, Alexandra Russell, Alice Rose, Louise Mullineaux
BACKGROUND: There is a growing interest in using cognitive-behavioural therapy (CBT) with people who have Asperger syndrome and comorbid mental health problems. AIMS: To examine whether modified group CBT for clinically significant anxiety in an Asperger syndrome population is feasible and likely to be efficacious. METHOD: Using a randomised assessor-blind trial, 52 individuals with Asperger syndrome were randomised into a treatment arm or a waiting-list control arm...
March 2016: BJPsych Open
https://www.readbyqxmd.com/read/27669633/aging-with-autism-spectrum-disorder-an-emerging-public-health-problem
#10
Ana Hategan, James A Bourgeois, Jeremy Goldberg
From 1943, when Leo Kanner originally described autism, and to the first objective criteria for "infantile autism" in DSM-III and the inclusion of Asperger's disorder in DSM-IV, the subsequent classification scheme for autistic disorders has led to a substantial change with the 2013 issuance of the DSM-5 by including subcategories into one umbrella diagnosis of autism spectrum disorder (ASD) (Baker, 2013). ASD is a lifelong neurodevelopmental disorder, characterized by social and communication impairments and restricted, stereotypical patterns of behavior (Baker, 2013)...
September 27, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27624646/kanner-asperger-and-frankl-a-third-man-at-the-genesis-of-the-autism-diagnosis
#11
John E Robison
Scholars have long speculated about how Kanner and Asperger's descriptions of autistic behavior appeared just 1 year apart in America and Austria even as World War II had severed communication between the two countries. Both conspiracy and serendipity have been alleged, but a simpler explanation has now emerged. Autistic knowledge crossed the Atlantic with Georg Frankl-a previously unrecognized "man in the middle" who followed his fiancé to America. The evidence presented here fills in many blanks and suggests both Kanner and Asperger benefited from Frankl's insight...
September 13, 2016: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/27563293/autism-and-classical-eyeblink-conditioning-performance-changes-of-the-conditioned-response-related-to-autism-spectrum-disorder-diagnosis
#12
John P Welsh, Jeffrey T Oristaglio
Changes in the timing performance of conditioned responses (CRs) acquired during trace and delay eyeblink conditioning (EBC) are presented for diagnostic subgroups of children having autism spectrum disorder (ASD) aged 6-15 years. Children diagnosed with autistic disorder (AD) were analyzed separately from children diagnosed with either Asperger's syndrome or Pervasive developmental disorder (Asp/PDD) not otherwise specified and compared to an age- and IQ-matched group of children who were typically developing (TD)...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27556593/metformin-for-treatment-of-overweight-induced-by-atypical-antipsychotic-medication-in-young-people-with-autism-spectrum-disorder-a-randomized-clinical-trial
#13
Evdokia Anagnostou, Michael G Aman, Benjamin L Handen, Kevin B Sanders, Amy Shui, Jill A Hollway, Jessica Brian, L Eugene Arnold, Lucia Capano, Jessica A Hellings, Eric Butter, Deepali Mankad, Rameshwari Tumuluru, Jessica Kettel, Cassandra R Newsom, Stasia Hadjiyannakis, Naomi Peleg, Dina Odrobina, Sarah McAuliffe-Bellin, Pearl Zakroysky, Sarah Marler, Alexis Wagner, Taylor Wong, Eric A Macklin, Jeremy Veenstra-VanderWeele
IMPORTANCE: Atypical antipsychotic medications are indicated for the treatment of irritability and agitation symptoms in children with autism spectrum disorder (ASD). Unfortunately, these medications are associated with weight gain and metabolic complications that are especially troubling in children and with long-term use. OBJECTIVE: To evaluate the efficacy of metformin for weight gain associated with atypical antipsychotic medications in children and adolescents with ASD (defined in the protocol as DSM-IV diagnosis of autistic disorder, Asperger disorder, or pervasive developmental disorder not otherwise specified), aged 6 to 17 years...
September 1, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27556112/impaired-social-cognition-processes-in-asperger-syndrome-and-anorexia-nervosa-in-search-for-endophenotypes-of-social-cognition
#14
REVIEW
Beata Joanna Kasperek-Zimowska, Janusz Grzegorz Zimowski, Katarzyna Biernacka, Katarzyna Kucharska-Pietura, Filip Rybakowski
A growing number of publications indicates presence of significant deficits in social cognition in patients with anorexia nervosa (AN). These deficits appear to be comparable in qualitative and quantitative dimension with impairment of the same functions among people with Asperger syndrome (AS). The aim of this study is to identify subject areas in the field of impairment of social cognition processes among people with Asperger syndrome and anorexia nervosa taking into consideration the potential contribution of genetic pathways of oxytocin and vasopressin in the pathogenesis of these diseases...
2016: Psychiatria Polska
https://www.readbyqxmd.com/read/27515416/the-concurrent-validity-of-a-new-ediagnostic-system-for-mental-disorders-in-primary-care
#15
Ies Dijksman, Geert Jan Dinant, Mark Spigt
BACKGROUND: An eDiagnostic system was implemented to classify mental disorders, to support general practitioners. OBJECTIVE: Assessing the validity of the system, compared to the psychologists' judgment. METHODS: Concurrent validity, using routinely collected data of 675 primary care patients with a suspicion of a mental disorder in the Netherlands. Four psychologists classified the patients according to the DSM-IV. Hundred records were randomly selected to investigate the inter-rater reliability among psychologists...
August 11, 2016: Family Practice
https://www.readbyqxmd.com/read/27501063/-is-voice-a-marker-for-autism-spectrum-disorder-a-systematic-review-and-meta-analysis
#16
Riccardo Fusaroli, Anna Lambrechts, Dan Bang, Dermot M Bowler, Sebastian B Gaigg
Individuals with Autism Spectrum Disorder (ASD) are reported to speak in distinctive ways. Distinctive vocal production should be better understood as it can affect social interactions and social development and could represent a non-invasive marker for ASD. We systematically review the existing scientific literature reporting quantitative acoustic analysis of vocal production in ASD and identify repeated and consistent findings of higher pitch mean and variability but not of other differences in acoustic features...
August 8, 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27500602/conscious-and-non-conscious-representations-of-emotional-faces-in-asperger-s-syndrome
#17
Vincent S C Chien, Arthur C Tsai, Han Hsuan Yang, Yi-Li Tseng, Alexander N Savostyanov, Michelle Liou
Several neuroimaging studies have suggested that the low spatial frequency content in an emotional face mainly activates the amygdala, pulvinar, and superior colliculus especially with fearful faces(1-3). These regions constitute the limbic structure in non-conscious perception of emotions and modulate cortical activity either directly or indirectly(2). In contrast, the conscious representation of emotions is more pronounced in the anterior cingulate, prefrontal cortex, and somatosensory cortex for directing voluntary attention to details in faces(3,4)...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27399225/segmental-hair-testing-to-disclose-chronic-exposure-to-psychoactive-drugs
#18
Emilia Marchei, Ilaria Palmi, Simona Pichini, Roberta Pacifici, Ileana-Rita Anton Airaldi, Juan Antonio Costa Orvay, Joan García Serra, Bartolomé Bonet Serra, Óscar García-Algar
This study presents the case of a 4-year-old healthy child admitted to the paediatric ward for suspected accidental intoxication due to ingestion of narcoleptic drugs (methylphenidate, sertraline and quetiapine), taken on a regular basis by his 8-year-old brother affected by Asperger syndrome.Intoxication can be objectively assessed by measurements of drugs and metabolites in biological matrices with short-term (blood and urine) or long-term (hair) detection windows. At the hospital, the child's blood and urine were analysed by immunoassay (confirmed by liquid chromatography-mass spectrometry), and sertraline and quetiapine and their metabolites were identified...
2016: Adicciones
https://www.readbyqxmd.com/read/27374252/the-capacity-to-tell-a-joke-reflections-from-work-with-asperger-s-children
#19
Lawrence J Brown
The capacity to tell a joke is a highly complex interpersonal event that depends upon the maturation of certain developmental achievements which are absent or stunted in children with Asperger's Syndrome. These include the ability to know another's mind, a sense of interpersonal timing and, most notably, a capacity for abstract thinking. The author discusses Freud's () notion of joke-work, which is akin to dream-work, both of which are pathways to forming mental representations. Freud considered joke-work as a mental activity that operated on the verbal level and the author examines the preverbal dimensions that are rooted in the earliest mother/infant interactions...
July 4, 2016: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/27344135/aripiprazole-for-autism-spectrum-disorders-asd
#20
REVIEW
Lauren E Hirsch, Tamara Pringsheim
BACKGROUND: Autism spectrum disorders (ASD) include autistic disorder, Asperger's disorder and pervasive developmental disorder - not otherwise specified (PDD-NOS). Antipsychotics have been used as a medication intervention for irritability related to ASD. Aripiprazole, a third-generation, atypical antipsychotic, is a relatively new drug that has a unique mechanism of action different from that of other antipsychotics. This review updates a previous Cochrane review on the safety and efficacy of aripiprazole for individuals with ASD, published in 2011 (Ching 2011)...
2016: Cochrane Database of Systematic Reviews
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