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https://www.readbyqxmd.com/read/27916367/esophageal-duplication-cysts-and-closure-of-the-muscle-layer
#1
Leo Andrew Benedict, Sigrid Bairdain, Jessica K Paulus, Carl-Christian Jackson, Catherine Chen, Cassandra Kelleher
BACKGROUND: Foregut duplication cysts are rare congenital anomalies that require surgical intervention with approximately 10%-15% of all gastrointestinal duplication cysts originating from the esophagus. Consensus is lacking among surgeons regarding closure of the esophageal muscle layer after resection of an esophageal duplication cyst and long-term outcomes are poorly documented. Therefore, we conducted the first study comparing complication rates in patients undergoing closure versus nonclosure of the esophageal muscle layer after esophageal duplication cyst resection...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27913306/effect-of-bradykinin-receptor-antagonism-on-ace-inhibitor-associated-angioedema
#2
Brittany T Straka, Claudia E Ramirez, James B Byrd, Elizabeth Stone, Alencia Woodard-Grice, Hui Nian, Chang Yu, Aleena Banerji, Nancy J Brown
BACKGROUND: The B2 receptor antagonist icatibant is approved for treatment of attacks of hereditary angioedema. Icatibant has been reported to decrease time-to-resolution of angiotensin-converting enzyme (ACE) inhibitor-associated angioedema in one study of European patients. METHODS: Patients with ACE inhibitor-associated angioedema (defined as swelling of lips, tongue, pharynx or face during ACE inhibitor use and no swelling in the absence of ACE inhibitor use) were enrolled at Vanderbilt University Medical Center from October 2007 through September 2015 and at Massachusetts General Hospital in 2012...
November 29, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27893544/visceral-adiposity-genetic-susceptibility-and-risk-of-complications-among-individuals-with-crohn-s-disease
#3
Kimberley W J Van Der Sloot, Amit D Joshi, Danielle R Bellavance, Katherine K Gilpin, Kathleen O Stewart, Paul Lochhead, John J Garber, Cosmas Giallourakis, Vijay Yajnik, Ashwin N Ananthakrishnan, Behrooz Z Alizadeh, Ramnik J Xavier, Hamed Khalili
INTRODUCTION: Adipose tissue in mesenteric fat plays a key role in systemic and luminal inflammation. However, little is known about the role of visceral adipose tissue (VAT) and its interaction with genetic predisposition in Crohn's disease (CD) progression. METHODS: Our study population included patients with CD enrolled in Prospective Registry in Inflammatory Bowel Disease Study at Massachusetts General Hospital (PRISM). VAT volume was measured from computed tomography using Aquarius 3D...
November 22, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27888150/coenzyme-q10-intake-from-foods-and-semen-parameters-in-a-subfertile-population
#4
Bruno C Tiseo, Audrey J Gaskins, Russ Hauser, Jorge E Chavarro, Cigdem Tanrikut
OBJECTIVE: To assess the association between coenzyme Q10 (CoQ10) intake from food sources and semen quality. We assessed this association in a prospective cohort of men attending a fertility clinic. CoQ10 supplementation has been associated with improvements in semen parameters. However, impact of CoQ10 intake from food sources on semen quality has not been investigated. METHODS: Subfertile couples seeking fertility evaluation at the Massachusetts General Hospital Fertility Center were invited to participate in an ongoing study of environmental factors and fertility...
November 22, 2016: Urology
https://www.readbyqxmd.com/read/27886972/the-resident-run-minor-surgery-clinic-a-pilot-study-to-safely-increase-operative-autonomy
#5
REVIEW
Brandon M Wojcik, Zhi Ven Fong, Madhukar S Patel, David C Chang, Emil Petrusa, John T Mullen, Roy Phitayakorn
OBJECTIVE: General surgery training has evolved to align with changes in work hour restrictions, supervision regulations, and reimbursement practices. This has culminated in a lack of operative autonomy, leaving residents feeling inadequately prepared to perform surgery independently when beginning fellowship or practice. A resident-run minor surgery clinic increases junior resident autonomy, but its effects on patient outcomes have not been formally established. This pilot study evaluated the safety of implementing a resident-run minor surgery clinic within a university-based general surgery training program...
November 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27867487/hypoxia-therapy-a-new-hope-for-the-treatment-of-mitochondrial-dysfunctions
#6
Jun-Long Huang, Anatol Manaenko, Zhou-Heng Ye, Xue-Jun Sun, Qin Hu
Mitochondrial dysfunctions are characteristic features of numerous diseases and play a critical role in disease pathogenesis. Despite intensive research in this area, there are no approved therapies that directly target mitochondria. Recently a study by Jain et al. from Massachusetts General Hospital, USA reported the effectiveness of hypoxia for treatment of mitochondrial disease in mice. In this commentary, we summarized the potential mechanisms underlying the therapeutic effects of hypoxia on mitochondrial dysfunction, and clinical limitations of hypoxia as a therapy for human patients...
July 2016: Medical Gas Research
https://www.readbyqxmd.com/read/27863545/porcine-treg-depletion-with-a-novel-diphtheria-toxin-based-anti-human-ccr4-immunotoxin
#7
Zhaohui Wang, Nalu Navarro-Alvarez, Jigesh A Shah, Huiping Zhang, Qi Huang, Qian Zheng, Joren C Madsen, David H Sachs, Christene A Huang, Zhirui Wang
Regulatory T cells (Tregs) are known to play an important role in immunoregulation and have been shown to facilitate induction of transplantation tolerance. Chemokine (C-C motif) receptor 4 (CCR4) is expressed on the surface of effector Tregs involved in controlling alloimmune and autoimmune responses. Recently we have developed a novel diphtheria-toxin based anti-human CCR4 immunotoxin for depleting CCR4(+) cells in vivo. In this study, we have demonstrated that the anti-human CCR4 immunotoxin bound to porcine lymphocytes including CD4(+)FoxP3(+) Tregs...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27835722/effects-of-adjunctive-brexpiprazole-on-sleep-disturbances-in-patients-with-major-depressive-disorder-an-open-label-flexible-dose-exploratory-study
#8
Andrew D Krystal, Aurélia Mittoux, Peter Meisels, Ross A Baker
Background: Brexpiprazole is a serotonin-dopamine activity modulator. We evaluated the effects of adjunctive treatment with brexpiprazole on sleep disturbances in patients with DSM-IV-TR major depressive disorder (MDD) and inadequate response to antidepressant treatment. Methods: This study was conducted between September 27, 2013, and August 19, 2014. Patients with inadequate response to antidepressant treatment and sleep disturbances continued treatment with their current antidepressant for 2 weeks...
September 8, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27834192/prescribing-outdoor-play-outdoors-rx
#9
Aisha K James, Pam Hess, Meghan E Perkins, Elsie M Taveras, Christina S Scirica
Studies support the use of exercise prescriptions in adults, but few studies have evaluated their use in children. One common barrier to effective physical activity counseling is lack of resources. Outdoors Rx is a collaboration between the Appalachian Mountain Club and the Massachusetts General Hospital for Children that pairs exercise prescriptions with guided outdoor programs to increase physical activity among children. This article describes the design and implementation of Outdoors Rx at 2 community health centers serving ethnically diverse, low-income, urban families, as well as evaluates feedback from participating pediatricians regarding the utility of the program, barriers to success, and suggestions for improvement...
November 9, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27826766/implementation-of-the-vocera-communication-system-in-a-quaternary-perioperative-environment
#10
Tynan H Friend, Samantha J Jennings, Martin S Copenhaver, Wilton C Levine
In the hospital, fast and efficient communication among clinicians and other employees is paramount to ensure optimal patient care, workflow efficiency, patient safety and patient comfort. The implementation of the wireless Vocera® Badge, a hands-free wearable device distributed to perioperative team members, has increased communication efficiency across the perioperative environment at Massachusetts General Hospital (MGH). This quality improvement project, based upon identical pre- and post-implementation surveys, used qualitative and quantitative analysis to determine if and how the Vocera system affected the timeliness of information flow, ease of communication, and operating room noise levels throughout the perioperative environment...
January 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/27826755/using-machine-learning-to-parse-breast-pathology-reports
#11
Adam Yala, Regina Barzilay, Laura Salama, Molly Griffin, Grace Sollender, Aditya Bardia, Constance Lehman, Julliette M Buckley, Suzanne B Coopey, Fernanda Polubriaginof, Judy E Garber, Barbara L Smith, Michele A Gadd, Michelle C Specht, Thomas M Gudewicz, Anthony J Guidi, Alphonse Taghian, Kevin S Hughes
PURPOSE: Extracting information from electronic medical record is a time-consuming and expensive process when done manually. Rule-based and machine learning techniques are two approaches to solving this problem. In this study, we trained a machine learning model on pathology reports to extract pertinent tumor characteristics, which enabled us to create a large database of attribute searchable pathology reports. This database can be used to identify cohorts of patients with characteristics of interest...
November 8, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27824633/a-double-blind-placebo-controlled-study-of-inositol-in-trichotillomania
#12
Eric W Leppink, Sarah A Redden, Jon E Grant
Trichotillomania is characterized by repetitive pulling that causes noticeable hair loss. Data on the pharmacological treatment of trichotillomania are limited, with no clear first-line agent. The aim of the current study was to determine the efficacy and tolerability of inositol in adults with trichotillomania. A total of 38 individuals (35 women; mean age: 28.9±11.4) with trichotillomania entered a 10-week, double-blind, placebo-controlled trial to evaluate the safety and efficacy of inositol (dosing ranging from 6 to 18 g/day)...
November 7, 2016: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27816324/differences-in-clinical-presentation-between-bipolar-i-and-ii-disorders-in-the-early-stages-of-bipolar-disorder-a-naturalistic-study
#13
Maj Vinberg, Rie Lambaek Mikkelsen, Thomas Kirkegaard, Ellen Margrethe Christensen, Lars Vedel Kessing
AIM: In a naturalistic clinical study of patients in the early stages of bipolar disorders the aim was to assess differences between patients with bipolar I (BD I) and bipolar II (BD II) disorders on clinical characteristics including affective symptoms, subjective cognitive complaints, functional level, the presence of comorbid personality disorders and coping strategies. METHODS: Diagnoses were confirmed using the Structured Clinical Interview for DSM-IV Disorders...
October 25, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27805947/bone-marrow-chimerism-as-a-strategy-to-produce-tolerance-in-solid-organ-allotransplantation
#14
Min Hu, Stephen I Alexander, Shounan Yi
PURPOSE OF REVIEW: Clinical transplant tolerance has been most successfully achieved combining hematopoietic chimerism with kidney transplantation. This review outlines this strategy in animal models and human transplantation, and possible clinical challenges. RECENT FINDINGS: Kidney transplant tolerance has been achieved through chimerism in several centers beginning with Massachusetts General Hospital's success with mixed chimerism in human leukocyte antigen (HLA)-mismatched patients and the Stanford group with HLA-matched patients, and the more recent success of the Northwestern protocol achieving full chimerism...
December 2016: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/27777276/improving-health-care-quality-and-patient-safety-through-peer-to-peer-assessment-demonstration-project-in-two-academic-medical-centers
#15
Elizabeth Mort, Jeffrey Bruckel, Karen Donelan, Lori Paine, Michael Rosen, David Thompson, Sallie Weaver, Daniel Yagoda, Peter Pronovost
Despite decades of investment in patient safety, unintentional patient harm remains a major challenge in the health care industry. Peer-to-peer assessment in the nuclear industry has been shown to reduce harm. The study team's goal was to pilot and assess the feasibility of this approach in health care. The team developed tools and piloted a peer-to-peer assessment at 2 academic hospitals: Massachusetts General Hospital and Johns Hopkins Hospital. The assessment evaluated both the institutions' organizational approach to quality and safety as well as their approach to reducing 2 specific areas of patient harm...
October 23, 2016: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/27764872/-crawford-williamson-long-the-true-discoverer-of-anesthesia
#16
Heike Petermann
October 16, 1846 is regarded as the birth of anaesthesia at the Massachusetts General Hospital in Boston. However, was this really the first anaesthesia with sulphuric ether? In the priority dispute that started already in 1846 there were more participants: WTG Morton, CT Jackson and H Wells. Not involved was CW Long, who has already administered ether anaesthesia in 1842. He has published his results only 1849 and therefore he gained no glory.
October 2016: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/27692808/surgery-clerkship-evaluations-are-insufficient-for-clinical-skills-appraisal-the-value-of-a-medical-student-surgical-objective-structured-clinical-examination
#17
Kathryn L Butler, David A Hirsh, Emil R Petrusa, D Dante Yeh, Dana Stearns, David E Sloane, Jeffrey A Linder, Gaurab Basu, Lisa A Thompson, Marc A de Moya
OBJECTIVE: Optimal methods for medical student assessment in surgery remain elusive. Faculty- and housestaff-written evaluations constitute the chief means of student assessment in medical education. However, numerous studies show that this approach has poor specificity and a high degree of subjectivity. We hypothesized that an objective structured clinical examination (OSCE) in the surgery clerkship would provide additional data on student performance that would confirm or augment other measures of assessment...
September 27, 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27685842/is-the-noradrenergic-symptom-cluster-a-valid-construct-in-adjunctive-treatment-of-major-depressive-disorder
#18
Virginia L Stauffer, Peng Liu, Celine Goldberger, Lauren B Marangell, Craig Nelson, Philip Gorwood, Maurizio Fava
OBJECTIVE: To identify symptoms potentially representative of a noradrenergic symptom cluster as possible predictors of response to the selective norepinephrine reuptake inhibitor (NRI) edivoxetine when used as monotherapy or adjunctive treatment in patients with DSM-IV-TR major depressive disorder (MDD). METHODS: Pooled data from 4 adjunctive treatment trials (selective serotonin reuptake inhibitor [SSRI] + edivoxetine 6-18 mg/d vs SSRI + placebo; N = 2,066) and data from 1 monotherapy trial (edivoxetine 6-18 mg/d versus placebo; N = 495) were used to identify predictors of response related to noradrenergic symptoms using a resampling-based ensemble tree method...
September 27, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27682353/clinical-outcomes-and-self-reported-symptoms-in-patients-with-acromegaly-eight-year-follow-up-of-a-lanreotide-study
#19
Shafaq Khairi, Babak Torabi Sagvand, Karen J Pulaski-Liebert, Nicholas A Tritos, Anne Klibanski, Lisa B Nachtigall
OBJECTIVES: The aim of this study was to evaluate the proportion of patients with acromegaly who remained on long-term lanreotide depot after completion of an open label multicenter phase III clinical trial (SALSA), compare symptom score at long-term follow-up with baseline and correlate these with individual longitudinal clinical outcomes. METHODS: Records of all subjects previously enrolled at the Massachusetts General Hospital site of SALSA were reviewed. Those who remained on lanreotide were interviewed and asked to complete a questionnaire that they had completed in SALSA in 2007 regarding their current symptomatology and injection side effects as well as to complete the Acromegaly Quality of life questionnaire...
September 28, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27635768/dose-dependent-protective-effect-of-inhalational-anesthetics-against-postoperative-respiratory-complications-a-prospective-analysis-of-data-on-file-from-three-hospitals-in-new-england
#20
Stephanie D Grabitz, Hassan N Farhan, Katarina J Ruscic, Fanny P Timm, Christina H Shin, Tharusan Thevathasan, Anne K Staehr-Rye, Tobias Kurth, Matthias Eikermann
OBJECTIVES: Inhalational anesthetics are bronchodilators with immunomodulatory effects. We sought to determine the effect of inhalational anesthetic dose on risk of severe postoperative respiratory complications. DESIGN: Prospective analysis of data on file in surgical cases between January 2007 and December 2015. SETTING: Massachusetts General Hospital (tertiary referral center) and two affiliated community hospitals. PATIENTS: A total of 124,497 adult patients (105,267 in the study cohort and 19,230 in the validation cohort) undergoing noncardiac surgical procedures and requiring general anesthesia with endotracheal intubation...
September 15, 2016: Critical Care Medicine
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