keyword
MENU ▼
Read by QxMD icon Read
search

trpm8

keyword
https://www.readbyqxmd.com/read/29761267/porcine-fc%C3%AE%C2%B5ri-mediates-porcine-reproductive-and-respiratory-syndrome-virus-multiplication-and-regulates-the-inflammatory-reaction
#1
Peidian Shi, Lilin Zhang, Jiashun Wang, Dong Lu, Yi Li, Jie Ren, Menglu Shen, Lei Zhang, Jinhai Huang
Porcine reproductive and respiratory syndrome virus (PRRSV) shows characteristic antibody-dependent enhancement (ADE) of infection and causes porcine systemic inflammation, which is similar to a type I allergic reaction; however, the role of porcine FcεRI in ADE is still unclear. In this study, the expression of different Fc receptors (FcRs) on macrophages was investigated in a PRRSV 3D4/21 cell infection model in the presence or absence of PRRSV antibody. The transcription level of FcγII and FcεRI was significantly up-regulated under PRRSV-antibody complex infection...
May 14, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29746988/connexin36-expression-in-primary-afferent-neurons-in-relation-tothe-axon-reflex-modality-coding-of-somatic-sensation
#2
J I Nagy, B D Lynn, J M M Senecal, K Stecina
Electrical coupling mediated by connexin36-containing gap junctions that form electrical synapses is known to be prevalent in the central nervous system, but such coupling was long ago reported also to occur between cutaneous sensory fibers. Here, we provide evidence supporting the capability of primary afferent fibers to engage in electrical coupling. In transgenic mice with enhanced green fluorescent protein (eGFP) serving as a reporter for connexin36 expression, immunofluorescence labelling of eGFP was found in subpopulations of neurons in lumbar dorsal root and trigeminal sensory ganglia, and in fibers within peripheral nerves and tissues...
May 7, 2018: Neuroscience
https://www.readbyqxmd.com/read/29742796/hdac-inhibition-inhibits-brachial-plexus-avulsion-induced-neuropathic-pain
#3
Yingbo Zhao, Tianjian Wu
Introduction Neuropathic pain induced by brachial plexus avulsion (BPA) is a pathological condition. We hypothesized that inhibition of histone deacetylase (HDAC) could suppress BPA-induced neuropathic pain through inhibition of transient reception potential (TRP) overexpression and protein kinase B (Akt) mediated mammalian target of rapamycin (mTOR) activation. Methods We generated a rat BPA model, administered HDAC inhibitor Tricostatin A (TSA) for 7 days post-surgery and assessed the effects on HDAC expression, Akt phosphorylation, neuroinflammation and mTOR activation...
May 9, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29724821/phosphoinositide-interacting-regulator-of-trp-pirt-has-opposing-effects-on-human-and-mouse-trpm8-ion-channels
#4
Jacob K Hilton, Taraneh Salehpour, Nicholas J Sisco, Parthasarathi Rath, Wade D Van Horn
Transient receptor potential melastatin 8 (TRPM8) is a cold-sensitive ion channel with diverse physiological roles. TRPM8 activity is modulated by many mechanisms, including an interaction with the small membrane protein phosphoinositide-interacting regulator of TRP (PIRT). Here, using comparative electrophysiology experiments, we identified species-dependent differences between the human and mouse TRPM8-PIRT complexes. We found that human PIRT attenuated human TPRM8 conductance, unlike mouse PIRT, which enhanced mouse TRPM8 conductance...
May 3, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29723786/design-synthesis-and-biological-activities-of-2-3-dihydroquinazolin-4-1h-one-derivatives-as-trpm2-inhibitors
#5
Han Zhang, Huan Liu, Xiao Luo, Yuxi Wang, Yuan Liu, Hongwei Jin, Zhenming Liu, Wei Yang, Peilin Yu, Liangren Zhang, Lihe Zhang
Transient receptor potential melastatin 2 (TRPM2), a Ca2+ -permeable cationic channel, plays critical roles in insulin release, cytokine production, body temperature regulation and cell death as a reactive oxygen species (ROS) and temperature sensor. However, few TRPM2 inhibitors have been reported, especially TRP-subtype selective inhibitors, which hampers the investigation and validation of TRPM2 as a drug target. To discover novel TRPM2 inhibitors, 3D similarity-based virtual screening method was employed, by which 2,3-dihydroquinazolin-4(1H)-one derivative H1 was identified as a TRPM2 inhibitor...
April 25, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29723195/human-local-adaptation-of-the-trpm8-cold-receptor-along-a-latitudinal-cline
#6
Felix M Key, Muslihudeen A Abdul-Aziz, Roger Mundry, Benjamin M Peter, Aarthi Sekar, Mauro D'Amato, Megan Y Dennis, Joshua M Schmidt, Aida M Andrés
Ambient temperature is a critical environmental factor for all living organisms. It was likely an important selective force as modern humans recently colonized temperate and cold Eurasian environments. Nevertheless, as of yet we have limited evidence of local adaptation to ambient temperature in populations from those environments. To shed light on this question, we exploit the fact that humans are a cosmopolitan species that inhabit territories under a wide range of temperatures. Focusing on cold perception-which is central to thermoregulation and survival in cold environments-we show evidence of recent local adaptation on TRPM8...
May 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29698501/association-of-raynaud-s-phenomenon-with-a-polymorphism-in-the-nos1-gene
#7
Sabrina Munir, Maxim B Freidin, Susan Brain, Frances M K Williams
BACKGROUND: Raynaud's phenomenon (RP) describes the phenomenon of recurrent vasospasm of digital arteries, associated with skin colour changes: pallor, cyanosis and erythema. Twin studies have indicated a genetic predisposition for RP; however, the precise aetiology of RP remains unknown. It is thought that genetic variation in temperature-responsive or vasospastic genes might underlie RP so performed a candidate gene study in a large, population based sample. We assessed the association between RP and single nucleotide polymorphisms (SNPs) in the TRPA1, TRPM8, CALCA, CALCB and NOS1 genes...
2018: PloS One
https://www.readbyqxmd.com/read/29689522/differential-effects-of-lipopolysaccharide-on-mouse-sensory-trp-channels
#8
Brett Boonen, Yeranddy A Alpizar, Alicia Sanchez, Alejandro López-Requena, Thomas Voets, Karel Talavera
Acute neurogenic inflammation and pain associated to bacterial infection have been traditionally ascribed to sensitization and activation of sensory nerve afferents secondary to immune cell stimulation. However, we recently showed that lipopolysaccharides (LPS) directly activate the Transient Receptor Potential channels TRPA1 in sensory neurons and TRPV4 in airway epithelial cells. Here we investigated whether LPS activates other sensory TRP channels expressed in sensory neurons. Using intracellular Ca2+ imaging and patch-clamp we determined the effects of LPS on recombinant TRPV1, TRPV2, TRPM3 and TRPM8, heterologously expressed in HEK293T cells...
April 14, 2018: Cell Calcium
https://www.readbyqxmd.com/read/29678654/4tm-trpm8-channels-are-new-gatekeepers-of-the-er-mitochondria-ca-2-transfer
#9
Gabriel Bidaux, Dmitri Gordienko, George Shapovalov, Valerio Farfariello, Anne-Sophie Borowiec, Oksana Iamshanova, Loic Lemonnier, Maxime Gueguinou, Roseline Guibon, Gaelle Fromont, Mélanie Paillard, Yves Gouriou, Christophe Chouabe, Etienne Dewailly, Dimitra Gkika, Pilar López-Alvarado, J Carlos Menéndez, Laurent Héliot, Christian Slomianny, Natalia Prevarskaya
Calcium (Ca2+ ) release from the endoplasmic reticulum plays an important role in many cell-fate defining cellular processes. Traditionally, this Ca2+ release was associated with the ER Ca2+ release channels, inositol 1,4,5‑triphosphate receptor (IP3 R) and ryanodine receptor (RyR). Lately, however, other calcium conductances have been found to be intracellularly localized and to participate in cell fate regulation. Nonetheless, molecular identity and functional properties of the ER Ca2+ release mechanisms associated with multiple diseases, e...
April 17, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29668703/activation-of-host-transient-receptor-potential-trp-channels-by-praziquantel-stereoisomers
#10
Gihan S Gunaratne, Nawal Yahya, Peter I Dosa, Jonathan S Marchant
The anthelmintic praziquantel (±PZQ) serves as a highly effective antischistosomal therapy. ±PZQ causes a rapid paralysis of adult schistosome worms and deleterious effects on the worm tegument. In addition to these activities against the parasite, ±PZQ also modulates host vascular tone in blood vessels where the adult worms reside. In resting mesenteric arteries ±PZQ causes a constriction of basal tone, an effect mediated by (R)-PZQ activation of endogenous serotoninergic G protein coupled receptors (GPCRs)...
April 18, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29664111/morphological-and-functional-changes-in-trpm8-expressing-corneal-cold-thermoreceptor-neurons-during-aging-and-their-impact-on-tearing-in-mice
#11
Ignacio Alcalde, Almudena Íñigo-Portugués, Omar González-González, Laura Almaraz, Enol Artime, Cruz Morenilla-Palao, Juana Gallar, Félix Viana, Jesús Merayo-Lloves, Carlos Belmonte
Morphological and functional alterations of peripheral somatosensory neurons during the aging process lead to a decline of somatosensory perception. Here, we analyze the changes occurring with aging in trigeminal ganglion (TG), TRPM8-expressing cold thermoreceptor neurons innervating the mouse cornea, which participate in the regulation of basal tearing and blinking and have been implicated in the pathogenesis of dry eye disease (DED). TG cell bodies and axonal branches were examined in a mouse line (TRPM8BAC -EYFP) expressing a fluorescent reporter...
April 17, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29655911/antinociceptive-activity-of-riparin-ii-from-aniba-riparia-further-elucidation-of-the-possible-mechanisms
#12
Alyne Mara Rodrigues de Carvalho, Leonardo Freire Vasconcelos, Nayrton Flávio Moura Rocha, Emiliano Ricardo Vasconcelos Rios, Marília Leite Dias, Marta Maria de França Fonteles, Danielle Macêdo Gaspar, José Maria Barbosa Filho, Stanley Juan Chavez Gutierrez, Francisca Cléa Florenço de Sousa
Riparin II (RipII) has an anti-inflammatory activity potentially due its ability to decrease TNF-α and IL-1β production and its histamine antagonism. The objective of this study was to evaluate the role of RipII in the pain process and the possible antinociceptive mechanisms involved, using classic models of nociception. Male Swiss mice were used in the assays. Determinate the acute toxicity according to the OECD 425 test guideline. The models used were the acetic acid-, formalin-, hot plate and glutamate-induced nociception...
April 12, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29629494/cold-stimuli-facilitate-inflammatory-responses-through-transient-receptor-potential-melastatin-8-trpm8-in-primary-airway-epithelial-cells-of-asthmatic-mice
#13
Haipei Liu, Li Hua, Quanhua Liu, Jun Pan, Yixiao Bao
Bronchial asthma is a chronic inflammatory airway disease that can be aggravated by cold air. However, its mechanism remains largely unknown. As a thermo-sensing cation channel, transient receptor potential melastatin 8 (TRPM8) can be activated by cold stimuli (8-22 °C) and cooling agents. Whereas TRPM8 activation leads to enhanced expression of inflammatory cytokines and mucus hypersecretion in human bronchial epithelial cell lines, no previous study has examined its role in regulating the cold-induced inflammatory responses and its mechanism in asthmatic airway epithelium...
April 9, 2018: Inflammation
https://www.readbyqxmd.com/read/29622593/transient-receptor-potential-melastatin-8-activation-induces-relaxation-of-pulmonary-artery-by-inhibition-of-store-operated-calcium-entry-in-normoxic-and-chronic-hypoxic-pulmonary-hypertensive-rats
#14
Yun-Ping Mu, Da-Cen Lin, Si-Yi Zheng, Hai-Xia Jiao, James Sham, Mo-Jun Lin
Pulmonary hypertension (PH) is characterized by enhanced vasoconstriction and vascular remodeling, which are attributable to the alteration of Ca2+ homeostasis in pulmonary arterial smooth muscle cells (PASMCs). It is well established that store-operated Ca2+ entry (SOCE) is augmented in PASMCs during PH and it plays crucial roles in PH development. Our previous studies showed that the melastatin-related transient receptor potential 8 (TRPM8) is down-regulated in PASMCs of PH animal models; and activation of TRPM8 causes relaxation of pulmonary arteries (PAs)...
April 5, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29590195/the-neurochemistry-and-morphology-of-functionally-identified-corneal-polymodal-nociceptors-and-cold-thermoreceptors
#15
Abdulhakeem S Alamri, Rhiannon J Wood, Jason J Ivanusic, James A Brock
It is generally believed that the unencapsulated sensory nerve terminals of modality specific C- and Aδ-neurons lack structural specialization. Here we determined the morphology of functionally defined polymodal receptors and cold thermoreceptors in the guinea pig corneal epithelium. Polymodal receptors and cold thermoreceptors were identified by extracellular recording at the surface of the corneal epithelium. After marking the recording sites, corneas were processed to reveal immunoreactivity for the transient receptor potential channels TRPV1 (transient receptor potential cation channel, subfamily V, member 1) or TPRM8 (transient receptor potential cation channel subfamily M member 8)...
2018: PloS One
https://www.readbyqxmd.com/read/29560109/trpm8-and-raas-mediated-hypertension-is-critical-for-cold-induced-immunosuppression-in-mice
#16
Hao Chan, Hsuan-Shun Huang, Der-Shan Sun, Chung-Jen Lee, Te-Sheng Lien, Hsin-Hou Chang
Mechanisms underlying cold-induced immunosuppression remain unclear. Here we found that cold exposure leads to transient receptor potential melastatin 8 (TRPM8)-dependent, renin-angiotensin-aldosterone system (RAAS)-mediated hypertension, which subsequently induces small molecule and fluid extravasation, increases plasma Ig levels, and elicits immunosuppression. An effect is similar to the clinically-used immunosuppressive treatments of intravenous immunoglobulin (IVIg) against various inflammatory diseases, such as immune thrombocytopenia (ITP)...
February 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29541177/rna-interference-mediated-depletion-of-trpm8-enhances-the-efficacy-of-epirubicin-chemotherapy-in-prostate-cancer-lncap-and-pc3-cells
#17
Tao Liu, Yixiang Liao, Huangheng Tao, Jinmin Zeng, Gang Wang, Zhonghua Yang, Yongzhi Wang, Yu Xiao, Jiajie Zhou, Xinghuan Wang
Several studies have shown that transient receptor potential cation channel subfamily M member 8 (TRPM8), which has been regarded as a novel prostate-specific marker, serves a key role in processes such as the proliferation, viability and cell migration of prostate cancer cells. Efforts have been made to uncover the potential role of targeting TRPM8 in the management of prostate cancer; it has been verified that TRPM8-targeted blockade, either by RNA interference-mediated depletion or specific TRPM8 inhibitors, could reduce the rate of proliferation and proliferative fraction, and induce apoptosis in prostate cancer cells...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29530988/deletion-of-the-cold-thermoreceptor-trpm8-increases-heat-loss-and-food-intake-leading-to-reduced-body-temperature-and-obesity-in-mice
#18
Alfonso Reimúndez, Carlos Fernández-Peña, Guillermo García, Rubén Fernández, Purificación Ordás, Rosalía Gallego, Jose L Pardo-Vazquez, Victor Arce, Félix Viana, Rosa Señarís
The coupling of energy homeostasis to thermoregulation is essential to maintain homeothermy in changing external environments. We studied the role of the cold thermoreceptor TRPM8 in this interplay in mice of both sexes. We demonstrate that TRPM8 is required for a precise thermoregulation in response to cold, in fed and fasting. Trpm8 -/- mice exhibited a fall of 0.7°C in core body temperature when housed at cold temperatures, and a deep hypothermia (<30°C) during food deprivation. In both situations, TRPM8 deficiency induced an increase in tail heat loss...
April 11, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29524352/the-role-and-mechanism-of-action-of-menthol-in-topical-analgesic-products
#19
REVIEW
J V Pergolizzi, R Taylor, J-A LeQuang, R B Raffa
WHAT IS KNOWN AND OBJECTIVE: Menthol has been used as a non-opioid pain reliever since ancient times. A modern understanding of its molecular mechanism of action could form the basis for generating targets for discovery of novel non-opioid analgesic drugs. METHODS: The PubMed database was queried using search words related to menthol, pain and analgesia. The results were limited to relevant preclinical studies and clinical trials and reviews published in English during the past 5 years, which yielded 31 reports...
June 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29518656/copper-induced-activation-of-trp-channels-promotes-extracellular-calcium-entry-and-activation-of-camk-pka-pkc-pkg-and-cblpk-leading-to-increased-expression-of-antioxidant-enzymes-in-ectocarpus-siliculosus
#20
Alberto González, Claudio A Sáez, Bernardo Morales, Alejandra Moenne
The existence of functional Transient Receptor Potential (TRP) channels was analyzed in Ectocarpus siliculosus using agonists of human TRPs and specific antagonists of TRPA1, TRPC5, TRPM8 and TRPV; intracellular calcium was detected for 60 min. Increases in intracellular calcium were observed at 13, 29, 39 and 50-52 min, which appeared to be mediated by the activation of TRPM8/V1 at 13 min, TRPV1 at 29 min, TRPA1/V1 at 39 min and TRPA1/C5 at 50-52 min. In addition, intracellular calcium increases appear to be due to extracellular calcium entry, not requiring protein kinase activation...
May 2018: Plant Physiology and Biochemistry: PPB
keyword
keyword
25198
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"