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https://www.readbyqxmd.com/read/27912932/trauma-surgery-by-general-surgeons-still-an-option-for-proximal-femoral-fractures
#1
Kaij Treskes, Stijn C Voeten, Maria C J M Tol, Wietse P Zuidema, Jefrey Vermeulen, J Carel Goslings, Niels W L Schep
INTRODUCTION: Surgery for proximal femoral fractures in the Netherlands is performed by trauma surgeons, general surgeons and orthopaedic surgeons. The aim of this study was to assess whether there is a difference in outcome for patients with proximal femoral fractures operated by trauma surgeons versus general surgeons. Secondly, the relation between hospital and surgeon volume and postoperative complications was explored. METHODS: Patients of 18 years and older were included if operated for a proximal femoral fracture by a trauma surgeon or a general surgeon in two academic, eight teaching and two non-teaching hospitals in the Netherlands from January 2010 until December 2013...
November 18, 2016: Injury
https://www.readbyqxmd.com/read/27898723/pth1r-mutants-found-in-patients-with-primary-failure-of-tooth-eruption-disrupt-g-protein-signaling
#2
Hariharan Subramanian, Frank Döring, Sina Kollert, Natalia Rukoyatkina, Julia Sturm, Stepan Gambaryan, Angelika Stellzig-Eisenhauer, Philipp Meyer-Marcotty, Martin Eigenthaler, Erhard Wischmeyer
AIM: Primary failure of tooth eruption (PFE) is causally linked to heterozygous mutations of the parathyroid hormone receptor (PTH1R) gene. The mutants described so far lead to exchange of amino acids or truncation of the protein that may result in structural changes of the expressed PTH1R. However, functional effects of these mutations have not been investigated yet. MATERIALS AND METHODS: In HEK293 cells, PTH1R wild type was co-transfected with selected PTH1R mutants identified in patients with PFE...
2016: PloS One
https://www.readbyqxmd.com/read/27896470/erratum-to-high-rates-of-clinically-relevant-incidental-findings-by-total-body-ct-scanning-in-trauma-patients-results-of-the-react-2-trial
#3
K Treskes, S A Bos, L F M Beenen, J C Sierink, M J R Edwards, B J A Beuker, G S R Muradin, J Hohmann, J S K Luitse, M W Hollmann, M G W Dijkgraaf, J C Goslings
No abstract text is available yet for this article.
November 28, 2016: European Radiology
https://www.readbyqxmd.com/read/27789381/tresk-contributes-to-pain-threshold-changes-by-mediating-apoptosis-via-mapk-pathway-in-the-spinal-cord
#4
Jun Zhou, Wenjing Lin, Hongtao Chen, Youling Fan, Chengxiang Yang
The mechanism underlying neuropathic pain (NP) is complex and has not been fully elucidated. The TWIK-related spinal cord K(+) (TRESK) is the major background potassium current in dorsal root ganglia (DRG), we found that mitogen-activated protein kinase (MAPK) signal pathway were activated in spinal cord accompanied by TRESK down regulation in response to NP. Therefore, we investigated whether TRESK mediates inflammation and apoptosis by MAPK pathway in the spinal cord of NP rats. SNI rats exhibited reduced TRESK expression in DRG and spinal cord and higher sensitivity to mechanical stimuli but no effect on thermal stimuli...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27709280/high-rates-of-clinically-relevant-incidental-findings-by-total-body-ct-scanning-in-trauma-patients-results-of-the-react-2-trial
#5
K Treskes, S A Bos, L F M Beenen, J C Sierink, M J R Edwards, B J A Beuker, G S R Muradin, J Hohmann, J S K Luitse, M W Hollmann, M G W Dijkgraaf, J C Goslings
OBJECTIVES: To determine whether there is a difference in frequency and clinical relevance of incidental findings detected by total-body computed tomography scanning (TBCT) compared to those by the standard work-up (STWU) with selective computed tomography (CT) scanning. METHODS: Trauma patients from five trauma centres were randomized between April 2011 and January 2014 to TBCT imaging or STWU consisting of conventional imaging with selective CT scanning. Incidental findings were divided into three categories: 1) major finding, may cause mortality; 2) moderate finding, may cause morbidity; and 3) minor finding, hardly relevant...
October 5, 2016: European Radiology
https://www.readbyqxmd.com/read/27641472/investigation-of-the-structure-activity-relationship-of-flufenamic-acid-derivatives-at-the-human-tresk-channel-k2p18-1
#6
Aymeric Monteillier, Alexandre Loucif, Kiyoyuki Omoto, Edward B Stevens, Sergio L Vicente, Pierre-Philippe Saintot, Lishuang Cao, David C Pryde
TRESK (Twik RElated Spinal cord K(+) channel) is a member of the Twin Pore Domain potassium channel (K2P) family responsible for regulating neuronal excitability in dorsal root ganglion (DRG) and trigeminal (TG) neurons, peripheral neurons involved in pain transmission. As channel opening causes an outward K(+) current responsible for cell hyperpolarisation, TRESK represents a potentially interesting target for pain treatment. However, as no crystal structure exists for this protein, the mechanisms involved in the opening action of its ligands are still poorly understood, making the development of new potent and selective openers challenging...
October 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27477584/mobile-health-in-cardiology-a-review-of-currently-available-medical-apps-and-equipment-for-remote-monitoring
#7
Roderick Willem Treskes, Enno Tjeerd van der Velde, Rogier Barendse, Nico Bruining
INTRODUCTION: Recent developments in implantable cardioverter-defibrillators (ICDs) and smartphone technology have increased the possibilities for remote monitoring. It is the purpose of this review to give an overview of these new possibilities. AREAS COVERED: Remote monitoring in ICD allows for early detection of lead fractures and remote follow-up of patients. Possible limitations are the lack of standardization and the possible unsafety of the data stored on the ICD...
September 2016: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/27475306/increased-activation-of-the-tresk-k-channel-mediates-vago-vagal-reflex-malfunction-in-diabetic-rats
#8
Gintautas Grabauskas, Xiaoyin Wu, Il Song, Shi-Yi Zhou, Thomas Lanigan, Chung Owyang
BACKGROUND & AIMS: Patients with diabetes have defects in the vagal afferent pathway that result in abnormal gastrointestinal function. We investigated whether selective increased activation of the 2 pore domain potassium channel TRESK contributes to nodose ganglia (NG) malfunction, disrupting gastrointestinal function in diabetic rats. METHODS: We conducted whole-cell current-clamp and single-unit recordings in NG neurons from diabetes-prone BioBreeding/Worcester rats and streptozotocin-induced diabetic (STZ-D) rats and compared with control rats...
July 27, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27435196/indications-for-total-body-computed-tomography-in-blunt-trauma-patients-a-systematic-review
#9
K Treskes, T P Saltzherr, J S K Luitse, L F M Beenen, J C Goslings
PURPOSE: Total-body CT scanning (TBCT) could improve the initial in-hospital evaluation of severe trauma patients. Indications for TBCT, however, differ between trauma centers, so more insight in how to select patients that could benefit from TBCT is required. The aim of this review was to give an overview of currently used indications for total-body CT in trauma patients and to describe mortality and Injury Severity Scores of patient groups selected for TBCT. METHODS: A systematic review was performed by searching MEDLINE and Embase databases...
July 19, 2016: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/27382354/effects-of-analgesics-and-antidepressants-on-trek-2-and-tresk-currents
#10
Hyun Park, Eun-Jin Kim, Jaehee Han, Jongwoo Han, Dawon Kang
TWIK-related K(+) channel-2 (TREK-2) and TWIK-related spinal cord K(+) (TRESK) channel are members of two-pore domain K(+) channel family. They are well expressed and help to set the resting membrane potential in sensory neurons. Modulation of TREK-2 and TRESK channels are involved in the pathogenesis of pain, and specifi c activators of TREK-2 and TRESK may be benefi cial for the treatment of pain symptoms. However, the effect of commonly used analgesics on TREK-2 and TRESK channels are not known. Here, we investigated the effect of analgesics on TREK-2 and TRESK channels...
July 2016: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/27371185/immediate-total-body-ct-scanning-versus-conventional-imaging-and-selective-ct-scanning-in-patients-with-severe-trauma-react-2-a-randomised-controlled-trial
#11
RANDOMIZED CONTROLLED TRIAL
Joanne C Sierink, Kaij Treskes, Michael J R Edwards, Benn J A Beuker, Dennis den Hartog, Joachim Hohmann, Marcel G W Dijkgraaf, Jan S K Luitse, Ludo F M Beenen, Markus W Hollmann, J Carel Goslings
BACKGROUND: Published work suggests a survival benefit for patients with trauma who undergo total-body CT scanning during the initial trauma assessment; however, level 1 evidence is absent. We aimed to assess the effect of total-body CT scanning compared with the standard work-up on in-hospital mortality in patients with trauma. METHODS: We undertook an international, multicentre, randomised controlled trial at four hospitals in the Netherlands and one in Switzerland...
August 13, 2016: Lancet
https://www.readbyqxmd.com/read/27368608/proteomic-profiling-of-cellular-steatosis-with-concomitant-oxidative-stress-in-vitro
#12
Khalida Ann Lockman, Varanand Htun, Rohit Sinha, Philipp Treskes, Leonard J Nelson, Sarah F Martin, Sophie M Rogers, Thierry Le Bihan, Peter C Hayes, John N Plevris
BACKGROUND: Nutrient excess underpins the development of nonalcoholic fatty liver disease (NAFLD). The ensuing metabolic derangement is characterised by increased cellular respiration, oxidative stress and mitochondrial impairment. We have previously recapitulated these events in an in vitro cellular steatosis model. Here, we examined the distinct patterns of protein expression involved using a proteomics approach. METHODS: Human hepatoblastoma C3A cells were treated with a combination of energy substrates; lactate (L), pyruvate (P), octanoate (O) and ammonia (N)...
2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27285124/human-hepatic-heparg-cells-maintain-an-organotypic-phenotype-with-high-intrinsic-cyp450-activity-metabolism-and-significantly-outperform-standard-hepg2-c3a-cells-for-pharmaceutical-and-therapeutic-applications
#13
Leonard J Nelson, Katie Morgan, Philipp Treskes, Kay Samuel, Catherine J Henderson, Claire LeBled, Natalie Homer, M Helen Grant, Peter C Hayes, John N Plevris
Conventional in vitro human hepatic models for drug testing are based on the use of standard cell lines derived from hepatomas or primary human hepatocytes (PHHs). Limited availability, inter-donor functional variability and early phenotypic alterations of PHHs restrict their use; whilst standard cell lines such as HepG2 lack a substantial and variable set of liver-specific functions such as CYP450 activity. Alternatives include the HepG2-derivative C3A cells selected as a more differentiated and metabolically active hepatic phenotype...
June 10, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27052894/redesigning-healthcare-the-2-4-billion-euro-question-connecting-smart-technology-to-improve-outcome-of-patients
#14
REVIEW
R W Treskes, E T Van Der Velde, D E Atsma, M J Schalij
Although it has been possible to transfer electrocardiograms via a phone line for more than 100 years, use of internet-based patient monitoring and communication systems in daily care is uncommon. Despite the introduction of numerous health-monitoring devices, and despite most patients having internet access, the implementation of individualised healthcare services is still limited. On the other hand, hospitals have invested heavily in massive information systems offering limited value for money and connectivity...
July 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/26914156/aristolochic-acid-a-plant-extract-used-in-the-treatment-of-pain-and-linked-to-balkan-endemic-nephropathy-is-a-regulator-of-k2p-channels
#15
Emma L Veale, Alistair Mathie
BACKGROUND AND PURPOSE: Aristolochic acid (AristA) is found in plants used in traditional medicines to treat pain. We investigated the action of AristA on TREK and TRESK, potassium (K2P) channels, which are potential therapeutic targets in pain. Balkan endemic nephropathy (BEN) is a renal disease associated with AristA consumption. A mutation of TASK-2 (K2P 5.1) channels (T108P) is seen in some patients susceptible to BEN, so we investigated how both this mutation and AristA affected TASK-2 channels...
May 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/26632255/acetaminophen-cytotoxicity-is-ameliorated-in-a-human-liver-organotypic-co-culture-model
#16
Leonard J Nelson, Maria Navarro, Philipp Treskes, Kay Samuel, Olga Tura-Ceide, Steven D Morley, Peter C Hayes, John N Plevris
Organotypic liver culture models for hepatotoxicity studies that mimic in vivo hepatic functionality could help facilitate improved strategies for early safety risk assessment during drug development. Interspecies differences in drug sensitivity and mechanistic profiles, low predictive capacity, and limitations of conventional monocultures of human hepatocytes, with high attrition rates remain major challenges. Herein, we show stable, cell-type specific phenotype/cellular polarity with differentiated functionality in human hepatocyte-like C3A cells (enhanced CYP3A4 activity/albumin synthesis) when in co-culture with human vascular endothelial cells (HUVECs), thus demonstrating biocompatibility and relevance for evaluating drug metabolism and toxicity...
December 3, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26489821/electrocardiographic-detection-of-pulmonary-hypertension-in-patients-with-systemic-sclerosis-using-the-ventricular-gradient
#17
L E Couperus, H W Vliegen, I R Henkens, A C Maan, R W Treskes, J K de Vries, A A Schouffoer, C A Swenne, M J Schalij, R W C Scherptong
BACKGROUND: Pulmonary hypertension (PH) is a leading cause of death in systemic sclerosis (SSc) patients. The current study assessed the ability of the ECG-derived ventricular gradient (VG-RVPO) to detect PH and predict all-cause mortality in PH patients with subtypes of SSc differing in the extent of multi-organ involvement. METHODS: ECGs were obtained from 196 patients with limited and 77 patients with diffuse SSc included from our screening programme on cardiac complications...
January 2016: Journal of Electrocardiology
https://www.readbyqxmd.com/read/26357517/dynamic-support-culture-of-murine-skeletal-muscle-derived-stem-cells-improves-their-cardiogenic-potential-in-vitro
#18
Klaus Neef, Philipp Treskes, Guoxing Xu, Florian Drey, Sureshkumar Perumal Srinivasan, Tomo Saric, Erastus Nembo, Judith Semmler, Filomain Nguemo, Christof Stamm, Douglas B Cowan, Antje-Christin Deppe, Maximilian Scherner, Thorsten Wittwer, Jürgen Hescheler, Thorsten Wahlers, Yeong-Hoon Choi
Ischemic heart disease is the main cause of death in western countries and its burden is increasing worldwide. It typically involves irreversible degeneration and loss of myocardial tissue leading to poor prognosis and fatal outcome. Autologous cells with the potential to regenerate damaged heart tissue would be an ideal source for cell therapeutic approaches. Here, we compared different methods of conditional culture for increasing the yield and cardiogenic potential of murine skeletal muscle-derived stem cells...
2015: Stem Cells International
https://www.readbyqxmd.com/read/26321392/role-of-leak-potassium-channels-in-pain-signaling
#19
REVIEW
Xiang-Yao Li, Hiroki Toyoda
Potassium (K(+)) channels are membrane proteins that allow rapid and selective flow of K(+) ions across the cell membrane, generating electrical signals in neurons. Thus, K(+) channels play a critical role in determining the neuronal excitability. Two-pore domain (K2P) "leak" K(+) channels give rise to leak K(+) currents that are responsible for the resting membrane potential and input resistance. The wide expression of leak K(+) channels in the central and peripheral nervous system suggests that these channels are critically involved in pain signaling and behavior...
October 2015: Brain Research Bulletin
https://www.readbyqxmd.com/read/26256973/twik-related-spinal-cord-k%C3%A2-%C2%BA-channel-expression-is-increased-in-the-spinal-dorsal-horn-after-spinal-nerve-ligation
#20
Hee Youn Hwang, Enji Zhang, Sangil Park, Woosuk Chung, Sunyeul Lee, Dong Woon Kim, Youngkwon Ko, Wonhyung Lee
PURPOSE: The TWIK-related spinal cord K⁺ channel (TRESK) has recently been discovered and plays an important role in nociceptor excitability in the pain pathway. Because there have been no reports on the TRESK expression or its function in the dorsal horn of the spinal cord in neuropathic pain, we analyzed TRESK expression in the spinal dorsal horn in a spinal nerve ligation (SNL) model. MATERIALS AND METHODS: We established a SNL mouse model by using the L5-6 spinal nerves ligation...
September 2015: Yonsei Medical Journal
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