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https://www.readbyqxmd.com/read/28939546/using-smart-technology-to-improve-outcomes-in-myocardial-infarction-patients-rationale-and-design-of-a-protocol-for-a-randomized-controlled-trial-the-box
#1
Roderick Willem Treskes, Louise Anna van Winden, Nicole van Keulen, Douwe Ekke Atsma, Enno Tjeerd van der Velde, Elske van den Akker-van Marle, Bart Mertens, Martin Jan Schalij
BACKGROUND: Recent evidence suggests that frequent monitoring using smartphone-compatible wearable technologies might improve clinical effectiveness and patient satisfaction of care. OBJECTIVE: The aim of this study is to investigate the clinical effectiveness and patient satisfaction of a smart technology intervention in patients admitted with a ST elevation myocardial infarction (STEMI) or non-ST acute coronary syndrome (NST-ACS). METHODS: In this single center, open, randomized controlled trial patients who suffered from STEMI or NST-ACS will be randomized 1:1 to an intervention group or control group...
September 22, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28937579/pyrethroids-inhibit-k2p-channels-and-activate-sensory-neurons-basis-of-insecticide-induced-paraesthesias
#2
Aida Castellanos, Alba Andres, Laura Bernal, Gerard Callejo, Nuria Comes, Arcadi Gual, Jonathan P Giblin, Carolina Roza, Xavier Gasull
Pyrethroid insecticides are widely used for pest control, in agriculture or in human public health commonly as a topical treatment for scabies and head lice. Exposure to pyrethroids such as permethrin or tetramethrin (TM) causes sensory alterations such as transient pain, burning, stinging sensations and paraesthesias. Despite the well-known effects of pyrethroids on sodium channels, actions on other channels that control sensory neuron excitability are less studied. Given the role of two-pore domain potassium (K2P) channels in modulating sensory neuron excitability and firing, both in physiological and pathological conditions, we examined the effect of pyrethroids on K2P channels mainly expressed in sensory neurons...
September 25, 2017: Pain
https://www.readbyqxmd.com/read/28882594/terbinafine-is-a-novel-and-selective-activator-of-the-two-pore-domain-potassium-channel-task3
#3
Paul D Wright, Emma L Veale, David McCoull, David C Tickle, Jonathan M Large, Emma Ococks, Gemma Gothard, Catherine Kettleborough, Alistair Mathie, Jeffrey Jerman
Two-pore domain potassium channels (K2Ps) are characterized by their four transmembrane domain and two-pore topology. They carry background (or leak) potassium current in a variety of cell types. Despite a number of important roles there is currently a lack of pharmacological tools with which to further probe K2P function. We have developed a cell-based thallium flux assay, using baculovirus delivered TASK3 (TWIK-related acid-sensitive K(+) channel 3, KCNK9, K2P9.1) with the aim of identifying novel, selective TASK3 activators...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28851409/mobile-phones-in-cryptogenic-stroke-patients-bringing-single-lead-ecgs-for-atrial-fibrillation-detection-mobile-af-study-protocol-for-a-randomised-controlled-trial
#4
Roderick W Treskes, Willem Gielen, Marieke J Wermer, Robert W Grauss, Anouk P van Alem, Reza Alizadeh Dehnavi, Charles J Kirchhof, Enno T van der Velde, Arie C Maan, Ron Wolterbeek, Onno M Overbeek, Martin J Schalij, Serge A Trines
BACKGROUND: Recently published randomised clinical trials indicate that prolonged electrocardiom (ECG) monitoring might enhance the detection of paroxysmal atrial fibrillation (AF) in cryptogenic stroke or transient ischaemic attack (TIA) patients. A device that might be suitable for prolonged ECG monitoring is a smartphone-compatible ECG device (Kardia Mobile, Alivecor, San Francisco, CA, USA) that allows the patient to record a single-lead ECG without the presence of trained health care staff...
August 29, 2017: Trials
https://www.readbyqxmd.com/read/28731095/polarization-driven-conductance-variations-at-charged-ferroelectric-domain-walls
#5
A-S Pawlik, T Kämpfe, A Haußmann, T Woike, U Treske, M Knupfer, B Büchner, E Soergel, R Streubel, A Koitzsch, L M Eng
Conducting domain walls (CDWs) in ferroelectric materials are promising candidates for applications in a manifold of nanoscale, optoelectronic devices. Characterization of their microscopic properties, however, remains challenging due to their small dimension and highly insulating environment. Here, we inspect individual CDWs in single-crystalline LiNbO3 by the combination of photoemission electron microscopy (PEEM) and second harmonic generation (SHG) microscopy. While SHG unveils the overall domain wall inclination angle α, PEEM is sensitive to local conductance variations, both at and away from the domain wall...
August 3, 2017: Nanoscale
https://www.readbyqxmd.com/read/28664876/scaling-up-of-a-heparg-progenitor-cell-based-bioartificial-liver-optimization-for-clinical-application-and-transport
#6
Martien van Wenum, Philipp Treskes, Chung-Yin Tang, Esmee J Coppens, Koen Jansen, Erik J Hendriks, Sandrine Camus, Thomas M van Gulik, Robert A F M Chamuleau, Ruurdtje Hoekstra
A new generation of bioartificial livers, based on differentiated proliferative hepatocyte sources, has been developed. Several practicable and regulatory demands have to be addressed before these can be clinically evaluated. We identified three main hurdles: (1) expansion and preservation of the biocomponent, (2) development of scaled-up culture conditions and (3) transport of the device to the bedside. In this study we address these three issues for the HepaRG-progenitor cell line-loaded AMC-Bioartificial Liver...
June 30, 2017: Biofabrication
https://www.readbyqxmd.com/read/28457182/comparison-of-the-diagnostic-accuracy-of-four-smartphone-compatible-blood-pressure-monitors-in-post-myocardial-infarction-patients
#7
Roderick W Treskes, Ron Wolterbeek, Enno T van der Velde, Daniëlle C Eindhoven, Martin J Schalij
Introduction Smartphone-compatible blood pressure devices may be a good alternative to enable self-measurement of blood pressure by patients. Furthermore, automatic transferral of data to the hospital allows for remote monitoring. To our knowledge, no study has compared four of these smartphone-compatible blood pressure devices. Methods Patients who were followed up for acute myocardial infarction were asked to participate during their outpatient clinic visit. After five minutes of rest, six blood pressure devices were applied...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28419410/selective-and-state-dependent-activation-of-tresk-k2p-18-1-background-potassium-channel-by-cloxyquin
#8
Miklós Lengyel, Alice Dobolyi, Gábor Czirják, Péter Enyedi
BACKGROUND AND PURPOSE: Cloxyquin (5-cloroquinolin-8-ol) has been described as an activator of TRESK (K2P 18.1, TWIK-related spinal cord K(+) channel) background potassium channel. We have examined the specificity of the drug by testing several K2P channels. We have investigated the mechanism of cloxyquin-mediated TRESK activation, focusing on the differences between the physiologically relevant regulatory states of the channel. EXPERIMENTAL APPROACH: Potassium currents were measured by two-electrode voltage clamp in Xenopus oocytes and by whole-cell patch clamp in mouse dorsal root ganglion (DRG) neurons...
July 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28320618/corrigendum-to-investigation-of-the-structure-activity-relationship-of-flufenamic-acid-derivatives-at-the-human-tresk-channel-k2p18-1-bioorg-med-chem-lett-26-2016-4919-4924
#9
Aymeric Monteillier, Alexandre Loucif, Kiyoyuki Omoto, Edward B Stevens, Sergio Lainez, Pierre-Philippe Saintot, Lishuang Cao, David C Pryde
No abstract text is available yet for this article.
May 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28255817/family-studies-to-find-rare-high-risk-variants-in-migraine
#10
REVIEW
Rikke Dyhr Hansen, Anne Francke Christensen, Jes Olesen
INTRODUCTION: Migraine has long been known as a common complex disease caused by genetic and environmental factors. The pathophysiology and the specific genetic susceptibility are poorly understood. Common variants only explain a small part of the heritability of migraine. It is thought that rare genetic variants with bigger effect size may be involved in the disease. Since migraine has a tendency to cluster in families, a family approach might be the way to find these variants. This is also indicated by identification of migraine-associated loci in classical linkage-analyses in migraine families...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28160200/reversal-of-tresk-downregulation-alleviates-neuropathic-pain-by-inhibiting-activation-of-gliocytes-in-the-spinal-cord
#11
Jun Zhou, Hongtao Chen, Chengxiang Yang, Jiying Zhong, Wanyou He, Qingming Xiong
Despite the consensus that activation of TWIK-related spinal cord K(+) (TRESK) might contribute to the pathogenesis of chronic pain, the specific mechanisms underlying the transfer and development of pain signals still remain obscure. In the present study, we validated that TRESK was expressed in neurons instead of glial cells. Furthermore, in the SNI model of neuropathic pain (NP), downregulation of TRESK in spinal cord neurons resulted in upregulation of connexin 36 (Cx36) and connexin 43 (Cx43), both being subtypes of gap junctions in the spinal cord, with gliocytes in the spinal cord activated ultimately...
February 3, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28134251/low-dose-acetaminophen-induces-early-disruption-of-cell-cell-tight-junctions-in-human-hepatic-cells-and-mouse-liver
#12
Wesam Gamal, Philipp Treskes, Kay Samuel, Gareth J Sullivan, Richard Siller, Vlastimil Srsen, Katie Morgan, Anna Bryans, Ada Kozlowska, Andreas Koulovasilopoulos, Ian Underwood, Stewart Smith, Jorge Del-Pozo, Sharon Moss, Alexandra Inés Thompson, Neil C Henderson, Peter C Hayes, John N Plevris, Pierre-Olivier Bagnaninchi, Leonard J Nelson
Dysfunction of cell-cell tight junction (TJ) adhesions is a major feature in the pathogenesis of various diseases. Liver TJs preserve cellular polarity by delimiting functional bile-canalicular structures, forming the blood-biliary barrier. In acetaminophen-hepatotoxicity, the mechanism by which tissue cohesion and polarity are affected remains unclear. Here, we demonstrate that acetaminophen, even at low-dose, disrupts the integrity of TJ and cell-matrix adhesions, with indicators of cellular stress with liver injury in the human hepatic HepaRG cell line, and primary hepatocytes...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27912932/trauma-surgery-by-general-surgeons-still-an-option-for-proximal-femoral-fractures
#13
Kaij Treskes, Stijn C Voeten, Maria C J M Tol, Wietse P Zuidema, Jefrey Vermeulen, J Carel Goslings, Niels W L Schep, JG Han van den Brand, Romuald van Velde, Robert Haverlag, Jan M Ultee, Victor A Postma, Bas A Twigt, Bart A van Dijkman, Pieter Heres, Jasper Winkelhagen, Mariska Klooster, Annelies Toor
INTRODUCTION: Surgery for proximal femoral fractures in the Netherlands is performed by trauma surgeons, general surgeons and orthopaedic surgeons. The aim of this study was to assess whether there is a difference in outcome for patients with proximal femoral fractures operated by trauma surgeons versus general surgeons. Secondly, the relation between hospital and surgeon volume and postoperative complications was explored. METHODS: Patients of 18 years and older were included if operated for a proximal femoral fracture by a trauma surgeon or a general surgeon in two academic, eight teaching and two non-teaching hospitals in the Netherlands from January 2010 until December 2013...
February 2017: Injury
https://www.readbyqxmd.com/read/27898723/pth1r-mutants-found-in-patients-with-primary-failure-of-tooth-eruption-disrupt-g-protein-signaling
#14
Hariharan Subramanian, Frank Döring, Sina Kollert, Natalia Rukoyatkina, Julia Sturm, Stepan Gambaryan, Angelika Stellzig-Eisenhauer, Philipp Meyer-Marcotty, Martin Eigenthaler, Erhard Wischmeyer
AIM: Primary failure of tooth eruption (PFE) is causally linked to heterozygous mutations of the parathyroid hormone receptor (PTH1R) gene. The mutants described so far lead to exchange of amino acids or truncation of the protein that may result in structural changes of the expressed PTH1R. However, functional effects of these mutations have not been investigated yet. MATERIALS AND METHODS: In HEK293 cells, PTH1R wild type was co-transfected with selected PTH1R mutants identified in patients with PFE...
2016: PloS One
https://www.readbyqxmd.com/read/27896470/erratum-to-high-rates-of-clinically-relevant-incidental-findings-by-total-body-ct-scanning-in-trauma-patients-results-of-the-react-2-trial
#15
K Treskes, S A Bos, L F M Beenen, J C Sierink, M J R Edwards, B J A Beuker, G S R Muradin, J Hohmann, J S K Luitse, M W Hollmann, M G W Dijkgraaf, J C Goslings
No abstract text is available yet for this article.
November 28, 2016: European Radiology
https://www.readbyqxmd.com/read/27789381/tresk-contributes-to-pain-threshold-changes-by-mediating-apoptosis-via-mapk-pathway-in-the-spinal-cord
#16
Jun Zhou, Wenjing Lin, Hongtao Chen, Youling Fan, Chengxiang Yang
The mechanism underlying neuropathic pain (NP) is complex and has not been fully elucidated. The TWIK-related spinal cord K(+) (TRESK) is the major background potassium current in dorsal root ganglia (DRG), we found that mitogen-activated protein kinase (MAPK) signal pathway were activated in spinal cord accompanied by TRESK down regulation in response to NP. Therefore, we investigated whether TRESK mediates inflammation and apoptosis by MAPK pathway in the spinal cord of NP rats. SNI rats exhibited reduced TRESK expression in DRG and spinal cord and higher sensitivity to mechanical stimuli but no effect on thermal stimuli...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27709280/high-rates-of-clinically-relevant-incidental-findings-by-total-body-ct-scanning-in-trauma-patients-results-of-the-react-2-trial
#17
K Treskes, S A Bos, L F M Beenen, J C Sierink, M J R Edwards, B J A Beuker, G S R Muradin, J Hohmann, J S K Luitse, M W Hollmann, M G W Dijkgraaf, J C Goslings
OBJECTIVES: To determine whether there is a difference in frequency and clinical relevance of incidental findings detected by total-body computed tomography scanning (TBCT) compared to those by the standard work-up (STWU) with selective computed tomography (CT) scanning. METHODS: Trauma patients from five trauma centres were randomized between April 2011 and January 2014 to TBCT imaging or STWU consisting of conventional imaging with selective CT scanning. Incidental findings were divided into three categories: 1) major finding, may cause mortality; 2) moderate finding, may cause morbidity; and 3) minor finding, hardly relevant...
June 2017: European Radiology
https://www.readbyqxmd.com/read/27641472/investigation-of-the-structure-activity-relationship-of-flufenamic-acid-derivatives-at-the-human-tresk-channel-k2p18-1
#18
Aymeric Monteillier, Alexandre Loucif, Kiyoyuki Omoto, Edward B Stevens, Sergio Lainez, Pierre-Philippe Saintot, Lishuang Cao, David C Pryde
TRESK (Twik RElated Spinal cord K(+) channel) is a member of the Twin Pore Domain potassium channel (K2P) family responsible for regulating neuronal excitability in dorsal root ganglion (DRG) and trigeminal (TG) neurons, peripheral neurons involved in pain transmission. As channel opening causes an outward K(+) current responsible for cell hyperpolarisation, TRESK represents a potentially interesting target for pain treatment. However, as no crystal structure exists for this protein, the mechanisms involved in the opening action of its ligands are still poorly understood, making the development of new potent and selective openers challenging...
October 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27477584/mobile-health-in-cardiology-a-review-of-currently-available-medical-apps-and-equipment-for-remote-monitoring
#19
REVIEW
Roderick Willem Treskes, Enno Tjeerd van der Velde, Rogier Barendse, Nico Bruining
INTRODUCTION: Recent developments in implantable cardioverter-defibrillators (ICDs) and smartphone technology have increased the possibilities for remote monitoring. It is the purpose of this review to give an overview of these new possibilities. AREAS COVERED: Remote monitoring in ICD allows for early detection of lead fractures and remote follow-up of patients. Possible limitations are the lack of standardization and the possible unsafety of the data stored on the ICD...
September 2016: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/27475306/increased-activation-of-the-tresk-k-mediates-vago-vagal-reflex-malfunction-in-diabetic-rats
#20
Gintautas Grabauskas, Xiaoyin Wu, Il Song, Shi-Yi Zhou, Thomas Lanigan, Chung Owyang
BACKGROUND & AIMS: Patients with diabetes have defects in the vagal afferent pathway that result in abnormal gastrointestinal function. We investigated whether selective increased activation of the 2-pore domain potassium channel TRESK (2-pore-domain weak inward-rectifying potassium channel-related spinal cord potassium channel) contributes to nodose ganglia (NG) malfunction, disrupting gastrointestinal function in diabetic rats. METHODS: We conducted whole-cell current-clamp and single-unit recordings in NG neurons from diabetes-prone BioBreeding/Worcester rats and streptozotocin-induced diabetic (STZ-D) rats and compared them with control rats...
November 2016: Gastroenterology
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