Kruttika Phalnikar, M Srividya, S V Mythri, N S Vasavi, Archisha Ganguly, Aparajita Kumar, Padmaja S, Kishan Kalia, Srishti S Mishra, Sreeja Kumari Dhanya, Pradip Paul, Bharath Holla, Suhas Ganesh, Puli Chandramouli Reddy, Reeteka Sud, Biju Viswanath, Bhavana Muralidharan
Bipolar disorder (BD) is a severe mental illness that can result from neurodevelopmental aberrations, particularly in familial BD, which may include causative genetic variants. In the present study, we derived cortical organoids from BD patients and healthy (control) individuals from a clinically dense family in the Indian population. Our data reveal that the patient organoids show neurodevelopmental anomalies, including organisational, proliferation and migration defects. The BD organoids show a reduction in both the number of neuroepithelial buds/cortical rosettes and the ventricular zone size...
2024: Oxf Open Neurosci