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https://www.readbyqxmd.com/read/28212347/molecularly-imprinted-sol-gel-based-qcm-sensor-arrays-for-the-detection-and-recognition-of-volatile-aldehydes
#1
Chuanjun Liu, Bartosz Wyszynski, Rui Yatabe, Kenshi Hayashi, Kiyoshi Toko
The detection and recognition of metabolically derived aldehydes, which have been identified as important products of oxidative stress and biomarkers of cancers; are considered as an effective approach for early cancer detection as well as health status monitoring. Quartz crystal microbalance (QCM) sensor arrays based on molecularly imprinted sol-gel (MISG) materials were developed in this work for highly sensitive detection and highly selective recognition of typical aldehyde vapors including hexanal (HAL); nonanal (NAL) and bezaldehyde (BAL)...
February 16, 2017: Sensors
https://www.readbyqxmd.com/read/28212311/detection-of-atmospheric-methyl-mercaptan-using-wavelength-modulation-spectroscopy-with-multicomponent-spectral-fitting
#2
Zhenhui Du, Jiaxin Wan, Jinyi Li, Gang Luo, Hong Gao, Yiwen Ma
Detection of methyl mercaptan (CH₃SH) is essential for environmental atmosphere assessment and exhaled-breath analysis. This paper presents a sensitive CH₃SH sensor based on wavelength modulation spectroscopy (WMS) with a mid-infrared distributed feedback interband cascade laser (DFB-ICL). Multicomponent spectral fitting was used not only to enhance the sensitivity of the sensor but also to determine the concentration of interferents (atmospheric water and methane). The results showed that the uncertainties in the measurement of CH₃SH, H₂O, and CH₄ were less than 1...
February 16, 2017: Sensors
https://www.readbyqxmd.com/read/28209042/-determination-of-biomarkers-in-exhaled-breath-condensation-of-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-and-its-clinical-implications
#3
X Q Dong, Q Shen, Y N Yao, J J Chen, G H Lu, J Y Zhou
Objective: To analyse the changes and clinical implication of biomarkers in exhaled breath condensates (EBC) of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) before and after treatment. Methods: 20 patients with AECOPD were enrolled, including 15 males and 5 females. The average age was 71±10, ranging from 50-85. The concentrations of Leukotriene B4 (LTB4) and Interleukin 6 (IL-6) from EBC were assayed by ELISA kit before and after treatment. Serum inflammatory indexes, pulmonary function test and quality of life (CAT) were observed at the same time, the relationship between EBC biomarkers and clinical markers were investigated...
February 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28209039/-the-value-of-fractionated-exhaled-nitric-oxide-in-the-diagnosis-of-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome
#4
D D Deng, A Y Zhou, Q C Shuang, P Chen
Objective: To explore the diagnostic value of fractionated exhaled nitric oxide (FeNO) measurement in patients with asthma-chronic obstructive pulmonary disease(COPD) overlap syndrome (ACOS). Methods: Eighty-one patients with ACOS, 76 patients with asthma, 82 patients with COPD and 39 healthy non-smoking subjects were recruited in the study. Naku Lun breath analyzer was used to measure the level of FeNO in the 4 groups. Pulmonary function was also measured. The ROC curve was used to differentiate ACOS from patients with COPD...
February 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28208871/clinical-utility-of-fractional-exhaled-nitric-oxide-feno-as-a-biomarker-to-predict-severity-of-disease-and-response-to-inhaled-corticosteroid-ics-in-asthma-patients
#5
Revathy Neelamegan, Vinodkumar Saka, Kadhiravan Tamilarasu, Manju Rajaram, Sandhiya Selvarajan, Adithan Chandrasekaran
INTRODUCTION: Bronchial asthma is a common chronic inflammatory airway disease diagnosed and is based on symptomatic history and Pulmonary Function Tests (PFT). Fractional exhaled Nitric Oxide (FeNO) is exclusively a non-invasive biomarker of on-going eosinophilic airway inflammation which remains unpredictable only with PFTs. FeNO measurement is recommended in predicting asthma severity and Inhaled Corticosteroid (ICS) response but further research is required to understand its clinical utility and agreement with current recommendations in a specific population...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28207233/nanoscale-pdo-catalyst-functionalized-co3o4-hollow-nanocages-using-mof-templates-for-selective-detection-of-acetone-molecules-in-exhaled-breath
#6
Won-Tae Koo, Sunmoon Yu, Seon-Jin Choi, Ji-Soo Jang, Jun Young Cheong, Il-Doo Kim
The increase of surface area and the functionalization of catalyst are crucial to develop high-performance semiconductor metal oxide (SMO) based chemi-resistive gas sensors. Herein, nanoscale catalyst loaded Co3O4 hollow nanocages (HNCs) by using metal-organic framework (MOF) templates have been developed as a new sensing platform. Nanoscale Pd nanoparticles (NPs) were easily loaded on the cavity of Co based zeolite imidazole framework (ZIF-67). The porous structure of ZIF-67 can restrict the size of Pd NPs (2-3 nm) and separate Pd NPs from each other...
February 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28204886/environmental-and-biological-determination-of-acrolein-using-new-cold-fiber-solid-phase-microextraction-with-gas-chromatography-mass-spectrometry
#7
Cláudia M Dias, Helvécio C Menezes, Zenilda L Cardeal
Acrolein is a pollutant released daily to the indoor environment from different sources. The present study reports the development of a simple and sensitive cold fiber solid phase microextraction sampling method for the determination of acrolein in exhaled air and indoor air by gas chromatography mass spectrometry. O-(2,3,4,5,6-pentafluorobenzyl) hydroxylamine was used as derivatizing agent supported on a 65-μm polydimethylsiloxane-divinylbenzene SPME fiber. An acrolein permeation tube at 326.25 ng min(-1) rate was used to generate gaseous standards...
February 15, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28203110/variability-in-delivered-dose-and-respirable-delivered-dose-from-nebulizers-are-current-regulatory-testing-guidelines-sufficient-to-produce-meaningful-information
#8
Ross Hm Hatley, Sarah M Byrne
BACKGROUND: To improve convenience to patients, there have been advances in the operation of nebulizers, resulting in fast treatment times and less drug lost to the environment. However, limited attention has been paid to the effects of these developments on the delivered dose (DD) and respirable delivered dose (RDD). Published pharmacopoeia and ISO testing guidelines for adult-use testing utilize a single breathing pattern, which may not be sufficient to enable effective comparisons between the devices...
2017: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/28199989/presence-of-cancer-associated-mutations-in-exhaled-breath-condensates-of-healthy-individuals-by-next-generation-sequencing
#9
Omar Youssef, Aija Knuuttila, Päivi Piirilä, Tom Böhling, Virinder Sarhadi, Sakari Knuutila
Exhaled breath condensate (EBC) is a non-invasive source that can be used for studying different genetic alterations occurring in lung tissue. However, the low yield of DNA available from EBC has hampered the more detailed mutation analysis by conventional methods. We applied the more sensitive amplicon-based next generation sequencing (NGS) to identify cancer related mutations in DNA isolated from EBC. In order to apply any method for the purpose of mutation screening in cancer patients, it is important to clarify the incidence of these mutations in healthy individuals...
February 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28187733/early-detection-of-copd-patients-in-gold-0-population-an-observational-non-interventional-cohort-study-marko-study
#10
Žarko Vrbica, Marina Labor, Ivan Gudelj, Slavica Labor, Iva Jurić, Davor Plavec
BACKGROUND: Main risk factor for the development of chronic obstructive pulmonary disease (COPD) is smoking, although only less than 1/3 of smokers develop clinically manifest COPD. COPD's progressive nature with high disability and mortality makes it plausible to detect it as early as possible thus allowing for an early intervention. The only tool for an early diagnosis that could be used on the global scale is spirometry, even though symptoms and deprivation of health related quality of life (HRQoL) precede relevant spirometric changes...
February 10, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28182502/effect-of-dietary-nitrate-supplementation-on-swimming-performance-in-trained-swimmers
#11
Sam Lowings, Oliver Michael Shannon, Kevin Deighton, Jamie Matu, Matthew John Barlow
Nitrate supplementation appears to be most ergogenic when oxygen availability is restricted and subsequently may be particularly beneficial for swimming performance due to the breath-hold element of this sport. This represents the first investigation of nitrate supplementation and swimming time-trial (TT) performance. In a randomised double-blind repeated-measures crossover study, ten (5male, 5female) trained swimmers ingested 140ml nitrate-rich (~12.5mmol nitrate) or nitrate-depleted (~0.01mmol nitrate) beetroot juice...
February 9, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28169345/bronchoalveolar-lavage-proteomics-in-patients-with-suspected-lung-cancer
#12
Ana Sofia Carvalho, Célia Marina Cuco, Carla Lavareda, Francisco Miguel, Mafalda Ventura, Sónia Almeida, Paula Pinto, Tiago Tavares de Abreu, Luís Vaz Rodrigues, Susana Seixas, Cristina Bárbara, Mikel Azkargorta, Felix Elortza, Júlio Semedo, John K Field, Leonor Mota, Rune Matthiesen
Lung cancer configures as one of the deadliest types of cancer. The future implementation of early screening methods such as exhaled breath condensate analysis and low dose computed tomography (CT) as an alternative to current chest imaging based screening will lead to an increased burden on bronchoscopy units. New approaches for improvement of diagnosis in bronchoscopy units, regarding patient management, are likely to have clinical impact in the future. Diagnostic approaches to address mortality of lung cancer include improved early detection and stratification of the cancers according to its prognosis and further response to drug treatment...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28167000/urine-cysteinyl-leukotriene-levels-in-children-with-sleep-disordered-breathing-before-and-after-adenotonsillectomy
#13
A Satdhabudha, P Sritipsukho, S Manochantr, W Chanvimalueng, U Chaumrattanakul, P Chaumphol
OBJECTIVES: Obstructive sleep apnea (OSA) is a common problem in children and is associated with increased cardiovascular, neurobehavioral and somatic growth consequences. Cysteinyl leukotrienes (CysLTs) play a major role with local and systemic relations to the pathophysiology of OSA. The level of CysLTs in urine, blood, exhaled breath and adenotonsillar tissue of OSA children are increased. However it remains unclear whether inflammatory marker levels are alleviated after adenotonsillectomy...
March 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28165388/diagnosis-by-volatile-organic-compounds-in-exhaled-breath-from-lung-cancer-patients-using-support-vector-machine-algorithm
#14
Yuichi Sakumura, Yutaro Koyama, Hiroaki Tokutake, Toyoaki Hida, Kazuo Sato, Toshio Itoh, Takafumi Akamatsu, Woosuck Shin
Monitoring exhaled breath is a very attractive, noninvasive screening technique for early diagnosis of diseases, especially lung cancer. However, the technique provides insufficient accuracy because the exhaled air has many crucial volatile organic compounds (VOCs) at very low concentrations (ppb level). We analyzed the breath exhaled by lung cancer patients and healthy subjects (controls) using gas chromatography/mass spectrometry (GC/MS), and performed a subsequent statistical analysis to diagnose lung cancer based on the combination of multiple lung cancer-related VOCs...
February 4, 2017: Sensors
https://www.readbyqxmd.com/read/28165332/exhaled-breath-and-oral-cavity-vocs-as-potential-biomarkers-in-oral-cancer-patients
#15
Marcos Bouza, Jesus Gonzalez-Soto, Rosario Pereiro, Juan Carlos de Vicente, Alfredo Sanz-Medel
Corporal mechanisms attributed to cancer, such as oxidative stress or the action of cytochrome P450 enzymes, seem to be responsible of the generation of a variety of volatile organic compounds (VOCs) that could be used as non-invasive diagnosis biomarkers. The present work presents an attempt of using VOCs from exhaled breath and oral cavity air as biomarkers for oral squamous cell carcinoma (OSCC) patients. 52 breath samples were collected (3 L Tedlar bags) from 26 OSCC patients and 26 cancer-free controls...
February 6, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28163602/differential-pattern-of-deposition-of-nanoparticles-in-the-airways-of-exposed-workers
#16
Elizabeth Fireman, Rinat Edelheit, Moshe Stark, Amir Bar Shai
Ultrafine particles (UFP) have been postulated to significantly contribute to the adverse health effects associated with exposure to particulate matter (PM). Due to their extremely small size (aerodynamic diameter <100 nm), UFP are able to deposit deep within the lung after inhalation and evade many mechanisms responsible for the clearance of larger particles. There is a lack of biologically relevant personal exposure metrics for exposure to occupational- and environmental-related micro- and nano-sized PM...
2017: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
https://www.readbyqxmd.com/read/28154922/experimental-measurement-of-breath-exit-velocity-and-expirated-bloodstain-patterns-produced-under-different-exhalation-mechanisms
#17
P H Geoghegan, A M Laffra, N K Hoogendorp, M C Taylor, M C Jermy
In an attempt to obtain a deeper understanding of the factors which determine the characteristics of expirated bloodstain patterns, the mechanism of formation of airborne droplets was studied. Hot wire anemometry measured air velocity, 25 mm from the lips, for 31 individuals spitting, coughing and blowing. Expirated stains were produced by the same mechanisms performed by one individual with different volumes of a synthetic blood substitute in their mouth. The atomization of the liquid at the lips was captured with high-speed video, and the resulting stain patterns were captured on paper targets...
February 2, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28153745/development-verification-of-methods-for-measurement-of-exhaled-breath-and-environmental-e-vapor-product-aerosol
#18
Michael J Oldham, Karl A Wagner, I Gene Gilman, James B Beach, Jianmin Liu, Ali A Rostami, Mohamadi A Sarkar
Concerns have been raised about the potential health effects of potential bystander exposure to exhaled aerosols from e-vapor products (EVPs). An exhaled breath collection system (EBS) was developed and analytical methods were verified for collection and analysis of exhaled breath from users of EVPs. Analytical methods were adapted and verified for collection of environmental air samples during EVP use in an exposure chamber. Analysis of constituents in exhaled breath focused on nicotine, propylene glycol, and glycerin (because these are reported as the major constituents in EVPs) and selected carbonyl compounds (acetaldehyde, acrolein, and formaldehyde)...
January 30, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28152602/feasibility-of-early-detection-of-cystic-fibrosis-acute-pulmonary-exacerbations-by-exhaled-breath-condensate-metabolomics-a-pilot-study
#19
Xiaoling Zang, María Eugenia Monge, Nael A McCarty, Arlene A Stecenko, Facundo M Fernández
Progressive lung function decline and, ultimately, respiratory failure are the most common cause of death in patients with cystic fibrosis (CF). This decline is punctuated by acute pulmonary exacerbations (APEs), and in many cases, there is a failure to return to baseline lung function. Ultraperformance liquid chromatography quadrupole-time-of-flight mass spectrometry was used to profile metabolites in exhaled breath condensate (EBC) samples from 17 clinically stable CF patients, 9 CF patients with an APE severe enough to require hospitalization (termed APE), 5 CF patients during recovery from a severe APE (termed post-APE), and 4 CF patients who were clinically stable at the time of collection but in the subsequent 1-3 months developed a severe APE (termed pre-APE)...
February 3, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28144686/-new-technical-developments-for-inhaled-sedation
#20
A Meiser, H Bomberg, T Volk, H V Groesdonk
The circle system has been in use for more than 100 years, whereas the first clinical application of an anaesthetic reflector was reported just 15 years ago. In the circle system, all breathing gas is rebreathed after carbon dioxide absorption. A reflector, on the other hand, with the breathing gas flowing to and fro, specifically retains the anaesthetic during expiration and resupplies it during the next inspiration. A high reflection efficiency (number of molecules resupplied/number of molecules exhaled, RE 80-90%) decreases consumption...
January 31, 2017: Der Anaesthesist
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