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https://www.readbyqxmd.com/read/28446741/methodology-to-define-biological-reference-values-in-the-environmental-and-occupational-fields-the-contribution-of-the-italian-society-for-reference-values-sivr
#1
Maria Cristina Aprea, Maria Luisa Scapellato, Maria Carmen Valsania, Andrea Perico, Luigi Perbellini, Maria Cristina Ricossa, Marco Pradella, Sara Negri, Ivo Iavicoli, Piero Lovreglio, Fabiola Salamon, Maurizio Bettinelli, Pietro Apostoli
BACKGROUND: Biological reference values (RVs) explore the relationships between humans and their environment and habits. RVs are fundamental in the environmental field for assessing illnesses possibly associated with environmental pollution, and also in the occupational field, especially in the absence of established biological or environmental limits. OBJECTIVES: The Italian Society for Reference Values (SIVR) determined to test criteria and procedures for the definition of RVs to be used in the environmental and occupational fields...
April 21, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28446552/a-european-respiratory-society-technical-standard-exhaled-biomarkers-in-lung-disease
#2
Ildiko Horváth, Peter J Barnes, Stelios Loukides, Peter J Sterk, Marieann Högman, Anna-Carin Olin, Anton Amann, Balazs Antus, Eugenio Baraldi, Andras Bikov, Agnes W Boots, Lieuwe D Bos, Paul Brinkman, Caterina Bucca, Giovanna E Carpagnano, Massimo Corradi, Simona Cristescu, Johan C de Jongste, Anh-Tuan Dinh-Xuan, Edward Dompeling, Niki Fens, Stephen Fowler, Jens M Hohlfeld, Olaf Holz, Quirijn Jöbsis, Kim Van De Kant, Hugo H Knobel, Konstantinos Kostikas, Lauri Lehtimäki, Jon Lundberg, Paolo Montuschi, Alain Van Muylem, Giorgio Pennazza, Petra Reinhold, Fabio L M Ricciardolo, Philippe Rosias, Marco Santonico, Marc P van der Schee, Frederik-Jan van Schooten, Antonio Spanevello, Thomy Tonia, Teunis J Vink
Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FeNO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FeNO, new developments and advances in technology have been evaluated in the current document...
April 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28443871/rapid-detection-of-nicotine-from-breath-using-desorption-ionisation-on-porous-silicon
#3
T M Guinan, H Abdelmaksoud, N H Voelcker
Desorption ionisation on porous silicon (DIOS) was used for the detection of nicotine from exhaled breath. This result represents proof-of-principle of the ability of DIOS to detect small molecular analytes in breath including biomarkers and illicit drugs.
April 26, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28443679/emerging-roles-of-carbonyl-sulfide-cos-in-chemical-biology-sulfide-transporter-or-gasotransmitter
#4
Andrea K Steiger, Yu Zhao, Michael D Pluth
SIGNIFICANCE: Carbonyl sulfide (COS) is the most prevalent sulfur-containing gas in Earth's atmosphere and plays important roles in the global sulfur cycle. COS has been implicated in origin of life peptide ligation, is the primary energy source for certain bacteria, and has been detected in mammalian systems. Despite this long and intertwined history with terrestrial biology, limited attention has focused on potential roles of COS as a biological mediator. Recent Advances. Although bacterial COS production is well documented, definitive sources of mammalian COS production have not been confirmed...
April 26, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28440601/measurement-of-exhaled-breath-carbon-monoxide-in-clinical-practice-a-study-of-levels-in-central-pennsylvania-community-members
#5
Shari Hrabovsky, Jessica M Yingst, Susan Veldheer, Erin Hammett, Jonathan Foulds
BACKGROUND AND PURPOSE: Exhaled breath carbon monoxide (eBCO) reading is a useful tool for nurse practitioners to evaluate smoking status and other exposures to carbon monoxide (CO) to identify risk for cancer and chronic disease. This study aimed to measure one community's eBCO and identify potential environmental factors that may affect eBCO among nonsmokers. METHODS: Data collected by convenience sampling at community health events included self-reported tobacco use and potential CO exposure...
April 25, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28440225/observation-of-nonanoic-acid-and-aldehydes-in-exhaled-breath-of-patients-with-lung-cancer
#6
L Callol-Sanchez, M A Munoz-Lucas, O Gomez-Martin, J A Maldonado-Sanz, C Civera-Tejuca, C Gutierrez-Ortega, G Rodriguez-Trigo, J Jareno-Esteban
Lung cancer (LC) is the leading cause of cancer death in men and the second leading cause in women worldwide. The use of low-dose computed tomography in early diagnosis was shown to reduce mortality by 20% with a median follow-up time of 6.5 years. In order to increase profitability and reduce radiation risks and costs, exhaled biomarkers could serve to help establish narrower inclusion criteria. The aim of this study was to identify new, well-founded volatile organic compounds in exhaled breath which distinguish LC patients from chronic obstructive pulmonary disease (COPD) patients and healthy subjects...
April 25, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28415460/poly-arginine-graphene-quantum-dots-as-a-biocompatible-and-non-toxic-nanocomposite-layer-by-layer-electrochemical-preparation-characterization-and-non-invasive-malondialdehyde-sensory-application-in-exhaled-breath-condensate
#7
Mohammad Hasanzadeh, Fozieh Mokhtari, Nasrin Shadjou, Aziz Eftekhari, Ahad Mokhtarzadeh, Vahid Jouyban-Gharamaleki, Soltanali Mahboob
This study reports on the electropolymerization of a low toxic and biocompatible polymer with entitle poly arginine-graphene quantum dots (PARG-GQDs) as a novel strategy for surface modification of glassy carbon (GC) surface and preparation a new interface for biomedical application. The fabrication of PARG-GQDs on GCE was performed using Layer-by-layer regime. Scanning electron microscopy (SEM) was confirmed dispersion of GQDs on the surface of PARG which lead to increase of surface coverage of PARG. The redox behavior of prepared sensor was then characterized by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry (CHA), square wave voltammetry (SWV), linear sweep voltammetry (LSV)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28411827/sensitive-determination-of-malondialdehyde-in-exhaled-breath-condensate-and-biological-fluids-by-capillary-electrophoresis-with-laser-induced-fluorescence-detection
#8
Júlia Lačná, František Foret, Petr Kubáň
In this work, a sensitive capillary electrophoresis method with laser induced fluorescence detection for determination of malondialdehyde in various biological fluids was developed. Malondialdehyde reacts with thiobarbituric acid under optimized conditions of pH=2, reaction time of 60min and temperature of 90°C, yielding an adduct that can be separated in a 50mM sodium borate background electrolyte at pH 9. The separation of the formed adduct was accomplished in less than 6min with limit of detection of 1...
July 1, 2017: Talanta
https://www.readbyqxmd.com/read/28411465/simultaneous-and-multi-point-measurement-of-ammonia-emanating-from-human-skin-surface-for-the-estimation-of-whole-body-dermal-emission-rate
#9
Shota Furukawa, Yoshika Sekine, Keita Kimura, Kazuo Umezawa, Satomi Asai, Hayato Miyachi
Ammonia is one of the members of odor gases and a possible source of odor in indoor environment. However, little has been known on the actual emission rate of ammonia from the human skin surface. Then, this study aimed to estimate the whole-body dermal emission rate of ammonia by simultaneous and multi-point measurement of emission fluxes of ammonia employing a passive flux sampler - ion chromatography system. Firstly, the emission fluxes of ammonia were non-invasively measured for ten volunteers at 13 sampling positions set in 13 anatomical regions classified by Kurazumi et al...
April 2, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28410001/respiratory-pattern-and-tidal-volumes-differ-for-pressure-support-and-volume-assured-pressure-support-in-amyotrophic-lateral-sclerosis
#10
Trevor T Nicholson, Sean B Smith, Teepu Siddique, Robert Sufit, Senda Ajroud-Driss, John M Coleman, Lisa F Wolfe
RATIONALE: Amyotrophic Lateral Sclerosis is a progressive neuromuscular disease resulting in respiratory failure and death. Use of non-invasive ventilation (NIV) improves survival. However, use of Volume-Assured Pressure Support (VAPS) has not been extensively studied in ALS. OBJECTIVES: To explore the clinical utility of a detailed evaluation of device-recorded NIV data in the management of chronic respiratory failure in ALS. To determine if there are differences in efficacy between patients using VAPS or PS...
April 14, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28408153/refinement-of-the-oral-exposure-description-in-the-cyclic-siloxane-pbpk-model-for-rats-and-humans-implications-for-exposure-assessment
#11
Jerry L Campbell, Melvin E Andersen, Cynthia Van Landingham, Robinan Gentry, Elke Jensen, Jean Y Domoradzki, Harvey J Clewell
The multi-compound, and multi-dose (MC-MD) route physiologically based pharmacokinetic (PBPK) model for cyclic siloxanes reported by McMullin et al. (2016) brought together the series of models for octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) in rat and human into a unified code structure that would allow simulation of both compounds following the inhalation and dermal routes of exposure. The refined MC-MD PBPK model presented here expands upon this effort to include representation of rat kinetic data in plasma, tissues and exhaled breath for the parent compounds after oral bolus administration...
April 10, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28406294/non-invasive-respiratory-metabolite-analysis-associated-with-clinical-disease-in-cetaceans-a-deepwater-horizon-oil-spill-study
#12
Alberto Pasamontes, Alexander A Aksenov, Michael Schivo, Teri Rowles, Cynthia R Smith, Lori H Schwacke, Randall S Wells, Laura Yeates, Stephanie Venn-Watson, Cristina E Davis
Health assessments of wild cetaceans can be challenging due to the difficulty of gaining access to conventional diagnostic matrices of blood, serum and others. While the non-invasive detection of metabolites in exhaled breath could potentially help to address this problem, there exists a knowledge gap regarding associations between known disease states and breath metabolite profiles in cetaceans. This technology was applied to the largest marine oil spill in U.S. history (The 2010 Deepwater Horizon oil spill in the Gulf of Mexico)...
April 13, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28403875/determining-the-presence-of-asthma-related-molecules-and-salivary-contamination-in-exhaled-breath-condensate
#13
Charmion Cruickshank-Quinn, Michael Armstrong, Roger Powell, Joe Gomez, Marc Elie, Nichole Reisdorph
BACKGROUND: Researchers investigating lung diseases, such as asthma, have questioned whether certain compounds previously reported in exhaled breath condensate (EBC) originate from saliva contamination. Moreover, despite its increasing use in 'omics profiling studies, the constituents of EBC remain largely uncharacterized. The present study aims to define the usefulness of EBC in investigating lung disease by comparing EBC, saliva, and saliva-contaminated EBC using targeted and untargeted mass spectrometry and the potential of metabolite loss from adsorption to EBC sample collection tubes...
April 12, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28397711/volatile-organic-compounds-in-exhaled-breath-are-independent-of-systemic-inflammatory-syndrome-caused-by-intravenous-lipopolysaccharide-infusion-in-humans-results-from-an-experiment-in-healthy-volunteers
#14
Anna L Peters, Marije G Gerritsen, Paul Brinkman, Koos A H Zwinderman, Alexander P J Vlaar, Lieuwe D Bos
Systemic inflammatory response syndrome (SIRS) is observed during critical illness in most patients. It is defined by a clinical definition. The composition of volatile organic compounds (VOCs) in exhaled breath may change during SIRS and may thus serve as a diagnostic tool. We investigated whether exhaled breath VOCs can serve as biomarker for SIRS in a human model of endotoxemia. Eighteen healthy volunteers received 2 ng Eschericia coli lipopolysaccharide (LPS) kg(-1) body weight intravenously. Venous blood and exhaled breath were collected before infusion of LPS and every 2 h thereafter, up to 8 h after infusion...
April 11, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28396088/erythrocyte-aging-as-a-mechanism-of-anemia-and-a-biomarker-of-device-thrombosis-in-continuous-flow-left-ventricular-assist-devices
#15
Ziad Taimeh, Ryan J Koene, Julie Furne, Ashish Singal, Peter M Eckman, Michael D Levitt, Marc R Pritzker
BACKGROUND: Blood trauma caused by continuous-flow left ventricular assist devices (CF-LVADs) has been associated with device thrombosis and anemia. Accurate in vivo quantification of erythrocyte turnover and its contribution to CF-LVAD complications have yet to be elucidated. METHODS: We investigated the age (lifespan) of circulating erythrocytes in subjects with CF-LVAD. Erythrocyte lifespan is a quantitative indicator of in vivo erythrocyte turnover that can be accurately derived from measurement of the exhaled carbon monoxide (CO) level...
February 9, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28392708/lung-sound-analysis-helps-localize-airway-inflammation-in-patients-with-bronchial-asthma
#16
Terufumi Shimoda, Yasushi Obase, Yukio Nagasaka, Hiroshi Nakano, Akiko Ishimatsu, Reiko Kishikawa, Tomoaki Iwanaga
PURPOSE: Airway inflammation can be detected by lung sound analysis (LSA) at a single point in the posterior lower lung field. We performed LSA at 7 points to examine whether the technique could identify the location of airway inflammation in patients with asthma. PATIENTS AND METHODS: Breath sounds were recorded at 7 points on the body surface of 22 asthmatic subjects. Inspiration sound pressure level (ISPL), expiration sound pressure level (ESPL), and the expiration-to-inspiration sound pressure ratio (E/I) were calculated in 6 frequency bands...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28391735/diet-derived-changes-by-sourdough-fermented-rye-bread-in-exhaled-breath-aspiration-ion-mobility-spectrometry-profiles-in-individuals-with-mild-gastrointestinal-symptoms
#17
Kaisa Raninen, Jenni Lappi, Mikko Kolehmainen, Marjukka Kolehmainen, Hannu Mykkänen, Kaisa Poutanen, Olavi Raatikainen
The potential of utilising exhaled breath volatile organic compound (VOC) profiles in studying diet-derived metabolic changes was examined. After a four-week initial diet period with white wheat bread (WW), seven participants received in randomised order high-fibre diets containing sourdough whole grain rye bread (WGR) or white wheat bread enriched with bioprocessed rye bran (WW + BRB), both for 4 weeks. Alveolar exhaled breath samples were analysed with ChemPro(®)100i analyser (Environics OY, Mikkeli, Finland) at the end of each diet period in fasting state and after a standardised meal...
April 9, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28390585/biomarkers-of-oxidative-stress-and-antioxidants-in-severe-asthma-a-prospective-case-control-study
#18
Abigail Bishopp, Ramamurthy Sathyamurthy, Sarah Manney, Craig Webbster, Mamidipudi Thirumala Krishna, Adel H Mansur
BACKGROUND: Bronchial airway inflammation is the hallmark of asthma, which may be driven by an imbalance between oxidative stress and antioxidant defenses. Antioxidants deficiency may play a role, but this has remained unconfirmed. OBJECTIVE: To evaluate the oxidative stress burden and antioxidants defenses in patients with increasing asthma severity. METHODS: This prospective case-control study compared fractional exhaled nitric oxide (FeNO), exhaled breath condensate nitrite/nitrate (EBC-NOx), spirometry, and serum vitamins and trace elements among patients with and without asthma...
April 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28389539/microbiota-in-exhaled-breath-condensate-and-the-lung
#19
Laura Glendinning, Steven Wright, Peter Tennant, Andrew C Gill, David Collie, Gerry McLachlan
The lung microbiota is commonly sampled using relatively invasive bronchoscopic procedures. Exhaled breath condensate (EBC) collection potentially offers a less invasive alternative for lung microbiota sampling. We compared lung microbiota samples retrieved by protected specimen brushings (PSB) and exhaled breath condensate collection. We also sought to assess whether aerosolised antibiotic treatment would influence the lung microbiota and whether EBC was sensitive enough to detect such changes.EBC was collected from 6 conscious sheep, and then from the same anaesthetised sheep during mechanical ventilation...
April 7, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28385290/post-prandial-systemic-8-isoprostane-increases-after-consumption-of-moderate-and-high-fat-meals-in-insufficiently-active-males
#20
S P Kurti, S R Emerson, S K Rosenkranz, C S Teeman, E M Emerson, B J Cull, J R Smith, C A Harms
A single high-fat meal (HFM) leads to an increase in triglycerides and oxidative stress. Oxidative stress can be assessed via 8-isoprostane generation, which is associated with the development of asthma and cardiovascular disease. No previous research has investigated whether airway and systemic 8-isoprostane increases postprandially in nonasthmatic participants according to the energy and fat content of a meal. Our purpose was to assess airway and systemic 8-isoprostane after a HFM and a true-to-life moderate-fat meal (MFM)...
March 2017: Nutrition Research
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