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https://www.readbyqxmd.com/read/28730303/exhaled-breath-online-measurement-for-cervical-cancer-patients-and-healthy-subjects-by-proton-transfer-reaction-mass-spectrometry
#1
Wenzhao Zhou, Chaoqun Huang, Xue Zou, Yan Lu, Chengyin Shen, Xiping Ding, Hongzhi Wang, Haihe Jiang, Yannan Chu
Cervical cancer is a common cancer among women and has a high morbidity and mortality. The traditional clinical methods for cervical cancer screening are invasive and limited in terms of cost and time. There is an unmet clinical need for new methods to aid clinicians in the rapid screening and auxiliary diagnosis of cervical precancer. Recently, breath analysis has become an attractive approach for investigation of cancer biomarkers and shows great potential in cancer screening owing to its high sensitivity, quickness, and non-invasive nature...
July 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28725455/effect-of-respiratory-pattern-on-automated-clinical-blood-pressure-measurement-an-observational-study-with-normotensive-subjects
#2
Natalia Herakova, Nnenna Harmony Nzeribe Nwobodo, Ying Wang, Fei Chen, Dingchang Zheng
BACKGROUND: It has been reported that deep breathing could reduce blood pressures (BP) in general. It is also known that BP is decreased during inhalation and increased during exhalation. Therefore, the measured BPs could be potentially different during deep breathing with different lengths of inhalation and exhalation. This study aimed to quantitatively investigate the effect of different respiratory patterns on BPs. METHODS: Forty healthy subjects (20 males and 20 females, aged from 18 to 60 years) were recruited...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/28715576/association-of-ozone-exposure-with-cardiorespiratory-pathophysiologic-mechanisms-in-healthy-adults
#3
Drew B Day, Jianbang Xiang, Jinhan Mo, Feng Li, Mingkei Chung, Jicheng Gong, Charles J Weschler, Pamela A Ohman-Strickland, Jan Sundell, Wenguo Weng, Yinping Zhang, Junfeng Jim Zhang
Importance: Exposure to ozone has been associated with cardiovascular mortality, but the underlying biological mechanisms are not yet understood. Objective: To examine the association between ozone exposure and cardiopulmonary pathophysiologic mechanisms. Design, Setting, and Participants: A longitudinal study involving 89 healthy adult participants living on a work campus in Changsha City, China, was conducted from December 1, 2014, to January 31, 2015...
July 17, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28715250/the-development-of-technology-for-effective-respiratory-gated-irradiation-using-an-image-guided-small-animal-irradiator
#4
M A Hill, J Thompson, A Kavanagh, I D C Tullis, R G Newman, J Prentice, J Beech, S Gilchrist, S Smart, E Fokas, B Vojnovic
The development of image-guided small animal irradiators represents a significant improvement over standard irradiators by enabling preclinical studies to mimic radiotherapy in humans. The ability to deliver tightly collimated targeted beams, in conjunction with gantry or animal couch rotation, has the potential to maximize tumor dose while sparing normal tissues. However, the current commercial platforms do not incorporate respiratory gating, which is required for accurate and precise targeting in organs subject to respiration related motions that may be up to the order of 5 mm in mice...
July 17, 2017: Radiation Research
https://www.readbyqxmd.com/read/28714270/resistive-breathing-and-respiratory-muscle-fatigue-a-load-of-concern-just-expired
#5
Ken D O'Halloran
Pulmonary ventilation is a cyclical process of inhalation and exhalation of air providing dynamic tidal exchange between alveolar gas-exchanging units of the lungs and the external environment. This article is protected by copyright. All rights reserved.
July 17, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28709937/detection-of-lung-cancer-and-egfr-mutation-by-electronic-nose-system
#6
Dekel Shlomi, Manal Abud, Ori Liran, Jair Bar, Naomi Gai-Mor, Maya Ilouze, Amir Onn, Alon Ben-Nun, Hossam Haick, Nir Peled
BACKGROUND: Early detection of lung cancer (LC) has been well established as a significant key point in patient survival and prognosis. New highly sensitive nanoarray sensors for exhaled Volatile Organic Compounds (VOCs) have been developed and coupled with powerful statistical programs may be used when diseases such as LC are suspected. Detection of genetic aberration mutation by nanoarray sensors is the next target. METHODS: Breath samples were taken from patients who were evaluated for suspicious pulmonary lesions...
July 11, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28701890/relationship-between-oxidative-stress-physical-activity-and-vitamin-intake-in-patients-with-asthma
#7
Akira Yamasaki, Yuji Kawasaki, Kenichi Takeda, Tomoya Harada, Yasuyuki Hasegawa, Takehito Fukushima, Ryota Okazaki, Haruhiko Makino, Yoshihiro Funaki, Yuriko Sueda, Akihiro Yamamoto, Jun Kurai, Masanari Watanabe, Eiji Shimizu
BACKGROUND: Oxidative stress plays an important role in the pathogenesis of bronchial asthma. Antioxidant nutrition and supplementation have been used to reduce oxidative stress. However, a clinical trial with antioxidant supplementation showed no beneficial effects in patients with asthma. On the other hand, physical activity is related to the prognosis of chronic obstructive pulmonary disease (COPD) and is also related to oxidant status. We investigated the relationships between oxidative stress, serum levels of vitamins, dietary vitamin intake, daily activities, and pulmonary functions in patients with asthma...
June 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28697414/analytical-methodologies-for-broad-metabolite-coverage-of-exhaled-breath-condensate
#8
Alexander A Aksenov, Konstantin O Zamuruyev, Alberto Pasamontes, Joshua F Brown, Michael Schivo, Soraya Foutouhi, Bart C Weimer, Nicholas J Kenyon, Cristina E Davis
Breath analysis has been gaining popularity as a non-invasive technique that is amenable to a broad range of medical uses. One of the persistent problems hampering the wide application of the breath analysis method is measurement variability of metabolite abundances stemming from differences in both sampling and analysis methodologies used in various studies. Mass spectrometry has been a method of choice for comprehensive metabolomic analysis. For the first time in the present study, we juxtapose the most commonly employed mass spectrometry-based analysis methodologies and directly compare the resultant coverages of detected compounds in exhaled breath condensate in order to guide methodology choices for exhaled breath condensate analysis studies...
June 27, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28696336/perspectives-on-exhaled-nitric-oxide
#9
Fabio Luigi Massimo Ricciardolo, Philip E Silkoff
The history of nitric oxide (NO) in respiratory field dates back to the beginning of '90s with the ancestral study by Lars Gustafsson et al. describing the presence of endogenous NO in the exhaled breath of human beings. Soon after, independent studies showed that exhaled NO concentrations (FENO) is higher in asthmatics than in normal subjects. Not all asthmatics demonstrate a high FENO reflecting heterogeneity of asthma. High values of FENO are associated with over-expression of corticosteroid-sensitive iNOS isoform and allergic/eosinophilic inflammation...
July 11, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28686173/comparison-of-fractional-exhaled-nitric-oxide-levels-in-chronic-obstructive-pulmonary-disease-bronchial-asthma-and-healthy-subjects-of-nepal
#10
Sanjeet Krishna Shrestha, Sanjeev Shrestha, Lucky Sharma, Subash Pant, Arpana Neopane
INTRODUCTION Fractional exhaled nitric oxide levels in exhaled breath can indicate on-going eosinophilic airway inflammation, specifically in asthma. But, its utility is being explored for airway centric inflammations including chronic obstructive pulmonary disease. Normal levels of fractional exhaled nitric oxide (FENO50) have been defined in different studies but not in Nepal. This study compares fractional exhaled nitric oxide levels in all three groups: normal, asthma and chronic obstructive pulmonary disease...
July 7, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28680796/usefulness-of-biomarkers-in-work-related-airway-disease
#11
REVIEW
Agnieszka Lipińska-Ojrzanowska, Andrzej Marcinkiewicz, Jolanta Walusiak-Skorupa
Determination of biomarkers may be useful in the surveillance of occupational exposure and workers' health. The possibility of predicting development/clinical course of specific disorders or current disease, diagnosing in early steps, and health condition monitoring is a real necessity. Various agents present in the workplace environment (or their metabolites) can be measured in samples possessed from human body (blood and urine, saliva, etc.). On the other hand, inhalant exposure may induce specific or non-specific, local or systemic, acute or chronic biological response expressed by synthesis or releasing specific or non-specific substances/mediators that also can be determined in blood, nasal and bronchial lavage or sputum, tear fluid, exhaled breath, etc...
2017: Current Treatment Options in Allergy
https://www.readbyqxmd.com/read/28673875/numerical-investigation-of-transient-transport-and-deposition-of-microparticles-under-unsteady-inspiratory-flow-in-human-upper-airways
#12
Arash Naseri, Sana Shaghaghian, Omid Abouali, Goodarz Ahmadi
In the present study, unsteady airflow patterns and particle deposition in healthy human upper airways were simulated. A realistic 3-D computational model of the upper airways including the vestibule to the end of the trachea was developed using a series of CT scan images of a healthy human. Unsteady simulations of the inhaled and exhaled airflow fields in the upper airway passages were performed by solving the Navier-Stokes and continuity equations for low breathing rates corresponding to low and moderate activities...
July 1, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28672229/chloromethane-emissions-in-human-breath
#13
Frank Keppler, Jan Fischer, Tobias Sattler, Daniela Polag, Nicole Jaeger, Heinz Friedrich Schöler, Markus Greule
Chloromethane (CH3Cl), currently the most abundant chlorinated organic compound in the atmosphere at around ~550 parts per trillion by volume (pptv), is considered responsible for approximately 16% of halogen-catalyzed stratospheric ozone destruction. Although emissions of CH3Cl are known to occur from animals such as cattle, formation and release of CH3Cl from humans has not yet been reported. In this study a pre-concentration unit coupled with a gas chromatograph directly linked to a mass spectrometer was used to precisely measure concentrations of CH3Cl at the pptv level in exhaled breath from 31 human subjects with ages ranging from 3 to 87years...
June 30, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28671107/volatile-compounds-in-blood-headspace-and-nasal-breath
#14
Brian M Ross, Randa Babgi
Breath analysis is a form of metabolomics that utilises the identification and quantification of volatile chemicals to provide information about physiological or pathological processes occurring within the body. An inherent assumption of such analyses is that the concentration of the exhaled gases correlates with the concentration of the same gas in the tissue of interest. In this study we have investigated this assumption by quantifying some volatile compounds in peripheral venous blood headspace, and in nasal breath collected in Tedlar bags obtained at the same time from 30 healthy volunteers, prior to analysis by Selected Ion Flow Tube Mass Spectrometry...
July 3, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28670738/clinical-assessment-of-the-lag-time-and-tmax-of-pellets-with-controlled-release-of-glucose-in-vitro-in-vivo-comparison-using-13-c-breath-test
#15
David Neumann, Jan Muselík, Dana Sabadková, Sylvie Pavloková, Jana Špirková, Aleš Franc
Maintaining a stable glycemia in diabetes mellitus type 1 requires flexible insulin application and carbohydrates intake to affected individuals. In real life, there might be some situations limiting the insulin-sugar balance control, e.g. night sleep or prolonged sport activities. Glucose pellets with pre-determined time lag between pellet administration and glucose release were developed to mimic "snack eaten in advance". In this article, (13) C-glucose breath test is introduced to translate the laboratory dissolution testing to clinical confirmation of the glucose release pattern using 5 per cent of δ abundance to differentiate (13) C appearance in exhaled breath...
July 3, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28661230/circle-co2-reabsorbing-breathing-systems-human-applications
#16
Patrick Magee
Artificial breathing systems to help humans survive extreme environments are used over a range of ambient pressures, using various gases of different volumetric concentrations. These activities include anaesthesia and intensive care activity, high-altitude mountaineering, firefighting, aerospace extravehicular space activity and underwater diving operations. A circle breathing system is one in which the exhaled carbon dioxide is absorbed by an alkali substance and the remaining unused gases are recirculated, usually for the sake of economy and environment...
July 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28660856/innovative-exhaled-breath-analysis-with-old-breathing-manoeuvres-is-there-a-problem-or-an-advantage
#17
Marieann Högman
As the field of exhaled breath research is expanding, the question that arises is can the old usual method of spirometry be used in all cases? The answer is yes for some analysation methods and definitely not for others: it all depends on the result you are looking for. Exhaled breath condensate collection can be accomplished with silent tidal breathing, but not in the analysation of the amount of exhaled particles, as they become very low during tidal breathing. There are gases that are exhalation flow dependent, e...
June 29, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28659193/feasibility-of-a-prototype-newborn-resuscitation-monitor-to-study-transition-at-birth-measuring-heart-rate-and-ventilator-parameters-an-animal-experimental-study
#18
Jørgen E Linde, Joar Eilevstjønn, Knut Øymar, Hege L Ersdal
BACKGROUND: Every year, an estimated 10 million babies are born, non-breathing and in need of resuscitation. Advances in management have been made over the past decades, however, approximately 700.000 yearly deaths result from this global problem. A prototype newborn resuscitation monitor (NRM) (Laerdal Global Health, Stavanger, Norway) has been developed with the purpose of studying newborn resuscitation. The monitor has the ability to continuously display HR using dry electrode ECG technology, to measure tidal volume, pressure and end tidal CO2, and to store the results for later analysis...
June 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28658576/elaborate-manipulation-for-sub-10-nm-hollow-catalyst-sensitized-heterogeneous-oxide-nanofibers-for-room-temperature-chemical-sensors
#19
Ji-Soo Jang, Seon-Jin Choi, Won-Tae Koo, Sang-Joon Kim, Jun Young Cheong, Il-Doo Kim
Room-temperature (RT) operation sensors are constantly in increasing demand because of their low power consumption, simple operation, and long lifetime. However, critical challenges such as low sensing performance, vulnerability under highly humid state, and poor recyclability hinder their commercialization. In this work, sub-10 nm hollow, bimetallic Pt-Ag nanoparticles (NPs) were successfully formed by galvanic replacement reaction in bioinspired hollow protein templates and sensitized on the multidimensional SnO2-WO3 heterojunction nanofibers (HNFs)...
July 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28649963/the-effect-of-growth-medium-on-i-escherichia-coli-i-pathway-mirrored-into-gc-ms-profiles
#20
Ileana Andreea Ratiu, Tomasz Ligor, Victor Bocos-Bintintan, Hossam Al-Suod, Tomasz Kowalkowski, Katarzyna Rafińska, Boguslaw Buszewski
Escherichia coli (E. coli) is a gram-negative coliform bacterium that is commonly found in the lower intestine of warm-blooded organisms. Most of the strains are harmless, but some serotypes are pathogenic, meaning they can cause illness, either diarrhea or illness outside of the intestinal tract. The aim of this work was to assess which components are generated in case of E. coli target analysis needed. In this purpose our study intends to emphasize the importance of the cultivability and to prove the crucial role of growth media used in bacteria growing...
June 26, 2017: Journal of Breath Research
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