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https://www.readbyqxmd.com/read/29792826/fast-evolving-human-specific-neural-enhancers-are-associated-with-aging-related-diseases
#1
Han Chen, Chunyan Li, Zhicheng Zhou, Han Liang
The antagonistic pleiotropy theory hypothesizes that evolutionary adaptations maximizing the fitness in early age increase disease burden after reproduction. This theory remains largely untested at the molecular level. Here, we analyzed enhancer evolution in primates to investigate the relationships between aging-related diseases and enhancers acquired after the human-chimpanzee divergence. We report a 5-fold increased evolutionary rate of enhancers that are activated in neural tissues, leading to fixation of ∼100 human-specific enhancers potentially under adaptation...
May 23, 2018: Cell Systems
https://www.readbyqxmd.com/read/29792253/genocide-rape-trauma-a-conceptual-framework-for-understanding-the-psychological-suffering-of-rwandan-survivors
#2
Donatilla Mukamana, Anthony Collins, William E Rosa
In 1994, the Rwandan genocide claimed the lives of approximately 1 million Tutsi and moderate Hutu citizens. Systematic rape was a strategic component of the Hutu extremist plan to eradicate the Tutsi minority population. This involved collective and repeated sexual assaults with brutal violence, public humiliation, and torture. This article maps the ongoing psychological impact on Rwandan genocide rape survivors and identifies implications for international nursing practice. The research formalizes their narratives, identifying a number of interconnected elements that combine to produce myriad forms of chronic psychological suffering in the Rwandan context...
May 1, 2018: Research and Theory for Nursing Practice
https://www.readbyqxmd.com/read/29792063/integrating-childhood-obesity-resources-into-the-patient-centered-medical-home-provider-perspectives-in-the-united-states
#3
Samareh G Hill, Thao-Ly T Phan, George A Datto, Jobayer Hossain, Lloyd N Werk, Diane Abatemarco
Pediatric primary care providers play a critical role in managing obesity yet often lack the resources and support systems to provide effective care to children with obesity. The objective of this study was to identify system-level barriers to managing obesity and resources desired to better managing obesity from the perspective of pediatric primary care providers. A 64-item survey was electronically administered to 159 primary care providers from 26 practices within a large pediatric primary care network. Bivariate analyses were performed to compare survey responses based on provider and practice characteristics...
January 1, 2018: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29791753/double-jeopardy-missed-care-for-the-vulnerable-in-community-settings
#4
EDITORIAL
Annamaria Bagnasco, Fiona Timmins, Giuseppe Aleo, Loredana Sasso
Inequitable access of the world's population to quality health services is still a problem, despite the fact that good health and wellbeing are recognised as a fundamental human rights (United Nations, 2016). Reducing inequities in health is a major focus of international policy (World Health Organisation, 2015) and in the context of an ever-aging population, world recession, limited resources, and to promote independence in health, community care schemes are gaining increasing popularity (Phelan et al 2017)...
May 23, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29791553/epidemiological-aspects-clinical-manifestations-and-prevention-of-pediatric-tuberculosis-from-the-perspective-of-the-end-tb-strategy
#5
Anna Cristina Calçada Carvalho, Claudete Aparecida Araújo Cardoso, Terezinha Miceli Martire, Giovanni Battista Migliori, Clemax Couto Sant'Anna
Tuberculosis continues to be a public health priority in many countries. In 2015, tuberculosis killed 1.4 million people, including 210,000 children. Despite the recent progress made in the control of tuberculosis in Brazil, it is still one of the countries with the highest tuberculosis burdens. In 2015, there were 69,000 reported cases of tuberculosis in Brazil and tuberculosis was the cause of 4,500 deaths in the country. In 2014, the World Health Organization approved the End TB Strategy, which set a target date of 2035 for meeting its goals of reducing the tuberculosis incidence by 90% and reducing the number of tuberculosis deaths by 95%...
April 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29791303/the-timing-of-suicide-in-18-united-state-states-from-2003-2014
#6
Niu Tian, Matthew Zack, Katherine A Fowler, Dale C Hesdorffer
OBJECTIVES: We investigated suicide timing over different time periods by age, sex and race/ethnicity. METHODS: 122,107 suicide deaths were identified from the population-based U.S. National Violent Death Reporting System in 18 U.S. States from 2003 through 2014. RESULTS: Suicides significantly increased (p < 0.05) from March to peak in September before falling, the first week of the month, and early in the week. Suicides also significantly increased (p < 0...
May 23, 2018: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://www.readbyqxmd.com/read/29791184/expert-exchange-workgroup-on-children-aged-5-and-younger-with-severe-obesity-a-narrative-review-of-medical-and-genetic-risk-factors
#7
Nazrat Mirza, Thao-Ly Phan, June Tester, Angela Fals, Cristina Fernandez, George Datto, Elizabeth Estrada, Ihuoma Eneli
Severe obesity defined as an age- and gender-specific body mass index ≥120% of the 95th percentile in children younger than 5 years is well recognized as a significant challenge for prevention and treatment. This article provides an overview of the prevalence, classification of obesity severity, patterns of weight gain trajectory, medical and genetic risk factors, and comorbid disorders among young children with an emphasis on severe obesity. Studies suggest rapid weight gain trajectory in infancy, maternal smoking, maternal gestational diabetes, and genetic conditions are associated with an increased risk for severe obesity in early childhood...
May 23, 2018: Childhood Obesity
https://www.readbyqxmd.com/read/29791071/plastic-rates-of-development-and-the-effect-of-thermal-extremes-on-offspring-fitness-in-a-cold-climate-viviparous-lizard
#8
George D Cunningham, Luisa J Fitzpatrick, Geoffrey M While, Erik Wapstra
Populations at the climatic margins of a species' distribution can be exposed to conditions that cause developmental stress, resulting in developmental abnormalities. Even within the thermal range of normal development, phenotypes often vary with developmental temperature (i.e., thermal phenotypic plasticity). These effects can have significant consequences for organismal fitness and, thus, population persistence. Reptiles, as ectotherms, are particularly vulnerable to thermal effects on development and are, therefore, considered to be at comparatively high risk from changing climates...
May 23, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29790990/women-s-mental-health-in-the-perinatal-period-according-to-migrant-status-the-french-representative-elfe-birth-cohort
#9
Fabienne El-Khoury, Anne-Laure Sutter-Dallay, Lidia Panico, Marie-Aline Charles, Elie Azria, Judith Van der Waerden, Maria Melchior
Background: Mental health problems in the perinatal period are common. We examined associations between different categories of migrant status and region of origin in relation to mental health during pregnancy and at 2 months post-partum. Methods: We analyzed data from the French nationally representative Etude Longitudinale Française depuis l'Enfance birth cohort (n = 17 988). Migrant status was divided into five categories: 'majority population', 'descendants with one migrant parent', 'descendants with two migrant parents', 'naturalized migrant' and 'non-naturalized migrant women'...
June 1, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29790832/without-warning-worker-deaths-from-heat-2014-2016
#10
Cora Roelofs
Worker deaths from heat exposure are unlike heat deaths in the general population; workers tend to be outside in variable temperatures and younger than sixty-five years. Climate change will increase the frequency, duration, and variability of hot temperatures. Public health warning systems, such as the Heat Index of the National Weather Service, do not generally account for workers' greater likelihood of exposure to direct sunlight or exertion. Only 28% of the 79 worker heat-related fatalities during 2014-2016 occurred on days when the National Weather Service warning would have included the possibility of fatal heat stroke...
January 1, 2018: New Solutions: a Journal of Environmental and Occupational Health Policy: NS
https://www.readbyqxmd.com/read/29790827/the-effect-of-maternal-hiv-status-and-treatment-duration-on-body-composition-of-hiv-exposed-and-hiv-unexposed-preterm-very-and-extremely-low-birthweight-infants
#11
Klara Strydom, Daniel Gerhardus Nel, Muhammad Ali Dhansay, Evette Van Niekerk
BACKGROUND: There is an evidence gap regarding the relationship between HIV exposure, body composition (and the quality thereof) and preterm infants. AIM: This study determined the body composition of HIV-exposed, preterm very low-birthweight (VLBW) and extremely low-birthweight (ELBW) infants and to assess the effect of maternal HAART duration on the body composition of this vulnerable population. METHODS: A descriptive cross-sectional study was conducted...
May 23, 2018: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29790826/free-clinics-and-the-need-for-nursing-action-in-uncertain-political-times
#12
Marie Ghazal, Betty Rambur
Free clinics have been a source of health care for uninsured and low-income Americans for half a century and serve some of the nation's most vulnerable within their home community. Despite parallels to nursing's significant involvement in the formation of free public clinics and commitment to care for all, there is paucity of nursing literature about free clinics. This article details the history of U.S. free clinics and the intersections among free clinics and value-based care, health reform, and tax reform, including the Patient Protection and Affordable Care Act of 2010 and the Tax Cuts and Jobs Act of 2017...
January 1, 2018: Policy, Politics & Nursing Practice
https://www.readbyqxmd.com/read/29790246/a-review-of-predation-as-a-limiting-factor-for-bird-populations-in-mesopredator-rich-landscapes-a-case-study-of-the-uk
#13
Staffan Roos, Jennifer Smart, David W Gibbons, Jeremy D Wilson
The impact of increasing vertebrate predator numbers on bird populations is widely debated among the general public, game managers and conservationists across Europe. However, there are few systematic reviews of whether predation limits the population sizes of European bird species. Views on the impacts of predation are particularly polarised in the UK, probably because the UK has a globally exceptional culture of intensive, high-yield gamebird management where predator removal is the norm. In addition, most apex predators have been exterminated or much depleted in numbers, contributing to a widely held perception that the UK has high numbers of mesopredators...
May 22, 2018: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/29790238/personal-sleep-debt-and-daytime-sleepiness-mediate-the-relationship-between-sleep-and-mental-health-outcomes-in-young-adults
#14
David L Dickinson, Alexander P Wolkow, Shantha M W Rajaratnam, Sean P A Drummond
BACKGROUND: Sleep duration and chronotype (i.e., morningness-eveningness) are associated with increased depression and anxiety risk, but differences in individual sleep need and lifestyle may mean these sleep parameters do not present the same risk across all individuals. This study explored the mediating role of sleep debt and daytime sleepiness in the relationship between sleep and mental health symptoms in young adults, a particularly vulnerable population. METHODS: Young adult university students (n = 2,218) and young adults from the general population in the United States (n = 992) provided estimates of actual and optimal sleep duration, and completed validated measures of sleepiness, chronotype, and depression and anxiety risk...
May 22, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29790075/pathways-from-resilient-coping-to-safer-sex-communication-among-african-caribbean-and-black-women-in-toronto-canada-results-from-a-cross-sectional-survey
#15
Carmen H Logie, Moses Okumu, Shannon Ryan, Mary Yehdego
PURPOSE: African, Caribbean, and Black (ACB) women in Canada are disproportionately impacted by HIV and other sexually transmitted infections. Although there is reported suboptimal consistent condom use with ACB women, limited research has explored safer sex communication among this population. Coping frameworks highlight the role that resilient coping and condom use self-efficacy may play in facilitating safer sex communication. Structural perspectives stress the need to explore associations between HIV vulnerabilities and food insecurity...
May 22, 2018: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29789984/the-role-of-hiv-stigma-in-art-adherence-and-quality-of-life-among-rural-women-living-with-hiv-in-india
#16
Maria L Ekstrand, Elsa Heylen, Amanda Mazur, Wayne T Steward, Catherine Carpenter, Kartik Yadav, Sanjeev Sinha, Adey Nyamathi
HIV stigma continues to be a barrier to physical and mental health among people living with HIV globally, especially in vulnerable populations. We examined how stigma is associated with health outcomes and quality of life among rural women living with HIV in South India (N = 600). Interviewer-administered measures assessed multiple dimensions of stigma, as well as loneliness, social support, ART adherence, time since diagnosis, and quality of life. Internalized stigma and a lack of social support were associated with a lower quality of life, while the association between internalized stigma and adherence was mediated by the use of stigma-avoidant coping strategies, suggesting that keeping one's diagnosis a secret may make it more difficult to take one's medications...
May 22, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29789022/healthcare-disparities-amongst-vulnerable-populations-of-arabs-and-jews-in-israel
#17
Efrat Shadmi
The complex nature of studying health and healthcare disparities in general, and in the context of the Israeli healthcare system in particular, is depicted in two recent IJHPR articles. The first examines Emergency Department (ED) waiting times in a tertiary children's hospital and the second examines disparities in the health care for people with schizophrenia of an ethnic-national minority. Contrary to other Israeli studies on wide disparities in health and healthcare, these studies show no disparities -  ED waiting times did not differ among Arab and Jewish children and report no differences in performance of Hemoglobin A1C tests or in surgical interventions in patients with cardiovascular disease between Arabs and Jews with schizophrenia...
May 22, 2018: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/29788774/the-standardization-of-diagnostic-criteria-for-fetal-alcohol-spectrum-disorder-fasd-implications-for-research-clinical-practice-and-population-health
#18
Jasmine M Brown, Roger Bland, Egon Jonsson, Andrew J Greenshaw
OBJECTIVE: Fetal Alcohol Spectrum Disorder (FASD) is a preventable disorder caused by maternal alcohol consumption and marked by a range of physical and mental disabilities. Although recognized by the scientific and medical community as a clinical disorder, no internationally standardized diagnostic tool yet exists for FASD. METHODS AND RESULTS: This review seeks to analyse the discrepancies in existing diagnostic tools for FASD, and the repercussions these differences have on research, public health, and government policy...
January 1, 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29788771/understanding-design-vulnerabilities-in-the-physical-environment-relating-to-patient-fall-patterns-in-a-psychiatric-hospital-seven-years-of-sentinel-events
#19
Sara Bayramzadeh, Margaret Portillo, Candy Carmel-Gilfilen
BACKGROUND: The influence of the physical environment on patient falls has not been fully explored in psychiatric units, despite this patient population's vulnerability and the critical role of the physical environment in patient safety. AIMS: The research objective is to describe the spatial and temporal pattern of falls occurrences and their location in relation to the levels of safety continuum model. METHOD: This article presents an exploratory case study design...
May 1, 2018: Journal of the American Psychiatric Nurses Association
https://www.readbyqxmd.com/read/29787927/refugees-admission-to-mental-health-institutions-in-norway-is-there-an-ethnic-density-effect
#20
Jon Erik Finnvold, Elisabeth Ugreninov
Some recent European research claims that immigrants settle in urban areas with low scores on level-of-living conditions and a high prevalence of health-risk factors, and that these settlement patterns adversely affect their health. Other studies question the association between immigrant segregation and area deprivation on one hand, and negative health outcomes on the other hand, and identify possible beneficial effects of segregation, specifically the ethnic density effect. This paper aims to explore the possible ethnic density effect among refugees, a sub-population that often appears relatively vulnerable compared with immigrants in general...
May 16, 2018: Social Science & Medicine
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