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https://www.readbyqxmd.com/read/29158655/bikeshare-use-in-urban-communities-individual-and-neighborhood-factors
#1
Gabriela R Oates, Bryant W Hamby, Sejong Bae, Maria C Norena, H Olivia Hart, Mona N Fouad
Objective: Bicycling is an affordable way to increase access to employment, schooling, and services and an effective measure against obesity. Bikeshare programs can make bicycling accessible to diverse populations, but little evidence exists on their adoption in low-resource neighborhoods. Our study examined factors associated with bikeshare use in a metropolitan area in the southern United States. Methods: We performed a retrospective cross-sectional analysis of a database of clients (N=815) who rented a bicycle from Zyp Bikeshare in Birmingham, Alabama between October 2015 and November 2016...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/29155855/iron-status-and-anaemia-in-sri-lankan-secondary-school-children-a-cross-sectional-survey
#2
Angela Allen, Stephen Allen, Rexan Rodrigo, Lakshman Perera, Wei Shao, Chao Li, Duolao Wang, Nancy Olivieri, David J Weatherall, Anuja Premawardhena
BACKGROUND: Iron deficiency, the most common micronutrient disorder and cause of anaemia globally, impairs growth, cognition, behaviour and resistance to infection. METHODS/RESULTS: As part of a national survey of inherited haemoglobin variants in 7526 students from 72 secondary schools purposefully selected from the 25 districts of Sri Lanka, we studied 5912 students with a normal haemoglobin genotype. Median age was 16.0 (IQR 15.0-17.0) years and 3189 (53.9%) students were males...
2017: PloS One
https://www.readbyqxmd.com/read/29155772/preparation-of-primary-acute-lymphoblastic-leukemia-cells-in-different-cell-cycle-phases-by-centrifugal-elutriation
#3
Magdalena Delgado, Anisha Kothari, Walter N Hittelman, Timothy C Chambers
The ability to synchronize cells has been central to advancing our understanding of cell cycle regulation. Common techniques employed include serum deprivation; chemicals which arrest cells at different cell cycle phases; or the use of mitotic shake-off which exploits their reduced adherence. However, all of these have disadvantages. For example, serum starvation works well for normal cells but less well for tumor cells with compromised cell cycle checkpoints due to oncogene activation or tumor suppressor loss...
November 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29154183/use-of-healthcare-consumer-voices-to-increase-empathy-in-nursing-students
#4
Penny Heidke, Virginia Howie, Tabassum Ferdous
Nurses need to be well prepared to address the needs of a diverse population and facilitate positive experiences in an equitable and inclusive approach to care. The aim of the study was to determine whether the integration of consumer lived experience interviews into the content of a first-year course influenced empathy in nursing students. A one group pre-test, post-test design was used. A convenience sample of first-year undergraduate nursing students (N = 32) from a regional Australian university was recruited for the study...
November 13, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/29151865/effect-of-cell-cycle-duration-on-somatic-evolutionary-dynamics
#5
Dominik Wodarz, Ajay Goel, Natalia L Komarova
Cellular checkpoints prevent damage and mutation accumulation in tissue cells. DNA repair is one mechanism that can be triggered by checkpoints and involves temporary cell cycle arrest and thus delayed reproduction. Repair-deficient cells avoid this delay, which has been argued to lead to a selective advantage in the presence of frequent damage. We investigate this hypothesis with stochastic modeling, using mathematical analysis and agent-based computations. We first model competition between two cell types: a cell population that enters temporary cell cycle arrest, corresponding to repair (referred to as arresting cells), and one that does not enter arrest (referred to as nonarresting cells)...
December 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/29151365/effectiveness-of-direct-acting-antiviral-therapy-for-hepatitis-c-in-difficult-to-treat-patients-in-a-safety-net-health-system-a-retrospective-cohort-study
#6
Christina Yek, Carolina de la Flor, John Marshall, Cindy Zoellner, Grace Thompson, Lisa Quirk, Christian Mayorga, Barbara J Turner, Amit G Singal, Mamta K Jain
BACKGROUND: Direct-acting antivirals (DAAs) have revolutionized chronic hepatitis C (HCV) treatment, but real-world effectiveness among vulnerable populations, including uninsured patients, is lacking. This study was conducted to characterize the effectiveness of DAAs in a socioeconomically disadvantaged and underinsured patient cohort. METHODS: This retrospective observational study included all patients undergoing HCV treatment with DAA-based therapy between April 2014 and June 2016 at a large urban safety-net health system (Parkland Health and Hospital System, Dallas, TX, USA)...
November 20, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29148815/information-theoretic-approaches-to-atoms-in-molecules-hirshfeld-family-of-partitioning-schemes
#7
Farnaz Heidar-Zadeh, Paul Woodson Ayers, Toon Verstraelen, Ivan Vinogradov, Esteban Vöhringer-Martinez, Patrick Bultinck
Many population analysis methods are based on the precept that molecules should be built from fragments (typically atoms) that maximally resemble the isolated fragment. The resulting molecular building blocks are intuitive (because they maximally resemble well-understood systems) and transferable (because if two molecular fragments both resemble an isolated fragment, they necessarily resemble each other). Information theory is one way to measure the deviation between molecular fragments and their isolated counterparts, and one that lends itself to analysis...
November 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29146122/health-and-wellbeing-of-indigenous-adolescents-in-australia-a-systematic-synthesis-of-population-data
#8
Peter S Azzopardi, Susan M Sawyer, John B Carlin, Louisa Degenhardt, Ngiare Brown, Alex D Brown, George C Patton
BACKGROUND: Indigenous populations have high rates of disease and premature mortality. Most Indigenous communities are young, and adolescence (age 10-24 years) provides great opportunities for population health gain. However, the absence of a comprehensive account of Indigenous adolescents' health has been a barrier to effective policy. We aimed to report a national health profile for Indigenous adolescents in Australia. METHODS: We undertook a systematic synthesis of population data to report the health and wellbeing of Indigenous adolescents in Australia...
November 10, 2017: Lancet
https://www.readbyqxmd.com/read/29145590/who-uses-foodbanks-and-why-exploring-the-impact-of-financial-strain-and-adverse-life-events-on-food-insecurity
#9
E Prayogo, A Chater, S Chapman, M Barker, N Rahmawati, T Waterfall, G Grimble
Background: Rising use of foodbanks highlights food insecurity in the UK. Adverse life events (e.g. unemployment, benefit delays or sanctions) and financial strains are thought to be the drivers of foodbank use. This research aimed to explore who uses foodbanks, and factors associated with increased food insecurity. Methods: We surveyed those seeking help from front line crisis providers from foodbanks (N = 270) and a comparison group from Advice Centres (ACs) (N = 245) in relation to demographics, adverse life events, financial strain and household food security...
November 14, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/29144787/lessons-learned-from-a-food-environment-intervention-study-recruitment-and-retention-of-participants-in-disadvantaged-urban-inner-city-neighborhoods
#10
Rachel Engler-Stringer, Joelle Schaefer, Tracy Ridalls, Nazeem Muhajarine
Growing health inequities have led to calls for population health intervention research that can contribute to improving the health of marginalized populations, but conducting research with these communities can be challenging. When research aims to examine and understand an aspect of health in a population characterized as hard-to-reach or marginalized, recruitment techniques appear to have a significant impact on participation and sample retention in longitudinal studies. We examine and comment on the recruitment and retention techniques used in the Good Food, Healthy Families study conducted in low-income, inner-city neighborhoods in a midsized Canadian city; we hope that this will inform recruitment and retention approaches for population health intervention studies in similar populations...
November 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/29143897/anaplastic-lymphoma-kinase-testing-ihc-vs-fish-vs-ngs
#11
REVIEW
Xiaomin Niu, Jody C Chuang, Gerald J Berry, Heather A Wakelee
Personalized targeted therapy has emerged as a promising strategy in lung cancer treatment, with current attention focused on elucidation and detection of oncogenic drivers responsible for tumor initiation and maintenance and development of drug resistance. In lung cancer, several oncogenic drivers have been reported, triggering the application of tyrosine kinase inhibitors (TKIs) to target these dysfunctional genes. The anaplastic lymphoma kinase (ALK) rearrangement is responsible for about 4-7% of all non-small cell lung cancers (NSCLCs) and perhaps as high as a third in specific patient populations such as younger, male, non-smokers with advanced stage, epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) wild type, and signet ring cell adenocarcinoma with abundant intracytoplasmic mucin...
November 16, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29143531/the-population-mean-mood-predicts-the-prevalence-of-depression-in-an-australian-context
#12
Aaron D Sia, Lana J Williams, Julie A Pasco, Felice N Jacka, Sharon L Brennan-Olsen, J Lennert Veerman
BACKGROUND: The mean population mood has been demonstrated to strongly correlate with the prevalence of depression in European populations. Mean population mood has, therefore, been proposed as both a metric to measure the impact of population-level interventions to prevent depression and a target for public health policy. AIM: To demonstrate the relationship between mean population mood and the prevalence of depression using Australian data in order to broaden the applicability of this finding to the Australian population...
November 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29143237/john-henryism-gender-and-self-reported-health-among-roma-gypsies-in-serbia
#13
Jelena Čvorović, Sherman A James
We describe how self-reported health (SRH) varies with gender and John Henryism (a strong behavioral predisposition to engage in high-effort coping to overcome adversity) in a low income sample of Serbian Roma. Data were collected in 2016 in several Roma settlements around Belgrade, Serbia. The sample consisted of 90 men and 112 women. In addition to John Henryism (JH), measured by a Serbian version of the John Henryism Scale, demographic data and data on SRH and family relationships dynamics were collected...
November 15, 2017: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/29141634/the-effects-of-neoliberal-policies-on-access-to-healthcare-for-people-with-disabilities
#14
Dikaios Sakellariou, Elena S Rotarou
Neoliberal reforms lead to deep changes in healthcare systems around the world, on account of their emphasis on free market rather than the right to health. People with disabilities can be particularly disadvantaged by such reforms, due to their increased healthcare needs and lower socioeconomic status. In this article, we analyse the impacts of neoliberal reforms on access to healthcare for disabled people. This article is based on a critical analytical review of the literature and on two case studies, Chile and Greece...
November 15, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29136756/-the-advance-of-detection-technology-of-hiv-self-testing
#15
L Yan, P P Xiao, H J Yan, X P Huan, G F Fu, J J Li, H T Yang
At present, China's AIDS testing increased rapidly, but there are still many people living with HIV do not recognize their status, thus postponing the antiviral treatment time. HIV self-testing (HST) is an effective method to expand the testing, not only simple operation, easy to get a result, effectively protect the detection privacy, expand the selection of testers, suit to the entire population, but also the premise and basis of other AIDS comprehensive prevention measures, all over the world are promoting it...
November 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29136574/are-we-using-the-appropriate-reference-samples-to-develop-juvenile-age-estimation-methods-based-on-bone-size-an-exploration-of-growth-differences-between-average-children-and-those-who-become-victims-of-homicide
#16
Laure Spake, Hugo F V Cardoso
The population on which forensic juvenile skeletal age estimation methods are applied has not been critically considered. Previous research suggests that child victims of homicide tend to be from socioeconomically disadvantaged contexts, and that these contexts impair linear growth. This study investigates whether juvenile skeletal remains examined by forensic anthropologists are short for age compared to their normal healthy peers. Cadaver lengths were obtained from records of autopsies of 1256 individuals, aged birth to eighteen years at death, conducted between 2000 and 2015 in Australia, New Zealand, and the U...
November 7, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29132618/telehealth-attitudes-and-use-among-medical-professionals-medical-students-and-patients-in-china-a-cross-sectional-survey
#17
Peiran Chen, Lihong Xiao, Zhongping Gou, Liangcheng Xiang, Xinxing Zhang, Ping Feng
BACKGROUND: Telehealth aims to revolutionize health care by migrating health care from hospitals and satellite clinics directly into the home and onto mobile devices. Telehealth has the potential to increase public access to healthcare in China, where large segments of the population remain underserved, yet little is known about current attitudes and use of telehealth in the country. OBJECTIVE: Our aim was to determine attitudes and use of telehealth in China among medical professionals and patients, as well as identify factors that may affect its use...
December 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29132364/-i-m-not-strong-enough-i-m-not-good-enough-i-can-t-do-this-i-m-failing-a-qualitative-study-of-low-socioeconomic-status-smokers-experiences-with-accesssing-cessation-support-and-the-role-for-alternative-technology-based-support
#18
Veronica C Boland, Richard P Mattick, Hayden McRobbie, Mohammad Siahpush, Ryan J Courtney
BACKGROUND: The social gradient in smoking rates persist with an overrepresentation of smoking and its associated harms concentrated within lower socioeconomic status (SES) populations. Low-SES smokers are motivated to quit but face multiple barriers when engaging a quit attempt. An understanding of the current treatment service model from the perspectives of treatment-seeking low-SES smokers is needed to inform the design of alternative smoking cessation support services tailored to the needs of low-SES populations...
November 13, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29131873/longitudinal-trajectories-of-mental-health-in-australian-children-aged-4-5-to-14-15-years
#19
Daniel Christensen, Michael T Fahey, Rebecca Giallo, Kirsten J Hancock
Mental health can affect young people's sense of wellbeing and life satisfaction, their ability to participate in employment and education, and their onward opportunities in life. This paper offers a rare opportunity to longitudinally examine mental health in a population-representative study of children aged 4-5 years to 14-15 years. Using data from the Longitudinal Study of Australian Children (LSAC), this study examined maternally-reported child mental health over a 10 year period, in order to understand their initial mental health status early in life and its change over time, as measured by the Strengths and Difficulties Questionnaire...
2017: PloS One
https://www.readbyqxmd.com/read/29129823/autonomous-control-of-metabolic-state-by-a-quorum-sensing-qs-mediated-regulator-for-bisabolene-production-in-engineered-e-coli
#20
Eun-Mi Kim, Han Min Woo, Tian Tian, Suzan Yilmaz, Pouya Javidpour, Jay D Keasling, Taek Soon Lee
Inducible gene expression systems are widely used in microbial host strains for protein and commodity chemical production because of their extensive characterization and ease of use. However, some of these systems have disadvantages such as leaky expression, lack of dynamic control, and the prohibitively high costs of inducers associated with large-scale production. Quorum sensing (QS) systems in bacteria control gene expression in response to population density, and the LuxI/R system from Vibrio fischeri is a well-studied example...
November 9, 2017: Metabolic Engineering
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