Weiwei Zhu, Lisheng Xiao, Shouqiang Hong, Weijie Wang, Weiwei Li, Huan Luo, Xinyang Zhang, Xue Zhang, Yunxin Xue, Dai Wang, Jianjun Niu, Karl Drlica, Xilin Zhao
Glucose is widely used in the reconstitution of intravenous medications, which often include antimicrobials. How glucose affects antimicrobial activity has not been comprehensively studied. The present work reports that glucose added to bacteria growing in a rich medium suppresses the bactericidal but not the bacteriostatic activity of several antimicrobial classes, thereby revealing a phenomenon called glucose-mediated antimicrobial tolerance. Glucose, at concentrations corresponding to blood-sugar levels of humans, increased survival of Escherichia coli treated with quinolones, aminoglycosides, and cephalosporins with little effect on minimal inhibitory concentration...
May 12, 2024: ACS Infectious Diseases