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Testicular torsion

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https://www.readbyqxmd.com/read/28734114/effects-of-pomegranate-peel-extract-on-histopathology-testosterone-levels-and-sperm-of-testicular-torsion-detorsion-induced-in-adult-wistar-rats
#1
Mandana Beigi Boroujeni, Said Saied Shahrokhi, Mahdi Birjandi, Abolfazl Abbaszadeh, Fatemeh Beyranvand, Sakineh Hamoleh, Zohreh Zandbaf, Mohammadreza Gholami
Background In the present study, effects of pomegranate peel extract have been evaluated on decreasing the damage induced by testis torsion. Methods In this study, 30 adult Wistar rats were randomly divided into three groups of control, experimental (1) and experimental (2). CONTROL: no ischemia, received vehicle alone, exposed to sham operation. Experimental (1): Received the vehicle alone during ischemia followed by 60 days' reperfusion. Experimental (2): After performing ischemia reperfusion, 500 mg/kg of pomegranate peel extract has been used for 60 days...
July 22, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28730645/effect-of-metformin-on-germ-cell-specific-apoptosis-oxidative-stress-and-epididymal-sperm-quality-after-testicular-torsion-detorsion-in-rats
#2
M Ghasemnejad-Berenji, M Ghazi-Khansari, I Yazdani, M Nobakht, A Abdollahi, H Ghasemnejad-Berenji, J Mohajer Ansari, S Pashapour, A R Dehpour
The study was designed to evaluate the effects of metformin on apoptosis and epididymal sperm quality in a rat testicular ischaemia/reperfusion (I/R) injury model. A total of 72 male rats were divided into four groups (n = 18 for each group): group 1 (sham-operated group), group 2 (metformin group), group 3 (torsion/detorsion [T/D] + saline) and group 4 (T/D + 300 mg kg(-1) metformin). Testicular torsion was achieved by rotating the right testis 720° in a clockwise direction for 1 hr. Tissue malondialdehyde (MDA) level and caspase-3 activity increased and the activities of catalase, superoxide dismutase and glutathione peroxidase decreased in comparison with sham-operated group 4 hr after detorsion (p < ...
July 21, 2017: Andrologia
https://www.readbyqxmd.com/read/28727368/medical-ozone-therapy-reduces-oxidative-stress-and-testicular-damage-in-an-experimental-model-of-testicular-torsion-in-rats
#3
Mustafa Tusat, Ahmet Mentese, Selim Demir, Ahmet Alver, Mustafa Imamoglu
OBJECTIVE: Testicular torsion (TT) refers to rotation of the testis and twisting of the spermatic cord. TT results in ischemia-reperfusion (I/R) injury involving increased oxidative stress, inflammation and apoptosis, and can even lead to infertility. The aim of this study was to investigate the effect of ozone therapy on testicular damage due to I/R injury in an experimental torsion model. MATERIALS AND METHODS: 24 male Sprague-Dawley rats were divided into 3 groups; sham-operated, torsion/detorsion (T/D), and T/D+ozone...
June 14, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28725616/chronic-orchialgia-epidemiology-diagnosis-and-evaluation
#4
REVIEW
John T Sigalos, Alexander W Pastuszak
Chronic orchialgia is a vexing condition defined as chronic or intermittent scrotal pain lasting at least three months that significantly interferes with daily activities. There are currently no guidelines regarding the diagnosis and management of this condition despite it being the cause of 2.5-4.8% of urologic clinic visits. Men often present with chronic orchialgia in their mid to late 30s, although the condition can present at any age. A broad differential diagnosis of chronic orchialgia includes epididymitis, testicular torsion, tumors, obstruction, varicocele, epididymal cysts, hydrocele, iatrogenic injury following vasectomy or hernia repair, and referred pain from a variety of sources including mid-ureteral stone, indirect inguinal hernia, aortic or common iliac artery aneurysms, lower back disorders, interstitial cystitis, and nerve entrapment due to perineural fibrosis; approximately 25-50% of chronic orchialgia is idiopathic in nature...
May 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28714632/-diagnosis-and-management-of-testicular-torsion-in-children
#5
Vanina Estremadoyro, Blaise Julien Meyrat, Jacques Birraux, Isabelle Vidal, Oliver Sanchez
Testicular torsion is a true urologic emergency with a bimodal age presentation : the perinatal testicular torsion presenting with a hard, tender or non-tender scrotal mass usually with underlying dark discoloration of the skin and the peripubertal testicular torsion presenting with severe acute testicular pain, vomiting and frequently pain irradiation in the inguinal area, a high riding-horizontally positioned testis and absence of the cremasteric reflex. Obtaining a US Doppler must not add unnecessary delay to the urgent surgical treatment which entails detorsion and bilateral orchidopexy...
February 15, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28713006/ultrasonographic-findings-in-the-epididymis-of-pediatric-patients-with-testicular-torsion
#6
C E Afsarlar, R Elizondo, E Yilmaz, E Cakmakci, D J Ballow, E Demir, G Guney, C J Koh
INTRODUCTION: Although grayscale ultrasound and color Doppler ultrasound characteristics of the torsed testis are well established in the literature, less is known about its anatomic partner: the epididymis. OBJECTIVE: The purpose of this study was to describe the ultrasound characteristics of the epididymis in pediatric patients with testicular torsion, and to describe their potential role as prognostic criteria for testicular salvage outcomes. STUDY DESIGN: During a retrospective review of 217 pediatric patients with acute testicular torsion during 2009-2016, morphological features of the epididymis from scrotal ultrasounds (size, parenchymal characteristics, and vascular flow of both epididymis heads), as well as patient demographics, time duration, surgical outcomes, histopathology results, and follow-up periods were analyzed...
June 19, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28706858/antioxidants-in-experimental-ischemia-reperfusion-injury-of-the-testis-where-are-we-heading-towards
#7
REVIEW
George Vaos, Nick Zavras
Testicular torsion (TT) is a medical emergency that primary affects newborns and young adolescents. It causes testicular injury due to the torsion of the spermatic cord and its components, initially in the venous blood flow and finally in the arterial blood flow. Prompt diagnosis and early surgical management are necessary in managing this urgent situation. The process of the pathophysiological events in ischemia-reperfusion is multifactorial and deals with the perception of the oxidative stress responsible for the consequences of ischemia/reperfusion (I/R) stress following TT...
June 26, 2017: World Journal of Methodology
https://www.readbyqxmd.com/read/28705576/scrotal-ultrasound-for-pain-low-frequency-of-absolute-surgical-indications
#8
James A Kashanian, Daniel J Mazur, Marah C Hehemann, Christopher D Morrison, Daniel T Oberlin, Valary T Raup, Andrew W Choi, Brian Trinh, Mohammed A Said, Mary Kate Keeter, Robert E Brannigan
OBJECTIVE: To examine the results of scrotal ultrasounds conducted for scrotal or testicular pain and review the pathologic findings of orchiectomies done for lesions that were suspicious for malignancy on ultrasound. MATERIAL AND METHODS: We retrospectively reviewed the indications and findings of all scrotal ultrasounds completed at our institution from 2002-2014. If a patient underwent an orchiectomy for an intratesticular lesion that was concerning for malignancy on ultrasound, the pathology report was also reviewed...
July 10, 2017: Urology
https://www.readbyqxmd.com/read/28685129/does-intraperitoneal-injection-of-propofol-prior-to-detorsion-improve-testes-weight-and-histopathological-findings-in-a-rat-model
#9
Shahriar Amirhassani, Sasan Mehrabi, Seyed Mohammad Hosseinipanah, Abdolmajid Iloon Kashkouli, Saadat Torabian, Mohammad Kazem Moslemi
OBJECTIVES: To determine the long-term preventive effects of intraperitoneal propofol on testicular ischemia-reperfusion injury in a rat model. MATERIALS AND METHODS: Forty adult male albino Wistar rats were divided randomly into the following four groups according to the planned treatment (n=10 per group): group I, control; group II, sham-operated; group III, torsion/detorsion (T/D); and group IV, T/D plus propofol. Testicular ischemia was achieved by twisting the left testis 720° clockwise (ie, applying torsion) for 1 h...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28676067/chronic-scrotal-pain-in-young-adults
#10
Misgav Rottenstreich, Yuval Glick, Ofer Natan Gofrit
OBJECTIVE: Chronic scrotal pain (CSP) is a common and well recognized symptom of young males presenting to primary care units. Historically, CSP is defined as a testicular pain lasting for over 3 months. However, its etiology and outcome are poorly understood and its management is largely empirical. This study was conducted to examine the frequency, spectrum of pathology and outcome of CSP among young adults. RESULTS: The medical records of 382,036 young males were reviewed for anamnestic information, physical findings, primary care physician decisions, and final outcome...
July 4, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28673075/-triorchidism-which-therapy
#11
Eugenia Piro, Laura Abati, Veronica Zocca, Marta Brugnoni, Antonio D'Alessio
Polyorchidism is an anomaly characterized by more than two gonads; triorchidism is the most common variant. Its management is controversial, mostly when surgical treatment is occasional. CB, 14 year-old, came to the hospital due to right-sided testicular torsion. During surgery, testis was rotated and the contralateral testis, which presented as an anatomically continuum with a gonadic structure similar to the other testes but with a smaller diameter, was fixed. We performed biopsy on both left testes and decided to preserve the supernumerary one...
June 23, 2017: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
https://www.readbyqxmd.com/read/28630019/tunica-vaginalis-pedicle-flap-for-repair-of-ruptured-testis-a-single-center-experience-with-four-patients
#12
R N Damle, J F Lalikos, J T Aidlen, P Ellsworth
Management of testicular rupture with a large tunical defect may not be feasible without excision of viable tissue. This study describes the use of a vascularized tunica vaginalis flap, without debridement of viable tissue, in four adolescents. Postoperative ultrasound showed good blood flow and 80% volume of the contralateral testis in two cases. Postoperative exam revealed normal exam and ultrasonographic appearance in three patients, the fourth was demonstrated to be small and undescended during evaluation of contralateral testicular torsion...
May 24, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28620560/propionibacterium-acnes-is-an-unusual-cause-of-acute-scrotal-abscess-in-a-preterm-infant
#13
Naoto Nishizaki, Tadaharu Okazaki, Yu Adachi, Kaoru Obinata, Hiromichi Shoji, Toshiaki Shimizu
Acute scrotal abscess is an extremely rare condition in neonates and may mimic testicular torsion. Most of these abscesses have reportedly been due to Staphylococcus and Salmonella spp. infections. We herein report a unilateral acute scrotal abscess in a preterm infant born at 26 weeks in whom Propionibacterium acnes was isolated from the collected scrotal fluid culture. To our knowledge, this is the first case report implicating P. acnes as a causative agent of neonatal scrotal abscess. Based on such findings, P...
2017: Case Reports in Urology
https://www.readbyqxmd.com/read/28587411/erythropoietin-and-sildenafil-protect-against-ischemia-reperfusion-injury-following-testicular-torsion-in-adult-rats
#14
Ioannis D Kostakis, Nick Zavras, Christos Damaskos, Stratigoula Sakellariou, Penelope Korkolopoulou, Evangelos P Misiakos, Petros Tsaparas, George Vaos, Theodoros Karatzas
Testicular torsion/detorsion causes severe tissue damage due to ischemia/reperfusion injury. The present study investigated the protective effect of erythropoietin and sildenafil against ischemia/reperfusion injury following unilateral testicular torsion/detorsion in adult rats. A total of 28 adult male rats were included, and were divided into the following groups: Group A (n=5), sham operated; groups B (n=5), C (n=5), D (n=5) and E (n=8), undergoing right testis torsion and detorsion after 90 min. Group B received no drug treatment...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28580446/protective-effects-of-melatonin-on-testis-histology-following-acute-torsion-detorsion-in-rats
#15
Mehri Mirhoseini, Fereshteh Talebpour Amiri, Abbas Ali Karimpour Malekshah, Zahra Rezanejad Gatabi, Elmira Ghaffari
BACKGROUND: Testicular damage due to spermatic cord torsion may lead to infertility. It is probably because of changes in oxidative stress factors such as malondialdehyde. OBJECTIVE: To investigate the protective effect of melatonin (MLT), as an antioxidant, on testicular damage induced by acute unilateral spermatic cord torsion and detorsion (T/D) in rats. MATERIALS AND METHODS: In this experimental study, 48 adult male Wistar rats were randomly divided into three groups (8 rats/group): sham group underwent right scrotal surgery only...
March 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28569117/testicular-ultrasensitive-doppler-preliminary-experience-a-feasibility-study
#16
Laurence Rocher, Jean-Luc Gennisson, Sophie Ferlicot, Aline Criton, Laurence Albiges, Vincent Izard, Marie France Bellin, Jean-Michel Correas
Background Ultrasensitive Doppler is a novel non-invasive ultrasound (US) Doppler technique that improves sensitivity and resolution for the detection of slow flow. Purpose To investigate the feasibility of ultrasensitive Doppler (USD) for testicular disease diagnosis, using both qualitative and quantitative results. Material and Methods This prospective study was conducted in 160 successive men referred for scrotal US including B-mode and conventional Color-Doppler. A new USD sequence and algorithm dedicated to academic research were implemented into the US system...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28565817/medical-perspective-in-testicular-ischemia-reperfusion-injury
#17
Salvatore Arena, Roberta Iacona, Pietro Antonuccio, Tiziana Russo, Vincenzo Salvo, Eloisa Gitto, Pietro Impellizzeri, Carmelo Romeo
Testicular torsion or torsion of the spermatic cord is one of the most serious urological conditions. It causes testicular injury, which potentially leads to male subfertility. The turning of the spermatic cord and spermatic structures around themselves results in biochemical and histological changes; however, following testicular detorsion, tissues undergo reperfusion that causes more severe damage than that induced by ischemia. Since the primary causes of testicular damage are reactive oxygen species production, an increase in intra-mitochondrial calcium concentration and an increased rate of cellular apoptosis, different medications may potentially be effective...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28527721/indicators-and-outcomes-of-transfer-to-tertiary-pediatric-hospitals-for-patients-with-testicular-torsion
#18
Janae Preece, Christina Ching, Katelyn Yackey, Venkata Jayanthi, Daryl McLeod, Seth Alpert, Daniel DaJusta
INTRODUCTION: Testicular torsion threatens testicular viability with increased risk of loss with delayed management. Still, healthy adolescents continue to be transferred from community hospitals to tertiary hospitals for surgical management for torsion even though adult urologists may be available. We sought to determine reasons behind patient transfer and to evaluate whether transfer to tertiary centers for testicular torsion leads to increased rates of testicular loss. MATERIALS AND METHODS: A retrospective chart review was performed for patients presenting to our free-standing pediatric tertiary care facility with surgically confirmed testicular torsion during the 5-year period between January 2011 and January 2016...
April 27, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28514960/segmental-testicular-infarction-a-case-report
#19
Tine Smets, Gina Reichman, Dirk P J Michielsen
BACKGROUND: Segmental testicular infarction is a very rare condition, which can mimic a testicular torsion or testicular cancer. Correct diagnosis is difficult but it is important to avoid unnecessary radical treatment. CASE PRESENTATION: We report a clinical case of a 36-year-old white man who presented at our emergency department with subacute testicular pain. A urine analysis, Doppler ultrasound, surgical exploration, blood analysis, and magnetic resonance imaging were performed to diagnose his condition, to exclude a testicular torsion, and to raise confidence in its non-malignancy...
May 18, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28511233/-diagnostic-imaging-in-cases-of-acute-scrotum
#20
Natalie Ring, Gundula Staatz
Acute scrotum is one of the most common urologic emergencies in children and adolescents. This condition involves acute testicular pain, which is often accompanied by scrotal swelling and erythema. It is most important to distinguish between cases that require immediate surgery and those that can be treated conservatively. As patient history and physical findings may not always be unequivocal, ultrasound with Colour-Coded Doppler Sonography is the imaging modality of choice for further evaluation. Testicular torsion and other differential diagnoses such as epididymitis, appendiceal torsion, intratesticular haematoma after trauma, or complicated inguinal hernia have to be considered...
May 16, 2017: Aktuelle Urologie
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