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Cartilage imaging

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https://www.readbyqxmd.com/read/28653865/sagittal-plane-knee-moment-during-gait-and-knee-cartilage-thickness
#1
Randy J Schmitz, David Harrison, Hsin-Min Wang, Sandra J Shultz
CONTEXT:   Understanding the factors associated with thicker cartilage in a healthy population is important when developing strategies aimed at minimizing the cartilage thinning associated with knee osteoarthritis progression. Thicker articular cartilage is commonly thought to be healthier cartilage, but whether the sagittal-plane biomechanics important to gait are related to cartilage thickness is unknown. OBJECTIVE:   To determine the relationship of a weight-bearing region of the medial femoral condyle's cartilage thickness to sagittal gait biomechanics in healthy individuals...
June 2, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28651649/relationship-between-knee-osteoarthritis-and-meniscal-shape-in-observation-of-japanese-patients-by-using-magnetic-resonance-imaging
#2
Tsuneo Kawahara, Takahisa Sasho, Joe Katsuragi, Takashi Ohnishi, Hideaki Haneishi
BACKGROUND: The aims of this study were to reveal the characteristics of the meniscal shape at each knee osteoarthritis (OA) severity level and to predict trends or patterns of the meniscal shape change as associated with knee OA progression. METHODS: Fifty-one patients diagnosed with knee OA based on X-ray and magnetic resonance (MR) images were evaluated. They were divided into three groups based on the Kellgren-Lawrence (KL) grade: normal group (KL grade of 0 or 1), mild group (KL grade of 2 or 3), and severe group (KL grade of 4)...
June 26, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28650110/reproducibility-of-in-vivo-magnetic-resonance-imaging-t1-rho-and-t2-relaxation-time-measurements-of-hip-cartilage-at-3-0t-in-healthy-volunteers
#3
Angeline Nemeth, Lucy Di Marco, Florent Boutitie, Michael Sdika, Denis Grenier, Muriel Rabilloud, Olivier Beuf, Jean-Baptiste Pialat
PURPOSE: To assess the T1 ρ and T2 values in the hip cartilage of healthy volunteers and to evaluate the reproducibility of these measurements. MATERIALS AND METHODS: The right hip joint of 30 asymptomatic volunteers was explored with 3T magnetic resonance imaging (MRI). Quantitative 3D T1 ρ- and T2 -maps sequences were repeated twice with a 30-minute delay (immediate reproducibility). The same protocol was repeated 14 days later (short-term reproducibility). Immediate and short-term reproducibility were estimated using coefficients of variation and correlation concordance coefficients (CCC)...
June 26, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28647792/regeneration-of-hyaline-cartilage-promoted-by-xenogeneic-mesenchymal-stromal-cells-embedded-within-elastin-like-recombinamer-based-bioactive-hydrogels
#4
David Pescador, Arturo Ibáñez-Fonseca, Fermín Sánchez-Guijo, Jesús G Briñón, Francisco Javier Arias, Sandra Muntión, Cristina Hernández, Alessandra Girotti, Matilde Alonso, María Consuelo Del Cañizo, José Carlos Rodríguez-Cabello, Juan Francisco Blanco
Over the last decades, novel therapeutic tools for osteochondral regeneration have arisen from the combination of mesenchymal stromal cells (MSCs) and highly specialized smart biomaterials, such as hydrogel-forming elastin-like recombinamers (ELRs), which could serve as cell-carriers. Herein, we evaluate the delivery of xenogeneic human MSCs (hMSCs) within an injectable ELR-based hydrogel carrier for osteochondral regeneration in rabbits. First, a critical-size osteochondral defect was created in the femora of the animals and subsequently filled with the ELR-based hydrogel alone or with embedded hMSCs...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28645697/clinical-high-resolution-mapping-of-the-proteoglycan-bound-water-fraction-in-articular-cartilage-of-the-human-knee-joint
#5
Mustapha Bouhrara, David A Reiter, Kyle W Sexton, Christopher M Bergeron, Linda M Zukley, Richard G Spencer
PURPOSE: We applied our recently introduced Bayesian analytic method to achieve clinically-feasible in-vivo mapping of the proteoglycan water fraction (PgWF) of human knee cartilage with improved spatial resolution and stability as compared to existing methods. MATERIALS AND METHODS: Multicomponent driven equilibrium single-pulse observation of T1 and T2 (mcDESPOT) datasets were acquired from the knees of two healthy young subjects and one older subject with previous knee injury...
June 20, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28645289/degenerative-changes-of-the-canine-cervical-spine-after-discectomy-procedures-an-in-vivo-study
#6
Peter Grunert, Yu Moriguchi, Brian P Grossbard, Rodolfo J Ricart Arbona, Lawrence J Bonassar, Roger Härtl
BACKGROUND: Discectomies are a common surgical treatment for disc herniations in the canine spine. However, the effect of these procedures on intervertebral disc tissue is not fully understood. The objective of this study was to assess degenerative changes of cervical spinal segments undergoing discectomy procedures, in vivo. RESULTS: Discectomies led to a 60% drop in disc height and 24% drop in foraminal height. Segments did not fuse but showed osteophyte formation as well as endplate sclerosis...
June 23, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28643930/moving-towards-precision-orthodontics-an-evolving-paradigm-shift-in-the-planning-and-delivery-of-customized-orthodontic-therapy
#7
REVIEW
A H Jheon, S Oberoi, R C Solem, S Kapila
Advances in precision medicine portend similar progress in orthodontics and will be increasingly harnessed to achieve customized treatment approaches and enhance treatment efficiencies. Our goal is to provide a background on emerging advances in computer technologies and biomedicine and highlight their current and likely future applications to precision orthodontics. A review of orthodontically relevant technologies and advances in pertinent biological research was undertaken. Innovations in computer hardware and software, and 3D imaging technologies offer the ability for customized treatment and biomechanical planning that will be more fully realized within the next few decades...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28640163/mistletoe-fig-ficus-deltoidea-jack-leaf-extract-prevented-postmenopausal-osteoarthritis-by-attenuating-inflammation-and-cartilage-degradation-in-rat-model
#8
Nur Adeelah Che Ahmad Tantowi, Paisal Hussin, Seng Fong Lau, Suhaila Mohamed
OBJECTIVE: Ficus deltoidea Jack (mistletoe fig) is an ornamental plant found in various parts of the world and used as traditional herbal medicine in some countries. This study investigated the potential use of F deltoidea leaf extract to mitigate osteoarthritis (OA) in ovariectomized (estrogen-deficient postmenopausal model) rats and the mechanisms involved. Diclofenac was used for comparison. METHODS: Sprague-Dawley female rats (12 weeks old) were divided randomly into five groups (n = 6): healthy; nontreated OA; OA + diclofenac (5 mg/kg); OA + extract (200 mg/kg); and OA + extract (400 mg/kg)...
June 19, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28639852/osteochondritis-dissecans-etiology-pathology-and-imaging-with-a-special-focus-on-the-knee-joint
#9
Juergen Bruns, Mathias Werner, Christian Habermann
This article is a review of the current understanding of the etiology, pathogenesis, and how to diagnose and treat knee osteochondritis dissecans (OCD) followed by an analysis of and outcomes of the treatments available. OCD is seen in children and adolescents with open growth plates (juvenile OCD) and adults with closed growth plates (adult OCD). The etiology of OCD lesions remains unclear and is characterized by an aseptic necrosis in the subchondral bone area. Mechanical factors seem to play an important role...
June 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28638696/basic-radiological-assessment-of-synovial-diseases-a-pictorial-essay
#10
REVIEW
Aynur Turan, Pınar Çeltikçi, Abdurrahman Tufan, Mehmet Akif Öztürk
The synovium is a specialized tissue lining the synovial joints, bursae, and tendon sheaths of the body. It is affected by various localized or systemic disorders. Synovial diseases can be classified as inflammatory, infectious, degenerative, traumatic, hemorrhagic, and neoplastic. Damage in other intraarticular structures, particularly cartilages, generally occurs as a part of pathologic processes involving the synovium, leading to irreversible joint destruction. Imaging has an essential role in the early detection of synovial diseases prior to irreversible joint damage...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28638676/utilization-of-longitudinal-ultrasound-to-quantify-joint-soft-tissue-changes-in-a-mouse-model-of-posttraumatic-osteoarthritis
#11
Hao Xu, Echoe M Bouta, Ronald W Wood, Edward M Schwarz, Yongjun Wang, Lianping Xing
To assess the utility of longitudinal ultrasound (US) to quantify volumetric changes in joint soft tissues during the progression of posttraumatic osteoarthritis (PTOA) in mice, and validate the US results with histological findings. A longitudinal cohort of 3-month-old wild-type C57BL/6 male mice received the Hulth-Telhag surgical procedure on right knee to induce PTOA, and sham surgery on their left knee as control. US scans were performed on both knees before, 2, 4, 6, and 8 weeks post-surgery. Joint space volume and Power-Doppler (PD) volume were obtained from US images via Amira software...
2017: Bone Research
https://www.readbyqxmd.com/read/28633793/treatment-of-a-focal-articular-cartilage-defect-of-the-talus-with-polymer-based-autologous-chondrocyte-implantation-a-12-year-follow-up-period
#12
Peter Cornelius Kreuz, Richard Horst Kalkreuth, Philipp Niemeyer, Markus Uhl, Christoph Erggelet
Autologous chondrocyte implantation (ACI) is a first-line treatment option for large articular cartilage defects. Although well-established for cartilage defects in the knee, studies of the long-term outcomes of matrix-assisted ACI to treat cartilage defects in the ankle are rare. In the present report, we describe for the first time the long-term clinical and radiologic results 12 years after polymer-based matrix-assisted ACI treat a full-thickness talar cartilage defect in a 25-year-old male patient. The clinical outcome was assessed using the visual analog scale and Freiburg ankle score, magnetic resonance imaging evaluation using the Henderson-Kreuz scoring system and T2 mapping...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28632901/biexponential-t1%C3%AF-relaxation-mapping-of-human-knee-cartilage-in-vivo-at-3%C3%A2-t
#13
Azadeh Sharafi, Ding Xia, Gregory Chang, Ravinder R Regatte
The purpose of this study was to demonstrate the feasibility of biexponential T1ρ relaxation mapping of human knee cartilage in vivo. A three-dimensional, customized, turbo-flash sequence was used to acquire T1ρ -weighted images from healthy volunteers employing a standard 3-T MRI clinical scanner. A series of T1ρ -weighted images was fitted using monoexponential and biexponential models with two- and four-parametric non-linear approaches, respectively. Non-parametric Kruskal-Wallis and Mann-Whitney U-statistical tests were used to evaluate the regional relaxation and gender differences, respectively, with a level of significance of P = 0...
June 20, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28629070/fabrication-of-chitosan-graphene-oxide-polymer-nanofiber-and-its-biocompatibility-for-cartilage-tissue-engineering
#14
Lei Cao, Fei Zhang, Qiugen Wang, Xiaofeng Wu
In this work, Chitosan/Poly(vinyl alcohol) (PVA)/graphene oxide (GO) composite nanofibers were fabricated by electrospinning technique. The prepared nanofibers were characterized by using various spectroscopic and microscopic techniques. FESEM images have confirmed the uniform distributions of graphene oxide nanosheets in the nanofibers with self-assembly with chitosan/PVA chains. Additionally, the results of raman spectra confirmed the existence of GO sheets in the nanofibers. The tensile strength experiments revealed that the incorporation of GO increased the mechanical properties of nanofibers...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628801/evaluation-of-midcarpal-capitate-contact-mechanics-in-normal-injured-and-post-operative-wrists
#15
Saman Modaresi, Madhan S Kallem, Phil Lee, Terence E McIff, E Bruce Toby, Kenneth J Fischer
BACKGROUND: Scapholunate ligament injury is a commonly occurring carpal ligament injury. Pathology associated with scapholunate ligament injury depends on several factors such as the time after injury, type of injury (instability) and the development of osteoarthritis. The aim of this study was to investigate and compare contact mechanics in the lunocapitate and scaphocapitate joints in the normal, injured (scapholunate dissociation) and repaired (postoperative) wrist. METHODS: Four human subjects with scapholunate ligament dissociation participated in this study...
June 13, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28626842/automated-segmentation-of-knee-mri-using-hierarchical-classifiers-and-just-enough-interaction-based-learning-data-from-osteoarthritis-initiative
#16
Satyananda Kashyap, Ipek Oguz, Honghai Zhang, Milan Sonka
We present a fully automated learning-based approach for segmenting knee cartilage in presence of osteoarthritis (OA). The algorithm employs a hierarchical set of two random forest classifiers. The first is a neighborhood approximation forest, the output probability map of which is utilized as a feature set for the second random forest (RF) classifier. The output probabilities of the hierarchical approach are used as cost functions in a Layered Optimal Graph Segmentation of Multiple Objects and Surfaces (LOGISMOS)...
October 2016: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/28626099/-a-cross-sectional-study-on-the-correlation-between-mri-signal-for-ipfp-and-knee-osteoarthritis
#17
Song Wu, Hongliang Ba, Jinshen He, Yunjie Liao
To investigate the correlation between MRI signal for infrapatellar fat pad (IPFP) and pathological changes in knee osteoarthritis (KOA), and to analyze the role of IPFP in the development of knee osteoarthritis.
 Methods: A total of 114 subjects (without special knee disease) were enrolled for this study. The intensity of MRI signal for IPFP was determined by fat-suppressed proton-density-weighted turbospin-echo magnetic resonance imaging. Based on the cartilage defects and osteophytes of knee joint, the subjects were divided into a KOA group and a control group...
May 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28624013/femoral-torsion-assessment-with-mri-in-children-should-we-use-the-bony-or-cartilaginous-contours
#18
Andrea B Rosskopf, Christoph A Agten, Leonhard E Ramseier, Christian W A Pfirrmann, Florian M Buck
OBJECTIVE: To assess whether the use of cartilaginous contours at the femoral condyles instead of bony contours significantly changes femoral torsion measurements in children. MATERIALS AND METHODS: Femoral torsion was measured in 32 girls (mean age 10.1 years±2.3 standard deviation) and 42 boys (10.9 years±2.5) on axial magnetic resonance (MR) images by two independent readers (R1,R2). The femoral condyle angle was measured using each the cartilaginous and bony contours of the distal femur...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28621834/from-intricate-to-integrated-biofabrication-of-articulating-joints
#19
Wilhelmina Margaretha Groen, Paweena Diloksumpan, Paul René van Weeren, Riccardo Levato, Jos Malda
Articulating joints owe their function to the specialized architecture and the complex interplay between multiple tissues including cartilage, bone and synovium. Especially the cartilage component has limited self-healing capacity and damage often leads to the onset of osteoarthritis, eventually resulting in failure of the joint as an organ. Although in its infancy, biofabrication has emerged as a promising technology to reproduce the intricate organization of the joint, thus enabling the introduction of novel surgical treatments, regenerative therapies, and new sets of tools to enhance our understanding of joint physiology and pathology...
June 16, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28620621/matrix-assisted-autologous-chondrocyte-transplantation-in-the-knee-a-systematic-review-of-mid-to-long-term-clinical-outcomes
#20
REVIEW
Hayden B Schuette, Matthew J Kraeutler, Eric C McCarty
BACKGROUND: Matrix-assisted autologous chondrocyte transplantation (MACT) is a surgical treatment option for articular cartilage lesions of the knee joint. PURPOSE: To investigate mid- to long-term clinical outcomes of MACT in the patellofemoral (PF) and tibiofemoral (TF) joints. STUDY DESIGN: Systematic review; Level of evidence, 4. METHODS: A systematic review was performed by searching PubMed, Embase, and the Cochrane Library to find studies evaluating minimum 5-year clinical outcomes of patients undergoing MACT in the knee joint...
June 2017: Orthopaedic Journal of Sports Medicine
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