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Cartilage imaging

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https://www.readbyqxmd.com/read/28808768/high-resolution-mri-3t-mri-in-diagnosis-of-wrist-pain-is-diagnostic-arthroscopy-still-necessary
#1
Sabine Ochman, B Wieskötter, M Langer, V Vieth, M J Raschke, C Stehling
INTRODUCTION: 3T MRI has become increasingly available for better imaging of interosseous ligaments, TFCC, and avascular necrosis compared with 1.5T MRI. This study assesses the sensitivity and specificity of 3T MRI compared with arthroscopy as the gold standard. PATIENTS AND METHODS: Eighteen patients were examined with 3T MRI using coronal T1-TSE; PD-FS; and coronal, sagittal, and axial contrast-enhanced T1-FFE-FS sequences. Two musculoskeletal radiologists evaluated the images independently...
August 14, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28808630/systematic-review-on-the-use-of-autologous-matrix-induced-chondrogenesis-for-the-repair-of-articular-cartilage-defects-in-patients
#2
Nafisa Shaikh, Matthew K T Seah, Wasim S Khan
AIM: To systematically review the results of studies looking at autologous matrix-induced chondrogenesis (AMIC) in humans. METHODS: A literature search was performed, adhering to the PRISMA guidelines, to review any studies using such techniques in humans. Our initial search retrieved 297 articles listed on MEDLINE, Google Scholar, CINHal and EMBASE. From these studies, 15 studies meeting the eligibility criteria were selected and formed the basis of our systematic review...
July 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28808182/determination-of-serum-biomarkers-in-osteoarthritis-patients-a-previous-interventional-imaging-study-revisited
#3
Timothy McAlindon, Eckart Bartnik, Janina S Ried, Lenore Teichert, Matthias Herrmann, Klaus Flechsenhar
To evaluate in an interventional trial on knee osteoarthritis (OA) the level and change of two serum biomarkers and their correlation with imaging parameters. The previously reported interventional OA study (ClinicalTrials.gov: NCT00536302) identified a positive effect of collagen hydrolysate (CH) on cartilage morphology in patients with knee OA using delayed gadolinium enhanced magnetic resonance imaging (dGEMRIC). It was the objective in this research project to evaluate in an interventional clinical trial on knee OA the level and change of two serum biomarkers and their correlation with imaging parameters...
October 17, 2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28807512/non-linear-finite-element-model-to-assess-the-effect-of-tendon-forces-on-the-foot-ankle-complex
#4
Enrique Morales-Orcajo, Thales R Souza, Javier Bayod, Estevam Barbosa de Las Casas
A three-dimensional foot finite element model with actual geometry and non-linear behavior of tendons is presented. The model is intended for analysis of the lower limb tendon forces effect in the inner foot structure. The geometry of the model was obtained from computational tomographies and magnetic resonance images. Tendon tissue was characterized with the first order Ogden material model based on experimental data from human foot tendons. Kinetic data was employed to set the load conditions. After model validation, a force sensitivity study of the five major foot extrinsic tendons was conducted to evaluate the function of each tendon...
August 11, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28798878/treatment-of-knee-osteochondral-lesions-using-a-novel-clot-of-autologous-plasma-rich-in-growth-factors-mixed-with-healthy-hyaline-cartilage-chips-and-intra-articular-injection-of-prgf
#5
Ramón Cugat, Eduard Alentorn-Geli, Gilbert Steinbacher, Pedro Álvarez-Díaz, Xavier Cuscó, Roberto Seijas, David Barastegui, Jordi Navarro, Patricia Laiz, Montserrat García-Balletbó
Knee cartilage or osteochondral lesions are common and challenging injuries. To date, most symptomatic lesions warrant surgical treatment. We present two cases of patients with knee osteochondral defects treated with a one-step surgical procedure consisting of an autologous-based matrix composed of healthy hyaline cartilage chips, mixed plasma poor-rich in platelets clot, and plasma rich in growth factors (PRGF). Both patients returned to playing soccer at the preinjury activity level and demonstrated excellent defect filling in both magnetic resonance imaging and second-look arthroscopy (in one of them)...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28798204/imaging-igf-i-uptake-in-growth-plate-cartilage-using-in-vivo-multiphoton-microscopy
#6
Maria A Serrat, Gabriela Ion
Bones elongate through endochondral ossification in cartilaginous growth plates located at ends of primary long bones. Linear growth ensues from a cascade of biochemical signals initiated by actions of systemic and local regulators on growth plate chondrocytes. Although cellular processes are well defined, there is a fundamental gap in understanding how growth regulators are physically transported from surrounding blood vessels into and through dense, avascular cartilage matrix. Intravital imaging using in vivo multiphoton microscopy is one promising strategy to overcome this barrier by quantitatively tracking molecular delivery to cartilage from the vasculature in real time...
August 10, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28797093/influence-of-meniscus-on-cartilage-and-subchondral-bone-features-of-knees-from-older-individuals-a-cadaver-study
#7
Sébastien Touraine, Hamid Bouhadoun, Klaus Engelke, Jean Denis Laredo, Christine Chappard
OBJECTIVE: Cartilage and subchondral bone form a functional unit. Here, we aimed to examine the effect of meniscus coverage on the characteristics of this unit in knees of older individuals. METHODS: We assessed the hyaline cartilage, subchondral cortical plate (SCP), and subchondral trabecular bone in areas covered or uncovered by the meniscus from normal cadaver knees (without degeneration). Bone cores harvested from the medial tibial plateau at locations uncovered (central), partially covered (posterior), and completely covered (peripheral) by the meniscus were imaged by micro-CT...
2017: PloS One
https://www.readbyqxmd.com/read/28782498/results-of-arthroscopic-treatment-of-chondral-delamination-in-femoroacetabular-impingement-with-bone-marrow-stimulation-and-bst-cargel-%C3%A2
#8
Mahmoud Tahoun, Tamer Aly Shehata, Inmaculada Ormazabal, Jesús Mas, Javier Sanz, Marc Tey Pons
OBJECTIVES: The purpose of this study is to show the preliminary results of using chitosan-based scaffold (BST-CarGel(®)) with microfracture for treatment of acetabular chondral delamination associated with femoroacetabular impingement. METHODS: A prospective study was performed on 13 hips. Patients were selected in the age group between 18 and 50 years. Patients with delamination of acetabular cartilage associated with femoroacetabular impingement received arthroscopic debridement and microfracture technique...
2017: SICOT-J
https://www.readbyqxmd.com/read/28777893/age-related-vascularization-and-ossification-of-joints-in-children-an-international-pilot-study-to-test-multi-observer-ultrasound-reliability
#9
Daniel Windschall, Paz Collado, Jelena Vojinovic, Silvia Magni-Manzoni, Peter Balint, George A W Bruyn, Cristina Hernandez-Diaz, Juan Carlos Nieto, Viviana Ravagnani, Nikolay Tzaribachev, Annamaria Iagnocco, Maria Antonietta D'Agostino, Esperanza Naredo
OBJECTIVE: To determine the intra- and inter-observer reliability of ultrasound (US)-detected age-related joint vascularization and ossification grading in healthy children. METHODS: Following standardized image acquisition and machine setting protocols, 10 international US experts examined four joints (wrist, second metacarpophalangeal joint, knee, and ankle) in 12 healthy children (divided into four age groups: 2-4, 5-8, 9-12, and 13-16 years). Grey-scale was used to detect the ossification grade, and power Doppler (PD) US was used to detect physiological vascularization...
August 4, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28777666/shoulder-bone-geometry-affects-the-active-and-passive-axial-rotational-range-of-the-glenohumeral-joint
#10
Alexander Humphries, Srdjan Cirovic, Aliah F Shaheen
BACKGROUND: The range of motion of the glenohumeral joint varies substantially among individuals and is dependent on humeral position. How variation in shape of the humerus and scapula affects shoulder axial range of motion at various positions has not been established. PURPOSE: To quantify variation in the shape of the glenohumeral joint and investigate whether the scapula and humerus geometries affect the axial rotational range of the glenohumeral joint. STUDY DESIGN: Descriptive laboratory study...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28777662/clinical-and-radiological-regeneration-of-large-and-deep-osteochondral-defects-of-the-knee-by-bone-augmentation-combined-with-matrix-guided-autologous-chondrocyte-transplantation
#11
Johannes Zellner, Stephan Grechenig, Christian G Pfeifer, Werner Krutsch, Matthias Koch, Goetz Welsch, Madeleine Scherl, Johannes Seitz, Florian Zeman, Michael Nerlich, Peter Angele
BACKGROUND: Large osteochondral defects of the knee are a challenge for regenerative treatment. While matrix-guided autologous chondrocyte transplantation (MACT) represents a successful treatment for chondral defects, the treatment potential in combination with bone grafting by cancellous bone or bone block augmentation for large and deep osteochondral defects has not been evaluated. PURPOSE: To evaluate 1- to 3-year clinical outcomes and radiological results on magnetic resonance imaging (MRI) after the treatment of large osteochondral defects of the knee with bone augmentation and MACT...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28773080/estimation-of-articular-cartilage-surface-roughness-using-gray-level-co-occurrence-matrix-of-laser-speckle-image
#12
Doaa Youssef, Hatem El-Ghandoor, Hamed Kandel, Jala El-Azab, Salah Hassab-Elnaby
The application of He-Ne laser technologies for description of articular cartilage degeneration, one of the most common diseases worldwide, is an innovative usage of these technologies used primarily in material engineering. Plain radiography and magnetic resonance imaging are insufficient to allow the early assessment of the disease. As surface roughness of articular cartilage is an important indicator of articular cartilage degeneration progress, a safe and noncontact technique based on laser speckle image to estimate the surface roughness is provided...
June 28, 2017: Materials
https://www.readbyqxmd.com/read/28768528/safety-tolerability-clinical-and-joint-structural-outcomes-of-a-single-intra-articular-injection-of-allogeneic-mesenchymal-precursor-cells-in-patients-following-anterior-cruciate-ligament-reconstruction-a-controlled-double-blind-randomised-trial
#13
Yuanyuan Wang, Andrew Shimmin, Peter Ghosh, Paul Marks, James Linklater, David Connell, Stephen Hall, Donna Skerrett, Silviu Itescu, Flavia M Cicuttini
BACKGROUND: Few clinical trials have investigated the safety and efficacy of mesenchymal stem cells for the management of post-traumatic osteoarthritis. The objectives of this pilot study were to determine the safety and tolerability and to explore the efficacy of a single intra-articular injection of allogeneic human mesenchymal precursor cells (MPCs) to improve clinical symptoms and retard joint structural deterioration over 24 months in patients following anterior cruciate ligament (ACL) reconstruction...
August 2, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28768432/effects-of-surgical-factors-on-cartilage-can-be-detected-using-quantitative-magnetic-resonance-imaging-after-anterior-cruciate-ligament-reconstruction
#14
Keiko Amano, Alan K Li, Valentina Pedoia, Matthew F Koff, Aaron J Krych, Thomas M Link, Hollis Potter, Scott Rodeo, Xiaojuan Li, C Benjamin Ma, Sharmila Majumdar
BACKGROUND: Quantitative magnetic resonance (qMR) can be used to measure macromolecules in tissues and is a potential method of observing early cartilage changes in the development of posttraumatic osteoarthritis. Hypothesis/Purpose: We hypothesized that specific patient and surgical factors affecting cartilage matrix composition after anterior cruciate ligament (ACL) reconstruction (ACLR) can be detected using T1ρ and T2 relaxation times. Our purpose was to demonstrate this ability in a multicenter feasibility study...
April 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28766398/assessing-joint-destruction-in-the-knees-of-patients-with-rheumatoid-arthritis-by-using-a-semi-automated-software-for-magnetic-resonance-imaging-therapeutic-effect-of-methotrexate-plus-etanercept-compared-with-methotrexate-monotherapy
#15
Hiroyuki Oka, Yuho Kadono, Satoru Ohashi, Tetsuro Yasui, Kumiko Ono, Ko Matsudaira, Jinju Nishino, Sakae Tanaka
OBJECTIVES: To evaluate the prevention of knee joint destruction and clinical efficacy of methotrexate (MTX) plus etanercept (ETN) compared with MTX monotherapy in patients with rheumatoid arthritis (RA) by using semi-automated software for magnetic resonance imaging (MRI) scan analysis. MATERIALS AND METHODS: This study enrolled patients with active moderate-to-severe RA who displayed an inadequate response to oral MTX at screening. Patients were assigned to receive either MTX plus ETN or MTX monotherapy (≥10 mg/week)...
August 2, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28764643/detection-of-articular-perforations-of-the-proximal-humerus-fracture-using-a-mobile-3d-image-intensifier-a-cadaver-study
#16
Jan Theopold, Kevin Weihs, Christine Feja, Bastian Marquaß, Christoph Josten, Pierre Hepp
BACKGROUND: The purpose of this study was to investigate the accuracy of perforation detection with multiplanar reconstructions using a mobile 3D image intensifier. METHODS: In 12 paired human humeri, K-wires perforating the subchondral bone and placed just below the cartilage level were directed toward five specific regions in the humeral head. Image acquisition was initiated by a fluoroscopy scan. Within a range of 90°, 45° external rotation (ER) and 45° internal rotation (IR)...
August 1, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28762649/associations-between-systemic-bone-mineral-density-knee-cartilage-defects-and-bone-marrow-lesions-in-patients-with-knee-osteoarthritis
#17
Qicui Zhu, Jianhua Xu, Kang Wang, Jingyu Cai, Juan Wu, Jiale Ren, Shuang Zheng, Changhai Ding
AIM: The relationship between bone mineral density (BMD) and osteoarthritis (OA) remains controversial. This study aimed to explore the cross-sectional associations between BMD at the total body, hip and spine and joint structural abnormalities including cartilage defects and bone marrow lesions (BMLs) in patients with knee OA. METHOD: One hundred and eight-five subjects with symptomatic knee OA were included in this study. T2-weighted fast spin echo magnetic resonance imaging was used to assess knee cartilage defects and BMLs...
August 1, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28762158/the-validity-and-accuracy-of-mri-arthrogram-in-the-assessment-of-painful-articular-disorders-of-the-hip
#18
Aysha Rajeev, Wim Tuinebreijer, Abdalla Mohamed, Mike Newby
The assessment of a patient with chronic hip pain can be challenging. The differential diagnosis of intra-articular pathology causing hip pain can be diverse. These includes conditions such as osteoarthritis, fracture, and avascular necrosis, synovitis, loose bodies, labral tears, articular pathology and, femoro-acetabular impingement. Magnetic resonance imaging (MRI) arthrography of the hip has been widely used now for diagnosis of articular pathology of the hip. A retrospective analysis of 113 patients who had MRI arthrogram and who underwent hip arthroscopy was included in the study...
July 31, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28760354/t2-mr-imaging-vs-computational-modeling-of-human-articular-cartilage-tissue-functionality
#19
Kevin Linka, Mikhail Itskov, Daniel Truhn, Sven Nebelung, Johannes Thüring
The detection of early stages of cartilage degeneration remains diagnostically challenging. One promising non-invasive approach is to functionally assess the tissue response to loading by serial magnetic resonance (MR) imaging in terms of T2 mapping under simultaneous mechanical loading. As yet, however, it is not clear which cartilage component contributes to the tissue functionality as assessed by quantitative T2 mapping. To this end, quantitative T2 maps of histologically intact cartilage samples (n=8) were generated using a clinical 3...
July 19, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28758241/in-vivo-phase-imaging-of-human-epiphyseal-cartilage-at-7-t
#20
Barbara Dymerska, Klaus Bohndorf, Paul Schennach, Alexander Rauscher, Siegfried Trattnig, Simon D Robinson
PURPOSE: To assess the potential clinical utility of in vivo susceptibility-weighted imaging and quantitative susceptibility mapping of growth cartilage in the juvenile human knee at 7 T. METHODS: High-resolution gradient-echo images of the knees of six healthy children and adolescents aged 6 to 15 were acquired with a 28-channel coil at 7 T. Phase images from the coils were combined using a short echo-time reference scan method (COMPOSER). RESULTS: Veins oriented perpendicular to the static B0 field appeared doubled in susceptibility-weighted imaging, but not quantitative susceptibility mapping...
July 31, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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