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https://www.readbyqxmd.com/read/29028754/can-economic-model-transparency-improve-provider-interpretation-of-cost-effectiveness-analysis-a-response
#1
Joshua T Cohen, John B Wong
To enhance the credibility and the value of health economic analyses, we argue that the computer model source code underlying these analyses should be made publicly available. Only with open publication is it possible for others to assess whether alternative assumptions, beyond those examined by the model authors, alter the model's findings. Because reproducibility is critical for scientific acceptance and because computation increasingly permeates scientific inquiry, other fields have moved toward open publication of computer models, and health economics should avoid falling behind...
November 2017: Medical Care
https://www.readbyqxmd.com/read/29023630/the-hmgb1-is-increased-in-csf-of-patients-with-an-anti-nmdar-encephalitis
#2
P Ai, X Zhang, Z Xie, G Liu, X Liu, S Pan, H Wang
BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder of the central nervous system (CNS). Interleukin (IL)-6 and IL-17A may play important roles in the pathogenesis of this disease. High-mobility group box protein 1 (HMGB1), a small but highly conserved ubiquitous protein, is recognized to be a potent innate inflammatory mediator that can activate the nuclear factor light chain enhancer of activated B cells and release cytokines such as IL-6 and IL-17A when released extracellularly...
October 12, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28991735/aries-enabling-visual-exploration-and-organization-of-art-image-collections
#3
Lhaylla Crissaff, Louisa Wood Ruby, Samantha Deutch, R Luke DuBois, Jean-Daniel Fekete, Juliana Freire, Claudio Silva
Art historians have traditionally used physical light boxes to prepare exhibits or curate collections. On a light box, they can place slides or printed images, move the images around at will, group them as desired, and visually compare them. The transition to digital images has rendered this workflow obsolete. Now, art historians lack well-designed, unified interactive software tools that effectively support the operations they perform with physical light boxes. To address this problem, we designed ARIES (ARt Image Exploration Space), an interactive image manipulation system that enables the exploration and organization of fine digital art...
October 5, 2017: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/28981916/development-of-a-new-detector-system-to-evaluate-position-and-activity-of-plutonium-particles-in-nasal-cavities
#4
Yuki Morishita, Seiichi Yamamoto, Takumaro Momose, Junichi H Kaneko, Norio Nemoto
Plutonium dioxide (PuO2) is used to fabricate a mixed oxide fuel for fast breeder reactors. When a glove box containing PuO2 fails, such as by rupture of a glove or a vinyl bag, airborne contamination of plutonium (Pu) can occur. If a worker inhales PuO2 particles, they will be continually irradiating their lung tissue with alpha particles, and this could cause lung cancer. The nasal smear and nose blow methods are useful for checking workers for PuO2 intake in the field. However, neither method can evaluate the quantitative activity of Pu...
September 8, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28968216/exploitation-of-dark-fermented-effluent-of-cheese-whey-by-co-culture-of-rhodobacter-sphaeroides-and-bacillus-firmus-for-photo-hydrogen-production
#5
A Pandey, A Pandey
In this study photo-hydrogen production from cheese whey dark fermentation (DF) effluent by the co-culture of Rhodobacter sphaeroides -NMBL-01 and Bacillus firmus - NMBL-03 has been reported. The effect of pH, initial chemical oxygen demand (COD) and the concentration effect of FeSO4.7H2O on photo-hydrogen production have been investigated. The end products of dark fermentation effluent of cheese whey were mainly comprised of soluble organic acids, i.e. butyric acid and lactic acid. The batch process was carried out under light intensity of 2...
July 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28967436/the-angiogenic-properties-of-human-adipose-derived-stem-cells-hascs-are-modulated-by-the-high-mobility-group-box-protein-1-hmgb1
#6
Federico Biscetti, Stefano Gentileschi, Flavio Bertucci, Maria Servillo, Vincenzo Arena, Flavia Angelini, Egidio Stigliano, Giuseppina Bonanno, Giovanni Scambia, Benedetto Sacchetti, Luca Pierelli, Raffaele Landolfi, Andrea Flex
Peripheral arterial disease (PAD), is a major health problem. Many studies have been focused on the possibilities of treatment offered by vascular regeneration. Human adipose-derived stem cells (HASCs), multipotent CD34+ stem cells found in the stromal-vascular fraction of adipose tissues, which are capable to differentiate into multiple mesenchymal cell types. The High mobility group box 1 protein (HMGB1) is a nuclear protein involved in angiogenesis. The aim of the study was to define the role of HMGB1 in cell therapy with HASCs, in an animal model of PAD...
September 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28967123/antidepressant-like-effects-of-bu10119-a-novel-buprenorphine-analogue-with-mixed-kappa-mu-opioid-receptor-antagonist-properties-in-mice
#7
Abdulrahman Almatroudi, Mehrnoosh Ostovar, Christopher P Bailey, Stephen M Husbands, Sarah J Bailey
BACKGROUND AND PURPOSE: Κ-opioid receptor antagonists have potential for treating neuropsychiatric disorders. We have investigated the in vivo pharmacology of a novel buprenorphine analogue, BU10119, for the first time. EXPERIMENTAL APPROACH: To determine the opioid pharmacology of BU10119 (0.3-3 mg/kg, i.p.) in vivo, the warm-water tail withdrawal assay was used in adult male CD1 mice. A range of behavioural paradigms was used to investigate the locomotor effects, rewarding properties and antidepressant or anxiolytic potential of BU10119...
October 1, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28963242/storing-light-in-a-tiny-box
#8
Edo Waks, Elizabeth A Goldschmidt
No abstract text is available yet for this article.
September 29, 2017: Science
https://www.readbyqxmd.com/read/28951332/involvement-of-glucose-regulated-protein-78-and-spliced-x-box-binding-protein-1-in-the-protective-effect-of-gliclazide-in-diabetic-nephropathy
#9
Ying-Wen Zhang, Xiuping Wang, Xiaodan Ren, Manling Zhang
AIMS: To testing whether endoplasmic reticulum (ER) stress contributes to the development of diabetic nephropathy. Investigated the effect of gliclazide, an oral antihyperglycemic agent, in a rat model of diabetic nephropathy and the underlying mechanism related to the ER stress response. METHODS: Sixty SD rats were divided into six groups. Diabetic nephropathy was induced in 30 rats with a streptozotocin (STZ) injection and high fat diet, which were then treated with saline, gliclazide or 4-PBA...
May 4, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28939408/optimal-timing-of-exercise-for-influencing-energy-intake-in-children-during-school-lunch
#10
M-E Mathieu, A Lebkowski, E Laplante, V Drapeau, D Thivel
INTRODUCTION: Laboratory studies have shown that exercise can reduce energy intake, with a benefit to moderate-to-vigorous physical activity (MVPA) in individuals. The aim of the current study was to identify the impact of MVPA before lunch on ad libitum energy intake in very young children in a natural setting. METHODS: Three conditions were tested on three occasions, each using a counterbalance testing sequence as follows: A) Meal_MVPA: Meal at the beginning of the lunch period followed by a 40-min MVPA (reference condition); B) LPA_meal: 40 min of light intensity exercise session followed by lunch; C) MVPA_meal: MVPA followed by lunch...
September 20, 2017: Appetite
https://www.readbyqxmd.com/read/28939021/terminalia-arjuna-bark-extract-attenuates-picrotoxin-induced-behavioral-changes-by-activation-of-serotonergic-dopaminergic-gabaergic-and-antioxidant-systems
#11
Y Chandra Sekhar, G Phani Kumar, K R Anilakumar
Stress and emotion are associated with several illnesses from headaches to heart diseases and immune deficiencies to central nervous system. Terminalia arjuna has been referred as traditional Indian medicine for several ailments. The present study aimed to elucidate the effect of T. arjuna bark extract (TA) against picrotoxin-induced anxiety. Forty two male Balb/c mice were randomly divided into six experimental groups (n = 7): control, diazepam (1.5 mg·kg(-1)), picrotoxin (1 mg·kg(-1)) and three TA treatemt groups (25, 50, and 100 mg/kg)...
August 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28935007/an-international-survey-of-approaches-to-chair-restraint-of-nonhuman-primates
#12
Jennifer L McMillan, Mollie A Bloomsmith, Mark J Prescott
Specifically designed restraint chairs are the preferred method of restraint for research studies that require NHP to sit in place for sustained periods of time. In light of increasing emphasis on refinement of restraint to improve animal wellbeing, it is important to have a better understanding of this potentially stressful procedure. Although chair restraint is used internationally, very little published information is available on this subject. We developed a survey to obtain an overview of equipment, procedures, and plans for improvement regarding chair restraint...
October 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28929917/mercurius-solubilis-attenuates-scopolamine-induced-memory-deficits-and-enhances-the-motor-coordination-in-mice
#13
Simranjeet Kaur, Anudeep Kaur, Gurjit Singh, Rajbir Bhatti
The present study was designed to investigate the effect of mercurius solubilis (Merc sol) on scopolamine induced memory deficits and motor coordination in mice. The Three different formulations of merc sol (30X, 200 M, 1 M) were screened for their in vitro antioxidant potential and DPPH (2, 2-diphenyl-1-picrylhydrazyl) and nitric oxide scavenging activity using response surface methodology. The Merc sol 30X formulation was found to be most potent and further subjected for in vivo experiment. The Memory impairment was induced by the administration of scopolamine (1 mg/kg i...
September 20, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28924499/genome-wide-identification-of-the-mads-box-transcription-factor-family-in-pear-pyrus-bretschneideri-reveals-evolution-and-functional-divergence
#14
Runze Wang, Meiling Ming, Jiaming Li, Dongqing Shi, Xin Qiao, Leiting Li, Shaoling Zhang, Jun Wu
MADS-box transcription factors play significant roles in plant developmental processes such as floral organ conformation, flowering time, and fruit development. Pear (Pyrus), as the third-most crucial temperate fruit crop, has been fully sequenced. However, there is limited information about the MADS family and its functional divergence in pear. In this study, a total of 95 MADS-box genes were identified in the pear genome, and classified into two types by phylogenetic analysis. Type I MADS-box genes were divided into three subfamilies and type II genes into 14 subfamilies...
2017: PeerJ
https://www.readbyqxmd.com/read/28922622/light-signaling-differentially-regulates-the-expression-of-group-iv-of-the-b-box-zinc-finger-family
#15
Xinyu Zhang, Rongcheng Lin
Light is an important external signal that affects plant growth and development, such as photomorphogenesis. Transcriptional regulation defines a central regulatory mechanism in photomorphogenesis. The B-box zinc finger family consists of 32 proteins in Arabidopsis thaliana. Previous studies show that group IV of the B-box family (BBX18 to BBX25) plays either positive or negative roles in regulating photomorphogenesis. We investigated the expression patterns of BBX18 to BBX25 and the results demonstrate that the transcriptional levels of these genes are differentially regulated by the light signaling pathway...
September 18, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28919072/assessment-of-nicotine-withdrawal-induced-changes-in-sucrose-preference-in-mice
#16
Yasmin Alkhlaif, Deniz Bagdas, Asti Jackson, Abigail J Park, Imad M Damaj
Anhedonia, induced by nicotine withdrawal, may serve as an important affective sign that reinforces tobacco use and smoking relapse rates in humans. Animal models provide a way to investigate the underlying neurobiological factors involved in the decrease in responding for positive affective stimuli during nicotine withdrawal and may aid in drug development for nicotine dependence. Thus, we explored the use of the sucrose preference test to measure nicotine withdrawal-induced reduction in response for positive affective stimuli in mice...
October 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28903179/antinociceptive-anti-inflammatory-and-anxiolytic-like-effects-of-the-ethanolic-extract-fractions-and-hibalactone-isolated-from-hydrocotyle-umbellata-l-acari%C3%A3-oba-araliaceae
#17
Thiago Levi Silva Oliveira, Sandra Ribeiro de Morais, Stone de Sá, Matheus Gabriel de Oliveira, Iziara Ferreira Florentino, Dayane Moreira da Silva, Verônica Vale Carvalho, Vinícius Barreto da Silva, Boniek Gontijo Vaz, José Ricardo Sabino, Elson Alves Costa, José Realino de Paula
Hydrocotyle umbellata Linn. (Araliaceae) is specie used in the treatment of inflammatory diseases. Crude extract (E-HU) was prepared from H. umbellata subterraneous parts and fractionated by liquid-liquid partition, resulting hexane fraction (HF-HU), dichloromethane fraction (DF-HU), ethyl acetate fraction (EAF-HU) and aqueous fraction (AF-HU). The hibalactone (HU-1) was isolated from the DF-HU and its structure was elucidated by (1)H NMR and (13)C NMR Spectroscopy, mass spectrometry and crystallographic x-ray analysis...
September 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28902843/the-apostasia-genome-and-the-evolution-of-orchids
#18
Guo-Qiang Zhang, Ke-Wei Liu, Zhen Li, Rolf Lohaus, Yu-Yun Hsiao, Shan-Ce Niu, Jie-Yu Wang, Yao-Cheng Lin, Qing Xu, Li-Jun Chen, Kouki Yoshida, Sumire Fujiwara, Zhi-Wen Wang, Yong-Qiang Zhang, Nobutaka Mitsuda, Meina Wang, Guo-Hui Liu, Lorenzo Pecoraro, Hui-Xia Huang, Xin-Ju Xiao, Min Lin, Xin-Yi Wu, Wan-Lin Wu, You-Yi Chen, Song-Bin Chang, Shingo Sakamoto, Masaru Ohme-Takagi, Masafumi Yagi, Si-Jin Zeng, Ching-Yu Shen, Chuan-Ming Yeh, Yi-Bo Luo, Wen-Chieh Tsai, Yves Van de Peer, Zhong-Jian Liu
Constituting approximately 10% of flowering plant species, orchids (Orchidaceae) display unique flower morphologies, possess an extraordinary diversity in lifestyle, and have successfully colonized almost every habitat on Earth. Here we report the draft genome sequence of Apostasia shenzhenica, a representative of one of two genera that form a sister lineage to the rest of the Orchidaceae, providing a reference for inferring the genome content and structure of the most recent common ancestor of all extant orchids and improving our understanding of their origins and evolution...
September 21, 2017: Nature
https://www.readbyqxmd.com/read/28887196/enhanced-expression-of-heme-oxygenase-1-in-the-locus-coeruleus-can-be-associated-with-anxiolytic-like-effects
#19
Rafael Alves Cazuza, Olga Pol, Christie Ramos Andrade Leite-Panissi
Some researchers have shown that carbon monoxide (CO) plays a role in emotional behavior modulation through intracellular 3'-5'-guanosine monophosphate mechanisms in the locus coeruleus (LC). In fact, the LC region has a high expression of the heme-oxygenase (HO) enzymes, which are responsible for the production of CO. However, the physiological mechanism by which the HO-CO pathway participates in the modulation of emotional responses in the LC still needs clarification. This study evaluates whether a systemic intraperitoneal treatment is able to alter behavioral responses (in the elevated plus-maze and the light-dark box test) and the expression of the HO-1 and HO-2 enzymes in the LC...
January 15, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/28886533/artificial-light-at-night-affects-sleep-behaviour-differently-in-two-closely-related-songbird-species
#20
Jiachen Sun, Thomas Raap, Rianne Pinxten, Marcel Eens
Artificial light at night (ALAN) or light pollution is an increasing and worldwide problem. There is growing concern that because of the disruption of natural light cycles, ALAN may pose serious risks for wildlife. While ALAN has been shown to affect many aspects of animal behaviour and physiology, few studies have experimentally studied whether individuals of different species in the wild respond differently to ALAN. Here, we investigated the effect of ALAN on sleep behaviour in two closely related songbird species inhabiting the same study area and roosting/breeding in similar nest boxes...
September 5, 2017: Environmental Pollution
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