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https://www.readbyqxmd.com/read/29451280/a-remote-computing-based-point-of-care-colorimetric-detection-system-with-a-smartphone-under-complex-ambient-light-conditions
#1
Xu Bao, Shu Jiang, Yun Wang, Miao Yu, Juan Han
Smartphone-based colorimetric detection has been one of the most commonly used techniques for point-of-care detection in recent years. However, there are two defects in the current detection system. One is the need of a light-tight box to isolate the impact of ambient light, and the other is the increased calculation with the number of probes. In this paper, a colorimetric detection system was coupled with a new color calibration method for detection under complex ambient light conditions. A 3 × 4 colorimetric probe array was used to display the color changes of different analytes...
February 16, 2018: Analyst
https://www.readbyqxmd.com/read/29449458/a-barnes-maze-for-juvenile-rats-delineates-the-emergence-of-spatial-navigation-ability
#2
Daniel G McHail, Nazanin Valibeigi, Theodore C Dumas
The neural bases of cognition may be greatly informed by relating temporally defined developmental changes in behavior with concurrent alterations in neural function. A robust improvement in performance in spatial learning and memory tasks occurs at 3 wk of age in rodents. We reported that the developmental increase of spontaneous alternation in a Y-maze was related to changes in temporal dynamics of fast glutamatergic synaptic transmission in the hippocampus. We also showed that, during allothetic behaviors in the Y-maze, network oscillation power increased at frequency bands known to support spatial learning and memory in adults...
March 2018: Learning & Memory
https://www.readbyqxmd.com/read/29435632/chemometrics-assisted-microfluidic-paper-based-analytical-device-for-the-determination-of-uric-acid-by-silver-nanoparticle-plasmon-resonance
#3
Vahid Hamedpour, Geert J Postma, Edwin van den Heuvel, Jeroen J Jansen, Koji Suzuki, Daniel Citterio
This manuscript reports on the application of chemometric methods for the development of an optimized microfluidic paper-based analytical device (μPAD). As an example, we applied chemometric methods for both device optimization and data processing of results of a colorimetric uric acid assay. Box-Behnken designs (BBD) were utilized for the optimization of the device geometry and the amount of thermal inkjet-deposited assay reagents, which affect the assay performance. Measurement outliers were detected in real time by partial least squares discriminant analysis (PLS-DA) of scanned images...
February 12, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29420810/arabidopsis-thaliana-trihelix-transcription-factor-ast1-mediates-salt-and-osmotic-stress-tolerance-by-binding-to-a-novel-agag-box-and-some-gt-motifs
#4
Hongyun Xu, Xinxin Shi, Lin He, Yong Guo, Dandan Zang, Hongyan Li, Wenhui Zhang, Yucheng Wang
Trihelix transcription factors are characterized by containing a conserved trihelix (helix-loop-helix-loop-helix) domain that bind to GT elements required for light response, play roles in light stress, and also in abiotic stress responses. However, only few of them have been functionally characterised. In the present study, we characterized the function of AST1 (Arabidopsis SIP1 clade Trihelix1) in response to salt and osmotic stress. AST1 shows transcriptional activation activity, and its expression is induced by osmotic and salt stress...
February 6, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29417759/anxiety-and-activity-related-effects-of-paracetamol-on-healthy-and-neuropathic-rats
#5
Zuyue Chen, Hong Wei, Antti Pertovaara, Jianhong Wang, Synnöve Carlson
Paracetamol has recently been suggested to affect emotion processing in addition to alleviating pain in humans. We investigated in adult male Hannover-Wistar rats whether acute intraperitoneally administrated paracetamol affects behavior in tests measuring anxiety, mood, motor activity, and memory. Unoperated rats received saline or a low (50 mg/kg) or high (300 mg/kg) dose of paracetamol, while rats with a spared nerve injury (SNI) model of neuropathy and sham-operated rats received saline or the low dose of paracetamol...
February 2018: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/29415582/date-seed-oil-loaded-niosomes-development-optimization-and-anti-inflammatory-effect-evaluation-on-rats
#6
Mahmoud S Soliman, Fathy I Abd-Allah, Talib Hussain, Noha M Saeed, Hossam S El-Sawy
OBJECTIVE: An optimized Date seed oil (DSO) loaded niosomes was formulated. SIGNIFICANCE: Maximize the extract anti-inflammatory efficacy and govern its release characteristics from nanoparticles for osteoarthritis prevention and treatment purposes. METHODS: By using Box-Behnken Design, the effect of 3 formulation factors on the entrapment efficiency percentage (Y1), initial DSO release percentage after 2 h (Y2), and cumulative DSO release percentage of DSO after 12 h (Y3), were optimized and studied...
February 8, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29409506/the-molecular-mechanism-of-ovarian-granulosa-cell-tumors
#7
REVIEW
Jiaheng Li, Riqiang Bao, Shiwei Peng, Chunping Zhang
Over these years, more and more sex cord-stromal tumors have been reported. Granulosa cell tumor (GCT) is a rare tumor in ovaries, accounts for 2% to 5% of ovarian cancers. The main different feature of GCTs from other ovarian cancers is that GCTs can lead to abnormally secreted hormones (estrogen, inhibin and Müllerian inhibiting substance). The GCT is divided into two categories according to the age of patients, namely AGCT (adult granulosa cell tumor) and JGCT (Juvenile granulosa cell tumor). AGCT patients accounts for 95%...
February 6, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29401731/bc-box-motif-mediated-neuronal-differentiation-of-somatic-stem-cells
#8
Hiroshi Kanno, Yuqun Xu, Taykua Miyakawa, Atsuhiko Kubo, Tetsuhiro Higashida, Nahoko Baily Kobayashi, Tetsuhiko Yoshida, Masaru Tanokura
Von Hippel-Lindau tumor suppressor protein (pVHL) functions to induce neuronal differentiation of neural stem/progenitor cells (NSCs) and skin-derived precursors (SKPs). Here we identified a neuronal differentiation domain (NDD) in pVHL. Neuronal differentiation of SKPs was induced by intracellular delivery of a peptide composed of the amino-acid sequences encoded by the NDD. Neuronal differentiation mediated by the NDD was caused by the binding between it and elongin C followed by Janus kinase-2 (JAK2) ubiquitination of JAK2 and inhibition of the JAK2/the signal transducer and activator of transcription-3(STAT)3 pathway...
February 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29400632/ulinastatin-supplementation-during-human-amniotic-membrane-preservation-to-improve-its-viability
#9
Kyoung Woo Kim, Jung Huh, Soo Jin Lee, Sung Po Kim, Eung Bae Kim, Jae Chan Kim
PURPOSE: The amniotic membrane (AM) is the transparent innermost layer of the placenta and it facilitates rapid wound healing in a diversity of ocular surface disorders. However, extended periods of cryopreservation before use induce significant impairment of cell viability due to oxidative stresses and inflammatory responses. We investigated the effect of supplementing ulinastatin (ULI), a known serine protease inhibitor, and relevant mechanisms of action in AM preservation solution through the hypothermic continuum on inflammatory and apoptotic signals and viability of AM tissue...
February 5, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29399172/loss-of-beclin-1-expression-in-ovarian-cancer-a-potential-biomarker-for-predicting-unfavorable-outcomes
#10
Toshiko Minamoto, Kentaro Nakayama, Kohei Nakamura, Hiroshi Katagiri, Razia Sultana, Tomoka Ishibashi, Masako Ishikawa, Hitomi Yamashita, Kaori Sanuki, Kouji Iida, Satoru Nakayama, Yoshiro Otsuki, Noriyuki Ishikawa, Satoru Kyo
The clinicopathological significance and prognostic value of the expression of proteins associated with autophagy, beclin 1 (BECN1), 1A/1B-light chain 3 (LC3) and high mobility group box-1 protein (HMGB-1), were investigated in patients with ovarian carcinoma, receiving combination chemotherapy with a platinum agent and a taxane. Immunohistochemical staining was performed for autophagy-associated proteins in tumor tissues from 141 patients with ovarian carcinoma. Clinical data were collected retrospectively by reviewing medical charts, and the association between protein expression, clinicopathological features and survival was investigated...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29394445/association-of-impact-velocity-with-serious-injury-and-fatality-risks-to-cyclists-in-commercial-truck-cyclist-accidents
#11
Yasuhiro Matsui, Shoko Oikawa, Kazuhiro Sorimachi, Akira Imanishi, Takeshi Fujimura
This study aimed to clarify the relationship between truck-cyclist collision impact velocity and the serious-injury and fatality risks to cyclists, and to investigate the effects of road type and driving scenario on the frequency of cyclist fatalities due to collisions with vehicles. We used micro and macro truck-cyclist collision data from the Japanese Institute for Traffic Accident Research and Data Analysis (ITARDA) database. We classified vehicle type into five categories: heavy-duty trucks (gross vehicle weight [GVW] ≥11 × 103 kg [11 tons (t)], medium-duty trucks (5 × 103 kg [5 t] ≤ GVW < 11 × 103 kg [11 t]), light-duty trucks (GVW <5 × 103 kg [5 t]), box vans, and sedans...
November 2017: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/29388256/a-self-organizing-approach-to-subject-verb-number-agreement
#12
Garrett Smith, Julie Franck, Whitney Tabor
We present a self-organizing approach to sentence processing that sheds new light on notional plurality effects in agreement attraction, using pseudopartitive subject noun phrases (e.g., a bottle of pills). We first show that notional plurality ratings (numerosity judgments for subject noun phrases) predict verb agreement choices in pseudopartitives, in line with the "Marking" component of the Marking and Morphing theory of agreement processing. However, no account to date has derived notional plurality values from independently needed principles of language processing...
February 1, 2018: Cognitive Science
https://www.readbyqxmd.com/read/29382754/path-integration-in-place-cells-of-developing-rats
#13
Tale L Bjerknes, Nenitha C Dagslott, Edvard I Moser, May-Britt Moser
Place cells in the hippocampus and grid cells in the medial entorhinal cortex rely on self-motion information and path integration for spatially confined firing. Place cells can be observed in young rats as soon as they leave their nest at around 2.5 wk of postnatal life. In contrast, the regularly spaced firing of grid cells develops only after weaning, during the fourth week. In the present study, we sought to determine whether place cells are able to integrate self-motion information before maturation of the grid-cell system...
January 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29382562/behavioural-characterization-of-c57bl-6n-and-balb-c-female-mice-in-social-home-cage-effect-of-mixed-housing-in-complex-environment
#14
Indrek Heinla, Johanna Åhlgren, Eero Vasar, Vootele Voikar
Developing reliable mouse models for social behaviour is challenging. Different tests have been proposed, but most of them consist of rather artificial confrontations of unfamiliar mice in novel arenas or are relying on social stress induced by aggressive conspecifics. Natural social interaction in home cage in laboratory has not been investigated well. IntelliCage is a fully automated home-cage system, where activity of the group-housed mice can be monitored along with various cognitive tasks. Here we report the behavioural profile of C57BL/6N (B6) and BALB/c (BALB) female mice in IntelliCage when separated by strain, followed by monitoring of activity and formation of 'home-base' after mixing two strains...
January 27, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29379156/uvr8-interacts-with-wrky36-to-regulate-hy5-transcription-and-hypocotyl-elongation-in-arabidopsis
#15
Yu Yang, Tong Liang, Libo Zhang, Kai Shao, Xingxing Gu, Ruixin Shang, Nan Shi, Xu Li, Peng Zhang, Hongtao Liu
UV RESISTANCE LOCUS 8 (UVR8) is an ultraviolet-B (UVB) radiation photoreceptor that mediates light responses in plants. How plant UVR8 acts in response to UVB light is not well understood. Here, we report the identification and characterization of the Arabidopsis WRKY DNA-BINDING PROTEIN 36 (WRKY36) protein. WRKY36 interacts with UVR8 in yeast and Arabidopsis cells and it promotes hypocotyl elongation by inhibiting HY5 transcription. Inhibition of hypocotyl elongation under UVB requires the inhibition of WRKY36...
January 29, 2018: Nature Plants
https://www.readbyqxmd.com/read/29353091/adding-vibrotactile-feedback-to-a-myoelectric-controlled-hand-improves-performance-when-online-visual-feedback-is-disturbed
#16
Eitan Raveh, Sigal Portnoy, Jason Friedman
We investigated whether adding vibrotactile feedback to a myoelectric-controlled hand, when visual feedback is disturbed, can improve performance during a functional test. For this purpose, able-bodied subjects, activating a myoelectric-controlled hand attached to their right hand performed the modified Box & Blocks test, grasping and manipulating wooden blocks over a partition. This was performed in 3 conditions, using a repeated-measures design: in full light, in a dark room where visual feedback was disturbed and no auditory feedback - one time with the addition of tactile feedback provided during object grasping and manipulation, and one time without any tactile feedback...
January 17, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29352246/u-box-ubiquitin-ligase-ppil2-suppresses-breast-cancer-invasion-and-metastasis-by-altering-cell-morphology-and-promoting-snai1-ubiquitination-and-degradation
#17
Zhaojun Jia, Miao Wang, Shujing Li, Xiahui Li, Xiao-Yan Bai, Zhaowei Xu, Yangyang Yang, Bowen Li, Yanan Li, Huijian Wu
Metastasis is the leading cause of breast cancer fatalities. To develop new therapeutic strategies, the mechanisms underlying breast cancer invasion and metastasis need to be further investigated. Peptidylprolyl isomerase (cyclophilin)-like 2 (PPIL2) is a U-box-type E3 ubiquitin ligase belonging to the cyclophilin family. Proteins within this family are the major cytosolic binding proteins of the immunosuppressant drug cyclosporine A (CsA). Although PPIL2 has been reported to potentially be involved in cell migration, its role in breast cancer is still unclear...
January 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29341903/emerging-roles-and-mechanisms-of-foxc2-in-cancer
#18
REVIEW
Teng Wang, Lei Zheng, Qian Wang, Yan-Wei Hu
Forkhead box protein C2 (FOXC2), a transcription factor of the forkhead/winged-helix family, is required for embryonic and prenatal development. FOXC2 acts as a crucial modulator during both angiogenesis and lymphangiogenesis via multiple angiogenic and lymphangiogenic pathways, respectively. Although recent studies have shed light on the emerging role of FOXC2 in cancer, very little is known about the precise underlying mechanisms. The purpose of this review is to summarize the current understanding of FOXC2 and provide potential mechanistic explanations of the relationship between FOXC2 and cancer, as well as discuss the prospect for future research in the promising prognostic value of FOXC2 in cancer...
January 13, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29337078/circadian-waves-of-transcriptional-repression-shape-pif-regulated-photoperiod-responsive-growth-in-arabidopsis
#19
Guiomar Martín, Arnau Rovira, Nil Veciana, Judit Soy, Gabriela Toledo-Ortiz, Charlotte M M Gommers, Marc Boix, Rossana Henriques, Eugenio G Minguet, David Alabadí, Karen J Halliday, Pablo Leivar, Elena Monte
Plants coordinate their growth and development with the environment through integration of circadian clock and photosensory pathways. In Arabidopsis thaliana, rhythmic hypocotyl elongation in short days (SD) is enhanced at dawn by the basic-helix-loop-helix (bHLH) transcription factors PHYTOCHROME-INTERACTING FACTORS (PIFs) directly inducing expression of growth-related genes [1-6]. PIFs accumulate progressively during the night and are targeted for degradation by active phytochromes in the light, when growth is reduced...
January 9, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29326032/the-anxiolytic-effect-of-juniperus-virginiana-l-essential-oil-and-determination-of-its-active-constituents
#20
Kai Zhang, Lei Yao
Essential oil from Juniperus virginiana L. (eastern red cedarwood essential oil, CWO) has been used to relax mind and enhance comfort for medical purposes. Few reports showed its effect on anxiety behaviors in animal models. The present study investigated the anxiolytic effect of CWO using two anxiety tests in mice, then determined the major active constituents, examined the change of neurotransmitters after intraperitoneal (i.p.) administration. Analysis using GC/MS revealed that the CWO contained (-)-α-cedrene (28...
January 8, 2018: Physiology & Behavior
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