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https://www.readbyqxmd.com/read/28214677/photo-degradation-of-basic-green-1-and-basic-red-46-dyes-in-their-binary-solution-by-la2o3-al2o3nanocomposite-using-first-order-derivative-spectra-and-experimental-design-methodology
#1
Bahareh Fahimirad, Alireza Asghari, Maryam Rajabi
In this work, the lanthanum oxide-aluminum oxide (La2O3-Al2O3) nanocomposite is introduced as an efficient photocatalyst for the photo-degradation of the dyes basic green 1 (BG1) and basic red 46 (BR46) in their binary aqueous solution under the UV light irradiation. The properties of this catalyst are determined by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), Brunauer-Emmett-Teller (BET), and UV-visible spectrophotometry. The first-order derivative spectra are used for the simultaneous analysis of the dyes in their binary solution...
February 10, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28209508/systematic-review-of-measures-of-impairment-and-activity-limitation-for-person-with-upper-limb-trauma-and-amputation
#2
REVIEW
Linda Resnik, Matt Borgia, Ben Silver, Jill Cancio
OBJECTIVE: Study purposes were to 1) identify outcome measures used in studies of persons with traumatic upper limb injury and/or amputation and 2) evaluate focus, content and psychometric properties of each measure. DATA SOURCES: Searches of PubMed and CINAHL for terms including upper extremity, function, activities of daily living, outcome assessment, amputation and traumatic injuries. STUDY SELECTION: Included articles had a sample of ≥10 adults with limb trauma or amputation, and were in English...
February 13, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28207170/molding-photonic-boxes-into-fluorescent-emitters-by-direct-laser-writing
#3
Christof P Dietrich, Markus Karl, Jürgen Ohmer, Utz Fischer, Malte C Gather, Sven Höfling
Direct laser writing of photonic boxes into active layers of biologically produced recombinant fluorescent protein in optical microcavities is demonstrated. Irradiation with laser light above the photobleaching threshold induces photonic confinement potentials on the order of 40 meV. The technique provides high spatial selectivity and enables room-temperature lasing in protein rings, and circular and elliptical pillars with customized beam shapes.
February 16, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28199887/killing-colon-cancer-cells-through-pcd-pathways-by-a-novel-hyaluronic-acid-modified-shell-core-nanoparticle-loaded-with-rip3-in-combination-with-chloroquine
#4
Xueyan Hou, Chengli Yang, Lijing Zhang, Tingting Hu, Dan Sun, Hua Cao, Fan Yang, Gang Guo, Changyang Gong, Xiaoning Zhang, Aiping Tong, Rui Li, Yu Zheng
Due to extensive apoptosis defects and multidrug resistance, there is great interest regarding non-apoptotic programmed cell death (PCD) pathways, such as lysosomal-mediated programmed cell death (LM-PCD), necroptosis and autophagy. Because there is an intricate effector network among these PCD pathways, it is expected that they may act synergistically in cancer therapy. In this study, chloroquine (CQ) was found to significantly upregulate receptor-interacting protein kinase 3 (RIP3) expression, and RIP3 were involved in CQ-related autophagy...
January 2, 2017: Biomaterials
https://www.readbyqxmd.com/read/28197809/determination-of-diclofenac-and-n-acetylcysteine-by-an-optimized-luminescence-method-using-cds-quantum-dots-as-sensitizers
#5
Abdolraouf Samadi-Maybodi, Ali Tilehkan, Mohammad-Rasool Sadeghi-Maleki
A simple, sensitive and selective chemiluminescence method is proposed for the determination of Acetylcysteine and Diclofenac in pharmaceutical samples. The method is based on the measuring light intensity of NaHCO3-H2O2 @ CdS chemiluminescence system in the absence and presence of Acetylcysteine and Diclofenac. It was found that the intensity of chemiluminescence is increased by addition of acetylcysteine while the light intensity is decreased with increasing diclofenac concentration. The CdS quantum dots nanoparticles were characterized by X-ray diffraction (XRD), Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), UV-Vis spectrophotometry and Fluorescence spectroscopy...
February 14, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28194094/food-seeking-in-a-risky-environment-a-method-for-evaluating-risk-and-reward-value-in-food-seeking-and-consumption-in-mice
#6
Sarah H Lockie, Clare V McAuley, Sasha Rawlinson, Natalie Guiney, Zane B Andrews
Most studies that measure food intake in mice do so in the home cage environment. This necessarily means that mice do not engage in food seeking before consumption, a behavior that is ubiquitous in free-living animals. We modified and validated several commonly used anxiety tests to include a palatable food reward within the anxiogenic zone. This allowed us to assess risk-taking behavior in food seeking in mice in response to different metabolic stimuli. We modified the open field test and the light/dark box by placing palatable peanut butter chips within a designated food zone inside the anxiogenic zone of each apparatus...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28191447/reexamining-chronic-toxoplasma-gondii-infection-surprising-activity-for-a-dormant-parasite
#7
Anthony P Sinai, Elizabeth A Watts, Animesh Dhara, Robert D Murphy, Matthew S Gentry, Abhijit Patwardhan
PURPOSE OF REVIEW: Despite over a third of the world's population being chronically infected with Toxoplasma gondii, little is known about this largely asymptomatic phase of infection. This stage is mediated in vivo by bradyzoites within tissue cysts. The absence of overt symptoms has been attributed to the dormancy of bradyzoites. In this review, we reexamine the conventional view of chronic toxoplasmosis in light of emerging evidence challenging both the nature of dormancy and the consequences of infection in the CNS...
December 2016: Current Clinical Microbiology Reports
https://www.readbyqxmd.com/read/28187857/adaptive-and-behavioral-changes-in-kynurenine-3-monooxygenase-knockout-mice-relevance-to-psychotic-disorders
#8
Sophie Erhardt, Ana Pocivavsek, Mariaelena Repici, Xi-Cong Liu, Sophie Imbeault, Daniel C Maddison, Marian A R Thomas, Joshua L Smalley, Markus K Larsson, Paul J Muchowski, Flaviano Giorgini, Robert Schwarcz
BACKGROUND: Kynurenine 3-monooxygenase converts kynurenine to 3-hydroxykynurenine, and its inhibition shunts the kynurenine pathway-which is implicated as dysfunctional in various psychiatric disorders-toward enhanced synthesis of kynurenic acid, an antagonist of both α7 nicotinic acetylcholine and N-methyl-D-aspartate receptors. Possibly as a result of reduced kynurenine 3-monooxygenase activity, elevated central nervous system levels of kynurenic acid have been found in patients with psychotic disorders, including schizophrenia...
December 16, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28187450/nucleocytoplasmic-shuttling-of-sox14a-and-sox14b-transcription-factors
#9
Zhen-Yu She, Wan-Xi Yang
The nucleocytoplasmic shuttling of SOX transcription factors play a crucial role in the regulation of SOX protein functions during development. In this study, we have demonstrated two nuclear localization signals in the HMG box of Eriocheir sinensis SOX14A and SOX14B. These two conserved nuclear localization signals mediate nuclear transport. The N-termini nuclear localization signal mediates the calmodulin-dependent pathway and the C-termini nuclear localization signal interacts with the importin-β pathway...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28174623/expression-patterns-of-passiflora-edulis-apetala1-fruitfull-homologues-shed-light-onto-tendril-and-corona-identities
#10
Livia C T Scorza, Jose Hernandes-Lopes, Gladys F A Melo-de-Pinna, Marcelo C Dornelas
BACKGROUND: Passiflora (passionflowers) makes an excellent model for studying plant evolutionary development. They are mostly perennial climbers that display axillary tendrils, which are believed to be modifications of the inflorescence. Passionflowers are also recognized by their unique flower features, such as the extra whorls of floral organs composed of corona filaments and membranes enclosing the nectary. Although some work on Passiflora organ ontogeny has been done, the developmental identity of both Passiflora tendrils and the corona is still controversial...
2017: EvoDevo
https://www.readbyqxmd.com/read/28167764/hy5-a-positive-regulator-of-light-signaling-negatively-controls-the-unfolded-protein-response-in-arabidopsis
#11
Ganesh M Nawkar, Chang Ho Kang, Punyakishore Maibam, Joung Hun Park, Young Jun Jung, Ho Byoung Chae, Yong Hun Chi, In Jung Jung, Woe Yeon Kim, Dae-Jin Yun, Sang Yeol Lee
Light influences essentially all aspects of plant growth and development. Integration of light signaling with different stress response results in improvement of plant survival rates in ever changing environmental conditions. Diverse environmental stresses affect the protein-folding capacity of the endoplasmic reticulum (ER), thus evoking ER stress in plants. Consequently, the unfolded protein response (UPR), in which a set of molecular chaperones is expressed, is initiated in the ER to alleviate this stress...
February 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28162046/degradation-of-2-4-dichlorophenoxyacetate-isopropyl-amine-2-4-d-ipa-by-o3-ac-uv-in-an-internally-slurry-airlift-photo-reactor
#12
Jamshid Behin, Negin Farhadian
An externally illuminated slurry airlift reactor (ALR) was used to decompose 2,4-D IPA during catalytic ozonation with activated carbon. The effect of superficial gas velocity (0.05-0.15 cm/s), UVAB irradiation (0-60 W), treatment period (10-30 min) and amount of activated carbon (0-0.8 g/l) on removal efficiency was investigated using response surface methodology (RSM) based on Box-Behnken surface statistical design. Well-defined circulation pattern in the ALR allowed all the fluid elements to be exposed to high light intensity zone and achieve sufficient contact between the solid catalyst and the pollutant...
February 6, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28161436/higher-susceptibility-of-somatostatin-4-receptor-gene-deleted-mice-to-chronic-stress-induced-behavioral-and-neuroendocrine-alterations
#13
Bálint Scheich, Kata Csekő, Éva Borbély, István Ábrahám, Valér Csernus, Balázs Gaszner, Zsuzsanna Helyes
The somatostatin 4 receptor (sst4) is widely expressed in stress-related brain areas (e.g. hippocampus, amygdala) and regulates the emotional behavior in acute situations. Since its importance in chronic stress-induced complex pathophysiological alterations is unknown, we investigated the involvement of sst4 in the responsiveness to chronic variable stress (CVS). Sstr4 gene-deficient (Sstr4(-/-)) mice and their wildtype counterparts (Sstr4(+/+)) were used to examine the behavioral and neuroendocrine alterations as well as chronic neuronal activity (FosB expression) changes in response to CVS...
February 1, 2017: Neuroscience
https://www.readbyqxmd.com/read/28160425/anxiolytic-like-effect-of-2-4-1-phenyl-1h-pyrazol-4-yl-methyl-piperazin-1-yl-ethan-1-ol-is-mediated-through-the-benzodiazepine-and-nicotinic-pathways
#14
Adriane F Brito, James O Fajemiroye, Hiasmin F S Neri, Dayane M Silva, Daiany P B Silva, Germán Sanz, Boniek G Vaz, Flávio S de Carvalho, Paulo C Ghedini, Luciano M Lião, Ricardo Menegatti, Elson A Costa
In this study we proposed the design, synthesis of a new compound 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol (LQFM032), and pharmacological evaluation of its anxiolytic-like effect. This new compound was subjected to pharmacological screening refered to as Irwin test, prior to sodium pentobarbital-induced sleep, open field and wire tests. The anxiolytic-like effect of this compound was evaluated using elevated plus maze and light-dark box tests. In addition, the mnemonic activity was evaluated through step-down test...
February 3, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28147479/self-assembled-three-dimensional-graphene-based-polyhedrons-inducing-volumetric-light-confinement
#15
Daeha Joung, Andrei Nemilentsau, Kriti Agarwal, Chunhui Dai, Chao Liu, Qun Su, Jing Li, Tony Low, Steven J Koester, Jeong-Hyun Cho
The ability to transform two-dimensional (2D) materials into a three-dimensional (3D) structure while preserving their unique inherent properties might offer great enticing opportunities in the development of diverse applications for next generation micro/nano devices. Here a self-assembly process is introduced for building free-standing 3D, micro/nanoscale, hollow, polyhedral structures configured with a few layers of graphene-based materials: graphene and graphene oxide. The 3D structures have been further modified with surface patternings; realized through the inclusion of metal patterns on their 3D surfaces...
February 1, 2017: Nano Letters
https://www.readbyqxmd.com/read/28144887/phytochemical-screening-acute-toxicity-anxiolytic-and-antidepressant-activities-of-the-nelumbo-nucifera-fruit
#16
Muhammad Ali Rajput, Rafeeq Alam Khan
Recently use of herbal therapies and diet rich in flavonoids and vitamin C have increased significantly to treat minor to modest anxiety disorders and various forms of depression. But further research and studies are necessary to evaluate the pharmacological & toxicological effects of plants. Hence present study was designed to conduct phytochemical screening, acute toxicity study, anxiolytic and antidepressant activities of the ethanol extract of Nelumbo nucifera fruit in order to ascertain its therapeutic potential...
February 1, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28138095/long-lasting-memory-deficits-in-mice-withdrawn-from-cocaine-are-concomitant-to-neuroadaptations-in-hippocampal-basal-activity-gabaergic-interneurons-and-adult-neurogenesis
#17
David Ladrón de Guevara-Miranda, Carmelo Millón, Cristina Rosell-Valle, Mercedes Pérez-Fernández, Michele Missiroli, Antonia Serrano, Francisco J Pavón, Fernando Rodríguez de Fonseca, Magdalena Martínez-Losa, Manuel Álvarez-Dolado, Luis J Santín, Estela Castilla-Ortega
The cocaine addiction disorder is notably aggravated by concomitant cognitive and emotional pathology that impedes recovery. We studied whether a persistent cognitive/emotional dysregulation in mice withdrawn from cocaine holds a neurobiological correlate within the hippocampus, a limbic region with a key role in anxiety and memory but that has been scarcely investigated in cocaine addiction research. Mice were submitted to a chronic cocaine (20 mg/kg/day for 12 days) or vehicle treatment followed by 44 drug-free days...
January 30, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28137660/effects-of-moderate-treadmill-exercise-and-fluoxetine-on-behavioural-and-cognitive-deficits-hypothalamic-pituitary-adrenal-axis-dysfunction-and-alternations-in-hippocampal-bdnf-and-mrna-expression-of-apoptosis-related-proteins-in-a-rat-model-of-post-traumatic
#18
Sakineh Shafia, Abbas Ali Vafaei, Seyed Afshin Samaei, Ahmad Reza Bandegi, Alireza Rafiei, Reza Valadan, Zahra Hosseini-Khah, Raziyeh Mohammadkhani, Ali Rashidy-Pour
Post-traumatic stress disorder (PTSD) is a condition that develops after an individual has experienced a major trauma. Currently, selective serotonin reuptake inhibitors (SSRIs) like fluoxetine are the first-line choice in PTSD drug treatment but their moderate response rates and side effects indicate an urgent need for the development of new treatment. Physical activity is known to improve symptoms of certain neuropsychiatric disorders. The present study investigated the effects of moderate treadmill exercise, the antidepressant fluoxetine and the combined treatment on behavioural deficits, and hypothalamic-pituitary-adrenal (HPA) axis dysfunction...
January 28, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28130676/a-new-eimerian-apicomplexa-eimeriidae-from-ornate-box-turtle-terrapene-ornata-agassiz-testudines-emydidae-from-northwest-arkansas-usa
#19
Chris T McAllister, Dagmara Motriuk-Smith, Catherine M Kerr, Kristine N Carmen, R Scott Seville, Matthew B Connior
A new species of Eimeria Schneider, 1875 (Apicomplexa: Eimeriidae) collected from an ornate box turtle, Terrapene ornata (Agassiz) from Arkansas, USA, is described. Oöcysts of Eimeria doddi n. sp. are ovoidal to ellipsoidal with a smooth, light to darker brown, bi-layered wall, measure 21.1 × 14.0 µm, and have a length/width (L/W) ratio of 1.5; both micropyle and oöcyst residuum are absent, but a polar granule is present. Sporocysts are ellipsoidal, 9.9 × 6.1 µm, L/W 1.6; the Stieda body is present, but the sub-Stieda and para-Stieda bodies are absent and the sporocyst residuum is composed of small granules in a cluster...
February 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28129582/an-up-no-change-or-down-system-time-dependent-expression-of-mrnas-in-contused-skeletal-muscle-of-rats-used-for-wound-age-estimation
#20
Jun-Hong Sun, Xi-Yan Zhu, Ta-Na Dong, Xiao-Hong Zhang, Qi-Qing Liu, San-Qiang Li, Qiu-Xiang Du
The combined use of multiple markers is considered a promising strategy in estimating the age of wounds. We sought to develop an "up, no change, or down" system and to explore how to combine and use various parameters. In total, 78 Sprague Dawley rats were divided randomly into a control group and contusion groups of 4-, 8-, 12-, 16-, 20-, 24-, 28-, 32-, 36-, 40-, 44-, and 48-h post-injury (n=6 per group). A contusion was produced in the right limb of the rats under diethyl ether anesthesia by a drop-ball technique; the animals were sacrificed at certain time points thereafter, using a lethal dose of pentobarbital...
January 17, 2017: Forensic Science International
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