keyword
MENU ▼
Read by QxMD icon Read
search

Light box

keyword
https://www.readbyqxmd.com/read/27912874/the-anxiolytic-effect-of-essential-oil-of-cananga-odorata-exposure-on-mice-and-determination-of-its-major-active-constituents
#1
Nan Zhang, Lei Zhang, Linyin Feng, Lei Yao
BACKGROUND: Essential oil from Cananga odorata (ylang-ylang essential oil, YYO) is usually used in reducing blood pressure, improving cognitive functioning in aromatherapy in human. Few reports showed its effect on anxiety behaviors. HYPOTHESIS/PURPOSE: To investigate the anxiolytic effects of YYO exposure on anxiety animal models, determine the major active constituents and investigate the change of neurotransmitters after odor exposure. STUDY DESIGN AND METHODS: ICR mice were subjected to three anxiety models including open field, elevated plus maze and light-dark box tests after acute and chronic YYO exposure...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27899280/behavioural-phenotype-of-histamine-h4-receptor-knockout-mice-focus-on-central-neuronal-functions
#2
Maria Domenica Sanna, Carla Ghelardini, Robin L Thurmond, Emanuela Masini, Nicoletta Galeotti
The functional expression of H4 receptors (H4R) within neurons of the central nervous system has been recently reported, but their role is poorly understood. The present study aims to elucidate the role of neuronal H4R by providing the first description of the behavioural phenotype of H4R-deficient (H4R knockout, H4R-KO) mice. Mice lacking H4R underwent behavioural studies to evaluate locomotor activity, pain perception, anxiety, depression, memory and feeding behaviour. H4R-KO mice showed a significant increase in ambulation in an open field as well as in exploratory activity in the absence of any modification of motor coordination...
November 26, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27895577/fus1-ko-mouse-as-a-model-of-oxidative-stress-mediated-sporadic-alzheimer-s-disease-circadian-disruption-and-long-term-spatial-and-olfactory-memory-impairments
#3
Guillermo Coronas-Samano, Keeley L Baker, Winston J T Tan, Alla V Ivanova, Justus V Verhagen
Insufficient advances in the development of effective therapeutic treatments of sporadic Alzheimer's Disease (sAD) to date are largely due to the lack of sAD-relevant animal models. While the vast majority of models do recapitulate AD's hallmarks of plaques and tangles by virtue of tau and/or beta amyloid overexpression, these models do not reflect the fact that in sAD (unlike familial AD) these genes are not risk factors per se and that other mechanisms like oxidative stress, metabolic dysregulation and inflammation play key roles in AD etiology...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27893380/area-determination-of-diabetic-foot-ulcer-images-using-a-cascaded-two-stage-svm-based-classification
#4
Lei Wang, Peder Pedersen, Emmanuel Agu, Diane Strong, Bengisu Tulu
It is standard practice for clinicians and nurses to primarily assess patients' wounds via visual examination. This subjective method can be inaccurate in wound assessment and also represents a significant clinical workload. Hence, computer-based systems, especially implemented on mobile devices, can provide automatic, quantitative wound assessment and can thus be valuable for accurately monitoring wound healing status. Out of all wound assessment parameters, the measurement of the wound area is the most suitable for automated analysis...
November 23, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27892836/comparison-of-internal-adaptation-in-class-ii-bulk-fill-composite-restorations-using-micro-ct
#5
S H Han, S H Park
PURPOSE: This study compared the internal adaptation of bulk-fill composite restorations in class II cavities and explored the relationship between internal adaptation and polymerization shrinkage or stress. METHODS AND MATERIALS: Standardized mesio-occluso-distal cavities were prepared in 40 extracted human third molars and randomly divided into five groups (n=8). After having been applied by total-etch XP bond (Dentsply Caulk, Milford, DE, USA) and light curing, the teeth were restored with the following resin composites: group 1, Filtek Z350 (3M ESPE, St...
November 28, 2016: Operative Dentistry
https://www.readbyqxmd.com/read/27889482/the-red-light-receptor-phytochrome-b-directly-enhances-substrate-e3-ligase-interactions-to-attenuate-ethylene-responses
#6
Hui Shi, Xing Shen, Renlu Liu, Chang Xue, Ning Wei, Xing Wang Deng, Shangwei Zhong
Plants germinating under subterranean darkness assume skotomorphogenesis, a developmental program strengthened by ethylene in response to mechanical pressure of soil. Upon reaching the surface, light triggers a dramatic developmental transition termed de-etiolation that requires immediate termination of ethylene responses. Here, we report that light activation of photoreceptor phyB results in rapid degradation of EIN3, the master transcription factor in the ethylene signaling pathway. As a result, light rapidly and efficiently represses ethylene actions...
November 16, 2016: Developmental Cell
https://www.readbyqxmd.com/read/27886414/chronic-ghrelin-treatment-reduced-photophobia-and-anxiety-like-behaviors-in-ntg-induced-migraine-role-of-pituitary-adenylate-cyclase-activating-polypeptide
#7
Fereshteh Farajdokht, Shirin Babri, Pouran Karimi, Mohammad Reza Alipour, Ramin Bughchechi, Gisou Mohaddes
Chronic migraine is a debilitating disorder that has a significant impact on patients and society. Nearly all migraineurs frequently reported light sensitivity during a headache attack. Pituitary adenylate cyclase-activating polypeptide (PACAP) plays an important role in the activation of trigeminal system and migraine pain. To identify the effect of chronic ghrelin treatment on endogenous PACAP and associated symptoms of migraine, an experimental chronic migraine model was induced by intermittent intraperitoneal (i...
November 25, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27884756/repeated-unpredictable-threats-without-harm-impair-spatial-working-memory-in-the-barnes-maze
#8
Diane J Kim, Nathan St Louis, Ralph A Molaro, Glenn T Hudson, Robert C Chorley, Brenda J Anderson
Psychological stressors elicit the anticipation of homeostatic challenge, whereas physical stressors are direct threats to homeostasis. Many rodent models of stress include both types of stressors, yet deficits, like those reported for working memory, are often attributed to psychological stress. To empirically test whether intermittent psychological stressors, such as repeated threats, are solely sufficient to impair spatial working memory, we developed a novel rodent model of stress that is restricted to the anticipation of threat, and free of direct physical challenge...
November 21, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27877109/npas3-regulates-transcription-and-expression-of-vgf-implications-for-neurogenesis-and-psychiatric-disorders
#9
Dongxue Yang, Wenbo Zhang, Arshad Padhiar, Yao Yue, Yonghui Shi, Tiezheng Zheng, Kaspar Davis, Yu Zhang, Min Huang, Yuyuan Li, Li Sha
Neuronal PAS domain protein 3 (NPAS3) and VGF (VGF Nerve Growth Factor (NGF) Inducible) are important for neurogenesis and psychiatric disorders. Previously, we have demonstrated that NPAS3 regulates VGF at the transcriptional level. In this study, VGF (non-acronymic) was found regulated by NPAS3 in neuronal stem cells. However, the underlying mechanism of this regulation remains unclear. The aim of this study was to explore the correlation of NPAS3 and VGF, and their roles in neural cell proliferation, in the context of psychiatric illnesses...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27871097/association-of-impact-velocity-with-risks-of-serious-injuries-and-fatalities-to-pedestrians-in-commercial-truck-pedestrian-accidents
#10
Yasuhiro Matsui, Shoko Oikawa, Kazuhiro Sorimachi, Akira Imanishi, Takeshi Fujimura
This study aimed to clarify the relationship between truck-pedestrian crash impact velocity and the risks of serious injury and fatality to pedestrians. We used micro and macro truck-pedestrian accident data from the Japanese Institute for Traffic Accident Research and Data Analysis (ITARDA) database. We classified vehicle type into five categories: heavy-duty trucks (gross vehicle weight [GVW] ≥11 × 103 kg [11 tons (t)], medium-duty trucks (5 × 103 kg [5 t] ≤ GVW < 11 × 103 kg [11 t]), light-duty trucks (GVW <5 × 103 kg [5 t]), box vans, and sedans...
November 2016: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/27866991/parkinson-s-disease-like-motor-and-non-motor-symptoms-in-rotenone-treated-zebrafish
#11
Yali Wang, Wenwen Liu, Jing Yang, Fen Wang, Sima Yizhen, Zhao-Min Zhong, Han Wang, Li-Fang Hu, Chun-Feng Liu
The pesticide rotenone is widely used to produce Parkinson's disease (PD)-like symptoms in rodents, but few studies have examined whether rotenone-treated zebrafish can serve as an animal model of PD. Here, we report that 4 weeks of rotenone treatment induced motor and non-motor PD-like symptoms in adult zebrafish. Compared with control fish, rotenone-treated fish spent less time swimming at a fast speed, indicating a deficit in motor function. In the light-dark box test, rotenone-treated fish exhibited longer latencies to enter the dark compartment and spent more time in the light compartment, reflecting anxiety- and depression-like behavior...
November 17, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27866932/oxytocin-attenuates-aversive-response-to-nicotine-and-anxiety-like-behavior-in-adolescent-rats
#12
Hyunchan Lee, Minji Jang, Jihyun Noh
Initial tobacco use is initiated with rewarding and aversive properties of nicotine and aversive response to nicotine plays a critical role in nicotine dependency. Decrease of nicotine aversion increases the nicotine use that causes behavioral and neuronal changes of animals. Oxytocin influences drug abuse and reciprocally affect vulnerability to drug use. To assess the effect of oxytocin on initial nicotine aversion and anxiety, we examined voluntary oral nicotine intake and anxiety-like behavior following oxytocin treatment in adolescent rats...
November 17, 2016: Neuroscience Research
https://www.readbyqxmd.com/read/27863709/the-neuronal-basis-of-copper-induced-modulation-of-anxiety-state-in-rat
#13
Abbaoui Abdellatif, E L Hiba Omar, Gamrani Halima
Recently, studies have provided strong evidence indicating the involvement of trace elements in the physiopathology of psychiatric disorders, particularly anxiety. We aimed, through the present study, to describe the effect of acute exposure to Cu (10mg/kg BW) on anxiety state together with the serotoninergic and dopaminergic systems in rat by means of neurobehavioral tests (elevated plus maze, dark light box) and immunohistochemistry using anti-serotonin (5HT) and anti-tyrosine hydroxylase (TH). Our data report that Cu enhanced 5HT innervation in the dorsal raphe nucleus (DRN) together with a loss of TH expression within the ventral tegmental area (VTA), Substantia nigra compacta (SNc) and their subsequent outputs including the medial forebrain bundle (MFB) and striatum...
November 15, 2016: Acta Histochemica
https://www.readbyqxmd.com/read/27858514/involvement-of-sth7-in-light-adapted-development-in-arabidopsis-thaliana-promoted-by-both-strigolactone-and-karrikin
#14
Jutiporn Thussagunpanit, Yuko Nagai, Miyu Nagae, Kiyoshi Mashiguchi, Nobutaka Mitsuda, Masaru Ohme-Takagi, Takeshi Nakano, Hidemitsu Nakamura, Tadao Asami
Strigolactones (SLs) and karrikins (KARs) regulate photomorphogenesis. GR24, a synthetic SL and KAR1, a KAR, inhibit the hypocotyl elongation of Arabidopsis thaliana in a weak light. GR24 and KAR1 up-regulate the expression of STH7, encoding a transcription factor belonging to the double B-box zinc finger subfamily. In this study, we used STH7-overexpressing (STH7ox) lines and functionally defective STH7 (STH7-SRDX) mutants to investigate roles of SLs and KARs in photomorphogenesis of Arabidopsis. Hypocotyl elongation of STH7-SRDX mutants was less sensitive to both GR24 and KAR1 treatment than that of wild-type Arabidopsis under weak light conditions...
November 18, 2016: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/27854312/berberine-suppresses-cyclin-d1-expression-through-proteasomal-degradation-in-human-hepatoma-cells
#15
Ning Wang, Xuanbin Wang, Hor-Yue Tan, Sha Li, Chi Man Tsang, Sai-Wah Tsao, Yibin Feng
The aim of this study is to explore the underlying mechanism on berberine-induced Cyclin D1 degradation in human hepatic carcinoma. We observed that berberine could suppress both in vitro and in vivo expression of Cyclin D1 in hepatoma cells. Berberine exhibits dose- and time-dependent inhibition on Cyclin D1 expression in human hepatoma cell HepG2. Berberine increases the phosphorylation of Cyclin D1 at Thr286 site and potentiates Cyclin D1 nuclear export to cytoplasm for proteasomal degradation. In addition, berberine recruits the Skp, Cullin, F-box containing complex-β-Transducin Repeat Containing Protein (SCF(β-TrCP)) complex to facilitate Cyclin D1 ubiquitin-proteasome dependent proteolysis...
November 15, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27845603/effects-of-light-regime-and-substrain-on-behavioral-profiles-of-male-c57bl-6-mice-in-three-tests-of-unconditioned-anxiety
#16
Maaike Labots, Xiaochu Zheng, Golnaz Moattari, Frauke Ohl, Hein A van Lith
Substrains of the C57BL/6 inbred mouse are widely used in genetic, behavioral and physiological research, as well as models for human disease. Throughout, the choice of the respective substrain can have a large influence on experimental results. Likewise, the conditions under which experiments are performed, such as the light regime, can significantly affect the outcome of an experiment, especially when aiming at experimental behavior. Here, two commonly used mouse substrains, C57BL/6JOlaHsd and C57BL/6NCrl, were housed under either a conventional or a reverse light regime and were tested in either the light phase or the dark phase, respectively...
November 15, 2016: Journal of Neurogenetics
https://www.readbyqxmd.com/read/27833145/impacts-of-brown-carbon-from-biomass-burning-on-surface-uv-and-ozone-photochemistry-in-the-amazon-basin
#17
Jungbin Mok, Nickolay A Krotkov, Antti Arola, Omar Torres, Hiren Jethva, Marcos Andrade, Gordon Labow, Thomas F Eck, Zhanqing Li, Russell R Dickerson, Georgiy L Stenchikov, Sergey Osipov, Xinrong Ren
The spectral dependence of light absorption by atmospheric particulate matter has major implications for air quality and climate forcing, but remains uncertain especially in tropical areas with extensive biomass burning. In the September-October 2007 biomass-burning season in Santa Cruz, Bolivia, we studied light absorbing (chromophoric) organic or "brown" carbon (BrC) with surface and space-based remote sensing. We found that BrC has negligible absorption at visible wavelengths, but significant absorption and strong spectral dependence at UV wavelengths...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27818729/maternal-nicotine-exposure-during-late-gestation-and-lactation-increases-anxiety-like-and-impulsive-decision-making-behavior-in-adolescent-offspring-of-rat
#18
Hyunchan Lee, Sooyeon Chung, Jihyun Noh
Prenatal nicotine exposure over an entire pregnancy has been associated with an increased prevalence of hyperactivity, anxiety-like behavior and depression-like behavior in mature rats. However, the effects of maternal nicotine exposure in late gestation and lactation on the psychology and behavior of adolescent rat offspring are unclear. Thus, we investigated the effect of nicotine exposure during late gestation and lactation on anxiety-like and impulsive decision-making behavior in adolescent offspring of rat...
October 2016: Toxicological Research
https://www.readbyqxmd.com/read/27806608/beam-monitor-calibration-in-scanned-light-ion-beams
#19
Hugo Palmans, Stanislav M Vatnitsky
PURPOSE: To propose a formalism for the reference dosimetry of scanned light-ion beams consistent with IAEA TRS-398 and Alfonso et al. [Med. Phys. 35, 5179-5186 (2008)]. To identify machine-specific reference (msr) fields and plan-class specific reference (pcsr) fields consistent with the definitions given by Alfonso et al. To review the literature of beam monitor calibration in scanned beams using three different methods in terms of this common formalism. METHODS: Four types of msr fields are identified as those that are meant to calibrate the beam monitor for scanned beams with particular energies...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27801508/long-lasting-effects-of-chronic-intermittent-alcohol-exposure-in-adolescent-mice-on-object-recognition-and-hippocampal-neuronal-activity
#20
Gregory Beaudet, Samuel Valable, Joanna Bourgine, Véronique Lelong-Boulouard, Laurence Lanfumey, Thomas Freret, Michel Boulouard, Eleni Paizanis
BACKGROUND: Binge drinking is popular and highly prevalent in teenagers. However, the long-term cognitive and neurobiological consequences of such practices are not yet fully understood. In this context, we therefore assessed in mice whether a chronic intermittent alcohol (CIA) exposure in adolescence had long-term consequences on object discrimination and memory performances, emotional behaviors, brain activity, and morphology. METHODS: C57BL/6JRj mice were treated with either saline or ethanol (EtOH) (2 g/kg/d, i...
December 2016: Alcoholism, Clinical and Experimental Research
keyword
keyword
25136
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"