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https://www.readbyqxmd.com/read/28736168/light-dependent-degradation-of-pif3-by-scf-ebf1-2-promotes-a-photomorphogenic-response-in-arabidopsis
#1
Jie Dong, Weimin Ni, Renbo Yu, Xing Wang Deng, Haodong Chen, Ning Wei
Plant seedlings emerging from darkness into the light environment undergo photomorphogenesis, which enables autotrophic growth with optimized morphology and physiology. During this transition, plants must rapidly remove photomorphogenic repressors accumulated in the dark. Among them is PHYTOCHROME-INTERACTING FACTOR 3 (PIF3), a key transcription factor promoting hypocotyl growth. Here we report that, in response to light activation of phytochrome photoreceptors, EIN3-BINDING F BOX PROTEINs (EBFs) 1 and 2 mediate PIF3 protein degradation in a manner dependent on light-induced phosphorylation of PIF3...
July 18, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28733463/tlr4-and-c5ar-crosstalk-in-dendritic-cells-induces-a-core-regulatory-network-of-rsk2-pi3k%C3%AE-sgk1-and-foxo-transcription-factors
#2
Anouk Zaal, Benjamin Nota, Kat S Moore, Miranda Dieker, S Marieke van Ham, Anja Ten Brinke
Crosstalk between complement component 5a receptors (C5aRs) and TLRs in dendritic cells (DCs) occurs upon pathogen invasion; however, studies on C5aR and TLR crosstalk mainly focused on the modulating effect of C5a on TLR-induced cytokine production. To elucidate the breadth of C5aR and TLR4 crosstalk, the effect of simultaneous treatment with C5a and LPS was investigated in human monocyte-derived DCs (moDCs) 2 h after stimulation using whole transcriptome sequencing analysis. Although the effect of C5a on hallmark genes defining TLR4-induced DC maturation was limited at this time point, RNA sequencing analysis revealed a great variety of novel C5a targets, of which many interfere with TLR4-mediated immune activation...
July 21, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28729845/negative-affect-and-excessive-alcohol-intake-incubate-during-protracted-withdrawal-from-binge-drinking-in-adolescent-but-not-adult-mice
#3
Kaziya M Lee, Michal A Coehlo, Noah R Solton, Karen K Szumlinski
Binge-drinking is common in underage alcohol users, yet we know little regarding the biopsychological impact of binge-drinking during early periods of development. Prior work indicated that adolescent male C57BL6/J mice with a 2-week history of binge-drinking (PND28-41) are resilient to the anxiogenic effects of early alcohol withdrawal. Herein, we employed a comparable Drinking-in-the-Dark model to determine how a prior history of binge-drinking during adolescence (EtOH(adolescents)) influences emotionality (assayed with the light-dark box, marble burying test, and the forced swim test) and the propensity to consume alcohol in later life, compared to animals without prior drinking experience...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28711308/the-impact-of-scopolamine-pretreatment-on-3-iodothyronamine-t1am-effects-on-memory-and-pain-in-mice
#4
Annunziatina Laurino, Ersilia Lucenteforte, Gaetano De Siena, Laura Raimondi
We previously demonstrated that 3-iodothyronamine (T1AM), a by-product of thyroid hormone metabolism, pharmacologically administered to mice acutely stimulated learning and memory acquisition and provided hyperalgesia with a mechanism which remains to be defined. We now aimed to investigate whether the T1AM effect on memory and pain was maintained in mice pre-treated with scopolamine, a non-selective muscarinic antagonist expected to induce amnesia and, possibly, hyperalgesia. Mice were pre-treated with scopolamine and, after 20min, injected intracerebroventricularly (i...
July 19, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28707896/smart-floor-with-integrated-triboelectric-nanogenerator-as-energy-harvester-and-motion-sensor
#5
Chuan He, Weijun Zhu, Baodong Chen, Liang Xu, Tao Jiang, Chang Bao Han, Guang Qin Gu, Dichen Li, Zhong Lin Wang
A smart floor is demonstrated by integrating a square-frame triboelectric nanogenerator (SF-TENG) into a standard wood floor. The smart floor has two working modes based on two pairs of triboelectric materials: one is purposely chosen polytetrafluoroethylene (PTFE) films and aluminum (Al) balls, the other is the floor itself and the objects that can be triboelectrically charged, such as basketball, shoe soles, and scotch tape, etc. Utilizing the Al balls enclosed inside shallow boxes, the smart floor is capable of harvesting vibrational energy, hence provides a non-intrusive way to detect the sudden fall of the elderly...
July 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28705607/noise-induced-hearing-loss-induces-loudness-intolerance-in-a-rat-active-sound-avoidance-paradigm-asap
#6
Senthilvelan Manohar, Jaclyn Spoth, Kelly Radziwon, Benjamin D Auerbach, Richard Salvi
Hyperacusis is a loudness hypersensitivity disorder in which moderate-intensity sounds are perceived as extremely loud, aversive and/or painful. To assess the aversive nature of sounds, we developed an Active Sound Avoidance Paradigm (ASAP) in which rats altered their place preference in a Light/Dark shuttle box in response to sound. When no sound (NS) was present, rats spent more than 95% of the time in the Dark Box versus the transparent Light Box. However, when a 60 or 90 dB SPL noise (2-20 kHz, 2-8 kHz, or 16-20 kHz bandwidth) was presented in the Dark Box, the rats'' preference for the Dark Box significantly decreased...
July 8, 2017: Hearing Research
https://www.readbyqxmd.com/read/28698532/a-smartphone-based-automatic-measurement-method-for-colorimetric-ph-detection-using-a-color-adaptation-algorithm
#7
Sung Deuk Kim, Youngmi Koo, Yeoheung Yun
This paper proposes a smartphone-based colorimetric pH detection method using a color adaptation algorithm for point-of-care applications. Although a smartphone camera can be utilized to measure the color information of colorimetric sensors, ambient light changes and unknown built-in automatic image correction operations make it difficult to obtain stable color information. This paper utilizes a 3D printed mini light box and performs a calibration procedure with a paper-printed comparison chart and a reference image which overcomes the drawbacks of smartphone cameras and the difficulty in preparing for the calibration procedure...
July 10, 2017: Sensors
https://www.readbyqxmd.com/read/28695280/effect-of-post-weaning-isolation-on-anxiety-and-depressive-like-behaviors-of-c57bl-6j-mice
#8
Qian Huang, Ying Zhou, Lin-Yun Liu
Effects of post-weaning isolation on depressive- and anxiety-like behaviors in rodents have been well studied in the past. However, few studies included both sexes in a single experiment to study the sex difference in this animal model. The present study investigated the effect of post-weaning isolation on anxiety- and depressive-like behaviors in both male and female C57BL/6 J mice. Mice were individually or grouped housed from postnatal day 21 for 5 weeks until behavioral tests began. The results showed that social isolation resulted in increased anxiety in the open field...
July 10, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28692534/blood-neuron-derived-exosomes-as-biomarkers-of-cognitive-impairment-in-hiv
#9
Bing Sun, Pranjali Dalvi, Linda Abadjian, Norina Tang, Lynn Pulliam
OBJECTIVE: To investigate proteins associated with neuronal damage in plasma neuron-derived exosomes (NDE) of HIV-infected subjects as a liquid biomarker for cognitive impairment. METHODS: Plasma NDE were isolated using precipitation and immunoadsorption with antibody to a cell surface specific neuronal marker. Total exosomes and NDE were enumerated, characterized and proteins extracted and targets quantified by ELISA. RESULTS: Plasma NDE from 23 HIV seropositive individuals of which 11 had mild cognitive impairment, and 12 HIV seronegative controls of which 3 had cognitive impairment were isolated...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28687902/decreased-brain-serotonin-turnover-rate-following-administration-of-sharbat-e-ahmed-shah-produces-antidepressant-and-anxiolytic-effect-in-rats
#10
Muhammad Ahmed, Aisha Azmat
Sharbat-e-Ahmed Shah (SAS) has usually been used in Traditional Unani Medicine (TUM) for depression and insomnia but still not evaluated for its anti-depressant and Neuropharmacological activity. In the present study, a Human dose of SAS (0.6 ml/kg/d) was administered orally to the rats for 15 consecutive days. Antidepressant and anxiolytic were screened scientifically in rats by using Forced swim test and light and dark box test. At the end of study high-performance liquid chromatographic (HPLC) method with electrochemical (EC) detector was used for the measurement of blood and brain tryptophan and brain serotonin levels...
July 7, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28687557/a-pif1-pif3-hy5-bbx23-transcription-factor-cascade-affects-photomorphogenesis
#11
Xinyu Zhang, Fangfang Shang, Junling Huai, Gang Xu, Weijiang Tang, Yanjun Jing, Rongcheng Lin
Light signaling plays an essential role in controlling higher plants' early developmental process termed as photomorphogenesis. Transcriptional regulation is a vital mechanism that is orchestrated by transcription factors and other regulatory proteins working in concert to finely tune gene expression. Although many transcription factors/regulators have been characterized in the light signaling pathway, their inter-regulation remains largely unknown. Here, we show that PHYTOCHROME-INTERACTING FACTOR 3 (PIF3) and PIF1 transcription factors directly bind to the regulatory regions of ELONGATED HYPOCOTYL5 (HY5) and a B-box gene BBX23 and activate their expression in Arabidopsis thaliana...
July 7, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28687316/levodopa-l-dopa-attenuates-endoplasmic-reticulum-stress-response-and-cell-death-signaling-through-drd2-in-sh-sy5y-neuronal-cells-under-%C3%AE-synuclein-induced-toxicity
#12
Juhyun Song, Byeong C Kim, Dai-Trang T Nguyen, Manikandan Samidurai, Seong-Min Choi
Parkinson's disease (PD) is characterized by the formation of Lewy bodies (LBs) in dopaminergic neurons. α-Synuclein (α-syn), a major protein component of LBs, is known to regulate synaptic plasticity, with a crucial role in memory and motor function in the central nervous system. Levodopa (L-3,4-dihydroxyphenylalanine; also known as L-DOPA) is considered the most effective medication for controlling the symptoms of PD. However, it is unclear whether L-DOPA improves the neuropathology of PD. In the present study, we investigated the effect of L-DOPA on SH-SY5Y neuronal cells under α-syn-induced toxicity...
July 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/28667338/accurate-strain-sensing-based-on-super-mode-interference-in-strongly-coupled-multi-core-optical-fibres
#13
Joel Villatoro, Oskar Arrizabalaga, Gaizka Durana, Idurre Sáez de Ocáriz, Enrique Antonio-Lopez, Joseba Zubia, Axel Schülzgen, Rodrigo Amezcua-Correa
We report on the use of a multi-core fibre (MCF) comprising strongly-coupled cores for accurate strain sensing. Our MCF is designed to mode match a standard single mode optical fibre. This allows us to fabricate simple MCF interferometers whose interrogation is carried out with light sources, detectors and fibre components readily available from the optical communications tool box. Our MCF interferometers were used for sensing strain. The sensor calibration was carried out in a high-fidelity aerospace test laboratory...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28663116/short-term-selection-for-high-and-low-ethanol-intake-yields-differential-sensitivity-to-ethanol-s-motivational-effects-and-anxiety-like-responses-in-adolescent-wistar-rats
#14
Macarena Soledad Fernández, Bárbara Báez, Ana Bordón, Laura Espinosa, Eliana Martínez, Ricardo Marcos Pautassi
Alcohol use disorders are modulated by genetic factors, but the identification of specific genes and their concomitant biological changes that are associated with a higher risk for these disorders has proven difficult. Alterations in the sensitivity to the motivational effects of ethanol may be one way by which genes modulate the initiation and escalation of ethanol intake. Rats and mice have been selectively bred for high and low ethanol consumption during adulthood. However, selective breeding programs for ethanol intake have not focused on adolescence...
June 27, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28662189/affective-and-cognitive-behavior-in-the-alpha-galactosidase-a-deficient-mouse-model-of-fabry-disease
#15
Lukas Hofmann, Franziska Karl, Claudia Sommer, Nurcan Üçeyler
Fabry disease is an X-linked inherited lysosomal storage disorder with intracellular accumulation of globotriaosylceramide (Gb3) due to α-galactosidase A (α-Gal A) deficiency. Fabry patients frequently report of anxiety, depression, and impaired cognitive function. We characterized affective and cognitive phenotype of male mice with α-Gal A deficiency (Fabry KO) and compared results with those of age-matched male wildtype (WT) littermates. Young (3 months) and old (≥ 18 months) mice were tested in the naïve state and after i...
2017: PloS One
https://www.readbyqxmd.com/read/28659534/photo-degradation-ibuprofen-by-uv-h2o2-process-response-surface-analysis-and-degradation-mechanism
#16
Mingguo Peng, Huajie Li, Xu Kang, Erdeng Du, Dongdong Li
The removal of ibuprofen (IBP) in aqueous solution using UV/H2O2 process was evaluated. The response surface methodology (RSM) and Box-Behnken design were employed to investigate the effects of process parameters on IBP removal, including the initial IBP concentration, H2O2 dosage, UV light intensity, and initial pH value of solution. The RSM model developed herein fits well with the experiments, and provides a good insight into the OH radical irritated degradation mechanisms and kinetics. High resolution accurate mass spectrometry coupled with liquid chromatography was used to identify the degradation intermediates...
June 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28655697/banana-fruit-pulp-and-peel-involved-in-antianxiety-and-antidepressant-effects-while-invigorate-memory-performance-in-male-mice-possible-role-of-potential-antioxidants
#17
Noreen Samad, Aqsa Muneer, Najeeb Ullah, Aqal Zaman, M Mazhar Ayaz, Ijaz Ahmad
The present study was aimed to investigate the anti-stress and memory enhancing effects of banana (Musa sapientum L.) fruit pulp and peel extract in male mice. Locally bred albino Wistar mice were divided into control and 2 test groups (n=10). Control rats received drinking water while test groups were treated with banana fruit pulp (600 mg/kg; oral administration) and extract of banana peel (400mg/kg; oral administration). Behavioral activities of animals were monitored 14 days post administration of banana pulp and peel extract...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28655515/early-life-lipopolysaccharide-exposure-potentiates-forebrain-expression-of-nlrp3-inflammasome-proteins-and-anxiety-like-behavior-in-adolescent-rats
#18
Yuan Lei, Chu-Jun Chen, Xiao-Xin Yan, Zhiyuan Li, Xiao-Hua Deng
BACKGROUND: Neonatal inflammation may affect brain development and lead to cognitive and emotional deficits at adolescence and adulthood. The nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) is the core component of NLRP3 inflammasome, which may involve in neuroinflammation. We explored if early-life exposure to the bacterial endotoxin lipopolysaccharide (LPS) could promote the expression of proteins related to NLRP3 inflammasome, including NLRP3, the apoptosis-associated speck-like protein (ASC) and cysteiny aspartate-specific protease (Caspase-1) in the forebrain and behavioral alteration in adolescent rats...
June 24, 2017: Brain Research
https://www.readbyqxmd.com/read/28654316/active-gaming-as-a-form-of-exercise-to-induce-hypoalgesia
#19
Christopher Carey, Keith E Naugle, Dania Aqeel, Thomas Ohlman, Kelly M Naugle
OBJECTIVE: An acute bout of moderate-to-vigorous exercise temporarily reduces pain sensitivity in healthy adults. Recently, active gaming has been rising in popularity as a means of light-to-moderate exercise and may be particularly suitable for deconditioned individuals. Whether the physical activity elicited in active games can produce a hypoalgesic effect remains unknown. The purpose of this study was to determine whether active videogames can reduce pressure and heat pain sensitivity in healthy adults...
June 27, 2017: Games for Health
https://www.readbyqxmd.com/read/28654040/video-tracking-protocol-to-screen-deterrent-chemistries-for-honey-bees
#20
Nicholas R Larson, Troy D Anderson
The European honey bee, Apis mellifera L., is an economically and agriculturally important pollinator that generates billions of dollars annually. Honey bee colony numbers have been declining in the United States and many European countries since 1947. A number of factors play a role in this decline, including the unintentional exposure of honey bees to pesticides. The development of new methods and regulations are warranted to reduce pesticide exposures to these pollinators. One approach is the use of repellent chemistries that deter honey bees from a recently pesticide-treated crop...
June 12, 2017: Journal of Visualized Experiments: JoVE
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