Kosuke Yamazaki, Tomohiro Iguchi, Yutaka Kanoh, Kazuto Takayasu, Trinh Thi To Ngo, Ayaka Onuki, Hideya Kawaji, Shunji Oshima, Tomomasa Kanda, Hisao Masai, Hiroyuki Sasanuma
Acetaldehyde, a chemical that can cause DNA damage and contribute to cancer, is prevalently present in our environment, e.g. in alcohol, tobacco, and food. Although aldehyde potentially promotes crosslinking reactions among biological substances including DNA, RNA, and protein, it remains unclear what types of DNA damage are caused by acetaldehyde and how they are repaired. In this study, we explored mechanisms involved in the repair of acetaldehyde-induced DNA damage by examining the cellular sensitivity to acetaldehyde in the collection of human TK6 mutant deficient in each genome maintenance system...
April 3, 2024: Cell Cycle