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Audrey Long

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https://www.readbyqxmd.com/read/29915430/a-transcriptome-wide-association-study-of-229-000-women-identifies-new-candidate-susceptibility-genes-for-breast-cancer
#1
Lang Wu, Wei Shi, Jirong Long, Xingyi Guo, Kyriaki Michailidou, Jonathan Beesley, Manjeet K Bolla, Xiao-Ou Shu, Yingchang Lu, Qiuyin Cai, Fares Al-Ejeh, Esdy Rozali, Qin Wang, Joe Dennis, Bingshan Li, Chenjie Zeng, Helian Feng, Alexander Gusev, Richard T Barfield, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J Aronson, Paul L Auer, Myrto Barrdahl, Caroline Baynes, Matthias W Beckmann, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Natalia V Bogdanova, Stig E Bojesen, Hiltrud Brauch, Hermann Brenner, Louise Brinton, Per Broberg, Sara Y Brucker, Barbara Burwinkel, Trinidad Caldés, Federico Canzian, Brian D Carter, J Esteban Castelao, Jenny Chang-Claude, Xiaoqing Chen, Ting-Yuan David Cheng, Hans Christiansen, Christine L Clarke, Margriet Collée, Sten Cornelissen, Fergus J Couch, David Cox, Angela Cox, Simon S Cross, Julie M Cunningham, Kamila Czene, Mary B Daly, Peter Devilee, Kimberly F Doheny, Thilo Dörk, Isabel Dos-Santos-Silva, Martine Dumont, Miriam Dwek, Diana M Eccles, Ursula Eilber, A Heather Eliassen, Christoph Engel, Mikael Eriksson, Laura Fachal, Peter A Fasching, Jonine Figueroa, Dieter Flesch-Janys, Olivia Fletcher, Henrik Flyger, Lin Fritschi, Marike Gabrielson, Manuela Gago-Dominguez, Susan M Gapstur, Montserrat García-Closas, Mia M Gaudet, Maya Ghoussaini, Graham G Giles, Mark S Goldberg, David E Goldgar, Anna González-Neira, Pascal Guénel, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Per Hall, Emily Hallberg, Ute Hamann, Patricia Harrington, Alexander Hein, Belynda Hicks, Peter Hillemanns, Antoinette Hollestelle, Robert N Hoover, John L Hopper, Guanmengqian Huang, Keith Humphreys, David J Hunter, Anna Jakubowska, Wolfgang Janni, Esther M John, Nichola Johnson, Kristine Jones, Michael E Jones, Audrey Jung, Rudolf Kaaks, Michael J Kerin, Elza Khusnutdinova, Veli-Matti Kosma, Vessela N Kristensen, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Sara Lindström, Jolanta Lissowska, Wing-Yee Lo, Sibylle Loibl, Jan Lubinski, Craig Luccarini, Michael P Lux, Robert J MacInnis, Tom Maishman, Ivana Maleva Kostovska, Arto Mannermaa, JoAnn E Manson, Sara Margolin, Dimitrios Mavroudis, Hanne Meijers-Heijboer, Alfons Meindl, Usha Menon, Jeffery Meyer, Anna Marie Mulligan, Susan L Neuhausen, Heli Nevanlinna, Patrick Neven, Sune F Nielsen, Børge G Nordestgaard, Olufunmilayo I Olopade, Janet E Olson, Håkan Olsson, Paolo Peterlongo, Julian Peto, Dijana Plaseska-Karanfilska, Ross Prentice, Nadege Presneau, Katri Pylkäs, Brigitte Rack, Paolo Radice, Nazneen Rahman, Gad Rennert, Hedy S Rennert, Valerie Rhenius, Atocha Romero, Jane Romm, Anja Rudolph, Emmanouil Saloustros, Dale P Sandler, Elinor J Sawyer, Marjanka K Schmidt, Rita K Schmutzler, Andreas Schneeweiss, Rodney J Scott, Christopher G Scott, Sheila Seal, Mitul Shah, Martha J Shrubsole, Ann Smeets, Melissa C Southey, John J Spinelli, Jennifer Stone, Harald Surowy, Anthony J Swerdlow, Rulla M Tamimi, William Tapper, Jack A Taylor, Mary Beth Terry, Daniel C Tessier, Abigail Thomas, Kathrin Thöne, Rob A E M Tollenaar, Diana Torres, Thérèse Truong, Michael Untch, Celine Vachon, David Van Den Berg, Daniel Vincent, Quinten Waisfisz, Clarice R Weinberg, Camilla Wendt, Alice S Whittemore, Hans Wildiers, Walter C Willett, Robert Winqvist, Alicja Wolk, Lucy Xia, Xiaohong R Yang, Argyrios Ziogas, Elad Ziv, Alison M Dunning, Paul D P Pharoah, Jacques Simard, Roger L Milne, Stacey L Edwards, Peter Kraft, Douglas F Easton, Georgia Chenevix-Trench, Wei Zheng
The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify novel risk loci and likely causal genes, we performed a transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer risk in 122,977 cases and 105,974 controls of European ancestry. We used data from the Genotype-Tissue Expression Project to establish genetic models to predict gene expression in breast tissue and evaluated model performance using data from The Cancer Genome Atlas...
June 18, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29914867/progression-of-hypertrophy-and-myocardial-fibrosis-in-aortic-stenosis-a-multicenter-cardiac-magnetic-resonance-study
#2
Russell J Everett, Lionel Tastet, Marie-Annick Clavel, Calvin W L Chin, Romain Capoulade, Vassilios S Vassiliou, Jacek Kwiecinski, Miquel Gomez, Edwin J R van Beek, Audrey C White, Sanjay K Prasad, Eric Larose, Christopher Tuck, Scott Semple, David E Newby, Philippe Pibarot, Marc R Dweck
BACKGROUND: Aortic stenosis is accompanied by progressive left ventricular hypertrophy and fibrosis. We investigated the natural history of these processes in asymptomatic patients and their potential reversal post-aortic valve replacement (AVR). METHODS: Asymptomatic and symptomatic patients with aortic stenosis underwent repeat echocardiography and magnetic resonance imaging. Changes in peak aortic-jet velocity, left ventricular mass index, diffuse fibrosis (indexed extracellular volume), and replacement fibrosis (late gadolinium enhancement [LGE]) were quantified...
June 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29890906/the-effectiveness-of-using-neurofeedback-in-the-treatment-of-post-traumatic-stress-disorder-a-systematic-review
#3
Lisa S Panisch, Audrey Hang Hai
Neurofeedback is an innovative treatment for post-traumatic stress disorder (PTSD) that is readily accessible to mental health therapists. As a widespread mental health concern with potentially devastating long-term consequences on psychosocial functioning, PTSD can also adversely impact biophysiological processes, particularly those related to the brain. Neurofeedback has shown promise in alleviating overall PTSD symptoms, including these underlying neurobiological consequences. Successful results have been found among clients with PTSD who have not been responsive to prior treatment modalities...
January 1, 2018: Trauma, Violence & Abuse
https://www.readbyqxmd.com/read/29888007/feasibility-safety-and-preliminary-effectiveness-of-a-home-based-self-managed-high-intensity-interval-training-program-offered-to-long-term-manual-wheelchair-users
#4
Cindy Gauthier, Rachel Brosseau, Audrey L Hicks, Dany H Gagnon
Objectives: To investigate and compare the feasibility, safety, and preliminary effectiveness of home-based self-managed manual wheelchair high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) programs. Methods: Eleven manual wheelchair users were randomly assigned to the HIIT ( n = 6) or the MICT group ( n = 5). Both six-week programs consisted of three 40-minute propulsion training sessions per week. The HIIT group alternated between 30 s high-intensity intervals and 60 s low-intensity intervals, whereas the MICT group maintained a constant moderate intensity...
2018: Rehabilitation Research and Practice
https://www.readbyqxmd.com/read/29874471/dog-bite-injuries-of-the-eye-and-ocular-adnexa
#5
Benjamin P Erickson, Paula W Feng, Sophie D Liao, Yasha S Modi, Audrey C Ko, Wendy W Lee
Dog bites result in a diverse range of injuries and complications in the periocular region, particularly in school aged children. It is therefore incumbent on the oculoplastic surgeon to be well versed in both acute and long-term management. The intent of this review is to provide a systematic evaluation of the epidemiology, principles of dog bite wound care, and specific considerations related to common patterns of ophthalmic injury. Review of clinical literature from 1976 to 2014. The majority of periocular injuries result from seemingly benign interactions between young children and familiar dogs...
June 6, 2018: Orbit
https://www.readbyqxmd.com/read/29858200/improving-the-precepting-experience-in-a-burn-intensive-care-unit
#6
Amber Thompson, Maria Gonzales, Chelsea Bair, Sarah Ayers, Heather Mountain, Ashley Wrightenberry, Catherine Nevins, Audrey Boyles, Melanie Poe, Loree Kimball, Rayna Gorisek, Linda Long, Chris Turner
No abstract text is available yet for this article.
June 2018: Critical Care Nurse
https://www.readbyqxmd.com/read/29851204/safety-and-efficacy-of-vesatolimod-gs-9620-in-patients-with-chronic-hepatitis-b-who-are-not-currently-on-antiviral-treatment
#7
Kosh Agarwal, Sang Hoon Ahn, Magdy Elkhashab, Audrey H Lau, Anuj Gaggar, Anuradha Bulusu, Xinyu Tian, Andrea L Cathcart, Jacky Woo, G Mani Subramanian, Pietro Andreone, Hyung Joon Kim, Wan Long Chuang, Mindie H Nguyen
Vesatolimod is an oral agonist of toll-like receptor 7 designed to minimize systemic exposure and side effects. We assessed the safety and efficacy of vesatolimod in viremic chronic hepatitis B (CHB) patients not currently on oral antiviral treatment (OAV) in a Phase 2, multicenter, double-blind, randomized, placebo-controlled study. METHODS: 192 patients stratified by HBeAg status and alanine aminotransferase level were randomized 2:2:2:1 to receive oral vesatolimod (1-, 2-, or 4-mg) or placebo once weekly for 12 weeks; tenofovir disoproxil fumarate (300-mg daily) was administered daily for 48 weeks...
May 31, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29807186/optimal-post-operative-immobilisation-for-supracondylar-humeral-fractures
#8
Lucas Azzolin, Audrey Angelliaume, Luke Harper, Abdelfettah Lalioui, Anaïs Delgove, Yan Lefèvre
BACKGROUND: Supracondylar humeral fractures (SCHFs) are very common in paediatric patients. In France, percutaneous fixation with two lateral-entry pins is widely used after successful closed reduction. Post-operative immobilisation is typically with a long arm cast combined with a tubular-bandage sling that immobilises the shoulder and holds the arm in adduction and internal rotation to prevent external rotation of the shoulder, which might cause secondary displacement. The objective of this study was to compare this standard immobilisation technique to a posterior plaster splint with a simple sling...
May 25, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29800758/personal-and-perceived-public-mental-health-stigma-as-predictors-of-help-seeking-intentions-in-adolescents
#9
Finiki A Nearchou, Niamh Bird, Audrey Costello, Sophie Duggan, Jessica Gilroy, Roisin Long, Laura McHugh, Eilis Hennessy
This study aimed to determine predictors of help-seeking intentions for symptoms of depression/anxiety and self-harm in adolescents. It focused on personal and perceived public stigma to gather data of value for the design of anti-stigma interventions. Participants (n = 722; 368 girls) were recruited from three cohorts of secondary school students in Ireland (mean ages: 1st = 12.9 years; 3rd = 14.9 years; 5th = 16.6 years). Hierarchical regression models indicated that perceived public stigma is a significant unique predictor of help-seeking intentions for depression [F(4, 717) = 13...
May 22, 2018: Journal of Adolescence
https://www.readbyqxmd.com/read/29800673/long-term-follow-up-of-de-novo-chronic-phase-chronic-myelogenous-leukemia-patients-on-imatinib-first-line
#10
Franck Emmanuel Nicolini, Vincent Alcazer, Pascale Cony-Makhoul, Maël Heiblig, Stéphane Morisset, Gaëlle Fossard, Audrey Bidet, Anna Schmitt, Mohamad Sobh, Sandrine Hayette, François-Xavier Mahon, Stéphanie Dulucq, Gabriel Etienne
For the last 15 years, Imatinib mesylate (IM) has represented the gold standard treatment for chronic phase chronic myelogenous leukemia, however outcomes in the very long-term remain unknown. We retrospectively analyzed the outcome of 418 imatinib-first line CP-CML patients followed in 3 reference centers over 15 years, in and outside clinical trials, believed to represent the "real-life" care of such patients. Molecular analyses were standardized over the years. In case of intolerance or resistance or IM cessation and progression, all clinical data were available, collected and analyzed...
May 22, 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29800287/seafood-intake-sexual-activity-and-time-to-pregnancy
#11
Audrey J Gaskins, Rajeshwari Sundaram, Germaine M Buck Louis, Jorge E Chavarro
Context: Marine long-chain omega-3 fatty acids have been positively related to markers of fecundity in both men and women. However, seafood, their primary food source, can also be a source of toxicants, which may counteract the reproductive benefits. Objective: To examine the relationship of male and female seafood intake with time to pregnancy (TTP). Design: Our prospective cohort study included 501 couples planning pregnancy who participated in the Longitudinal Investigation of Fertility and the Environment Study (2005-2009) and were followed for up to1 year or until pregnancy was detected...
May 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29764856/-tp53-stk11-and-egfr-mutations-predict-tumor-immune-profile-and-the-response-to-anti-pd-1-in-lung-adenocarcinoma
#12
Jerome Biton, Audrey Mansuet-Lupo, Nicolas Pécuchet, Marco Alifano, Hanane Ouakrim, Jennifer Arrondeau, Pascaline Boudou-Rouquette, Francois Goldwasser, Karen Leroy, Jeremy Goc, Marie Wislez, Claire Germain, Pierre Laurent-Puig, Marie-Caroline Dieu-Nosjean, Isabelle Cremer, Ronald Herbst, Hélène F Blons, Diane Damotte
PURPOSE: By unlocking anti-tumor immunity, antibodies targeting programmed cell death 1 (PD-1) exhibit impressive clinical results in non-small cell lung cancer, underlining the strong interactions between tumor and immune cells. However, factors that can robustly predict long-lasting responses are still needed. EXPERIMENTAL DESIGN: We performed in depth immune profiling of lung adenocarcinoma using an integrative analysis based on immunohistochemistry, flow-cytometry and transcriptomic data...
May 15, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29763677/neurotoxic-lesions-of-the-pedunculopontine-tegmental-nucleus-impair-the-elaboration-of-postictal-antinociception
#13
Rithiele Cristina de Oliveira, Ricardo de Oliveira, Luiz Luciano Falconi-Sobrinho, Audrey Franceschi Biagioni, Rafael Carvalho Almada, Tayllon Dos Anjos-Garcia, Guilherme Bazaglia-de-Sousa, Asmat Ullah Khan, Norberto Cysne Coimbra
Generalised tonic-clonic seizures, generated by abnormal neuronal hyper-activity, cause a significant and long-lasting increase in the nociceptive threshold. The pedunculopontine tegmental nucleus (PPTN) plays a crucial role in the regulation of seizures as well as the modulation of pain, but its role in postictal antinociceptive processes remains unclear. In the present study, we aimed to investigate the involvement of PPTN neurons in the postictal antinociception. Wistar rats had their tail-flick baseline recorded and were injected with ibotenic acid (1...
May 12, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29756595/96-weeks-treatment-of-tenofovir-alafenamide-vs-tenofovir-disoproxil-fumarate-for-hepatitis-b-virus-infection
#14
Kosh Agarwal, Maurizia Brunetto, Wai Kay Seto, Young-Suk Lim, Scott Fung, Patrick Marcellin, Sang Hoon Ahn, Namiki Izumi, Wan-Long Chuang, Ho Bae, Manoj Sharma, Harry L A Janssen, Calvin Q Pan, Mustafa Kemal Çelen, Norihiro Furusyo, Dr Shalimar, Ki Tae Yoon, Huy Trinh, John F Flaherty, Anuj Gaggar, Audrey H Lau, Andrea L Cathcart, Lanjia Lin, Neeru Bhardwaj, Vithika Suri, G Mani Subramanian, Edward J Gane, Maria Buti, Henry L Y Chan
BACKGROUND & AIMS: Tenofovir alafenamide (TAF) is a new prodrug of tenofovir developed to treat patients with chronic hepatitis B virus (HBV) infection at a lower dose than tenofovir disoproxil fumarate (TDF) through more efficient delivery of tenofovir to hepatocytes. In 48-week results from two ongoing, double-blind, randomized phase III trials, TAF was non-inferior to TDF in efficacy with improved renal and bone safety. We report 96-week outcomes for both trials. METHODS: In two international trials, patients with chronic HBV infection were randomized 2:1 to receive 25 mg TAF or 300 mg TDF in a double-blinded fashion...
April 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29746441/cognitive-profile-of-children-with-intracranial-germ-cell-tumor-according-to-tumor-location
#15
Virginie Coutinho, Georges Dellatolas, Clemence Castaignede-Lalande, Audrey Longaud-Vales, Virginie Kieffer, Lea Guerrini-Rousseau, Jacques Grill, Dominique Valteau-Couanet, Christelle Dufour
PURPOSE: The purpose of this study was to evaluate the long-term cognitive sequelae and to describe the neuropsychological profile of patients with intracranial germ cell tumors according to tumor location (pineal or suprasellar site). PATIENTS AND METHODS: Forty-five children treated at Gustave Roussy between 1991 and 2010 were assessed with neuropsychological tests to measure IQ, memory, visuospatial, motor, and executive skills at a mean delay of 4.2 years after diagnosis...
May 9, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29744506/facile-synthesis-of-yolk-shell-mn-2-o-3-mn-5-o-8-as-an-effective-catalyst-for-peroxymonosulfate-activation
#16
Aimal Khan, Shuhua Zou, Ting Wang, Jerosha Ifthikar, Ali Jawad, Zhuwei Liao, Ajmal Shahzad, Audrey Ngambia, Zhuqi Chen
Yolk shell Mn2O3@Mn5O8 was prepared through a facile synthetic procedure and was demonstrated to be a highly efficient and stable catalyst in peroxymonosulfate (PMS) activation for the catalytic degradation of organic contaminants. Mn2O3@Mn5O8 exhibits much improved activity compared with other classic manganese catalysts such as ε-MnO2, Mn2O3 and Mn3O4, and this performance was due to its yolk shell structure, mesoporous shell, well-defined interior voids, particular particle size and mixed valence states...
May 10, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29738748/femur-sparing-pattern-of-abnormal-fetal-growth-in-pregnant-women-from-new-york-city-after-maternal-zika-virus-infection
#17
Christie L Walker, Audrey A Merriam, Eric O Ohuma, Manjiri K Dighe, Michael Gale, Lakshmi Rajagopal, Aris T Papageorghiou, Cynthia Gyamfi-Bannerman, Kristina M Adams Waldorf
BACKGROUND: Zika virus (ZIKV) is a mosquito-transmitted flavivirus, which can induce fetal brain injury and growth restriction following maternal infection during pregnancy. Prenatal diagnosis of ZIKV-associated fetal injury in the absence of microcephaly is challenging due to an incomplete understanding of how maternal ZIKV infection affects fetal growth and the use of different sonographic reference standards around the world. We hypothesized that skeletal growth is unaffected by ZIKV infection and that the femur length can represent an internal standard to detect growth deceleration of the fetal head and/or abdomen by ultrasound...
May 5, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29729518/short-term-effects-of-physical-activity-air-pollution-and-their-interaction-on-the-cardiovascular-and-respiratory-system
#18
Michelle Laeremans, Evi Dons, Ione Avila-Palencia, Glòria Carrasco-Turigas, Juan Pablo Orjuela, Esther Anaya, Tom Cole-Hunter, Audrey de Nazelle, Mark Nieuwenhuijsen, Arnout Standaert, Martine Van Poppel, Patrick De Boever, Luc Int Panis
Physical activity (PA) in urban environments may lead to increased inhalation of air pollutants. As PA and air pollution (AP) have respectively beneficial and detrimental effects on the cardiorespiratory system, the responses to these exposures can interact. Therefore, we assessed the short-term effects of PA, AP and their interaction on a set of subclinical cardiovascular and respiratory outcomes in a panel of healthy adults: heart rate variability (HRV), retinal vessel diameters, lung function and fractional exhaled nitric oxide (FeNO)...
May 2, 2018: Environment International
https://www.readbyqxmd.com/read/29727683/fasting-activates-fatty-acid-oxidation-to-enhance-intestinal-stem-cell-function-during-homeostasis-and-aging
#19
Maria M Mihaylova, Chia-Wei Cheng, Amanda Q Cao, Surya Tripathi, Miyeko D Mana, Khristian E Bauer-Rowe, Monther Abu-Remaileh, Laura Clavain, Aysegul Erdemir, Caroline A Lewis, Elizaveta Freinkman, Audrey S Dickey, Albert R La Spada, Yanmei Huang, George W Bell, Vikram Deshpande, Peter Carmeliet, Pekka Katajisto, David M Sabatini, Ömer H Yilmaz
Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric states such as intermittent fasting have beneficial effects on organismal health and age-associated loss of tissue function. The role of adult stem and progenitor cells in responding to short-term fasting and whether such responses improve regeneration are not well studied. Here we show that a 24 hr fast augments intestinal stem cell (ISC) function in young and aged mice by inducing a fatty acid oxidation (FAO) program and that pharmacological activation of this program mimics many effects of fasting...
May 3, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29716918/igf2-ir-igf1r-pathway-in-tumor-cells-and-myofibroblasts-mediates-resistance-to-egfr-inhibition-in-cholangiocarcinoma
#20
Javier Vaquero, Cindy Lobe, Sylvana Tahraoui, Audrey Clapéron, Martine Mergey, Fatiha Merabtene, Dominique Wendum, Cédric Coulouarn, Chantal Housset, Christèle Desbois-Mouthon, Francoise Praz, Laura Fouassier
PURPOSE: Cholangiocarcinoma (CCA) is a desmoplastic tumor of the biliary tree in which epidermal growth factor receptor (EGFR) is overexpressed and contributes to cancer progression. Although, EGFR has been envisaged as a target for therapy, treatment with tyrosine kinase inhibitors (TKI) such as erlotinib did not provide therapeutic benefit in patients with CCA, emphasizing the need to investigate resistance mechanisms against EGFR inhibition. EXPERIMENTAL DESIGN: Resistant CCA cells to EGFR inhibition were obtained upon long time exposure of cells with erlotinib...
May 1, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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