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Audrey Long

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https://www.readbyqxmd.com/read/29471480/family-medicine-clinic-a-case-study-of-a-hospital-family-medicine-practice-redesign-to-improve-chronic-disease-care-in-the-community-in-singapore
#1
Yee Wei Lim, Joanna Ling, Zoe Lim, Audrey Chia
Background: Singapore's health care system is strained by the health care needs of a rapidly aging population. The unprecedented collaboration between a public hospital and a private family practice to set up the Family Medicine Clinic (FMC) to co-manage patients with chronic disease is an example of efforts to shift care to the community. Objective: To explore patients' initial experience of shared chronic disease care in a private family practice setting. Methods: In this exploratory case study, we surveyed 330 patients with stable chronic diseases and interviewed 10 complex care patients and their caregivers...
February 17, 2018: Family Practice
https://www.readbyqxmd.com/read/29462773/unmatched-speed-perceptions-between-overground-and-treadmill-manual-wheelchair-propulsion-in-long-term-manual-wheelchair-users
#2
Félix Chénier, Audrey Champagne, Guillaume Desroches, Dany H Gagnon
BACKGROUND: Manual wheelchair (MWC) propulsion is increasingly assessed on a motorized treadmill (TM), which is often considered more ecologically valid than stationary rollers. However, no clear consensus on the similarities between overground (OG) and TM propulsion has yet been reached. Furthermore, no study has investigated the participants' perceptions of propelling a MWC on a TM compared to OG. RESEARCH QUESTION: The present study aims to assess the perception of speed when propelling on a TM vs OG, and to relate this perception to measured spatiotemporal variables, kinetics and work...
February 12, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29462203/a-generic-hts-assay-for-kinase-screening-validation-for-the-isolation-of-an-engineered-malate-kinase
#3
Romain Irague, Christopher M Topham, Nelly Martineau, Audrey Baylac, Clément Auriol, Thomas Walther, Jean-Marie François, Isabelle André, Magali Remaud-Siméon
An end-point ADP/NAD+ acid/alkali assay procedure, directly applicable to library screening of any type of ATP-utilising/ADP producing enzyme activity, was implemented. Typically, ADP production is coupled to NAD+ co-enzyme formation by the conventional addition of pyruvate kinase and lactate dehydrogenase. Transformation of enzymatically generated NAD+ into a photometrically active alkali derivative product is then achieved through the successive application of acidic/alkali treatment steps. The assay was successfully miniaturized to search for malate kinase activity in a structurally-guided library of LysC aspartate kinase variants comprising 6,700 clones...
2018: PloS One
https://www.readbyqxmd.com/read/29449669/predictive-biomarkers-of-gastroesophageal-reflux-disease-and-barrett-s-esophagus-in-world-trade-center-exposed-firefighters-a-15-year-longitudinal-study
#4
Syed H Haider, Sophia Kwon, Rachel Lam, Audrey K Lee, Erin J Caraher, George Crowley, Liqun Zhang, Theresa M Schwartz, Rachel Zeig-Owens, Mengling Liu, David J Prezant, Anna Nolan
Gastroesophageal reflux disease (GERD) and Barrett's Esophagus (BE), which are prevalent in the World Trade Center (WTC) exposed and general populations, negatively impact quality of life and cost of healthcare. GERD, a risk factor of BE, is linked to obstructive airways disease (OAD). We aim to identify serum biomarkers of GERD/BE, and assess the respiratory and clinical phenotype of a longitudinal cohort of never-smoking, male, WTC-exposed rescue workers presenting with pulmonary symptoms. Biomarkers collected soon after WTC-exposure were evaluated in optimized predictive models of GERD/BE...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29438460/practical-dietary-recommendations-for-the-prevention-and-management-of-nonalcoholic-fatty-liver-disease-in-adults
#5
Elena S George, Adrienne Forsyth, Catherine Itsiopoulos, Amanda J Nicoll, Marno Ryan, Siddharth Sood, Stuart K Roberts, Audrey C Tierney
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. In the absence of effective pharmacotherapies, clinical guidelines focus primarily on weight loss to treat this condition. Established consensus, evidence-based, and clinical dietary recommendations for NAFLD are currently lacking. The aim of this paper is to provide evidence-based practical dietary recommendations for the prevention and management of NAFLD in adults. A literature review focusing on established principles for the development of clinical practice recommendations was employed using the following criteria: based on substantial evidence, ensures risk minimization, is flexible for an individual patient approach, and is open to further modification as evidence emerges...
January 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29422660/deep-intronic-variation-in-splicing-regulatory-element-of-the-ercc8-gene-associated-with-severe-but-long-term-survival-cockayne-syndrome
#6
Audrey Schalk, Géraldine Greff, Nathalie Drouot, Cathy Obringer, Hélène Dollfus, Vincent Laugel, Jamel Chelly, Nadège Calmels
Cockayne syndrome is an autosomal recessive multisystem disorder characterized by intellectual disability, microcephaly, severe growth failure, sensory impairment, peripheral neuropathy, and cutaneous sensitivity. This rare disease is linked to disease-causing variations in the ERCC6 (CSB) and ERCC8 (CSA) genes. Various degrees of severity have been described according to age at onset and survival, without any clear genotype-phenotype correlation. All types of nucleotide changes have been observed in CS genes, including splice variations mainly affecting the splice site consensus sequences...
February 8, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29402632/prospective-longitudinal-overnight-video-eeg-evaluation-in-phelan-mcdermid-syndrome
#7
Omar I Khan, Xiangping Zhou, Jill Leon, Riley Kessler, Thomas Gaughan, Precilla D'Souza, Andrea Gropman, Ninette Cohen, Owen Rennert, Ashura Buckley, Sara Inati, Audrey Thurm
OBJECTIVE: Phelan-McDermid Syndrome (PMS) is a rare genetic condition associated with loss of function mutations, including deletions, in the chromosome 22q13 region. This PMS phenotype includes intellectual disability, often minimal to absent verbal skills, and other neurologic features including autism spectrum disorder and seizures. Reports indicate seizures and abnormal electroencephalograms (EEGs) in this population, but previous studies do not describe EEG findings during sleep or prognostic value of abnormal EEG over any time period...
February 2, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29400709/congenital-zika-virus-infection-as-a-silent-pathology-with-loss-of-neurogenic-output-in-the-fetal-brain
#8
Kristina M Adams Waldorf, Branden R Nelson, Jennifer E Stencel-Baerenwald, Colin Studholme, Raj P Kapur, Blair Armistead, Christie L Walker, Sean Merillat, Jay Vornhagen, Jennifer Tisoncik-Go, Audrey Baldessari, Michelle Coleman, Manjiri K Dighe, Dennis W W Shaw, Justin A Roby, Veronica Santana-Ufret, Erica Boldenow, Junwei Li, Xiaohu Gao, Michael A Davis, Jesica A Swanstrom, Kara Jensen, Douglas G Widman, Ralph S Baric, Joseph T Medwid, Kathryn A Hanley, Jason Ogle, G Michael Gough, Wonsok Lee, Chris English, W McIntyre Durning, Jeff Thiel, Chris Gatenby, Elyse C Dewey, Marian R Fairgrieve, Rebecca D Hodge, Richard F Grant, LaRene Kuller, William B Dobyns, Robert F Hevner, Michael Gale, Lakshmi Rajagopal
Zika virus (ZIKV) is a flavivirus with teratogenic effects on fetal brain, but the spectrum of ZIKV-induced brain injury is unknown, particularly when ultrasound imaging is normal. In a pregnant pigtail macaque (Macaca nemestrina) model of ZIKV infection, we demonstrate that ZIKV-induced injury to fetal brain is substantial, even in the absence of microcephaly, and may be challenging to detect in a clinical setting. A common and subtle injury pattern was identified, including (i) periventricular T2-hyperintense foci and loss of fetal noncortical brain volume, (ii) injury to the ependymal epithelium with underlying gliosis and (iii) loss of late fetal neuronal progenitor cells in the subventricular zone (temporal cortex) and subgranular zone (dentate gyrus, hippocampus) with dysmorphic granule neuron patterning...
February 5, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29386897/functional-impairment-in-patients-with-major-depressive-disorder-the-2-year-perform-study
#9
Lene Hammer-Helmich, Josep Maria Haro, Bengt Jönsson, Audrey Tanguy Melac, Sylvie Di Nicola, Julien Chollet, Dominique Milea, Benoît Rive, Delphine Saragoussi
Background: The Prospective Epidemiological Research on Functioning Outcomes Related to Major depressive disorder (PERFORM) study describes the course of depressive symptoms, perceived cognitive symptoms, and functional impairment over 2 years in outpatients with major depressive disorder (MDD) and investigates the patient-related factors associated with functional impairment. Methods: This was a 2-year observational study in 1,159 outpatients with MDD aged 18-65 years who were either initiating antidepressant monotherapy or undergoing their first switch of antidepressant...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29374222/measuring-dynamic-social-contacts-in-a-rehabilitation-hospital-effect-of-wards-patient-and-staff-characteristics
#10
Audrey Duval, Thomas Obadia, Lucie Martinet, Pierre-Yves Boëlle, Eric Fleury, Didier Guillemot, Lulla Opatowski, Laura Temime
Understanding transmission routes of hospital-acquired infections (HAI) is key to improve their control. In this context, describing and analyzing dynamic inter-individual contact patterns in hospitals is essential. In this study, we used wearable sensors to detect Close Proximity Interactions (CPIs) among patients and hospital staff in a 200-bed long-term care facility over 4 months. First, the dynamic CPI data was described in terms of contact frequency and duration per individual status or activity and per ward...
January 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29360998/concussion-microvascular-injury-and-early-tauopathy-in-young-athletes-after-impact-head-injury-and-an-impact-concussion-mouse-model
#11
Chad A Tagge, Andrew M Fisher, Olga V Minaeva, Amanda Gaudreau-Balderrama, Juliet A Moncaster, Xiao-Lei Zhang, Mark W Wojnarowicz, Noel Casey, Haiyan Lu, Olga N Kokiko-Cochran, Sudad Saman, Maria Ericsson, Kristen D Onos, Ronel Veksler, Vladimir V Senatorov, Asami Kondo, Xiao Z Zhou, Omid Miry, Linnea R Vose, Katisha R Gopaul, Chirag Upreti, Christopher J Nowinski, Robert C Cantu, Victor E Alvarez, Audrey M Hildebrandt, Erich S Franz, Janusz Konrad, James A Hamilton, Ning Hua, Yorghos Tripodis, Andrew T Anderson, Gareth R Howell, Daniela Kaufer, Garth F Hall, Kun P Lu, Richard M Ransohoff, Robin O Cleveland, Neil W Kowall, Thor D Stein, Bruce T Lamb, Bertrand R Huber, William C Moss, Alon Friedman, Patric K Stanton, Ann C McKee, Lee E Goldstein
The mechanisms underpinning concussion, traumatic brain injury, and chronic traumatic encephalopathy, and the relationships between these disorders, are poorly understood. We examined post-mortem brains from teenage athletes in the acute-subacute period after mild closed-head impact injury and found astrocytosis, myelinated axonopathy, microvascular injury, perivascular neuroinflammation, and phosphorylated tau protein pathology. To investigate causal mechanisms, we developed a mouse model of lateral closed-head impact injury that uses momentum transfer to induce traumatic head acceleration...
January 18, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29360453/the-abc-transporter-rv1272c-of-mycobacterium-tuberculosis-enhances-the-import-of-long-chain-fatty-acids-in-escherichia-coli
#12
Audrey Martin, Jaiyanth Daniel
Mycobacterium tuberculosis (Mtb), which causes tuberculosis, is capable of accumulating triacylglycerol (TAG) by utilizing fatty acids from host cells. ATP-binding cassette (ABC) transporters are involved in transport processes in all organisms. Among the classical ABC transporters in Mtb none have been implicated in fatty acid import. Since the transport of fatty acids from the host cell is important for dormancy-associated TAG synthesis in the pathogen, mycobacterial ABC transporter(s) could potentially be involved in this process...
January 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29358150/micromechanisms-of-fatigue-crack-growth-in-polycarbonate-polyurethane-time-dependent-and-hydration-effects
#13
Audrey C Ford, Hannah Gramling, Samuel C Li, Jessica V Sov, Amrita Srinivasan, Lisa A Pruitt
Polycarbonate polyurethane has cartilage-like, hygroscopic, and elastomeric properties that make it an attractive material for orthopedic joint replacement application. However, little data exists on the cyclic loading and fracture behavior of polycarbonate polyurethane. This study investigates the mechanisms of fatigue crack growth in polycarbonate polyurethane with respect to time dependent effects and conditioning. We studied two commercially available polycarbonate polyurethanes, Bionate® 75D and 80A. Tension testing was performed on specimens at variable time points after being removed from hydration and variable strain rates...
January 10, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29356722/early-noninvasive-ventilation-and-nonroutine-transfusion-for-acute-chest-syndrome-in-sickle-cell-disease-in-children-a-descriptive-study
#14
Claire Heilbronner, Audrey Merckx, Valentine Brousse, Slimane Allali, Philippe Hubert, Mariane de Montalembert, Fabrice Lesage
OBJECTIVES: To describe the need for transfusion and short- and long-term evolutions of pediatric sickle cell disease patients with acute chest syndrome for whom early continuous noninvasive ventilation represented first-line treatment. DESIGN: Single-center retrospective chart study in PICU. SETTING: A tertiary and quaternary referral PICU. PATIENTS: All sickle cell disease patients 5-20 years old admitted with confirmed acute chest syndrome and not transfused in the previous month were included...
January 19, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29336433/eosinophilic-esophagitis-relationship-of-subepithelial-eosinophilic-inflammation-with-epithelial-histology-endoscopy-blood-eosinophils-and-symptoms
#15
Alain M Schoepfer, Audrey Simko, Christian Bussmann, Ekaterina Safroneeva, Marcel Zwahlen, Thomas Greuter, Luc Biedermann, Stephan Vavricka, Sébastien Godat, Antoine Reinhard, Catherine Saner, Hugo Maye, Christine Sempoux, Christophe Brunel, Carine Blanchard, Dagmar Simon, Hans-Uwe Simon, Alex Straumann
OBJECTIVES: For technical reasons, the histologic characterization of eosinophilic esophagitis (EoE)-specific alterations is almost exclusively based on those found in the esophageal epithelium, whereas little is known about subepithelial abnormalities. In this study, we aimed to systematically assess the nature of subepithelial histologic alterations, and analyze their relationship with epithelial histologic findings, endoscopic features, and symptoms. METHODS: Adult patients with established EoE diagnosis were prospectively included during a yearly follow-up visit...
January 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29332119/autofluorescence-of-skin-advanced-glycation-end-products-as-a-risk-factor-for-open-angle-glaucoma-the-alienor-study
#16
Cedric Schweitzer, Audrey Cougnard-Gregoire, Vincent Rigalleau, Jean-Francois Dartigues, Florence Malet, Marie-Benedicte Rougier, Marie-Noelle Delyfer, Catherine Helmer, Jean-Francois Korobelnik, Cecile Delcourt
Purpose: To analyze the association between skin autofluorescence (sAF), estimating tissue accumulation of advanced glycation end-products (AGEs), and open angle glaucoma (OAG) in an elderly population. Methods: The Antioxydants, Lipides Essentiels, Nutrition and maladies OculaiRes (ALIENOR) study is an on-going epidemiologic population-based study on age-related eye diseases. In 2009 to 2010, 624 subjects, aged 74 years or older, were recruited. All subjects underwent a complete eye examination, including optic disc color photography and spectral-domain optical coherence tomography (SD-OCT) examination...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29330094/p21-activated-kinase-signaling-in-cancer
#17
REVIEW
Chetan K Rane, Audrey Minden
The p21 Activated Kinases (PAKs) are a family of serine threonine kinases, that consist of 6 members, PAKs 1-6, which are positioned at an intersection of multiple signaling pathways implicated in oncogenesis. The PAKs were originally identified as protein kinases that function downstream of the Ras related Rho GTPases Cdc42 and Rac. PAK1 and PAK4, which belong to Group I and Group II PAKs, respectively, are most often associated with tumorigenesis. On account of their well characterized roles in cancer, several small molecule inhibitors are being developed to inhibit the PAKs, and there is interest in investigating their efficacy as either first line or adjuvant treatments for cancer...
January 9, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29329425/comparison-of-hepatic-2d-sandwich-cultures-and-3d-spheroids-for-long-term-toxicity-applications-a-multi-center-study
#18
Catherine C Bell, Anita C A Dankers, Volker M Lauschke, Rowena Sison-Young, Roz Jenkins, Cliff Rowe, Chris Goldring, Kevin Park, Sophie Regan, Tracy Walker, Chris Schofield, Audrey Baze, Alison J Foster, Dominic Williams, Amy W M van de Ven, Frank Jacobs, Jos van Houdt, Tuula Lähteenmäki, Jan Snoeys, Satu Juhila, Lysiane Richert, Magnus Ingelman-Sundberg
Primary human hepatocytes (PHH) are commonly used for in vitro studies of drug-induced liver injury. However, when cultured as 2D monolayers, PHH lose crucial hepatic functions within hours. This dedifferentiation can be ameliorated when PHH are cultured in sandwich configuration (2Dsw), particularly when cultures are regularly re-overlaid with extracellular matrix, or as 3D spheroids. In this study, the six participating laboratories evaluated the robustness of these two model systems made from cryopreserved PHH from the same donors considering both inter-donor and inter-lab variability and compared their suitability for use in repeated-dose toxicity studies using 5 different hepatotoxins with different toxicity mechanisms...
January 10, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29315502/a-genome-wide-association-study-identifies-a-candidate-gene-associated-with-atazanavir-exposure-measured-in-hair
#19
Bani Tamraz, Yong Huang, Audrey L French, Seble Kassaye, Kathryn Anastos, Marek J Nowicki, Stephen Gange, Deborah R Gustafson, Peter Bacchetti, Ruth M Greenblatt, Pirro G Hysi, Bradley E Aouizerat
Hair provides a direct measure of long-term exposure of atazanavir (ATV). We report the results of the first genome-wide association study (GWAS) of ATV exposure measured in hair in an observational cohort representative of U.S. women living with HIV; the Women's Interagency HIV Study. Approximately 14.1 million SNPs were analyzed in linear regression-based GWAS, with replication, adjusted for non-genetic predictors collected under conditions of actual use of ATV in 398 participants. Lastly, the PharmGKB database was used to identify pharmacogene associations with ATV exposure...
January 9, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29302598/what-are-the-ethical-aspects-surrounding-intensive-care-unit-admission-in-patients-with-cancer
#20
REVIEW
Jean-Philippe Rigaud, Audrey Large, Nicolas Meunier-Beillard, Stéphanie Gélinotte, Pierre-Louis Declercq, Fiona Ecarnot, Auguste Dargent, Jean-Pierre Quenot
Improvements in living conditions and increasing life expectancy have combined to result in ever older patients being admitted to hospital. In parallel, the increasing incidence of cancer, along with the improved efficacy of anti-cancer therapies has led to greater needs for intensive care among cancer patients. The objectives underpinning the management of cancer patients in the intensive care unit (ICU) are to achieve a return to a clinical status that would allow the patient to be either, transferred back to the original unit, or discharged from the hospital with an acceptable quality of life, and where warranted, pursuit of cancer therapy...
December 2017: Annals of Translational Medicine
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