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Audrey Long

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https://www.readbyqxmd.com/read/28801233/t-cell-zone-resident-macrophages-silently-dispose-of-apoptotic-cells-in-the-lymph-node
#1
Myriam Baratin, Léa Simon, Audrey Jorquera, Clément Ghigo, Doulaye Dembele, Jonathan Nowak, Rebecca Gentek, Stephan Wienert, Frederick Klauschen, Bernard Malissen, Marc Dalod, Marc Bajénoff
In lymph nodes (LNs), dendritic cells (DCs) are thought to dispose of apoptotic cells, a function pertaining to macrophages in other tissues. We found that a population of CX3CR1(+) MERTK(+) cells located in the T cell zone of LNs, previously identified as DCs, are efferocytic macrophages. Lineage-tracing experiments and shield chimeras indicated that these T zone macrophages (TZM) are long-lived macrophages seeded in utero and slowly replaced by blood monocytes after birth. Imaging the LNs of mice in which TZM and DCs express different fluorescent proteins revealed that TZM-and not DCs-act as the only professional scavengers, clearing apoptotic cells in the LN T cell zone in a CX3CR1-dependent manner...
August 15, 2017: Immunity
https://www.readbyqxmd.com/read/28765286/long-delay-arterial-spin-labeling-provides-more-accurate-cerebral-blood-flow-measurements-in-moyamoya-patients-a-simultaneous-positron-emission-tomography-mri-study
#2
Audrey P Fan, Jia Guo, Mohammad M Khalighi, Praveen K Gulaka, Bin Shen, Jun Hyung Park, Harsh Gandhi, Dawn Holley, Omar Rutledge, Prachi Singh, Tom Haywood, Gary K Steinberg, Frederick T Chin, Greg Zaharchuk
BACKGROUND AND PURPOSE: Arterial spin labeling (ASL) MRI is a promising, noninvasive technique to image cerebral blood flow (CBF) but is difficult to use in cerebrovascular patients with abnormal, long arterial transit times through collateral pathways. To be clinically adopted, ASL must first be optimized and validated against a reference standard in these challenging patient cases. METHODS: We compared standard-delay ASL (post-label delay=2.025 seconds), multidelay ASL (post-label delay=0...
August 1, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28764776/costs-of-health-care-across-primary-care-models-in-ontario
#3
Maude Laberge, Walter P Wodchis, Jan Barnsley, Audrey Laporte
BACKGROUND: The purpose of this study is to analyze the relationship between newly introduced primary care models in Ontario, Canada, and patients' primary care and total health care costs. A specific focus is on the payment mechanisms for primary care physicians, i.e. fee-for-service (FFS), enhanced-FFS, and blended capitation, and whether providers practiced as part of a multidisciplinary team. METHODS: Utilization data for a one year period was measured using administrative databases for a 10% sample selected at random from the Ontario adult population...
August 1, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28763191/nanoporous-immunoprotective-device-for-stem-cell-derived-%C3%AE-cell-replacement-therapy
#4
Ryan Chang, Gaetano Faleo, Holger A Russ, Audrey V Parent, Susanna K Elledge, Daniel A Bernards, Jessica L Allen, Karina Villanueva, Matthias Hebrok, Qizhi Tang, Tejal A Desai
Encapsulation of human embryonic stem-cell-differentiated beta cell clusters (hES-βC) holds great promise for cell replacement therapy for the treatment of diabetics without the need for chronic systemic immune suppression. Here, we demonstrate a nanoporous immunoprotective polymer thin film cell encapsulation device that can exclude immune molecules while allowing exchange of oxygen and nutrients necessary for in vitro and in vivo stem cell viability and function. Biocompatibility studies show the device promotes neovascular formation with limited foreign body response in vivo...
August 7, 2017: ACS Nano
https://www.readbyqxmd.com/read/28754390/bariatric-surgery-induced-lower-angiopoietin-like-2-protein-is-associated-with-improved-cardiometabolic-profile
#5
Marie-Eve Piché, Nathalie Thorin-Trescases, Audrey Auclair, Simon Marceau, Julie Martin, Annik Fortier, Eric Thorin, Paul Poirier
BACKGROUND: Plasma angiopoietin-like 2 (Angptl2), a proinflammatory protein, has been associated with obesity and diabetes. Whether weight loss induced by bariatric surgery and associated improvement of the cardiometabolic risk profile influence circulating Angptl2 levels is unknown. We tested whether biliopancreatic diversion with duodenal switch (BPD-DS) surgery alters plasma Angptl2 concentrations. METHODS: Severely obese patients (n = 73; body mass index: 49...
August 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28740125/apoe-genotype-influences-insulin-resistance-apolipoprotein-cii-and-ciii-according-to-plasma-fatty-acid-profile-in-the-metabolic-syndrome
#6
Rosalind Fallaize, Andrew L Carvalho-Wells, Audrey C Tierney, Carmen Marin, Beata Kieć-Wilk, Aldona Dembińska-Kieć, Christian A Drevon, Catherine DeFoort, José Lopez-Miranda, Ulf Risérus, Wim H Saris, Ellen E Blaak, Helen M Roche, Julie A Lovegrove
Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions between the APOE genotype and plasma fatty acids (FA). In this study, we explored FA-gene interactions between the missense APOE polymorphisms and FA status on metabolic markers in MetS. Plasma FA, blood pressure, insulin sensitivity and lipid concentrations were determined at baseline and following a 12-week randomized, controlled, parallel, dietary FA intervention in 442 adults with MetS (LIPGENE study). FA-APOE gene interactions at baseline and following change in plasma FA were assessed using adjusted general linear models...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739279/eicosapentaenoic-acid-membrane-incorporation-impairs-cholesterol-efflux-from-cholesterol-loaded-human-macrophages-by-reducing-the-cholesteryl-ester-mobilization-from-lipid-droplets
#7
Natalie Fournier, Guillaume Sayet, Benoît Vedie, Maxime Nowak, Fatima Allaoui, Audrey Solgadi, Eric Caudron, Pierre Chaminade, Jean-François Benoist, Jean-Louis Paul
A diet containing a high n-3/n-6 polyunsaturated fatty acids (PUFA) ratio has cardioprotective properties. PUFAs incorporation into membranes influences the function of membrane proteins. We investigated the impact of the membrane incorporation of PUFAs, especially eicosapentaenoic acid (EPA) (C20:5 n-3), on the anti-atherogenic cholesterol efflux pathways. We used cholesteryl esters (CE)-loaded human monocyte-derived macrophages (HMDM) to mimic foam cells exposed to the FAs for a long period of time to ensure their incorporation into cellular membranes...
July 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28739091/laparoscopic-sleeve-gastrectomy-effect-on-long-term-remission-for-morbidly-obese-patients-with-type-2-diabetes-at-5-year-follow-up
#8
Marius Nedelcu, Marcelo Loureiro, Mehdi Skalli, Florence Galtier, Audrey Jaussent, Melanie Deloze, Michel Gagner, Jean Michel Fabre, David Nocca
BACKGROUND: In the short-term, laparoscopic sleeve gastrectomy has been shown to be effective for the treatment of the type 2 diabetes in patients with severe obesity. There are few data with greater follow-up. Our aim was to evaluate the results of laparoscopic sleeve gastrectomy on the control of type 2 diabetes in patients with severe obesity at 5 years at the University Hospital, France. METHODS: From a total of 355 patients with severe obesity operated between January 2006 and June 2010, 52 (15%) had a diagnosis of type 2 diabetes before undergoing laparoscopic sleeve gastrectomy...
July 21, 2017: Surgery
https://www.readbyqxmd.com/read/28729461/morphology-of-the-archaellar-motor-and-associated-cytoplasmic-cone-in-thermococcus-kodakaraensis
#9
Ariane Briegel, Catherine M Oikonomou, Yi-Wei Chang, Andreas Kjær, Audrey N Huang, Ki Woo Kim, Debnath Ghosal, Hong H Nguyen, Dorothy Kenny, Rachel R Ogorzalek Loo, Robert P Gunsalus, Grant J Jensen
Archaeal swimming motility is driven by archaella: rotary motors attached to long extracellular filaments. The structure of these motors, and particularly how they are anchored in the absence of a peptidoglycan cell wall, is unknown. Here, we use electron cryotomography to visualize the archaellar basal body in vivo in Thermococcus kodakaraensis KOD1. Compared to the homologous bacterial type IV pilus (T4P), we observe structural similarities as well as several unique features. While the position of the cytoplasmic ATPase appears conserved, it is not braced by linkages that extend upward through the cell envelope as in the T4P, but rather by cytoplasmic components that attach it to a large conical frustum up to 500 nm in diameter at its base...
July 19, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28722775/depression-recognition-and-capacity-for-self-report-among-ethnically-diverse-nursing-homes-residents-evidence-of-disparities-in-screening
#10
Audrey Chun, Joann P Reinhardt, Mildred Ramirez, Julie M Ellis, Stephanie Silver, Orah Burack, Joseph P Eimicke, Verena Cimarolli, Jeanne A Teresi
AIMS AND OBJECTIVES: To examine agreement between Minimum Data Set clinician ratings and researcher assessments of depression among ethnically diverse nursing home residents using the 9-item Patient Health Questionnaire. BACKGROUND: Although depression is common among nursing homes residents, its recognition remains a challenge. DESIGN: Observational baseline data from a longitudinal intervention study. METHODS: Sample of 155 residents from 12 long-term care units in one US facility; 50 were interviewed in Spanish...
July 19, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28719431/bispectral-index-measurements-are-not-degraded-during-aeromedical-evacuations
#11
Nicolas Donat, Audrey Cirodde, Clément Hoffmann, Jean-Vivien Schaal, Yannick Masson, Antoine Nau, Paul Vincent Martin, Samuel Madec, Thomas Leclerc
For a decade, depth of anesthesia monitoring has become a reality in the operating room. It provides valuable help for managing anesthesia, especially for unstable patients. This might be particularly relevant during aeromedical evacuation. In this study, we aimed to assess the validity of the bispectral index (BIS) during long-range patient transportation aboard fixed-wing aircraft. BIS was recorded in 30 patients, 25 under anesthesia and 5 awake, during aeromedical evacuations performed by the French Air Force...
July 14, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28714796/effect-of-bariatric-surgery-on-heart-failure
#12
Marcela Rodriguez Flores, Carlos Aguilar Salinas, Marie-Eve Piché, Audrey Auclair, Paul Poirier
Obesity increases the risk of heart failure (HF), which continues to be a significant proportion of all cardiovascular diseases and affects increasingly younger populations. The cross-talk between adipose and the heart involves insulin resistance, adipokine signaling and inflammation, with the capacity of adipose tissue to mediate hemodynamic signals, promoting progressive cardiomyopathy. Areas covered: From a therapeutic perspective, there is not yet a single obesity-related pathway that when addressed, can ameliorate cardiomyopathy in obese patients and this is a matter of ongoing research...
August 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28713191/long-term-recovery-in-stroke-accompanied-by-aphasia-a-reconsideration
#13
Audrey Holland, Davida Fromm, Margaret Forbes, Brian MacWhinney
BACKGROUND: This work focuses on the twenty-six individuals who provided data to AphasiaBank on at least two occasions, with initial testing between 6 months and 5.8 years post-onset of aphasia. The data are archival in nature and were collected from the extensive database of aphasic discourse in AphasiaBank. AIMS: The aim is to furnish data on the nature of long-term changes in both the impairment of aphasia as measured by the Western Aphasia Battery-Revised (WAB-R) and its expression in spoken discourse...
2017: Aphasiology
https://www.readbyqxmd.com/read/28706274/elovanoids-are-novel-cell-specific-lipid-mediators-necessary-for-neuroprotective-signaling-for-photoreceptor-cell-integrity
#14
Bokkyoo Jun, Pranab K Mukherjee, Aram Asatryan, Marie-Audrey Kautzmann, Jessica Heap, William C Gordon, Surjyadipta Bhattacharjee, Rong Yang, Nicos A Petasis, Nicolas G Bazan
Docosahexaenoic acid (DHA, 22:6 n-3) is abundant in the retina and is enzymatically converted into pro-homeostatic docosanoids. The DHA- or eicosapentaenoic acid (EPA)-derived 26 carbon fatty acid is a substrate of elongase ELOVL4, which is expressed in photoreceptor cells and generates very long chain (≥C28) polyunsaturated fatty acids including n-3 (VLC-PUFAs,n-3). While ELOVL4 mutations are linked to vision loss and neuronal dysfunctions, the roles of VLC-PUFAs remain unknown. Here we report a novel class of lipid mediators biosynthesized in human retinal pigment epithelial (RPE) cells that are oxygenated derivatives of VLC-PUFAs,n-3; we termed these mediators elovanoids (ELV)...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28701520/ligand-recognition-and-helical-stacking-formation-are-intimately-linked-in-the-sam-i-riboswitch-regulatory-mechanism
#15
Anne-Marie Dussault, Audrey Dubé, Frédéric Jacques, Jonathan P Grondin, Daniel Lafontaine
Riboswitches are non-coding mRNA elements that control gene expression by altering their structure upon metabolite binding. Although riboswitch crystal structures provide detailed information about RNA-ligand interactions, little knowledge has been gathered to understand how riboswitches modulate gene expression. Here, we study the molecular recognition mechanism of the S-adenosylmethionine SAM-I riboswitch by characterizing the formation of a helical stacking interaction involving the ligand binding process...
July 12, 2017: RNA
https://www.readbyqxmd.com/read/28685394/functional-improvement-among-intracerebral-hemorrhage-ich-survivors-up-to-12%C3%A2-months-post-injury
#16
Anirudh Sreekrishnan, Audrey C Leasure, Fu-Dong Shi, David Y Hwang, Joseph L Schindler, Nils H Petersen, Emily J Gilmore, Hooman Kamel, Lauren H Sansing, David M Greer, Kevin N Sheth
BACKGROUND AND PURPOSE: As survival rates have increased for intracerebral hemorrhage (ICH) patients, there is limited information regarding recovery beyond 3-6 months. This study was conducted to examine recovery curves using the modified Rankin Scale (mRS) and Barthel Index (BI) up to 12 months post-injury. METHODS: We prospectively enrolled 173 patients admitted with ICH who were subsequently evaluated using the mRS and BI at discharge as well as 3, 6, and 12 months...
July 6, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28679459/factors-associated-with-residential-long-term-care-wait-list-placement-in-north-west-ontario
#17
Audrey Laporte, Adrian Rohit Dass, Kerry Kuluski, Allie Peckham, Whitney Berta, Janet Lum, A Paul Williams
This article is based on a study that investigated factors associated with long-term care wait list placement in Ontario, Canada. We based the study's analysis on Resident Assessment Instrument for Home Care (RAI-HC) data for 2014 in the North West Local Health Integration Network (LHIN). Our analysis quantified the contribution of three factors on the likelihood of wait list placement: (1) care recipient, (2) informal caregiver, and (3) formal system. We find that all three factors are significantly related to wait list placement...
July 6, 2017: Canadian Journal on Aging, la Revue Canadienne du Vieillissement
https://www.readbyqxmd.com/read/28668621/circadian-disruption-affects-initial-learning-but-not-cognitive-flexibility-in-an-automated-set-shifting-task-in-adult-long-evans-rats
#18
Audrey L Robertson, Rekha C Balachandran, Megan M Mahoney, Paul A Eubig
A sizeable percent of adults are subject to circadian disturbances such as shift work, which involves misalignment of time of light exposure, activity periods, sleep, and eating. Chronic adherence to disruptive circadian schedules can negatively impact cognitive functioning. Developing preclinical models of circadian disruption allow investigation of the relationship and underlying mechanisms between circadian disruption and cognitive functioning. We placed adult Long-Evans rats of both sexes on a 12:12h light:dark schedule in which rats performed an automated operant-behavior task for 3months, with daily testing occurring either 4h after lights-on or lights-off...
June 29, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28667567/women-s-experience-with-non-invasive-prenatal-testing-and-emotional-well-being-and-satisfaction-after-test-results
#19
Rachèl V van Schendel, G C M Lieve Page-Christiaens, Lean Beulen, Caterina M Bilardo, Marjon A de Boer, Audrey B C Coumans, Brigitte H W Faas, Irene M van Langen, Klaske D Lichtenbelt, Merel C van Maarle, Merryn V E Macville, Dick Oepkes, Eva Pajkrt, Lidewij Henneman
Increasingly, high-risk pregnant women opt for non-invasive prenatal testing (NIPT) instead of invasive diagnostic testing. Since NIPT is less accurate than invasive testing, a normal NIPT result might leave women less reassured. A questionnaire study was performed among pregnant women with elevated risk for fetal aneuploidy based on first-trimester combined test (risk ≥1:200) or medical history, who were offered NIPT in the nationwide Dutch TRIDENT study. Pre- and post-test questionnaires (n = 682) included measures on: experiences with NIPT procedure, feelings of reassurance, anxiety (State-Trait Anxiety Inventory, STAI), child-related anxiety (PRAQ-R), and satisfaction...
June 30, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28666775/effects-of-empagliflozin-on-the-urinary-albumin-to-creatinine-ratio-in-patients-with-type-2-diabetes-and-established-cardiovascular-disease-an-exploratory-analysis-from-the-empa-reg-outcome-randomised-placebo-controlled-trial
#20
David Z I Cherney, Bernard Zinman, Silvio E Inzucchi, Audrey Koitka-Weber, Michaela Mattheus, Maximilian von Eynatten, Christoph Wanner
BACKGROUND: In a pooled analysis of short-term trials, short-term treatment with the sodium-glucose co-transporter-2 (SGLT2) inhibitor empagliflozin reduced albuminuria in patients with type 2 diabetes and prevalent albuminuria. In this exploratory analysis of the EMPA-REG OUTCOME trial, we report the short-term and long-term effects of empagliflozin on albuminuria in patients with type 2 diabetes and established cardiovascular disease, according to patients' baseline albuminuria status...
June 27, 2017: Lancet Diabetes & Endocrinology
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