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Audrey Long

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https://www.readbyqxmd.com/read/28219945/novel-fixed-z-dimension-fizd-kidney-primordia-and-an-organoid-culture-system-for-time-lapse-confocal-imaging
#1
Ulla Saarela, Saad Ullah Akram, Audrey Desgrange, Aleksandra Rak-Raszewska, Jingdong Shan, Silvia Cereghini, Veli-Pekka Ronkainen, Janne Heikkilä, Ilya Skovorodkin, Seppo J Vainio
Tissue, organ and organoid cultures provide suitable models for developmental studies, but our understanding of how the organs are assembled at the single cell level still remains unclear. We describe here a novel Fixed Z-Dimension (FiZD) culture setup that permits high-resolution confocal imaging of organoids and embryonic tissues. In a FiZD culture a permeable membrane compresses the tissues onto a glass coverslip and the spacers adjust the thickness, enabling the tissue to grow for up to 12 days. Thus the kidney rudiment and the organoids can adjust to the limited Z-dimensional space and yet advance the process of kidney morphogenesis, enabling long-term time-lapse and high-resolution confocal imaging...
February 20, 2017: Development
https://www.readbyqxmd.com/read/28214146/impact-of-anti-tnf-therapy-on-nk-cells-function-and-on-immunosurveillance-against-b-cell-lymphomas
#2
Gaetane Nocturne, Saida Boudaoud, Bineta Ly, Juliette Pascaud, Audrey Paoletti, Xavier Mariette
OBJECTIVES: Rheumatoid arthritis (RA) is associated with an increased risk of lymphoma linked to activity of the disease. Immunosuppressive drugs have been suspected to induce an additional risk. Since, NK cells have been recently shown to participate to anti-lymphoma immunosurveillance, we aimed to assess if anti-TNF might impact their anti-lymphoma activity. METHODS: NK cells have been assessed ex vivo in patients with RA treated with methotrexate (MTX) with or without anti-TNF...
February 14, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28167697/prc2-is-dispensable-for-hotair-mediated-transcriptional-repression
#3
Manuela Portoso, Roberta Ragazzini, Živa Brenčič, Arianna Moiani, Audrey Michaud, Ivaylo Vassilev, Michel Wassef, Nicolas Servant, Bruno Sargueil, Raphaël Margueron
Long non-coding RNAs (lncRNAs) play diverse roles in physiological and pathological processes. Several lncRNAs have been suggested to modulate gene expression by guiding chromatin-modifying complexes to specific sites in the genome. However, besides the example of Xist, clear-cut evidence demonstrating this novel mode of regulation remains sparse. Here, we focus on HOTAIR, a lncRNA that is overexpressed in several tumor types and previously proposed to play a key role in gene silencing through direct recruitment of Polycomb Repressive Complex 2 (PRC2) to defined genomic loci...
February 6, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28129346/temperature-of-a-dengue-rapid-diagnostic-test-under-tropical-climatic-conditions-a-follow-up-study
#4
Onanong Sengvilaipaseuth, Koukeo Phommasone, Xavier de Lamballerie, Manivanh Vongsouvath, Ooyanong Phonemixay, Stuart D Blacksell, Mayfong Mayxay, Sommay Keomany, Phoutthalavanh Souvannasing, Paul N Newton, Audrey Dubot-Pérès
The Dengue Duo Rapid Diagnostic Test (SD Dengue RDT) has good specificity and sensitivity for dengue diagnosis in rural tropical areas. In a previous study, using four control sera, we demonstrated that that the diagnostic accuracy of these RDTs remains stable after long-term storage at high temperatures. We extended this study by testing sera from 119 febrile patients collected between July-November 2012 at Salavan Provincial Hospital (southern Laos) with RDTs stored for 6 months at 4°C, 35° and in a hut (miniature traditional house) at Lao ambient temperatures...
2017: PloS One
https://www.readbyqxmd.com/read/28111040/-immunotherapy-in-brain-tumors
#5
Emilie De Carli, Matthieu Delion, Audrey Rousseau
Diffuse gliomas represent the most common primary central nervous system (CNS) tumors in adults and children alike. Glioblastoma is the most frequent and malignant form of diffuse glioma with a median overall survival of 15 months despite aggressive treatments. New therapeutic approaches are needed to prolong survival in this always fatal disease. The CNS has been considered for a long time as an immune privileged organ, in part because of the existence of the blood-brain barrier. Nonetheless, immunotherapy is a novel approach in the therapeutic management of glioma patients, which has shown promising results in several clinical trials, especially in the adult population...
February 2017: Annales de Pathologie
https://www.readbyqxmd.com/read/28096032/creation-of-an-intensive-care-unit-and-organizational-changes-in-an-adult-emergency-department-impact-on-acute-stroke-management
#6
Laurent Puy, Chantal Lamy, Sandrine Canaple, Audrey Arnoux, Nicolas Laine, Ella Iacob, Jean-Marc Constans, Olivier Godefroy
BACKGROUND AND PURPOSE: Following the reorganization of a University Medical Center onto a single campus, an Intensive Care Unit was created within the adult Emergency Department (ED ICU). We assessed the effects of these organizational changes on acute stroke management and the intravenous administration of recombinant tissue plasminogen activator (IV rtPA), as characterized by the thrombolysis rate, door-to-needle time (DNT) and outcome at 3months. METHODS: Between October 2013 and September 2015, we performed a retrospective, observational, single-center, comparative study of patients admitted for ischemic stroke and treated with IV rtPA during two 321-day periods (before and after the creation of the ED ICU)...
January 10, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28095003/cocaine-addiction-as-a-homeostatic-reinforcement-learning-disorder
#7
Mehdi Keramati, Audrey Durand, Paul Girardeau, Boris Gutkin, Serge H Ahmed
Drug addiction implicates both reward learning and homeostatic regulation mechanisms of the brain. This has stimulated 2 partially successful theoretical perspectives on addiction. Many important aspects of addiction, however, remain to be explained within a single, unified framework that integrates the 2 mechanisms. Building upon a recently developed homeostatic reinforcement learning theory, the authors focus on a key transition stage of addiction that is well modeled in animals, escalation of drug use, and propose a computational theory of cocaine addiction where cocaine reinforces behavior due to its rapid homeostatic corrective effect, whereas its chronic use induces slow and long-lasting changes in homeostatic setpoint...
January 16, 2017: Psychological Review
https://www.readbyqxmd.com/read/28053114/feelnc-a-tool-for-long-non-coding-rna-annotation-and-its-application-to-the-dog-transcriptome
#8
Valentin Wucher, Fabrice Legeai, Benoît Hédan, Guillaume Rizk, Lætitia Lagoutte, Tosso Leeb, Vidhya Jagannathan, Edouard Cadieu, Audrey David, Hannes Lohi, Susanna Cirera, Merete Fredholm, Nadine Botherel, Peter A J Leegwater, Céline Le Béguec, Hille Fieten, Jeremy Johnson, Jessica Alföldi, Catherine André, Kerstin Lindblad-Toh, Christophe Hitte, Thomas Derrien
Whole transcriptome sequencing (RNA-seq) has become a standard for cataloguing and monitoring RNA populations. One of the main bottlenecks, however, is to correctly identify the different classes of RNAs among the plethora of reconstructed transcripts, particularly those that will be translated (mRNAs) from the class of long non-coding RNAs (lncRNAs). Here, we present FEELnc (FlExible Extraction of LncRNAs), an alignment-free program that accurately annotates lncRNAs based on a Random Forest model trained with general features such as multi k-mer frequencies and relaxed open reading frames...
January 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28008465/five-year-results-of-laparoscopic-sleeve-gastrectomy-for-the-treatment-of-severe-obesity
#9
David Nocca, Marcelo Loureiro, El Mehdi Skalli, Marius Nedelcu, Audrey Jaussent, Melanie Deloze, Patrick Lefebvre, Jean Michel Fabre
BACKGROUND: Since 2011, the most used bariatric technique in France has been the sleeve gastrectomy. There are still few studies exploring the medium and long-term results of this technique. OBJECTIVE: To describe medium-long-term (5 years) results of a cohort of CHU Montpellier experience in sleeve gastrectomy for morbid obesity. METHODS: All patients that underwent laparoscopic sleeve gastrectomy (LSG) from January 2005 to June 2013 were included in this study...
December 23, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27997987/long-term-outcome-in-liver-transplantation-candidates-with-portopulmonary-hypertension
#10
Laurent Savale, Caroline Sattler, Audrey Coilly, Filoména Conti, Sébastien Renard, Claire Francoz, Hélène Bouvaist, Cyrille Feray, Patrick Borentain, Xavier Jaïs, David Montani, Florence Parent, Caroline O'Connell, Philippe Hervé, Marc Humbert, Gérald Simonneau, Didier Samuel, Yvon Calmus, Christophe Duvoux, François Durand, Jean Charles Duclos-Vallée, Olivier Sitbon
BACKGROUND: Portopulmonary hypertension (PoPH) is diagnosed in 2-6% of liver transplantation (LT) candidates. OBJECTIVE AND METHODS: To study outcomes of candidates for LT suffering from PoPH. Data were collected retrospectively from a prospective registry. Pulmonary hemodynamic variables were collected at the time of PoPH diagnosis, at last evaluation before LT, within 6 months and beyond 6 months after LT. RESULTS: Forty-nine patients (35 males, 48±8 years) were analysed (median MELD score 20)...
December 20, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27988060/syncope-and-risk-of-sudden-cardiac-arrest-in-coronary-artery-disease
#11
Aapo L Aro, Carmen Rusinaru, Audrey Uy-Evanado, Kyndaron Reinier, Derek Phan, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Syncope has been associated with increased risk of sudden cardiac arrest (SCA) in specific patient populations, such as hypertrophic cardiomyopathy, heart failure, and long QT syndrome, but data are lacking on the risk of SCA associated with syncope among patients with coronary artery disease (CAD), the most common cause of SCA. We investigated this association among CAD patients in the community. METHODS: All cases of SCA due to CAD were prospectively identified in Portland, Oregon (population approximately 1 million) as part of the Oregon Sudden Unexpected Death Study 2002-2015, and compared to geographical controls...
March 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27984662/long-term-structural-and-biomass-dynamics-of-virgin-tsuga-canadensis-pinus-strobus-forests-after-hurricane-disturbance
#12
Anthony W D'Amato, David A Orwig, David R Foster, Audrey Barker Plotkin, Peter K Schoonmaker, Maggie R Wagner
The development of old-growth forests in northeastern North America has largely been within the context of gap-scale disturbances given the rarity of stand-replacing disturbances. Using the 10-ha old-growth Harvard Tract and its associated 90-year history of measurements, including detailed surveys in 1989 and 2009, we document the long-term structural and biomass development of an old-growth Tsuga canadensis-Pinus strobus forest in southern New Hampshire, USA following a stand-replacing hurricane in 1938. Measurements of aboveground biomass pools were integrated with data from second- and old-growth T...
December 16, 2016: Ecology
https://www.readbyqxmd.com/read/27955802/-transient-epileptic-amnesia
#13
REVIEW
Audrey-Anne Fouchard, Karl Mondon, Bertrand De Toffol
Transient epileptic amnesia (TEA) is a sub-type of mesial temporal lobe epilepsy, with amnesic seizures. TEA is characterized by recurrent episodes of amnesia. Diagnostic criteria are available for TEA, and these memory disturbances should not be misdiagnosed with transient global amnesia. The neuropsychological evaluation is normal, however, autobiographical memory impairment is present in 70% of the cases and accelerated long term forgetting in 44%. When a patient complains of memory disturbances, especially autobiographical memory, TEA must be considered especially if there was an amnesic episode and symptoms that suggest temporal epilepsia...
January 2017: La Presse Médicale
https://www.readbyqxmd.com/read/27930953/adolescent-binge-alcohol-exposure-increases-risk-assessment-behaviors-in-male-wistar-rats-after-exposure-to-an-acute-psychological-stressor-in-adulthood
#14
Audrey Torcaso, AnnaDorothea Asimes, Margaret Meagher, Toni R Pak
Teenage binge drinking is a common practice that has been shown to increase the risk for developing mood disorders in adulthood. The hypothalamo-pituitary-adrenal (HPA) axis is often dysfunctional in mood disorder patients, and animal models of adolescent binge alcohol exposure similarly show disordered HPA axis function, even after long periods of alcohol abstinence. Here, we sought to investigate the anxiety-like behavioral consequences of binge alcohol exposure in a Wistar rat model. Male rats were administered alcohol in a binge pattern during peri-puberty, and one month later, anxiety-like behaviors were measured using the elevated plus maze...
February 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27906371/depolarization-of-a-randomly-distributed-plasmonic-meander-metasurface-characterized-by-mueller-matrix-spectroscopic-ellipsometry
#15
Liwei Fu, Audrey Berrier, Huiyu Li, Philipp Schau, Karsten Frenner, Martin Dressel, Wolfgang Osten
Metallic nanostructures offer efficient solutions in polarization control with a very low thickness. In this report, we investigate the optical properties of a nano-fabricated plasmonic pseudo-depolarizer using Mueller matrix spectroscopic ellipsometry in transmission configuration. The depolarizer is composed of 256 square cells, each containing a periodically corrugated metallic film with random orientation. The full Mueller matrix was analyzed as a function of incident angle in a range between 0 and 20° and over the whole rotation angle range...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27886626/describing-clinical-faculty-experiences-with-patient-safety-and-quality-care-in-acute-care-settings-a-mixed-methods-study
#16
Linda Roney, Catherine Sumpio, Audrey M Beauvais, Eileen R O'Shea
BACKGROUND: A major safety initiative in acute care settings across the United States has been to transform hospitals into High Reliability Organizations. The initiative requires developing cognitive awareness, best practices, and infrastructure so that all healthcare providers including clinical faculty are accountable to deliver quality and safe care. OBJECTIVE: To describe the experience of baccalaureate clinical nursing faculty concerning safety and near miss events, in acute care hospital settings...
February 2017: Nurse Education Today
https://www.readbyqxmd.com/read/27881140/early-signs-of-multi-walled-carbon-nanotbues-degradation-in-macrophages-via-an-intracellular-ph-dependent-biological-mechanism-importance-of-length-and-functionalization
#17
Marion Landry, Mathieu Pinault, Stéphane Tchankouo, Émeline Charon, Audrey Ridoux, Jorge Boczkowski, Martine Mayne-L'Hermite, Sophie Lanone
BACKGROUND: Carbon nanotubes (CNT) can interact with the biological environment, which could participate in their associated toxicity. We recently demonstrated that pH is an important player of CNT fate inside macrophages. We wanted to further characterize such process, and therefore designed a study dedicated to decipher CNT biodegradation by macrophages, as a function of two major physico-chemical properties in regard with nanotoxicology; length and degree of functionalization. To achieve our aim, we synthesized, following a single initial production process, four MWCNT differing in length and/or surface chemistry: S-CNT (short), SF-CNT (short functionalized), L-CNT (long) and LF-CNT (long functionalized)...
24, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27870902/sleep-duration-exercise-shift-work-and-polycystic-ovarian-syndrome-related-outcomes-in-a-healthy-population-a-cross-sectional-study
#18
Audrey J R Lim, Zhongwei Huang, Seok Eng Chua, Michael S Kramer, Eu-Leong Yong
CONTEXT: Few studies have examined the associations between sleep duration, shiftwork, and exercise to the infrequent menstruation, hyperandrogenism, and ovarian morphological changes observed in women with polycystic ovarian syndrome (PCOS). OBJECTIVE: To examine whether lifestyle factors, including short sleep duration, insufficient exercise, and shiftwork, alone or in combination, are associated with the reproductive and metabolic abnormalities typical of PCOS in a healthy population...
2016: PloS One
https://www.readbyqxmd.com/read/27783195/characterization-of-the-distribution-retention-and-efficacy-of-internal-radiation-of-188-re-lipid-nanocapsules-in-an-immunocompromised-human-glioblastoma-model
#19
Annabelle Cikankowitz, Anne Clavreul, Clément Tétaud, Laurent Lemaire, Audrey Rousseau, Nicolas Lepareur, Djamel Dabli, Francis Bouchet, Emmanuel Garcion, Philippe Menei, Olivier Couturier, François Hindré
Internal radiation strategies hold great promise for glioblastoma (GB) therapy. We previously developed a nanovectorized radiotherapy that consists of lipid nanocapsules loaded with a lipophilic complex of Rhenium-188 (LNC(188)Re-SSS). This approach resulted in an 83 % cure rate in the 9L rat glioma model, showing great promise. The efficacy of LNC(188)Re-SSS treatment was optimized through the induction of a T-cell immune response in this model, as it is highly immunogenic. However, this is not representative of the human situation where T-cell suppression is usually encountered in GB patients...
October 25, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27781378/mass-cytometry-reveals-a-distinct-immunoprofile-of-operational-tolerance-in-pediatric-liver-transplantation
#20
Audrey H Lau, Matthew J Vitalone, Kelly Haas, Todd Shawler, Carlos O Esquivel, William E Berquist, Olivia M Martinez, Ricardo O Castillo, Sheri M Krams
Long-term IS in transplant patients has significant morbidity, poorer quality of life, and substantial economic costs. TOL, defined as graft acceptance without functional impairment in the absence of IS, has been achieved in some pediatric LT recipients. Using mass cytometry, peripheral blood immunotyping was performed to characterize differences between tolerant patients and patients who are stable on single-agent IS. Single-cell mass cytometry was performed using blood samples from a single-center pediatric LT population of operationally tolerant patients to comprehensively characterize the immune cell populations in the tolerant state compared with patients on chronic low-dose IS...
December 2016: Pediatric Transplantation
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