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Joanna moncrieff

Tom Stockmann, Dolapo Odegbaro, Sami Timimi, Joanna Moncrieff
BACKGROUND: Antidepressant withdrawal symptoms are well-recognised, but their potential duration remains uncertain. OBJECTIVE: We aimed to describe the characteristics of withdrawal associated with two popular classes of antidepressants, including duration. METHODS: We analysed the content of a sample of posts on an antidepressant withdrawal website. We compared the characteristics of withdrawal associated with SSRIs and SNRIs, including time of onset, duration and nature of symptoms...
May 9, 2018: International Journal of Risk & Safety in Medicine
Joanna Moncrieff
Although antidepressants are regarded as effective and specific treatments, they are barely superior to placebo in randomised trials, and differences are unlikely to be clinically relevant. The conventional disease-centred understanding of drug action regards antidepressants as targeting an underlying brain process, but an alternative 'drug-centred' view suggests they are psychoactive substances that modify normal mental states and behaviour. These alterations, such as numbing of emotions, may reduce feelings of depression, and also create amplified placebo effects in randomised trials...
February 2018: BJPsych Bulletin
Anika Mandla, Jo Billings, Joanna Moncrieff
In the light of debates about the nature of bipolar disorder (BD), the current article presents a thematic analysis of Internet "blogs" by self-identified bipolar sufferers. Extreme and frequent fluctuation of mood was considered the principal feature of BD, along with a broad range of other problems. BD was often invoked as an explanation for life difficulties or lack of achievement, and was mostly regarded as a brain disease. Most bloggers emphasized the importance of drug treatment, along with the self-management techniques...
October 2017: Issues in Mental Health Nursing
Nicola Morant, Kiran Azam, Sonia Johnson, Joanna Moncrieff
BACKGROUND: Treatment decision-making that fully involves service users is an aim across medicine, including mental health. AIM: To explore service users experiences of taking antipsychotic medication for psychotic disorders and their perceptions of decision-making about this. METHOD: Semi-structured interviews with 20 users of community mental health services, conducted by service user researchers and analysed using thematic analysis. RESULTS: Antipsychotic medication was perceived to have beneficial effects on symptoms and relapse risk, but adverse effects were prominent, including a global state of lethargy and demotivation...
August 31, 2017: Journal of Mental Health
Joanna Moncrieff
No abstract text is available yet for this article.
November 2016: British Journal of Psychiatry: the Journal of Mental Science
SebastiĆ£o Viola, Joanna Moncrieff
BACKGROUND: There is international concern about the levels of sickness and disability benefits, with mental disorders known to account for a large proportion of claims. AIMS: To examine trends in sickness and disability benefits awarded for mental disorders in the UK. METHOD: The researchers analysed UK Government data from 1995 to 2014. RESULTS: Mental disorders have become the most common cause of receiving benefits, with the number of claimants rising by 103% from 1995 to 1...
January 2016: BJPsych Open
Joanna Moncrieff, Kiran Azam, Sonia Johnson, Louise Marston, Nicola Morant, Katherine Darton, Neil Wood
BACKGROUND: Government policy encourages increasing involvement of patients in their long-term care. This paper describes the development and pilot evaluation of a 'Medication Review Tool' designed to assist people to participate more effectively in discussions about antipsychotic drug treatment. METHODS: The Medication Review Tool developed consisted of a form to help patients identify pros and cons of their current antipsychotic treatment and any desired changes...
July 4, 2016: BMC Psychiatry
Joanna Moncrieff
No abstract text is available yet for this article.
2016: BMJ: British Medical Journal
Joanna Moncrieff
No abstract text is available yet for this article.
October 2015: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
Joanna Moncrieff
Joanna Moncrieff looks at the lack of long-term evidence for antipsychotic medication and considers what is needed to ensure we have the knowledge to maximize benefits and minimize harms.
August 2015: PLoS Medicine
Mauricio Silva de Lima, Joanna Moncrieff, Bernardo G O Soares
No abstract text is available yet for this article.
2015: Cochrane Database of Systematic Reviews
Joanna Moncrieff, Irving Kirsch
Meta-analyses indicate that antidepressants are superior to placebos in statistical terms, but the clinical relevance of the differences has not been established. Previous suggestions of clinically relevant effect sizes have not been supported by empirical evidence. In the current paper we apply an empirical method that consists of comparing scores obtained on the Hamilton rating scale for depression (HAM-D) and scores from the Clinical Global Impressions-Improvement (CGI-I) scale. This method reveals that a HAM-D difference of 3 points is undetectable by clinicians using the CGI-I scale...
July 2015: Contemporary Clinical Trials
Paul Hutton, Peter J Taylor, Lee Mulligan, Sarah Tully, Joanna Moncrieff
BACKGROUND: Immediate-release (IR) quetiapine has been used to treat schizophrenia since 1997, although all the principal placebo-controlled trials have >50% missing outcome data. New studies with relatively lower rates of participant withdrawal have since been published. AIMS: To assess the efficacy and adverse effects of quetiapine IR for schizophrenia, with consideration of outcome quality and clinical meaningfulness of results, and to examine the potential impact of missing data on the main efficacy findings...
May 2015: British Journal of Psychiatry: the Journal of Mental Science
Joanna Moncrieff, Hugh Middleton
PURPOSE OF REVIEW: The term 'schizophrenia' has been hotly contested over recent years. The current review explores the meanings of the term, whether it is valid and helpful and how alternative conceptions of severe mental disturbance would shape clinical practice. RECENT FINDINGS: Schizophrenia is a label that implies the presence of a biological disease, but no specific bodily disorder has been demonstrated, and the language of 'illness' and 'disease' is ill-suited to the complexities of mental health problems...
May 2015: Current Opinion in Psychiatry
Joanna Moncrieff
The concept of bipolar disorder has undergone a transformation over the last two decades. Once considered a rare and serious mental disorder, bipolar disorder is being diagnosed with increasing frequency in Europe and North America, and is suggested to replace many other diagnoses. The current article shows how the modern concept of bipolar disorder has been created in the course of efforts to market new antipsychotics and other drugs for bipolar disorder, to enable these drugs to migrate out of the arena of serious mental disorder and into the more profitable realm of everyday emotional problems...
August 2014: Transcultural Psychiatry
Laura Allison, Joanna Moncrieff
This paper examines factors involved in the theory and practice of emergency sedation for behavioural disturbance in psychiatry in the mid-twentieth century, and the emergence of the concept of 'rapid tranquillisation'. The practice received little attention until the arrival of antipsychotic drugs, which replaced older sedatives and became the agents most strongly associated with the treatment of aggression and challenging behaviour. Emergency sedation was subsequently portrayed in psychiatric literature and advertising as a therapeutic and diagnosis-driven endeavour, and the concept of rapid tranquillisation emerged in this context in the 1970s...
March 2014: History of Psychiatry
Joanna Moncrieff, David Cohen, Sally Porter
The psychoactive effects of psychiatric medications have been obscured by the presumption that these medications have disease-specific actions. Exploiting the parallels with the psychoactive effects and uses of recreational substances helps to highlight the psychoactive properties of psychiatric medications and their impact on people with psychiatric problems. We discuss how psychoactive effects produced by different drugs prescribed in psychiatric practice might modify various disturbing and distressing symptoms, and we also consider the costs of these psychoactive effects on the mental well-being of the user...
November 2013: Journal of Psychoactive Drugs
Stuart Watson, Peter Gallagher, Dominic Dougall, Richard Porter, Joanna Moncrieff, I Nicol Ferrier, Allan H Young
OBJECTIVE: There has been little investigation of early trauma in bipolar disorder despite evidence that stress impacts on the course of this illness. We aimed to compare the rates of childhood trauma in adults with bipolar disorder to a healthy control group, and to investigate the impact of childhood trauma on the clinical course of bipolar disorder. METHODS: Retrospective assessment of childhood trauma was conducted using the Childhood Trauma Questionnaire (CTQ) in 60 outpatients with bipolar disorder being treated for a depressive episode and 55 control participants across two centres in north-east England and New Zealand...
June 2014: Australian and New Zealand Journal of Psychiatry
Joanna Moncrieff, Sami Timimi
The current paper presents an analysis of the NICE guidelines on depression and attention deficit hyperactivity disorder (ADHD) from the perspective of the philosophy of science, guided particularly by Foucault's notion of the symbiosis of knowledge and power. It examines how data that challenged the orthodox position on the validity and drug treatment of these conditions was managed in the process of guideline development. The depression guideline briefly considered the complexity and heterogeneity of depression, and numerous methodological problems with evaluating treatments, including antidepressants...
April 2013: Anthropology & Medicine
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