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Maria Felicia Faienza, Giacomina Brunetti, Lorenzo Sanesi, Graziana Colaianni, Monica Celi, Laura Piacente, Gabriele D'Amato, Ernestina Schipani, Silvia Colucci, Maria Grano
AIM: Irisin is a new peptide produced mainly by the skeletal muscle playing an important role both in glucose/energy homeostasis and bone metabolism. Childhood type 1 diabetes mellitus (T1DM) is associated with decreased bone mass. We aimed to evaluate irisin levels in TD1M children and their correlation with bone metabolism and glycaemic control. METHODS: Ninety-six T1DM subjects (12.2 ± 4 years), 56 on multiple daily injections (MDI), 40 on continuous subcutaneous insulin infusion (CSII), and 34 controls were included in the study...
April 18, 2018: Diabetes Research and Clinical Practice
Francisco Ivison Rodrigues Limeira, Patrícia Ravena Meneses Rebouças, Denise Nóbrega Diniz, Daniela Pita de Melo, Patrícia Meira Bento
In this study we analyzed the mandibular cortical bone of patients with type 1 diabetes mellitus (T1DM) and non-diabetic. Fifty patients with T1DM and 100 non-diabetic ones paired by age and gender were analyzed. Two double-blinded observers evaluated 150 digital panoramic images of both groups. The mandibular cortical bone was analyzed using the Mandibular Cortical Index (MCI), Mental Index (MI), Gonial Index (GI), Antegonial Index (AI) and Upper and Lower Panoramic Mandibular Indexes (UPMI and LPMI), with the aid of RADIOIMP® software...
September 2017: Brazilian Dental Journal
A Geraud, P Beuzeboc, H Xu, Y M Kirova
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
A Dias, W Claudino, R Sinha, C A Perez, D Jain
The Human Epidermal growth factor Receptor 2 (HER2) is a potent mediator of cellular growth and proliferation. It plays an important role in cardiac development and maintaining the physiologic function of an adult heart. Amplification of the HER2 gene, and the corresponding overexpression of the HER2 receptor, occurs in roughly 20% of breast tumors and is associated with a poor outcome. Molecular targeting of the HER2 receptor with the humanized monoclonal antibody, Trastuzumab has improved disease-free and overall survival in patients with both metastatic and early HER2-positive breast cancer...
August 2016: Critical Reviews in Oncology/hematology
E Vanbergue, J L Peyraud, J Guinard-Flament, C Charton, S Barbey, R Lefebvre, Y Gallard, C Hurtaud
Milk spontaneous lipolysis (SL) of milk triglycerides is induced by the lipoprotein lipase, a milk native enzyme, and leads to an accumulation of partial glycerides and free fatty acids that are responsible for the deterioration of the taste of milk products. The gene coding for diacylglycerol acyltransferase 1 (DGAT1), an enzyme implicated in triglycerides synthesis, has an important polymorphic site at the K232A locus. This gene is well known to modulate milk composition. No data are available on the effects of DGAT1 on SL...
July 2016: Journal of Dairy Science
Kevin C Keith, Yueh Lee, Matthew G Ewend, Timothy M Zagar, Carey K Anders
The incidence of breast cancer brain metastasis (BCBM) is increasing due in part to improved management of systemic disease and prolonged survival. Despite this growing population of patients, there exists little consensus for the treatment of HER2-positive BCBM. Lapatinib, the only brain permeable targeted agent for HER2-positive cancer, has demonstrated limited intracranial response rates and little improvement in progression free survival (PFS) for HER-2 positive patients. Size constraints are believed to prevent larger monoclonal antibodies, such as pertuzumab and trastuzumab, from crossing the blood brain barrier (BBB)...
2016: Cancer Treatment Communications
Marta Cifuentes, Sylvie Jolivet, Laurence Cromer, Hirofumi Harashima, Petra Bulankova, Charlotte Renne, Wayne Crismani, Yuko Nomura, Hirofumi Nakagami, Keiko Sugimoto, Arp Schnittger, Karel Riha, Raphael Mercier
Cell cycle control must be modified at meiosis to allow two divisions to follow a single round of DNA replication, resulting in ploidy reduction. The mechanisms that ensure meiosis termination at the end of the second and not at the end of first division are poorly understood. We show here that Arabidopsis thaliana TDM1, which has been previously shown to be essential for meiotic termination, interacts directly with the Anaphase-Promoting Complex. Further, mutations in TDM1 in a conserved putative Cyclin-Dependant Kinase (CDK) phosphorylation site (T16-P17) dominantly provoked premature meiosis termination after the first division, and the production of diploid spores and gametes...
February 2016: PLoS Genetics
Srikumar M Raja, Swapnil S Desale, Bhopal Mohapatra, Haitao Luan, Kruti Soni, Jinjin Zhang, Matthew A Storck, Dan Feng, Timothy A Bielecki, Vimla Band, Samuel M Cohen, Tatiana K Bronich, Hamid Band
Targeted delivery of anticancer drugs to tumor cells using monoclonal antibodies against oncogenic cell surface receptors is an emerging therapeutic strategy. These strategies include drugs directly conjugated to monoclonal antibodies through chemical linkers (Antibody-Drug Conjugates, ADCs) or those encapsulated within nanoparticles that in turn are conjugated to targeting antibodies (Antibody-Nanoparticle Conjugates, ANPs). The recent FDA approval of the ADC Trastuzumab-TDM1 (Kadcyla; Genentech; San Francisco) for the treatment of ErbB2-overexpressing metastatic breast cancer patients has validated the strong potential of these strategies...
March 1, 2016: Oncotarget
Sébastien Andreuzza, Bindu Nishal, Aparna Singh, Imran Siddiqi
Meiosis produces haploid cells essential for sexual reproduction. In yeast, entry into meiosis activates transcription factors which trigger a transcriptional cascade that results in sequential co-expression of early, middle and late meiotic genes. However, these factors are not conserved, and the factors and regulatory mechanisms that ensure proper meiotic gene expression in multicellular eukaryotes are poorly understood. Here, we report that DUET/MMD1, a PHD finger protein essential for Arabidopsis male meiosis, functions as a transcriptional regulator in plant meiosis...
September 2015: PLoS Genetics
Valentina D'Amato, Lucia Raimondo, Luigi Formisano, Mario Giuliano, Sabino De Placido, Roberta Rosa, Roberto Bianco
Targeted therapies have been approved for various malignancies but the acquisition of resistance remains a substantial challenge in the clinical management of advanced cancers. Twenty-five per cent of breast cancers overexpress ErbB2/HER2, which confers a more aggressive phenotype and is associated with a poor prognosis. HER2-targeting therapies (trastuzumab, pertuzumab, TDM1 and lapatinib) are available, but a significant fraction of HER2-positive breast cancers eventually relapse or progress. This suggests that acquired or intrinsic resistance enables escape from HER2 inhibition...
December 2015: Cancer Treatment Reviews
Martin J Holzmann, Björn Rathsman, Björn Eliasson, Jeanette Kuhl, Ann-Marie Svensson, Thomas Nyström, Ulrik Sartipy
BACKGROUND: Patients with diabetes mellitus (DM) have an increased risk of adverse outcomes after coronary artery bypass grafting (CABG). Previous studies have reported prognosis in relation to treatment with or without insulin, and not to the type of diabetes. OBJECTIVES: This study investigated long-term survival in patients with type 1 DM (T1DM) and type 2 DM (T2DM) following CABG. METHODS: We included all patients from the SWEDEHEART (Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies) register who underwent primary isolated CABG in Sweden during 2003 through 2013...
April 28, 2015: Journal of the American College of Cardiology
M Franciosi, G Lucisano, R Amoretti, F Capani, D Bruttomesso, P Di Bartolo, A Girelli, F Leonetti, L Morviducci, E Vitacolonna, A Nicolucci
BACKGROUND AND AIMS: Costs associated with diabetes represent a large burden for patients and the health-care system. However, few studies examined the costs for diabetes treatment in adults with type 1 diabetes (T1DM). This analysis was aimed to assess the costs of treatment associated with T1DM among adults in Italy from the national health-care system perspective. METHODS AND RESULTS: Data were collected using a questionnaire assessing resource consumption retrospectively (drugs, visits, diagnostics, hospitalisations and self-monitoring of blood glucose (SMBG))...
July 2013: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Petra Bulankova, Nina Riehs-Kearnan, Moritz K Nowack, Arp Schnittger, Karel Riha
Meiosis is a modified cell division that produces four haploid nuclei from a single diploid cell in two rounds of chromosome segregation. Here, we analyze the role of Arabidopsis thaliana SUPPRESSOR WITH MORPHOGENETIC EFFECTS ON GENITALIA7 (SMG7), THREE DIVISION MUTANT1 (TDM1), and TARDY ASYNCHRONOUS MEIOSIS (TAM) in meiotic progression. SMG7 is a conserved nonsense-mediated mRNA decay factor that is also, in Arabidopsis, essential for completion of meiosis. Examination of activating CYCLIN DEPENDENT KINASE A;1 phosophorylation at Thr-161 suggests that the meiotic arrest observed in smg7 mutants is likely caused by a failure to downregulate cyclin-dependent kinase (CDK) activity at the end of the second meiotic division...
November 2010: Plant Cell
Volkmar Müller, Isabell Witzel, Elmar Stickeler
A better understanding of tumor biology has led to the development of a number of antibody-based targeted therapies in breast cancer. Several of these newer agents, such as trastuzumab and bevacizumab have demonstrated clinical activity and have improved the treatment of patients with metastatic breast cancer (MBC). Trastuzumab is a monoclonal antibody that binds to the extracellular domain of the HER2 receptor. The addition of trastuzumab to chemotherapy and also to endocrine therapy has enhanced efficacy of treatment...
2009: Breast Care
Lorenzo Lenzi, Silvia Mirri, Marta Generoso, Monica Guasti, Federica Barni, Rossella Pepe, Laura Nanni, Sonia Toni
BACKGROUND AND AIMS: The incidence of autoimmune thyroiditis in patients with type 1 diabetes mellitus (T1DM) is higher than in healthy population. The aim of this study is to investigate epidemiology and natural history of thyroid autoimmunity (AIT), thyroiditis diagnosis and need for therapy in paediatric patients with T1DM and to find the most suitable timing of AIT screening. METHODS: T1DM patients (493 pts., 268 males and 225 females) treated in the Juvenile Diabetes Tuscany Regional Centre at Meyer's Children Hospital were enrolled to determine TSH, fT4, thyroid autoantibodies levels and to undergo thyroid ultrasound...
2009: Acta Bio-medica: Atenei Parmensis
W D Sing, T R Klaenhammer
Agar surface conjugal matings were used to introduce heat-sensitive phage resistance (Hsp) determinants carried on the conjugal plasmid pTR2030 into Streptococcus cremoris KH, HP, 924, and TDM1. Lactose-fermenting (Lac) transconjugants were selected from matings of Lac variants of S. cremoris KH, HP, 924, and TDM1 with Streptococcus lactis ME2 or a high-frequency donor, S. lactis T-EK1 (pTR1040, Lac; pTR2030, Hsp). For all of the S. cremoris strains examined, select Lac transconjugants were completely resistant to plaquing by their homologous lytic phages...
June 1986: Applied and Environmental Microbiology
M C Simmler, P R Avner
A number of mouse strains of known F9 resistance phenotype have been tested for their in vitro natural killer activity against both F9 and YAC target cells. The pattern of in vitro natural killer activity observed does not correlate with the pattern of in vivo F9 resistance. The relative efficiencies of in vitro lysis of the F9 and YAC targets by endogenous natural killer effectors from the 129/Sv, SJL/J, C57Bl/6J, and BALB/cJ strains do, however, parallel each other, even though overall levels of F9 target lysis are very low...
December 1982: American Journal of Reproductive Immunology: AJRI
C Crémisi, P Duprey
The endo A gene encoding for an intermediate filament protein, a cytokeratin is usually expressed in epithelial cells. The regulation of this gene, probed by using cycloheximide, an inhibitor of protein synthesis was studied in various cell lines. The lines explored were undifferentiated embryonal carcinoma PCC4 cells which normally do not express endo A gene, PCC4 cells cultivated permanently at 31 degrees C (PCC4-31), which are epithelial-like cells derived by differentiation from PCC4 cells, but which do express endo A gene, TDM1 cells, an epithelial teratocarcinoma cell line, and 3T6 mouse fibroblasts...
August 11, 1987: Nucleic Acids Research
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