keyword
MENU ▼
Read by QxMD icon Read
search

L-carnitine

keyword
https://www.readbyqxmd.com/read/28802113/l-carnitine-enhances-oocyte-maturation-and-improves-in%C3%A2-vitro-development-of-embryos-in-dromedary-camels-camelus-dromedaries
#1
Mohamed Fathi, K H El-Shahat
The aim of the present study was to investigate the effect of L-carnitine (LC) addition during either IVM or IVC on the developmental potential of camel oocytes. In Experiment 1; camel oocytes were matured in the absence (control) or presence of different concentrations of LC (0.25 mg, 0.5 mg, 0.75 mg and 1 mg/ml) for 30 h followed by in vitro fertilization and culture up to blastocyst stage. Our results demonstrated that oocytes treated with 0.5 mg/ml LC showed higher (P < 0.05) rates of maturation (74...
August 4, 2017: Theriogenology
https://www.readbyqxmd.com/read/28791854/l-carnitine-treatment-of-insulin-resistance-a-systematic-review-and-meta-analysis
#2
Ying Xu, Wenjie Jiang, Guochang Chen, Wenjiao Zhu, Weiliang Ding, Zhijun Ge, Yongfei Tan, Tieliang Ma, Guoxing Cui
BACKGROUND: L-carnitine has been used for several years as an adjuvant therapy in oxidative stress, blood sugar, high-sensitivity C-reactive protein (CRP), anemia, etc. However, the efficacy of L-carnitine treating insulin resistance (IR) remains controversial. Homeostasis model assessment of Insulin Resistance (HOMA-IR) is widely used in the clinical evaluation of patients with IR. OBJECTIVES: A meta-analysis, including randomized controlled trials (RCTs), was performed to assess the effect of L-carnitine on HOMA-IR patients...
March 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28774846/inhibited-fatty-acid-%C3%AE-oxidation-impairs-stress-resistance-ability-in-nile-tilapia-oreochromis-niloticus
#3
Han Pan, Ling-Yu Li, Jia-Min Li, Wei-Li Wang, Samwel Mchele Limbu, Pascal Degrace, Dong-Liang Li, Zhen-Yu Du
Energy metabolism plays important roles in stress resistance and immunity in mammals, however, such functions have not been established in fish. In the present study, Nile tilapia (Oreochromis niloticus) was fed with mildronate, an inhibitor of mitochondrial fatty acid (FA) β-oxidation, for six weeks subsequently challenged with Aeromonas hydrophila and ammonia nitrogen exposure. Mildronate treatment reduced significantly l-carnitine concentration and mitochondrial FA β-oxidation efficiency, while it increased lipid accumulation in liver...
July 31, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28774370/-recurrent-anorexia-and-pigmentation-of-skin-for-more-than-two-months-in-an-infant
#4
Zhang-Qian Zheng, Bing-Bing Wu, Miao-Ying Zhang, Wei Lu, Fei-Hong Luo
A 2-month-old boy presented with adrenal insufficiency, impaired liver function, hypertriglyceridemia, significantly elevated creatine kinase and electrolyte disturbance. Microarray comparative genomic hybridization (aCGH) analysis test showed a pathogenic 8.7 Mb deletion in the short arm of chromosome X (Xp21.3 - p21.1) and confirmed the diagnosis of complex glycerol kinase deficiency (cGKD). He was treated with hydrocortisone, coenzyme Q10 and L-carnitine and was subsequently followed up for 4 years. His serum cortisol levels returned to normal one week later after treatment, but the serum creatine kinase, triglyceride and aminotransferase levels were progressively increased along with mental retardation and decreased muscular strength...
August 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28774367/-myocardial-protective-effect-of-l-carnitine-in-children-with-hand-foot-and-mouth-disease-caused-by-coxsackie-a16-virus
#5
Ya-Jie Cui, Chun-Lan Song, Fang Chen, Peng Li, Yi-Bing Cheng
OBJECTIVE: To investigate the myocardial protective effect of L-carnitine in children with hand, foot and mouth disease (HFMD) caused by Coxsackie A16 virus and possible mechanisms. METHODS: A total of 60 HFMD children with abnormal myocardial enzyme after Coxsackie A16 virus infection were enrolled and randomly divided into L-carnitine group and fructose-1,6-diphosphate group (fructose group), with 30 children in each group. The two groups were given L-carnitine or fructose diphosphate in addition to antiviral and heat clearance treatment...
August 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28771840/influence-of-l-carnitine-and-l-arginine-on-protein-synthesis-and-maturation-of-the-semitendinosus-muscle-of-lightweight-piglets
#6
J G Madsen, E Seoni, M Kreuzer, P Silacci, G Bee
Lightweight (LW) piglets from large litters display impaired growth performance compared with heavier littermates. This study investigated the growth performance and muscle development of early-weaned LW piglets (birthweight <1.2 kg) from large litters (17.3 ± 3.0 total born per litter), fed ad libitum a milk replacer supplemented with either l-carnitine (CAR) or l-arginine (ARG) from day 7 to day 28 of age. In total, 36 female and entire male Swiss Large White piglets, weaned on day 7 of age, were artificially reared in pairs in rescue decks...
August 3, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28770317/mitochondrial-h-atp-synthase-in-human-skeletal-muscle-contribution-to-dyslipidaemia-and-insulin-resistance
#7
Laura Formentini, Alexander J Ryan, Manuel Gálvez-Santisteban, Leslie Carter, Pam Taub, John D Lapek, David J Gonzalez, Francisco Villarreal, Theodore P Ciaraldi, José M Cuezva, Robert R Henry
AIMS/HYPOTHESIS: Mitochondria are important regulators of the metabolic phenotype in type 2 diabetes. A key factor in mitochondrial physiology is the H(+)-ATP synthase. The expression and activity of its physiological inhibitor, ATPase inhibitory factor 1 (IF1), controls tissue homeostasis, metabolic reprogramming and signalling. We aimed to characterise the putative role of IF1 in mediating skeletal muscle metabolism in obesity and diabetes. METHODS: We examined the 'mitochondrial signature' of obesity and type 2 diabetes in a cohort of 100 metabolically characterised human skeletal muscle biopsy samples...
August 2, 2017: Diabetologia
https://www.readbyqxmd.com/read/28768996/functional-expression-of-organic-ion-transporters-in-astrocytes-and-their-potential-as-a-drug-target-in-the-treatment-of-central-nervous-system-diseases
#8
Tomomi Furihata, Naohiko Anzai
It has become widely acknowledged that astrocytes play essential roles in maintaining physiological central nervous system (CNS) activities. Astrocytes fulfill their roles partly through the manipulation of their plasma membrane transporter functions, and therefore these transporters have been regarded as promising drug targets for various CNS diseases. A representative example is excitatory amino acid transporter 2 (EAAT2), which works as a critical regulator of excitatory signal transduction through its glutamate uptake activity at the tripartite synapse...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28768106/development-of-high-capacity-enterosorbents-for-aflatoxin-b1-and-other-hazardous-chemicals
#9
Meichen Wang, Cody R Maki, Youjun Deng, Yanan Tian, Timothy D Phillips
Previously, a calcium montmorillonite clay (NovaSil) included in diet of animals has been shown to bind aflatoxin B1 (AfB1) and reduce the symptoms of aflatoxicosis. To investigate and improve the capacity and efficacy of clay-based materials as aflatoxin sorbents, we developed and tested calcium and sodium montmorillonite clays amended with nutrients including L-carnitine and choline. Also we determined the sorption of AfB1 by isothermal analysis and tested the ability of these amended sorbents to protect adult hydra from AfB1 toxicity...
August 2, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28752591/comparison-and-evaluation-of-capacitation-and-acrosomal-reaction-in-freeze-thawed-human-ejaculated-spermatozoa-treated-with-l-carnitine-and-pentoxifylline
#10
E Aliabadi, S Jahanshahi, T Talaei-Khozani, M Banaei
Cryopreservation is used to preserve the spermatozoa; however, it leads to a reduction in sperm quality. L-carnitine (LC) influences sperm motility and preserves the sperm membrane and DNA integrity. The objectives of this study were to evaluate the protective effects of LC on the membrane integrity of normal human spermatozoa and compare it with pentoxifylline (PT) during cryopreservation. Thirty normal semen samples, prepared by swim-up procedure, were divided into three aliquots: a control without any treatment and two experimental aliquots that were incubated in PT or LC for 30 min...
July 28, 2017: Andrologia
https://www.readbyqxmd.com/read/28745680/-the-decreased-level-of-plasma-carnitine-in-patients-with-epilepsy
#11
E D Belousova
Antiepileptic drugs (AEDs) have long been known to affect carnitine metabolism, dropping the plasma free carnitine. Valproate (VPA) was considered to be the strongest carnitine-reducing agent. VPA-induced hyperammonemic encephalopathy and hepatotoxicity are well known, and pre-existing carnitine deficiency can be a predisposing factor, especially in congenital metabolic disorders. Several studies have shown that carnitine supplementation in patients receiving VPA to result in subjective and objective improvements and to prevent VPA-induced hepatotoxicity and encephalopathy, in parallel with increases in carnitine serum concentrations...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28745401/trimethylamine-n-oxide-tmao-breathe-new-life
#12
REVIEW
Saravanan Subramaniam, Craig Fletcher
Associations between an elevated level of systemic trimethylamine N-oxide (TMAO) and an increased risk for adverse cardiovascular events have been proposed in recent years. Increasing experimental studies suggest a possible impact of TMAO in cardiovascular diseases. TMAO, the oxygenated product of TMA, is belonging to the class of amine oxides. Most of TMA derived from the bacterial metabolism of choline and L-carnitine is absorbed into the bloodstream, and then TMA is rapidly oxidized to TMAO by flavin-containing monooxygenase-3 (FMO3), a hepatic enzyme...
July 26, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28733980/importance-of-the-skeletal-muscle-carnitine-stores-in-fuel-selection
#13
Stephan Krähenbühl
No abstract text is available yet for this article.
July 22, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28730830/preventive-effect-of-l-carnitine-on-the-disorder-of-lipid-metabolism-and-circadian-cclock-of-mice-subjected-to-chronic-jet-lag
#14
X Xie, A Guo, T Wu, Q Hu, L Huang, C Yao, B Zhao, W Zhang, B Chi, P Lu, Z Zhao, Z Fu
Circadian clock plays an essential role in orchestrating daily physiology, and its disruption can evoke metabolic diseases such as obesity. L-Carnitine can reduce blood lipid levels, and ameliorate fatty liver through regulating lipid metabolism. However, whether L-Carnitine administration may affect the disturbance of lipid metabolism and circadian rhythm of mice induced by prolonged circadian disruption is still unknown. Herein, we investigated the effects of L-Carnitine on conditions of circadian clock and lipid metabolism through a chronic jet-lag mice model which was developed by reversing12 h light/12 h dark cycle every 4 days for a continuous 12 weeks...
July 18, 2017: Physiological Research
https://www.readbyqxmd.com/read/28724183/physiological-intra-cytoplasmic-sperm-injection-picsi-outcomes-after-oral-pretreatment-and-semen-incubation-with-myo-inositol-in-oligoasthenoteratozoospermic-men-results-from-a-prospective-randomized-controlled-trial
#15
T Korosi, C Barta, K Rokob, T Torok
OBJECTIVE: The aim of the current study was to evaluate the effect of an oral pretreatment with a mix of myo-inositol (Myo-Ins), folic acid, vitamin E, L-carnitine, L-arginine and selenium (Folandrol, Exeltis, Hungary) and subsequent direct Myo-Ins incubation of spermatozoa before Physiological Intra-Cytoplasmic Sperm Injection (PICSI) procedures in infertile couples due to oligoasthenoteratozoospermia with previous failed PICSI procedures. PATIENTS AND METHODS: We performed a prospective, randomized controlled trial at the Assisted Reproduction Unit of the Kaáli Institute (Győr, Hungary)...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28719824/supplementation-of-l-carnitine-during-in%C3%A2-vitro-maturation-improves-embryo-development-from-less-competent-bovine-oocytes
#16
Drahomira Knitlova, Pavlina Hulinska, Michal Jeseta, Katerina Hanzalova, Bartosz Kempisty, Marie Machatkova
The present study was designed to define the impact of l-carnitine, supplemented during maturation, on bovine oocytes with different meiotic competence in terms of their IVF outcomes. Meiotically more competent (MMC) and less competent (MLC) oocytes were obtained separately from differently sized follicles at selected phases of folliculogenesis. The oocytes were matured with or without l-carnitine, fertilized and cultured to the blastocyst stage. The oocytes were examined for nuclear maturation, mitochondrial cluster formation, lipid consumption, fertilization and embryo development...
July 5, 2017: Theriogenology
https://www.readbyqxmd.com/read/28717107/human-plasma-and-urinary-metabolic-profiles-of-trimethylamine-and-trimethylamine-n-oxide-extrapolated-using-a-simple-physiologically-based-pharmacokinetic-model
#17
Makiko Shimizu, Hiroshi Yamazaki
Trimethylamine, a dietary- and medicinal carnitine-derived amine, is extensively metabolized by liver to non-malodorous trimethylamine N-oxide. Although trimethylamine and trimethylamine N-oxide under daily dietary consumption or carnitine treatment are generally regarded as nontoxic, they have been, and remain, of toxicological and clinical interest because of their potential association with atherosclerosis. The aim of the current study was to model the pharmacokinetics of trimethylamine after oral administration of trimethylamine in humans and compare the results with reported measured values...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28714912/urinary-excretion-of-tetrodotoxin-modeled-in-a-porcine-renal-proximal-tubule-epithelial-cell-line-llc-pk%C3%A2
#18
Takuya Matsumoto, Yui Ishizaki, Keika Mochizuki, Mitsuru Aoyagi, Yoshiharu Mitoma, Shoichiro Ishizaki, Yuji Nagashima
This study examined the urinary excretion of tetrodotoxin (TTX) modeled in a porcine renal proximal tubule epithelial cell line, LLC-PK₁. Time course profiles of TTX excretion and reabsorption across the cell monolayers at 37 °C showed that the amount of TTX transported increased linearly for 60 min. However, at 4 °C, the amount of TTX transported was approximately 20% of the value at 37 °C. These results indicate that TTX transport is both a transcellular and carrier-mediated process. Using a transport inhibition assay in which cell monolayers were incubated with 50 µM TTX and 5 mM of a transport inhibitor at 37 °C for 30 min, urinary excretion was significantly reduced by probenecid, tetraethylammonium (TEA), l-carnitine, and cimetidine, slightly reduced by p-aminohippuric acid (PAH), and unaffected by 1-methyl-4-phenylpyridinium (MPP+), oxaliplatin, and cefalexin...
July 17, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28712316/disturbed-bovine-mitochondrial-lipid-metabolism-a-review
#19
J H van der Kolk, J J Gross, V Gerber, R M Bruckmaier
In mammals, excess energy is stored primarily as triglycerides, which are mobilized when energy demands arise and cannot be covered by feed intake. This review mainly focuses on the role of long chain fatty acids in disturbed energy metabolism of the bovine species. Long chain fatty acids regulate energy metabolism as ligands of peroxisome proliferator-activated receptors. β-Oxidation is the process by which fatty acid molecules are broken down in the mitochondria or peroxisomes to generate acetyl-CoA. Carnitine acts as a carrier of fatty acyl groups as long-chain acyl-CoA derivatives do not penetrate the mitochondrial inner membrane...
July 17, 2017: Veterinary Quarterly
https://www.readbyqxmd.com/read/28698672/metabolic-effects-of-clenbuterol-and-salbutamol-on-pork-meat-studied-using-internal-extractive-electrospray-ionization-mass-spectrometry
#20
Haiyan Lu, Hua Zhang, Tenggao Zhu, Yipo Xiao, Shaoxian Xie, Haiwei Gu, Meng Cui, Liping Luo
Direct mass spectrometry analysis of metabolic effects of clenbuterol and salbutamol on pork quality at the molecular level is incredibly beneficial for food regulations, public health and the development of new anti-obesity drugs. With internal extractive electrospray ionization mass spectrometry (iEESI-MS), nutrients including creatine, amino acids, L-carnitine, vitamin B6, carnosine and phosphatidylcholines in pork tissue were identified, without sample pretreatment, using collision-induced dissociation (CID) experiments and by comparison with authentic compounds...
July 11, 2017: Scientific Reports
keyword
keyword
25120
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"