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Coenzyme Q10

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https://www.readbyqxmd.com/read/29776437/coenzyme-q10-combined-with-trimetazidine-in-the-prevention-of-contrast-induced-nephropathy-in-patients-with-coronary-heart-disease-complicated-with-renal-dysfunction-undergoing-elective-cardiac-catheterization-a-randomized-control-study-and-in-vivo-study
#1
Fei Chen, Fan Liu, Jingchao Lu, Xiuchun Yang, Bing Xiao, Yaqiong Jin, Jie Zhang
BACKGROUND: Contrast-induced nephropathy (CIN) is one of the common hospital-acquired acute renal failures. The purpose of this study was to investigate whether Coenzyme Q10 (CoQ10) and trimetazidine (TMZ) can prevent the occurrence of CIN after elective cardiac catheterization in patients with coronary artery disease complicated with renal dysfunction. METHODS: Consecutive coronary artery disease patients with renal insufficiency scheduled for coronary angiography were enrolled in randomized, paralleled, double-blind, controlled trial...
May 18, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29773394/grafting-of-steroids-to-hyaluronan-towards-the-design-of-delivery-systems-for-antioxidants-the-role-of-hydrophobic-core
#2
Gloria Huerta-Ángeles, Martina Brandejsová, Jaroslav Novotný, Kateřina Kopecká, Jana Šógorková, Daniela Šmejkalová, Vladimír Velebný
In this work, amphiphilic hyaluronic acid (HA) was synthesized by the chemical bonding of steroids. Particularly, succinyl cholesterol (SCH), cholic acid (CA), deoxycholic acid (DOCA), and 18β-glycyrrhetinic acid (GA) were activated by benzoyl chloride towards the esterification reaction of HA in water. The degree of substitution can be controlled by varying the feed ratio of mixed anhydride to HA and up to 25% (mol/mol) can be obtained. Due to mild reaction conditions, no degradation of the polysaccharide was observed...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29766349/recent-developments-in-the-role-of-coenzyme-q10-for-coronary-heart-disease-a-systematic-review
#3
REVIEW
Jessica Ayers, Jamie Cook, Rachel A Koenig, Evan M Sisson, Dave L Dixon
PURPOSE OF REVIEW: This review examines recent randomized clinical trials evaluating the role of coenzyme Q10 (CoQ10) in the management of coronary heart disease. RECENT FINDINGS: CoQ10 is one of the most commonly used dietary supplements in the USA. Due to its antioxidant and anti-inflammatory effects, CoQ10 has been studied extensively for possible use in managing coronary heart disease. One of the most common applications of CoQ10 is to mitigate statin-associated muscle symptoms (SAMS) based on the theory that SAMS are caused by statin depletion of CoQ10 in the muscle...
May 16, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29755918/coq10-a-super-vitamin-review-on-application-and-biosynthesis
#4
REVIEW
Shraddha Shukla, Kashyap Kumar Dubey
Coenzyme Q10 (CoQ) or ubiquinone is found in the biological system which is synthesized by the conjugation of benzoquinone ring with isoprenoid chain of variable length. Coenzyme Q10 supplementation energizes the body and increases body energy production in the form of ATP and helps to treat various human diseases such as cardiomyopathy, muscular dystrophy, periodontal disease, etc. Reports of these potential therapeutic advantages of CoQ10 have resulted in its high market demand, which focus the researchers to work on this molecule and develop better bioprocess methods for commercial level production...
May 2018: 3 Biotech
https://www.readbyqxmd.com/read/29735117/pediatric-ataxia-focus-on-chronic-disorders
#5
David R Lynch, Ashley McCormick, Kimberly Schadt, Elizabeth Kichula
Evaluation of a pediatric patient presenting with ataxia can be expensive and time consuming. Acute causes tend to have a clear developmental paradigm, but chronic presentations are more likely to be secondary to a genetic disorder, either one that primarily causes ataxia or that presents ataxia as one of a multitude of symptoms. Evaluation should focus on a quick diagnosis for those that have treatment options and for those that require other systemic monitoring. Friedreich ataxia is the most common, and genetic testing can easily confirm the suspicion...
April 2018: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/29734881/effect-of-ubiquinol-supplementation-on-biochemical-and-oxidative-stress-indexes-after-intense-exercise-in-young-athletes
#6
Patrick Orlando, Sonia Silvestri, Roberta Galeazzi, Roberto Antonicelli, Fabio Marcheggiani, Ilenia Cirilli, Tiziana Bacchetti, Luca Tiano
OBJECTIVES: Physical exercise significantly impacts the biochemistry of the organism. Ubiquinone is a key component of the mitochondrial respiratory chain and ubiquinol, its reduced and active form, is an emerging molecule in sport nutrition. The aim of this study was to evaluate the effect of ubiquinol supplementation on biochemical and oxidative stress indexes after an intense bout of exercise. METHODS: 21 male young athletes (26 + 5 years of age) were randomized in two groups according to a double blind cross-over study, either supplemented with ubiquinol (200 mg/day) or placebo for 1 month...
December 2018: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/29731611/self-reported-adherence-and-biomarker-levels-of-coq10-and-alpha-tocopherol
#7
Mara Z Vitolins, L Douglas Case, Stephen R Rapp, Mark O Lively, Edward G Shaw, Michelle J Naughton, Jeffrey Giguere, Glenn J Lesser
Purpose: Women with breast cancer were randomized to receive coenzyme Q10 (CoQ10) plus Vitamin E or placebo in a clinical trial. The objective of this evaluation is to examine the association between participant self-reported adherence to the study supplements and changes in plasma biomarker levels. Patients and methods: Correlation coefficients quantified the association between changes in alpha-tocopherol and CoQ10 levels and the association between self-reported adherence and changes in biomarkers...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29707741/myocardial-energetics-and-heart-failure-a-review-of-recent-therapeutic-trials
#8
REVIEW
Kunal N Bhatt, Javed Butler
PURPOSE OF REVIEW: Several novel therapeutics being tested in patients with heart failure are based on myocardial energetics. This review will provide a summary of the recent trials in this area, including therapeutic options targeting various aspects of cellular and mitochondrial metabolism. RECENT FINDINGS: Agents that improve the energetic balance in myocardial cells have the potential to improve clinical heart failure status. The most promising therapies currently under investigation in this arena include (1) elamipretide, a cardiolipin stabilizer; (2) repletion of iron deficiency with intravenous ferrous carboxymaltose; (3) coenzyme Q10; and (4) the partial adenosine receptor antagonists capadenoson and neladenosone...
April 30, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29698813/neuropathic-keratopathy
#9
REVIEW
Harminder S Dua, Dalia G Said, Elisabeth M Messmer, Maurizio Rolando, Jose M Benitez-Del-Castillo, Parwez N Hossain, Alex J Shortt, Gerd Gerling, Mario Nubile, Francisco C Figueiredo, Saaeha Rauz, Leonardo Mastropasqua, Paolo Rama, Christophe Baudouin
Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to frank epithelial defect with or without stromal ulceration (melting) is associated with reduced or absent corneal sensations. Sensory nerves serve nociceptor and trophic functions, which can be affected independently or simultaneously. Loss of trophic function and consequent epithelial breakdown exposes the stroma making it susceptible to enzymatic degradation. Nerve pathology can range from attrition to aberrant re-generation with corresponding symptoms from anaesthesia to hyperaesthesia/allodynia...
April 23, 2018: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29694831/atorvastatin-in-nano-particulate-formulation-abates-muscle-and-liver-affliction-when-coalesced-with-coenzyme-q10-and-or-vitamin-e-in-hyperlipidemic-rats
#10
S M Farrag, M A Hamzawy, M F El-Yamany, M A Saad, N N Nassar
AIMS: Statins are the most widely used to lower elevated low-density lipoprotein levels and preventing cardiovascular diseases in humans. However, about 20% of patients treated with this medication suffer from statin-related myalgia. To this end, this study investigated the potential effect of nano-particulate formulation in alleviating the muscles and liver damage either alone or when co-administered with nano coenzyme Q10 and nano vitamin E. MATERIALS AND METHODS: Male Wistar rats were fed normal diet or high-fat diet for 12 weeks, following which rats were treated with either (i) atorvastatin (5 or 20 mg/kg/day, p...
April 22, 2018: Life Sciences
https://www.readbyqxmd.com/read/29670833/interaction-of-coenzyme-q10-with-liposomes-and-its-impact-on-suppression-of-selenite-induced-experimental-cataract
#11
Medhat Wahba Shafaa, Amany Hasan Elshazly, Amira Zaki Dakrory, Maha Reda Elsyed
Purpose: To stress the influence of Coenzyme Q10 (CoQ10) on the structural properties of liposomes as model membranes and to investigate the possible role of CoQ10 or CoQ10 doped in liposomes when topically instilled as eye drops, in preventing cataract. Methods: The molecular interaction between liposomes and Coenzyme Q10 was examined using differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). Rat pups were randomly divided into six groups comprising 15 pups. Group (1), control group...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29665577/the-effect-of-long-term-treatment-with-coenzyme-q10-on-nucleic-acid-modifications-by-oxidation-in-children-with-down-syndrome
#12
Emil List Larsen, Lucia Padella, Helle Kirstine Mørup Bergholdt, Trine Henriksen, Lucia Santoro, Orazio Gabrielli, Henrik Enghusen Poulsen, Gian Paolo Littarru, Patrick Orlando, Luca Tiano
Elevated levels of oxidative nucleic acid modifications have been proposed to be associated with some of the clinical characteristics of Down syndrome. Oral intake of coenzyme Q10 improves oxidative status and shows a tendency toward protective effect on DNA oxidation in certain age groups of children with Down syndrome. Here, we demonstrate that long-term (i.e., 4 years) treatment with coenzyme Q10 (ubiquinone) at the dosage of 4 mg/kg/d does not affect whole body DNA and RNA oxidation.
March 15, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29663894/coenzyme-q10-in-cardiovascular-and-metabolic-diseases-current-state-of-the-problem
#13
Vladlena I Zozina, Serghei Covantev, Olga A Goroshko, Liudmila M Krasnykh, Vladimir G Kukes
The burden of cardiovascular and metabolic diseases is increasing with every year. Although the management of these conditions has improved greatly over the years it is still far from perfect. With all of this in mind, there is a need for new methods of prophylaxis and treatment. Coenzyme Q10 (CoQ10) is an essential compound of the human body. There is growing evidence that CoQ10 is tightly linked to cardiometabolic disorders. Its supplementation can be useful in a variety of chronic and acute disorders. This review analyses the role of CoQ10 in hypertension, ischemic heart disease, myocardial infarction, heart failure, viral myocarditis, cardiomyopathies, cardiac toxicity, dyslipidemia, obesity, type 2 diabetes mellitus, metabolic syndrome, cardiac procedures and resuscitation...
April 15, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29649786/nanoemulsions-and-topical-creams-for-the-safe-and-effective-delivery-of-lipophilic-antioxidant-coenzyme-q10
#14
M Kaci, A Belhaffef, S Meziane, G Dostert, P Menu, É Velot, S Desobry, E Arab-Tehrany
Emulsion-based delivery systems have been developed to increase the topical bioavailability of lipophilic active compounds within skin membrane. The aim was to develop nanoemulsion from natural sources (rapeseed oil) with the same sources of pure phospholipids (lecithin) rich on mono and polyunsaturated fatty acids for encapsulation of hydrophobic antioxidant (Coenzyme Q10 ) giving nanoemulsion with double functionality. Nanoemulsions were used for cream preparation using xanthan gum and carboxylmethylcellulose as texturizing agents...
April 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29623830/the-effects-of-coenzyme-q10-supplementation-on-lipid-profiles-among-patients-with-metabolic-diseases-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#15
Nasrin Sharifi, Reza Tabrizi, Mahmood Moosazadeh, Naghmeh Mirhosseini, Kamran B Lankarani, Maryam Akbari, Maryam Chamani, Fariba Kolahdooz, Zatollah Asemi
BACKGROUND AND OBJECTIVE: Oxidative stress and inflammation are key parameters in developing metabolic disorders. Hence, antioxidant intake might be an appropriate approach. Several studies have evaluated the effect of coenzyme Q10 (CoQ10) supplementation on lipid profile among patients with metabolic diseases, though findings are controversial. The aim of this systematic review and meta-analysis was to determine the effects of CoQ10 supplementation on lipid profile in patients with metabolic disorders...
April 5, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29619575/the-evidence-for-the-role-of-nutraceuticals-in-the-management-of-pediatric-migraine-a-review
#16
REVIEW
Serena L Orr
PURPOSE OF REVIEW: Nutraceuticals are a form of complementary and alternative medicine that is commonly used by children and adolescents with migraine. In this review, observational studies, randomized controlled trials, systematic reviews, and meta-analyses on the efficacy and safety of single compound nutraceuticals for the management of migraine in children and adolescents were identified through a literature search of MEDLINE, Embase, and EBM Reviews-Cochrane Central Register of Controlled Trials...
April 4, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29610157/clinical-benefit-of-nmda-receptor-antagonists-in-a-patient-with-atp1a2-gene-mutation
#17
Keisuke Ueda, Fatema Serajee, Ahm M Huq
Mutations in the ATP1A2 gene cause familial hemiplegic migraine type 2, alternating hemiplegia of childhood, and cerebellar function deficits, epilepsy, and mental retardation. These symptoms are likely related to glutamatergic hyperexcitability. Our patient is a 12-year-old boy with a history of complex partial seizures, attention-deficit/hyperactivity disorder, and fine motor difficulty. During early childhood, he had episodes of a self-resolving right-sided hemiparesis and focal epilepsy. His seizures did not respond to several antiepileptic medications but stopped after he received valproate...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29606104/study-protocol-randomized-controlled-trial-reducing-symptom-burden-in-patients-with-heart-failure-with-preserved-ejection-fraction-using-ubiquinol-and-or-d-ribose
#18
Janet D Pierce, Diane E Mahoney, John B Hiebert, Amanda R Thimmesch, Francisco J Diaz, Carol Smith, Qiuhua Shen, Dinesh Pal Mudaranthakam, Richard L Clancy
BACKGROUND: Heart failure (HF), the leading cause of morbidity and mortality in the US, affects 6.6 million adults with an estimated additional 3 million people by 2030. More than 50% of HF patients have heart failure with preserved left ventricular ejection fraction (HFpEF). These patients have impaired cardiac muscle relaxation and diastolic filling, which investigators have associated with cellular energetic impairment. Patients with HFpEF experience symptoms of: (1) fatigue; (2) shortness of breath; and (3) swelling (edema) of the lower extremities...
April 2, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29605683/development-and-validation-of-a-rp-hplc-method-for-the-simultaneous-detection-and-quantification-of-simvastatin-s-isoforms-and-coenzyme-q10-in-lecithin-chitosan-nanoparticles
#19
Adryana Clementino, Fabio Sonvico
Hybrid nanocapsules constituted of phospholipids and polysaccharides have been proposed as colloidal systems for the delivery of drugs via non-parenteral administration routes, due their capacity of high drug loading, controlled drug release and targeted delivery to the specific organ. Moreover, nanoparticles systems offer the possibility of co-encapsulation of drugs in the same drug delivery system and, consequently, the simultaneous administration of compounds. Characterization of nanoparticles properties, specifically involves quantification of the active pharmaceutical ingredients and is pivotal in the development of innovative nanomedicines...
March 23, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29589596/coq10-loaded-liposomes-combined-with-utmd-prevented-early-nephropathy-of-diabetic-rats
#20
Pian-Pian Chen, He-Lin Xu, Ting-Yue, De-Li ZhuGe, Bing-Hui Jin, Qun-Yan Zhu, Bi-Xin Shen, Li-Fen Wang, Cui-Tao Lu, Ying-Zheng Zhao, Xiao-Kun Li
Nephropathy is one of the most severe complications of diabetic patients. The therapeutic strategies for diabetic patients should not only focus on the control of blood glucose but also pay attention to the occurrence of diabetic nephropathy (DN). Coenzyme Q10 (CoQ10) has great therapeutic potential for DN. However, the clinical application of CoQ10 has been limited because of its low water-solubility and non-specific distribution. Liposomes were supposed to be an effective way for delivering CoQ10 to kidney...
February 20, 2018: Oncotarget
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