keyword
MENU ▼
Read by QxMD icon Read
search

Coenzyme Q10

keyword
https://www.readbyqxmd.com/read/29330704/the-effects-of-coenzyme-q10-supplementation-on-blood-pressures-among-patients-with-metabolic-diseases-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#1
Reza Tabrizi, Maryam Akbari, Nasrin Sharifi, Kamran B Lankarani, Mahmood Moosazadeh, Fariba Kolahdooz, Mohsen Taghizadeh, Zatollah Asemi
INTRODUCTION: Although several trials have assessed the effect of coenzyme Q10 (CoQ10) supplementation on blood pressures among patients with metabolic diseases, findings are controversial. AIM: This review of randomized controlled trials (RCTs) was performed to summarize the evidence on the effects of CoQ10 supplementation on blood pressures among patients with metabolic diseases. METHODS: Randomized-controlled trials (RCTs) published in PubMed, EMBASE, Web of Science and Cochrane Library databases up to 10 August 2017 were searched...
January 12, 2018: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/29329705/low-cost-and-disposable-sensors-for-the-simultaneous-determination-of-coenzyme-q10-and-%C3%AE-lipoic-acid-using-manganese-iv-oxide-modified-screen-printed-graphene-electrodes
#2
Kanokwan Charoenkitamorn, Sudkate Chaiyo, Orawon Chailapakul, Weena Siangproh
In this work, for the first time, manganese (IV) oxide-modified screen-printed graphene electrodes (MnO2/SPGEs) were developed for the simultaneous electrochemical detection of coenzyme Q10 (CoQ10) and α-lipoic acid (ALA). This sensor exhibits attractive benefits such as simplicity, low production costs, and disposability. Cyclic voltammetry (CV) was used to characterize the electrochemical behavior of the analyte and investigate the capacitance and electroactive surface area of the unmodified and modified electrode surfaces...
April 3, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29323033/coenzyme-q10-as-a-therapeutic-candidate-for-treating-inherited-photoreceptor-degeneration
#3
Xun Zhang, Lincoln Biswas, Ali Mohammad Tohari, James Reilly, Luca Tiano, Xinhua Shu
No abstract text is available yet for this article.
December 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29303137/comparison-of-icodextrin-with-thymoquinone-a-new-hope-for-postoperative-adhesions
#4
Ö Yilmaz, R Kiziltan, S Çelik, S Yildirm, H H Alp, A Aras, Ç Kotan
OBJECTIVE: The purpose of this study was to compare the effects of thymoquinone and icodextrin in rats within the framework of an experimental adhesion model. MATERIALS AND METHODS: Rats were separated into three groups: (1) a control group consisting of rats that had 2 ml of isotonic solution administered intraperitoneally, (2) an ICO group administered with 2 ml of 4% icodextrin, and (3) a TQ group administered thymoquinone (10 mg/kg), all following cecal abrasion...
November 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29298622/oral-coenzyme-q10-supplementation-in-patients-with-migraine-effects-on-clinical-features-and-inflammatory-markers
#5
Monireh Dahri, Ali Tarighat-Esfanjani, Mohammad Asghari-Jafarabadi, Mazyar Hashemilar
BACKGROUNDS AND AIMS: Migraine and inflammation are correlated. Coenzyme Q10 (CoQ10) as an anti-inflammatory agent has shown useful effects in other diseases. The present study aimed to assess the effect of CoQ10 supplementation on inflammation and clinical features of migraine. METHODS: This randomized double-blind placebo-controlled clinical trial was conducted among 45 non-menopausal women aged 18-50 years, diagnosed for episodic migraine according to the International Headache Society...
January 3, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29291430/the-potential-benefit-of-combined-versus-monotherapy-of-coenzyme-q10-and-fluoxetine-on-depressive-like-behaviors-and-intermediates-coupled-to-gsk-3%C3%AE-in-rats
#6
Sally A Abuelezz, Nevien Hendawy, Yosra Magdy
As a part of the serotoninergic dysfunction implicated in neurobiology of depression, evidence has focused on serotonin (5-HT) receptors downstream signaling intermediates including glycogen synthase kinase-3β (GSK-3β), cAMP response element binding protein (CREB) and brain derived neurotrophic factor (BDNF). Our team previously reported that coenzyme Q10 (CoQ10) exerted antidepressant-like effect in rats exposed to chronic unpredictable mid stress (CUMS) via elevating serotonin levels. However, the effect of CoQ10 has not been elucidated in downstream signaling molecules mediating 5HT receptors' effect involved in depressive disorder hitherto...
December 29, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29289598/why-should-neuroscientists-worry-about-iron-the-emerging-role-of-ferroptosis-in-the-pathophysiology-of-neuroprogressive-diseases
#7
REVIEW
Gerwyn Morris, Michael Berk, André F Carvalho, Michael Maes, Adam J Walker, Basant K Puri
Ferroptosis is a unique form of programmed death, characterised by cytosolic accumulation of iron, lipid hydroperoxides and their metabolites, and effected by the fatal peroxidation of polyunsaturated fatty acids in the plasma membrane. It is a major driver of cell death in neurodegenerative neurological diseases. Moreover, cascades underpinning ferroptosis could be active drivers of neuropathology in major psychiatric disorders. Oxidative and nitrosative stress can adversely affect mechanisms and proteins governing cellular iron homeostasis, such as the iron regulatory protein/iron response element system, and can ultimately be a source of abnormally high levels of iron and a source of lethal levels of lipid membrane peroxidation...
December 28, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29288336/cytotoxicity-of-propofol-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#8
Koji Kido, Hiroyuki Ito, Yudai Yamamoto, Koshi Makita, Tokujiro Uchida
PURPOSE: Propofol infusion syndrome (PRIS) is a lethal condition caused by propofol overdose. Previous studies suggest that pathophysiological mechanisms underlying PRIS involve mitochondrial dysfunction; however, these mechanisms have not been fully elucidated. This study aimed to establish an experimental model of propofol-induced cytotoxicity using cultured human induced pluripotent stem cell (iPSC)-derived cardiomyocytes to determine the mechanisms behind propofol-induced mitochondrial dysfunction, and to evaluate the protective effects of coenzyme Q10 (CoQ10)...
December 29, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/29285660/effect-of-blood-phenylalanine-levels-on-oxidative-stress-in-classical-phenylketonuric-patients
#9
Burcu Kumru, Davut Sinan Kaplan, Burcu Oztürk Hismi, Hakim Celik
Mental retardation, which occurs in phenylketonuric patients, is associated with increased levels of phenylalanine, increased oxidative stress, and an imbalance of amino acids in the brain. Recent studies have shown that oxidative stress plays a role in the pathogenesis of phenylketonuria. In this work, we aimed to compare the influence of blood phenylalanine levels on oxidative stress parameters in phenylketonuric patients who divided patients into groups according to blood Phe levels during follow-up visits and compared these groups with healthy controls...
December 28, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29274518/one-step-treatment-and-resource-recovery-of-high-concentration-non-toxic-organic-wastewater-by-photosynthetic-bacteria
#10
Fan Meng, Anqi Yang, Hangyao Wang, Guangming Zhang, Xuemei Li, Yi Zhang, Zhiguo Zou
In order to achieve simple pollutant removal and simultaneous resource recovery in high-COD-non-toxic wastewater treatment, a one-step photosynthetic bacteria (PSB) method was established using batch study experiment. The effluent COD met the national discharge standard, and biomass with rich protein and high-value substances was efficiently produced. It eliminated the demand of post-treatment for conventional PSB treatment. Results showed that Rhodopseudomonas effectively treated brewery wastewater and achieved biomass proliferation...
December 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29258174/co-enzyme-q10-and-n-3-polyunsaturated-fatty-acid-supplementation-reverse-intermittent-hypoxia-induced-growth-restriction-and-improved-antioxidant-profiles-in-neonatal-rats
#11
Kay D Beharry, Charles L Cai, Michael M Henry, Sara Chowdhury, Gloria B Valencia, Jacob V Aranda
Neonatal intermittent hypoxia (IH) increases the risk for many morbidities in extremely low birth weight/gestational age (ELBW/ELGA) neonates with compromised antioxidant systems and poor growth. We hypothesized that supplementation with coenzyme Q10 (CoQ10, ubiquinol) or n-3 polyunsaturated fatty acids (PUFAs) during neonatal IH improves antioxidant profiles and somatic growth in neonatal rats. Newborn rats were exposed to two IH paradigms at birth (P0): (1) 50% O₂ with brief hypoxic episodes (12% O₂); or (2) room air (RA) with brief hypoxia, until P14 during which they received daily oral CoQ10 in olive oil, n-3 PUFAs in fish oil, or olive oil only from P0 to P14...
December 16, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29246431/bypassing-human-coq10-deficiency
#12
Diran Herebian, Luis C López, Felix Distelmaier
Primary disorders of the human coenzyme Q10 (CoQ10) biosynthesis pathway are a known cause of severe pediatric diseases. So far, oral administration of CoQ10 is the only treatment strategy for affected individuals. However, the real benefit of CoQ10 supplementation remains questionable and clinical studies regarding efficiency are lacking. Here we provide an outlook on novel treatment approaches using CoQ precursor compounds. These metabolic bypass strategies might be a promising alternative for oral CoQ10 supplementation regimens...
December 9, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29239815/provider-recommendations-for-patient-reported-muscle-symptoms-on-statin-therapy-insights-from-the-understanding-statin-use-in-america-and-gaps-in-patient-education-survey
#13
Terry A Jacobson, Abdullah Khan, Kevin C Maki, Eliot A Brinton, Jerome D Cohen
BACKGROUND: Statin-associated muscle symptoms are reported by 10% to 29% of patients in clinical practice and are a major determinant of statin nonadherence, discontinuation, and switching. Little is known about what advice patients receive from their providers when dealing with these symptoms. OBJECTIVE: The objective of the study was to assess patient's reports of provider advice when experiencing new or worsened muscle symptoms while taking a statin. METHODS: Data were analyzed from the Understanding Statin Use in America and Gaps in Education survey, a self-administered internet-based survey of 10,138 adults with a reported history of high cholesterol and statin use...
October 12, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29228766/the-effects-of-addition-of-coenzyme-q10-to-metformin-on-sirolimus-induced-diabetes-mellitus
#14
In O Sun, Long Jin, Jian Jin, Sun Woo Lim, Byung Ha Chung, Chul Woo Yang
Background/Aims: This study was performed to determine whether adding coenzyme Q10 (CoQ10) to metformin (MET) has a beneficial effect as a treatment for sirolimus (SRL)-induced diabetes mellitus (DM). Methods: DM was induced in rats by daily treatment with SRL (0.3 mg/kg, subcutaneous) for 28 days, and animals were treated with CoQ10 (20 mg/kg, oral) and MET (250 mg/kg, oral) alone or in combination for the latter 14 days of SRL treatment. The effects of CoQ10 and MET on SRL-induced DM were assessed with the intraperitoneal glucose tolerance test (IPGTT) and by determining plasma insulin concentration and the homeostatic model assessment of insulin resistance (HOMA-R) index...
December 13, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29226435/high-capacity-and-high-rate-discharging-of-a-coenzyme-q10-catalyzed-li-o2-battery
#15
Yantao Zhang, Liang Wang, Xiaozheng Zhang, Limin Guo, Ying Wang, Zhangquan Peng
Discharging of the aprotic Li-O2 battery relies on O2 reduction to insulating solid Li2 O2 , which can either deposit as thin films on the cathode surface or precipitate as large particles in the electrolyte solution. Toward realizing Li-O2 batteries with high capacity and high rate capability, it is crucially important to discharge Li2 O2 in the electrolyte solution rather than on the cathode surface. Here, a soluble electrocatalyst of coenzyme Q10 (CoQ10 ) that can efficaciously drive solution phase formation of Li2 O2 in current benchmark ether-based Li-O2 batteries is reported, which would otherwise lead to Li2 O2 surface-film growth and premature cell death...
December 11, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29220105/less-fibrosis-in-elderly-subjects-supplemented-with-selenium-and-coenzyme-q10-a-mechanism-behind-reduced-cardiovascular-mortality
#16
Urban Alehagen, Jan Aaseth, Jan Alexander, Erland Svensson, Peter Johansson, Anders Larsson
BACKGROUND: In an intervention study where 221 healthy elderly persons received selenium and coenzyme Q10 as a dietary supplement, and 222 received placebo for 4 years we observed improved cardiac function and reduced cardiovascular mortality. As fibrosis is central in the aging process, we investigated the effect of the intervention on biomarkers of fibrogenic activity in a subanalysis of this intervention study. MATERIAL AND METHODS: In the present subanalysis 122 actively treated individuals and 101 controls, the effect of the treatment on eight biomarkers of fibrogenic activity were assessed...
December 8, 2017: BioFactors
https://www.readbyqxmd.com/read/29204172/protective-effects-of-coenzyme-q10-and-l-carnitine-against-statin-induced-pancreatic-mitochondrial-toxicity-in-rats
#17
Melina Sadighara, Jalal Pourahamad Joktaji, Valiollah Hajhashemi, Mohsen Minaiyan
Statins are widely used in patients with hyperlipidemia and whom with high risk of cardiovascular diseases. Unfortunately, statins also exert some adverse effects on the liver and pancreas and enhance the risk of type 2 diabetes mellitus. The objective of the present research was to investigate the protective effects of coenzyme Q10 (Co-Q10) and L-carnitine (LC) on statins induced toxicity on pancreatic mitochondria in vivo. Seven groups of male Wistar rats received atorvastatin (20 mg/kg, p.o.), atorvastatin + Co-Q10 (10 mg/kg, i...
December 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29201667/the-effects-of-adjuvant-therapies-on-embryo-transfer-success
#18
Rachael Shirlow, Martin Healey, Michelle Volovsky, Vivien MacLachlan, Beverley Vollenhoven
Background: Many adjuvant therapies are employed during IVF treatment in an attempt to improve outcomes. The objective of our study was to evaluate the impact of thirteen adjuvants (Intralipid, steroids, melatonin, coenzyme Q10, Filgrastim, testosterone, DHEA, growth hormone, antibiotics, hCG infusion, aspirin, enoxaparin/heparin and dopamine agonists) on the success of embryo transfers. Methods: This is a retrospective cohort study of all embryo transfers between January 2010 and April 2015 from a multi-site IVF clinic...
October 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/29199241/packaging-of-the-coenzyme-q10-into-a-liposome-for-mitochondrial-delivery-and-the-intracellular-observation-in-patient-derived-mitochondrial-disease-cells
#19
Yuma Yamada, Laila Burger, Eriko Kawamura, Hideyoshi Harashima
While Coenzyme Q10 (CoQ10) is thought to be effective for the treatment of a variety of diseases, it limits its cellular uptake. Because of the hydrophobic nature of CoQ10, it is reasonable to assume that it could be encapsulated within a liposomal carrier. Several reports regarding the packaging of CoQ10 in liposomes have appeared, but detailed investigations of the preparation of CoQ10 encapsulated liposomes have not been reported. As a result, information regarding the optimal method of packaging CoQ10 in liposomes is not available...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29190916/coenzyme-q10-inhibits-the-activation-of-pancreatic-stellate-cells-through-pi3k-akt-mtor-signaling-pathway
#20
Ran Xue, Jing Yang, Jing Wu, Qinghua Meng, Jianyu Hao
Aim: Pancreatic stellate cells (PSCs) have a vital role in pancreatic fibrosis accompanied by pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). Any agents which can affect the activation of PSCs could become potential candidates for treatment strategies in PDAC and CP. Our aim was to explore the effect of Coenzyme Q10 (CoQ10) in the process of PSCs activation. Methods: Isolated PSCs from C57BL/6 mice were treated with various dosages of CoQ10 (1, 10, and 100μM) and different time (24h, 48h, and 72 h)...
November 3, 2017: Oncotarget
keyword
keyword
25118
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"